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Articular Cartilage Restoration in the PCL-Injured Knee

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Posterior Cruciate Ligament Injuries

Abstract

Posterior cruciate ligament (PCL) injuries represent a heterogeneous patient population, and many of these patients have concomitant ligamentous, meniscal, chondral, or osteochondral lesions. PCL insufficiency, especially in the multiligament setting, has known detrimental effects on joint mechanics of the knee, and the development of progressive degenerative changes is often ubiquitous with time. Many incidental or even acute traumatic chondral lesions will remain asymptomatic for a period of time without any treatment. Others may be quite debilitating and progress with time. The natural history of most acute chondral injuries is poorly understood, and it is often unknown if and to what degree treatment will alter this course, especially in a joint with abnormal kinematics. With limited evidence that procedures addressing the articular damage will necessarily alter the overall natural history of the joint, it is important to evaluate the lesion, joint, and patient characteristics to determine optimal treatment. Inherent to the discussion of articular cartilage surgery is the reality that optimal treatment is often unknown and controversial; thus, individual surgeon preferences and personal algorithms often play a significant role in treatment. The goal of the articular cartilage surgeon is to address symptomatic lesions in order to improve pain and function, with the hope of delaying the need for future arthroplasty procedures. Acute and secondary treatment algorithms for articular cartilage restoration in the PCL-deficient knee are presented in this chapter in an effort to assist those who treat this challenging patient group. Unfortunately, most who sustain major PCL and multiligamentous-knee injury with concomitant meniscus and articular cartilage injury will eventually go on to develop advanced posttraumatic degenerative arthritis.

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References

  1. Fanelli GC, Edson CJ. Posterior cruciate ligament injuries in trauma patients: part II. Arthroscopy. 1995 Oct;11(5):526–9.

    CAS  PubMed  Google Scholar 

  2. Casteleyn PP, Handelberg F, Opdecam P. Traumatic haemarthrosis of the knee. J Bone Joint Surg Br. 1988 May;70(3):404–6.

    CAS  PubMed  Google Scholar 

  3. Werner BC, Gwathmey FW Jr, Higgins ST, Hart JM, Miller MD. Ultra-low velocity knee dislocations: patient characteristics, complications, and outcomes. Am J Sports Med. 2014 Feb;42(2):358–63.

    PubMed  Google Scholar 

  4. Hirschman M, Iranpour F, Muller W, Friederich N. Surgical treatment of complex bicruciate knee ligament injuries in athletes; what long-term outcome can we expect? Am J Sports Med. 2010;Jun;38(6):1103–9.

    Google Scholar 

  5. Fanelli GC, Orcutt DR, Edson CJ. The multiple-ligament injured knee: evaluation, treatment and results. Arthroscopy. 2005;Apr;21(4):471–86.

    Google Scholar 

  6. Fanelli GC. A practical guide to management. The multiple ligament injured knee. New York: Springer; 2004.

    Google Scholar 

  7. Fanelli GC, Edson CJ. Arthroscopically assisted ACL/PCL reconstruction: 2–10 year follow-up. Arthroscopy. 2002;18(7):703–14.

    PubMed  Google Scholar 

  8. Cole BJ, Harner CD. The multiple ligament injured knee. Clin Sports Med. 1999;18:241–62.

    CAS  PubMed  Google Scholar 

  9. Sisto DJ, Warren RF. Complete knee dislocation; a follow-up study of operative treatment. Clin Orthop. 1985;198:94–101.

    PubMed  Google Scholar 

  10. Ibrahim SA, Ahmad FH, Salah M, et al. Surgical management of traumatic knee dislocation. Arthroscopy. 2008;24(2):178–87.

    PubMed  Google Scholar 

  11. Chhabra A, Cha PS, Rihn JA, et al. Surgical management of knee dislocations. Surgical technique. J Bone Joint Surg Am. 2005;87(Suppl. 1):1–21.

    PubMed  Google Scholar 

  12. Fowler PJ, Messieh SS. Isolated posterior cruciate ligament injuries in athletes. Am J Sports Med 1987;15:553–7.

    CAS  PubMed  Google Scholar 

  13. Geissler WB, Whipple TL. Intraarticular abnormalities in association with posterior cruciate ligament injuries. Am Sports Med 1993;21:846–9.

    CAS  Google Scholar 

  14. Hamada M, Shino K, Mitsuoka T, Toritsuka Y, Natsu-Ume T, Horibe S. Chondral injury associated with acute isolated posterior cruciate ligament injury. Arthroscopy. 2000 Jan–Feb;16(1):59–63

    CAS  PubMed  Google Scholar 

  15. Kaeding CC, Pderoza AD, Parker RD, et al. Intra-articular findings in the reconstructed multiligament-injured knee. Arthroscopy. 2005;21(4):424–30.

    PubMed  Google Scholar 

  16. Granan LP, Bahr R, Lie SA, et al. Timing of anterior cruciate ligament reconstructive surgery and risk of cartilage lesions and meniscal tears: a cohort study based on the Norwegian national knee ligament registry. Am J Sports Med. 2009;37(5):955–61.

    PubMed  Google Scholar 

  17. Slauterbeck JR, Kousa P, Clifton BC, et al. Geographic mapping of meniscus and cartilage lesions associated with anterior cruciate ligament injuries. J Bone Joint Surg Am. 2009;91(9):2094–103.

    PubMed  Google Scholar 

  18. Corten K, Bellemans J. Cartilage damage determines intermediate outcome in the late multiple ligament and posterolateral cornerreconstructed knee: a 5- to 10-year follow-up study. Am J Sports Med. 2008;36(2):267–75.

    PubMed  Google Scholar 

  19. Goyal K, Tashman S, Wang JH, Li K, Zhang X, Harner C. In vivo analysis of the isolated posterior cruciate ligament-deficient knee during functional activities. Am J Sports Med. 2012 Apr;40(4):777–85.

    PubMed  Google Scholar 

  20. MacDonald P, Miniaci A, Fowler P, Marks P, Finlay B. A biomechanical analysis of joint contact forces in the posterior cruciate deficient knee. Knee Surg Sports Traumatol Arthrosc 1996;3:252–5.

    CAS  PubMed  Google Scholar 

  21. Skyhar MJ, Warren RF, Ortiz GJ, Schwartz E, Otis JC. The effects of sectioning of the posterior cruciate ligament and the posterolateral complex on the articular contact pressures within the knee. J Bone Joint Surg Am. 1993 May;75(5):694–9.

    CAS  PubMed  Google Scholar 

  22. Van de Velde SK, Bingham JT, Gill TJ, Li G. Analysis of tibiofemoral cartilage deformation in the posterior cruciate ligament-deficient knee. J Bone Joint Surg Am. 2009 Jan;91(1):167–75.

    Google Scholar 

  23. Strobel MJ, Weiler A, Schulz MS, Russe K, Eichhorn HJ. Arthroscopic evaluation of articular cartilage lesions in posterior-cruciate-ligament-deficient knees. Arthroscopy. 2003 Mar;19(3):262–8.

    PubMed  Google Scholar 

  24. Shelbourne KD, Gray JS. Outcome of untreated traumatic articular cartilage defects of the knee: a natural history study. J Bone Joint Surg Am. 2003;85-A(Suppl. 2):8–16.

    PubMed  Google Scholar 

  25. Bowers AL, Spindler KP, McCarty EC, et al. Height, weight, and BMI predict intra-articular injuries observed during ACL reconstruction: evaluation of 456 cases from a prospective ACL database. Clin J Sports Med. 2005;15(1):9–13.

    Google Scholar 

  26. Hart JM, Blanchard BF, Hart JA, et al. Multiple ligament reconstruction clinical follow-up and gait analysis. Knee Surg Sports Traumatol Arthrosc. 2009;17(3):277–85.

    PubMed  Google Scholar 

  27. Nelson F, Billinghurst RC, Pidoux I, et al. Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament. Osteoarthr Cartil. 2006;14(2):114–9.

    CAS  PubMed  Google Scholar 

  28. Safran MR, Seiber K. The evidence for surgical repair of articular cartilage in the knee. J Am Acad Orthop Surg. 2010;18(5):259–66.

    PubMed  Google Scholar 

  29. Osti L, Papalia R, DelBuono A, et al. Good results five years after surgical management of anterior cruciate ligament tears, and meniscal and cartilage injuries. Knee Surg Sports Traumatol Arthrosc. 2010;18(10):1385–90.

    PubMed  Google Scholar 

  30. Magnussen RA, Mansour AA, Carey JL, Spindler KP. Meniscus status at anterior cruciate ligament reconstruction associated with radiographic signs of osteoarthritis at 5- to 10-year follow-up: a systemic review. J Knee Surg. 2009;22(4):347–57.

    PubMed Central  PubMed  Google Scholar 

  31. Bonner KF, Noel C. Articular cartilage restoration. In: Fanelli G, editor. The multiple ligament injured knee, a practical guide to management. 2nd ed. Philadelphia: Springer; 2013 (Chapter 28).

    Google Scholar 

  32. Clancy WG Jr, Shelbourne KD, Zoellner GB, Keene JS, Reider B, Rosenberg TD. Treatment of knee joint instability secondary to rupture of the posterior cruciate ligament. Report of a new procedure. J Bone Joint Surg Am. 1983 Mar;65(3):310–22.

    PubMed  Google Scholar 

  33. Patel DV, Allen AA, Warren RF, Wickiewicz TL, Simonian PT. The nonoperative treatment of acute, isolated (partial or complete) posterior cruciate ligament-deficient knees: an intermediate-term follow-up study. HSS J. 2007 Sep;3(2):137–46.

    PubMed Central  PubMed  Google Scholar 

  34. Shino K, Horibe S, Nakata K, Maeda A, Hamada M, Nakamura N. Conservative treatment of isolated injuries to the posterior cruciate ligament in athletes. J Bone Joint Surg Br. 1995 Nov;77(6):895–900.

    CAS  PubMed  Google Scholar 

  35. Fanelli GC, Stannard JP, Stuart MJ, et al. Management of complex knee ligament injuries. J Bone Joint Surg. 2010;92A:2235–46.

    Google Scholar 

  36. Widuchowski W, Widuchowski J, Koczy B, et al. Untreated asymptomatic deep cartilage lesions associated with anterior cruciate ligament injury: results at 10- and 15-year follow-up. Am J Sports Med. 2009;37:688–92.

    PubMed  Google Scholar 

  37. Aron A, Loken S, Heir S, et al. Articular cartilage lesions in 993 consecutive knee arthroscopies. Am J Sports Med. 2004;32(1):211–5.

    Google Scholar 

  38. Hanypsiak BT, Spindler KP, Rothrock CR, et al. Twelve-year follow-up on anterior cruciate ligament reconstruction: long-term outcomes of prospectively studied osseous and articular injuries. Am J Sports Med. 2008;36(4):671–7.

    PubMed  Google Scholar 

  39. Brophy RH, Zeltser D, Wright RW, et al. Anterior cruciate ligament reconstruction and concomitant articular cartilage injury: incidence and treatment. Arthroscopy. 2010;26(1):112–20.

    PubMed  Google Scholar 

  40. Loken S, Heir S, Holme I, et al. 6-Year follow-up of 84 patients with cartilage defects in the knee. Knee scores improved but recovery was incomplete. Acta Orthop. 2010;81(5):611–8.

    PubMed Central  PubMed  Google Scholar 

  41. Gudas R, Gudaitė A, Mickevičius T, Masiulis N, Simonaitytė R, Cekanauskas E, Skurvydas A. Comparison of osteochondral autologous transplantation, microfracture, or debridement techniques in articular cartilage lesions associated with anterior cruciate ligament injury: a prospective study with a 3-year follow-up. Arthroscopy. 2013;29(1):89–97

    PubMed  Google Scholar 

  42. Gudas R, Kalesinskas RJ, Kimtys V, Stankevicius E, Toliusis V, Bernotavicius G, Smailys A. A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes. Arthroscopy. 2005 Sep;21(9):1066–75.

    PubMed  Google Scholar 

  43. Knutsen G, Drogset JO, Engebretsen L, Grøntvedt T, Isaksen V, Ludvigsen TC, Roberts S, Solheim E, Strand T, Johansen O. A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. J Bone Joint Surg Am. 2007 Oct;89(10):2105–12.

    PubMed  Google Scholar 

  44. Gobbi A, Karnatzikos G, Kumar A. Long-term results after microfracture treatment for full-thickness knee chondral lesions in athletes. Knee Surg Sports Traumatol Arthrosc. 2013 Sep 20;22:1986–8.

    Google Scholar 

  45. Goyal D, Keyhani S, Lee EH, Hui JH. Evidence-based status of microfracture technique: a systematic review of level I and II studies. Arthroscopy. 2013 Sep;29(9):1579–88.

    PubMed  Google Scholar 

  46. Bae DK, Song SJ, Yoon KH, Heo DB, Kim TJ. Survival analysis of microfracture in the osteoarthritic knee-minimum 10-year follow-up. Arthroscopy. 2013 Feb;29(2):244–50.

    PubMed  Google Scholar 

  47. Spahn G, Kahl E, Muckley T, et al. Arthroscopic knee chondroplasty using a bipolar radiofrequency-based device compared to mechanical shaver: results of a prospective, randomized, controlled study. Knee Surg Sports Traumatol Arthrosc. 2008;16(6):565–73.

    PubMed  Google Scholar 

  48. Bedi A, Feeley BT, Williams 3rd RJ. Management of articular cartilage defects of the knee. J Bone Joint Surg Am. 2010;92:994–1009.

    PubMed  Google Scholar 

  49. Williams 3rd RJ, Harnly HW. Microfracture: indications, technique, and results. Instr Course Lect. 2007;56:419–28.

    PubMed  Google Scholar 

  50. Mithoefer K, Williams RJ, Warren RF, et al. The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study. J Bone Joint Surg Am. 2005;87(9):1911–20.

    PubMed  Google Scholar 

  51. Brown WE, Potter HG, Marx RG, et al. Magnetic resonance imaging appearance of cartilage repair in the knee. Clin Orthop Relat Res. 2004;422:214–23.

    PubMed  Google Scholar 

  52. Ramappa AJ, Gill TJ, Bradford CH, et al. Magnetic resonance imaging to assess knee cartilage repair tissue after microfracture of chondral defects. J Knee Surg. 2007;20(3):228–34.

    PubMed  Google Scholar 

  53. Blackman AJ, Smith MV, Flanigan DC, Matava MJ, Wright RW, Brophy RH. Correlation between magnetic resonance imaging and clinical outcomes after cartilage repair surgery in the knee: a systematic review and meta-analysis. Am J Sports Med. 2013 Jun;41(6):1426–34.

    PubMed  Google Scholar 

  54. Kreuz PC, Steinwachs MR, Erggelet C, Krause SJ, Konrad G, Uhl M, Südkamp N. Results after microfracture of full-thickness chondral defects in different compartments in the knee. Osteoarthr Cartil. 2006 Nov;14(11):1119–25.

    CAS  PubMed  Google Scholar 

  55. Mithoefer K, McAdam T, Williams RJ, et al. Clinical efficacy of the microfracture technique for articular cartilage repair in the knee; an evidence-based systematic analysis. Am J Sports Med. 2009;37:2053–63.

    PubMed  Google Scholar 

  56. Steadman JR, Briggs KK, Rodrigo JJ, et al. Outcomes of microfracture for traumatic chondral lesions of the knee; average 11-year follow-up. Arthroscopy. 2003;19(5):477–84.

    PubMed  Google Scholar 

  57. Asik M, Ciftci F, Sen C, et al. The microfracture technique for the treatment of full-thickness articular cartilage lesions of the knee: midterm results. Arthroscopy. 2008;24:1214–20.

    PubMed  Google Scholar 

  58. Gobbi A, Nunag P, Malinowski K. Treatment of full thickness chondral lesions of the knee with microfracture in a group of athletes. Knee Surg Sports Traumatol Arthrosc. 2005;13(3):213–21.

    PubMed  Google Scholar 

  59. Mithoefer K, Williams RJ, Warren RF, et al. High-impact athletics after knee articular cartilage repair; a prospective evaluation of the microfracture technique. Am J Sports Med. 2006;34(9):1413–8.

    PubMed  Google Scholar 

  60. Minas T, Gomoll AH, Rosenberger R, et al. Increased failure rate of autologous chondrocyte implantation after previous treatment with marrow stimulation techniques. Am J Sports Med. 2009;37(5):902–8.

    PubMed  Google Scholar 

  61. Zaslav K, Cole B, Brewster R, et al. A prospective study of autologous chondrocyte implantation in patients with failed prior treatment for articular cartilage defect of the knee. Am J Sports Med. 2009;37:42–55.

    PubMed  Google Scholar 

  62. Minas T, Von Keudell A, Bryant T, Gomoll AH. The John Insall Award: a minimum 10-year outcome study of autologous chondrocyte implantation. Clin Orthop Relat Res. 2014 Jan;472(1):41–51.

    PubMed Central  PubMed  Google Scholar 

  63. Levin AS, Angel M, Sgaglione NA. Chapter 10, introduction to osteochondral autograft transplantation. In: Cole BJ, Gomoll AH, editors. Biologic joint reconstruction. Thorofare: Slack Inc; 2008. pp. 93–105.

    Google Scholar 

  64. Brown OL, Morgan CD, Leitman EH. Chapter 12, osteochondral autograft transfer. In: Cole BJ, Gomoll AH, editors. Biologic joint reconstruction.Thorofare: Slack Inc; 2008. pp. 119–27.

    Google Scholar 

  65. Marcacci M, Kon E, Delcogliano M, et al. Arthroscopic autologous osteochondral grafting for cartilage defects of the knee: prospective study results at a minimum 7-year follow-up. Am J Sports Med. 2007;35(12):2014–21.

    PubMed  Google Scholar 

  66. Hangody L, Kish G, Kárpáti Z, Udvarhelyi I, Szigeti I, Bély M. Mosaicplasty for the treatment of articular cartilage defects: application in clinical practice. Orthopedics. 1998 Jul;21(7):751–6.

    CAS  PubMed  Google Scholar 

  67. Hangody L, Vásárhelyi G, Hangody LR, Sükösd Z, Tibay G, Bartha L, Bodó G. Autologous osteochondral grafting—technique and long-term results. Injury. 2008 Apr;39(Suppl. 1):S32–9.

    PubMed  Google Scholar 

  68. Keennedy JG, Murawski CD. The treatment of osteochondral lesions of the talus with autologous osteochondral transplantation and bone marrow aspirate concentrate: surgical technique. Cartilage. 2011;2(4):327–36.

    Google Scholar 

  69. Gautier E, Kolker D, Jakob RP. Treatment of cartilage defects of the talus by autologous osteochondral grafts. J Bone Joint Surg Br. 2002 Mar;84(2):237–44.

    CAS  PubMed  Google Scholar 

  70. Gobbi A, Francisco RA, Lubowitz JH, Allegra F, Canata G. Osteochondral lesions of the talus: randomized controlled trial comparing chondroplasty, microfracture, and osteochondral autograft transplantation. Arthroscopy. 2006 Oct;22(10):1085–92.

    PubMed  Google Scholar 

  71. Assenmacher JA, Kelikian AS, Gottlob C, Kodros S. Arthroscopically assisted autologous osteochondral transplantation for osteochondral lesions of the talar dome: an MRI and clinical follow-up study. Foot Ankle Int. 2001 Jul;22(7):544–51.

    CAS  PubMed  Google Scholar 

  72. Kim YS, Park EH, Lee HJ, Koh YG, Lee JW. Clinical comparison of the osteochondral autograft transfer system and subchondral drilling in osteochondral defects of the first metatarsal head. Am J Sports Med. 2012 Aug;40(8):1824–33.

    PubMed  Google Scholar 

  73. Kim YS, Park EH, Kim YC, Koh YG, Lee JW. Factors associated with the clinical outcomes of the osteochondral autograft transfer system in osteochondral lesions of the talus: second-look arthroscopic evaluation. Am J Sports Med. 2012 Dec;40(12):2709–19.

    PubMed  Google Scholar 

  74. Valderrabano V, Leumann A, Rasch H, et al. Knee-to-ankle mosaicplasty for the treatment of osteochondral lesions of the ankle joint. Am J Sports Med. 2009;37(Suppl. 1):S105–11.

    Google Scholar 

  75. Reddy S, Pedowitz DI, Parekh SG, Sennett BJ, Okereke E. The morbidity associated with osteochondral harvest from asymptomatic knees for the treatment of osteochondral lesions of the talus. Am J Sports Med. 2007 Jan;35(1):80–5.

    PubMed  Google Scholar 

  76. Sgaglione NA, Florence AS. Bone graft substitute failure with giant cell reaction in the treatment of osteochondral lesions of the distal femur:a report of 2 cases with operative revision. Arthroscopy. 2009;25(7):815–9.

    PubMed  Google Scholar 

  77. Fowler 3rd DE, Hart JM, Hart JA, Miller MD. Donor-site giant cell reaction following backfill with synthetic bone material during osteochondral plug transfer. J Knee Surg. 2009;22(4):372–4.

    PubMed  Google Scholar 

  78. Bedi AF, Foo LF, Williams RJ III, Potter HG, The Cartilage Study Group. The maturation of synthetic scaffolds for osteochondral donor sites of the knee: an MRI and T2-mapping analysis. Cartilage. 2010;1(1):20–8.

    Google Scholar 

  79. Barber FA, Dockery WD. A computed tomography scan assessment of synthetic multiphase polymer scaffolds used for osteochondral defect repair. Arthroscopy. 2011;27(1):60–4.

    PubMed  Google Scholar 

  80. Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. New Engl J Med. 1994;331:889–95.

    CAS  PubMed  Google Scholar 

  81. Freedman KB, Fox JA, Cole BJ. Chaper 54 knee cartilage: diagnosis and decision making. In: Miller MD, Cole BJ, editors. Textbook of arthroscopy. Maryland Heights: Saunders-Elsevier; 2004. pp. 555–67.

    Google Scholar 

  82. Miller M, Cole BJ. Atlas of chondral injury treatment. Oper Tech Orthop. 2001;11:145–50.

    Google Scholar 

  83. Bekkers JE, Inklaar M, Saris DB. Treatment selection in articular cartilage lesions of the knee. Am J Sports Med. 2009;37(Suppl. 1):S148–55.

    Google Scholar 

  84. Kent R, Kurtz CA, Bonner KF. Meniscus transplantation. In Williams G, Ramsey M, editors. Operative techniques in orthopaedic surgery. Philadelphia: Lippincott Williams Wilkins; 2009.

    Google Scholar 

  85. Harris JD, Brophy RH, Siston RA, et al. Treatment of chondral defects in the athlete’s knee. Arthroscopy. 2010;26(6):841–52.

    PubMed  Google Scholar 

  86. Namdari S, Baldwin K, Anakwenze O, et al. Results and performance after microfracture in national basketball association athletes. Am J Sports Med. 2009;37(5):943–8.

    PubMed  Google Scholar 

  87. Gudas R, Gudaite A, Pocius A, Gudiene A, Cekanauskas E, Monastyreckiene E, Basevicius A. Ten-year follow-up of a prospective, randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint of athletes. Am J Sports Med. 2012 Nov;40(11):2499–508.

    PubMed  Google Scholar 

  88. Aubin PP, Cheah HK, Davis AM, Gross AE. Long-term follow up of fresh femoral osteochondral allografts for posttraumatic knee defects. Clin Orthop. 2001;391S:S318–27.

    Google Scholar 

  89. Bugbee WD. Seminars Arthroplasty. 2000;11:1–7.

    Google Scholar 

  90. Bugbee WD. Fresh osteochondral allografting. Op Tech Sports Med. 2000;8(2):158–62.

    Google Scholar 

  91. Garrett J, Wyman J. The operative technique of fresh osteochondral allografting of the knee. Op Tech Orthop. 2001;11(2):132–7.

    Google Scholar 

  92. Lattermann C, Romine SE. Osteochondral allografts: state of the art. Clin Sports Med. 2009;28(2):285–301.

    PubMed  Google Scholar 

  93. Branam BR, Johnson DL. Allografts in knee surgery. Orthopedics. 2007;30(11):925–9.

    PubMed  Google Scholar 

  94. Robinson S, Bonner KF. Osteochondral allograft transplantation chapter. In: Insall JN, Scott WN, editors. Surgery of the knee. 5th ed. Maryland Heights: Saunders-Elsevier (Due for publication 2012).

    Google Scholar 

  95. Bonner KF, Bugbee WD. Chaper 60 fresh osteochondral allografts in the knee. In: Miller MD, Cole BJ, editors. Textbook of arthroscopy. Maryland Heights: Saunders-Elsevier; 2004. pp. 611–24.

    Google Scholar 

  96. Stevenson S, Dannucci GA, Sharkey NA, Pool RR. The fate of articular cartilage after transplantation of fresh and cryopreserved tissue-antigen-matched and mismatched osteochondral allografts in dogs. J Bone Joint Surg Am. 1989;71:1297–307.

    CAS  PubMed  Google Scholar 

  97. Simon WH, Richardson S, Harman W, Parsons JR, Lane J. Long-term effects of chondrocyte death on rabbit cartilage in vivo. J Bone Joint Surg. 1976;58A:517–26.

    CAS  Google Scholar 

  98. Jackson DW, Halbrecht J, Proctor C, et al. Assessment of donor cell and matrix survival in fresh articular cartilage allografts in a goat model. J Orthop Res. 1996;14(2):255–64.

    CAS  PubMed  Google Scholar 

  99. LaPrade RF, Botker J, Herzog M, Agel J. Refrigerated osteoarticular allografts to treat articular cartilage defects of the femoral condyles. A prospective outcomes study. J Bone Joint Surg Am. 2009;91(4):805–11.

    PubMed  Google Scholar 

  100. Langer F, Czitrom A, Prizker KP, Gross AE. The immunogenicity of fresh and frozen allogeneic bone. J Bone Joint Surg Am. 1975;57:216–22.

    CAS  PubMed  Google Scholar 

  101. Langer F, Gross AE. Immunogenicity of allograft articular cartilage. J Bone Joint Surg Am. 1974;56:297–304.

    CAS  PubMed  Google Scholar 

  102. Langer F, Gross AE, West M, Urovitz EP. The immunogenicity of allograft knee joint transplants. Clin Orthop. 1978;132:155–62.

    PubMed  Google Scholar 

  103. Phipatanakul WP, VandeVord PJ, Teitge RA, Wooley PH. Immune response in patients receiving fresh osteochondral allografts. Am J Orthop. 2004;33(7):345–8.

    PubMed  Google Scholar 

  104. Bugbee WD, Convery FR. Osteochondral allograft transplantation. Clin Sports Med. 1999;18:67–75.

    CAS  PubMed  Google Scholar 

  105. Czitrom AA, Keating S, Gross AE. The viability of articular cartilage in fresh osteochondral allografts after clinical transplantation. J Bone Joint Surg Am. 1990;72:574–81.

    CAS  PubMed  Google Scholar 

  106. Stevenson S, Horowitz M. Current concepts review: the response to bone allografts. J Bone Joint Surg. 1992;74A:939–50.

    Google Scholar 

  107. Sirlin CB, Brossman J, Boutin RD, et al. Shell osteochondral allografts of the knee: comparison of MR imaging findings and immunological responses. Radiology. 2001;219(1):35–43.

    CAS  PubMed  Google Scholar 

  108. Burchardt H. The biology of bone graft repair. Clin Orthop Relat Res. 1983;174:28–42.

    PubMed  Google Scholar 

  109. Furukawa T, Eyre DR, Koide S, Glimcher MJ. Biochemical studies on repair cartilage resurfacing experimental defects in the rabbit knee. J Bone Joint Surg Am. 1980;62:79–89.

    CAS  PubMed  Google Scholar 

  110. McDermott AG, Langer F, Pritzker PH, Gross AE. Fresh small-fragment osteochondral allografts-long term follow-up study on first one hundred cases. Clin Orthop. 1985;197:96–102.

    PubMed  Google Scholar 

  111. Oakeshott RD, Farine I, Pritzker KP, et al. A clinical and histologic analysis of failed fresh osteochondral allografts. Clin Orthop.1988;233:283–94.

    PubMed  Google Scholar 

  112. Maury AC, Safir O, Heras FL, Pritzker KP, Gross AE. Twenty-five-year chondrocyte viability in fresh osteochondral allograft: a case report. J Bone Joint Surg Am. 2007;89(1):159–65.

    CAS  PubMed  Google Scholar 

  113. Williams SK, Amiel D, Ball ST, et al. Analysis of cartilage tissue on a cellular level in fresh osteochondral allografts retrievals. Am J Sports Med. 2007;35(12):2022–32.

    PubMed  Google Scholar 

  114. Gross AE, Kim W, Las Heras F, et al. Fresh osteochondral allograft for post-traumatic knee defects: long-term follow-up. Clin Orthop Relat Res. 2008;466(8):1863–70.

    PubMed Central  CAS  PubMed  Google Scholar 

  115. Fitzpatrick PL, Morgan DA. Fresh osteochondral allografts: a 6–10 year review. Aust NZJ Surg. 1998;68(8):573–9.

    CAS  Google Scholar 

  116. Jamali AA, Hatcher SL, You Z. Donor cell survival in a fresh osteochondral allograft at twenty-nine years. A case report. J Bone Joint Surg Am. 2007;89(1):166–9.

    PubMed  Google Scholar 

  117. Krych AJ, Harnly HW, Rodeo SA, Williams RJ 3rd. Activity levels are higher after osteochondral autograft transfer mosaicplasty than after microfracture for articular cartilage defects of the knee: a retrospective comparative study. J Bone Joint Surg Am. 2012 Jun 6;94(11):971–8.

    PubMed  Google Scholar 

  118. Shaha JS, Cook JB, Rowles DJ, Bottoni CR, Shaha SH, Tokish JM. Return to an athletic lifestyle after osteochondral allograft transplantation of the knee. Am J Sports Med. 2013 Sep;41(9):2083–9.

    PubMed  Google Scholar 

  119. Farr J. Autologous chondrocyte implantation improves patellofemoral cartilage treatment options. Clin Orthop. 2007;463:187–94.

    PubMed  Google Scholar 

  120. Mollon B, Kandel R, Chahal J, Theodoropoulos J. The clinical status of cartilage tissue regeneration in humans. Osteoarthritis Cartilage. 2013 Dec;21(12):1824–33.

    CAS  PubMed  Google Scholar 

  121. Vavken P, Samartzis D. Effectiveness of autologous chondrocyte implantation in cartilage repair of the knee: a systematic review of controlled trials. Osteoarthritis Cartilage. 2010 Jun;18(6):857–63.

    CAS  PubMed  Google Scholar 

  122. Moseley JB Jr, Anderson AF, Browne JE, Mandelbaum BR, Micheli LJ, Fu F, Erggelet C. Effectiveness of autologous chondrocyte implantation in cartilage repair of the knee: a systematic review of controlled trials. Am J Sports Med. 2010 Feb;38(2):238–46.

    PubMed  Google Scholar 

  123. Gomoll AH, Farr J, Gillogly SD, et al. Surgical management of articular cartilage defects of the knee. J Bone Joint Surg Am. 2010;92(14):2470–90.

    CAS  PubMed  Google Scholar 

  124. Knutsen G, Engebretsen L, Ludvigsen TC, et al. Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am. 2004;86-A(3):455–64.

    PubMed  Google Scholar 

  125. Saris DB, Vanlauwe J, Victor J, et al. Treatment of symptomatic cartilage defects of the knee; characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture. Am J Sports Med. 2009;37(Suppl. 1):S10–9.

    Google Scholar 

  126. Saris DB, Vanlauwe J, Victor J, et al. Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med. 2008;36(2):235–46.

    PubMed  Google Scholar 

  127. Niemeyer P, Porichis S, Steinwachs M, Erggelet C, Kreuz PC, Schmal H, Uhl M, Ghanem N, Südkamp NP, Salzmann G. Long-term outcomes after first-generation autologous chondrocyte implantation for cartilage defects of the knee. Am J Sports Med. 2014 Jan;42(1):150–7.

    PubMed  Google Scholar 

  128. Moradi B, Schönit E, Nierhoff C, Hagmann S, Oberle D, Gotterbarm T, Schmitt H, Zeifang F. First-generation autologous chondrocyte implantation in patients with cartilage defects of the knee: 7–14 years’ clinical and magnetic resonance imaging follow-up evaluation. Arthroscopy. 2012 Dec;28(12):1851–61.

    PubMed  Google Scholar 

  129. Mithoefer K, Hambly K, Della Villa S, et al. Return to sports participation after articular cartilage repair in the knee: scientific evidence. Am J Sports Med. 2009 Nov;37;(Suppl. 1):S167–76.

    Google Scholar 

  130. Negrin LL, Vécsei V. Do meta-analyses reveal time-dependent differences between the clinical outcomes achieved by microfracture and autologous chondrocyte implantation in the treatment of cartilage defects of the knee? J Orthop Sci. 2013 Nov;18(6):940–8.

    CAS  PubMed  Google Scholar 

  131. Vasiliadis HS, Wasiak J. Autologous chondrocyte implantation for full thickness articular cartilage defects of the knee. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD003323.

    Google Scholar 

  132. Harris JD, Erickson BJ, Abrams GD, Cvetanovich GL, McCormick FM, Gupta AK, Bach BR Jr, Cole BJ. Methodologic quality of knee articular cartilage studies. Arthroscopy. 2013 Jul;29(7):1243–52.

    PubMed  Google Scholar 

  133. Behery O, Siston RA, Harris JD, Flanigan DC. Treatment of cartilage defects of the knee: expanding on the existing algorithm. Clin J Sport Med. 2014 Jan;24(1):21–30.

    PubMed  Google Scholar 

  134. Van Den Bekerom M, Patt TW, Kleinhout MY, et al. Early complications after high tibial osteotomy: a comparison of two techniques. J Knee Surg. 2008;21(1):68–74.

    PubMed  Google Scholar 

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Correspondence to Kevin F. Bonner MD .

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Nelson, C., Bonner, K. (2015). Articular Cartilage Restoration in the PCL-Injured Knee. In: Fanelli, MD, G. (eds) Posterior Cruciate Ligament Injuries. Springer, Cham. https://doi.org/10.1007/978-3-319-12072-0_23

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