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Targeted Drug Delivery to the Mitochondria

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Targeted Drug Delivery : Concepts and Design

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Mitochondria are of an increasing interest in pharmaceutical and medical research since it has emerged as an intriguing target for treatment of many diseases with a great diversity of clinical appearance. The efficiency of drug action relies largely on how well it is able to reach its target or even its target inside the cell such as mitochondria. Subsequently, drug delivery to the specific intracellular organelle dramatically enhances drug action. Mitochondria play a major function in a range of cell processes and mitochondrial dysfunction contributes to several human diseases. Increasing interest in delivering large molecules such as nucleic acids, peptides, enzyme mimetics, drugs, and probes have led to the emergence of “Mitochondrial Medicine” as an entire pioneering field of biomedical exploration. Targeting of biologically active molecules to mitochondria in living cells open up ways for modifying mitochondrial functions, which may come with selective protection, repair or eradication of cells. Furthermore, nanoscience offers unique tools and materials to target therapeutic agents to mitochondria. This chapter deals with different aspects of mitochondrial drug delivery, current strategies of mitochondrial targeting and their possible therapeutic applications.

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Abbreviations

CPPs:

Cell penetrating peptides

CsA:

Cyclosporin A

CTAB:

Cetyltrimethylammonium bromide

DOPE:

Di-oleoylphosphatidylethanolamine

DOPE:

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

DOTAP:

Dioleoyl-1,2-diacyl-3-trimethylammoniumpropane

DOTMA:

2,3-Bis-(oleoyl)oxipropyl-trimethyl ammonium chloride

GSH:

Glutathione

Mce 6:

Photosensitizer mesochlorine 6

MEND:

Multifunctional envelope-type nano-device

MLS:

Mitochondrial targeting sequences

MPPs:

Mitochondria-penetrating peptides

mPTPCs:

Mitochondrial permeability transition pore complexes

MTS:

Mitochondrial targeting signal peptide

PAA:

Polyacrylic acid

PAMAM:

Poly(amidoamine) dendrimer

PLGA:

Poly-lactide-co-glycolide

PT:

Permeability transition

PTD:

Protein transduction domain

PTPC:

Permeability transition pore complex

SOD:

Super-oxide dismutase

SOPC:

1-Stearoyl-2-oleoylphosphatidylcholine

SOPS:

Stearoyl-oleoyl-phosphatidylserine

STPP:

Stearyl triphenyl phosphonium

TAT:

Trans-activating transcriptional activator

tBHP:

t-Butylhydroperoxide

TPP:

Triphenylphosphonium

TPP:

Triphenylphosphonium

VDAC:

Voltage dependent anion channel

ZnO:

Zinc oxide

ZnPc:

Zinc phthalocyanine

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Authors and Affiliations

  1. Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya, Sagar, 470003, MP, India

    Udita Agrawal, Rajeev Sharma & Suresh P. Vyas

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  1. Udita Agrawal
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  2. Rajeev Sharma
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  3. Suresh P. Vyas
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Correspondence to Suresh P. Vyas .

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Editors and Affiliations

  1. Institute of Chemical Technology, Department of Pharmaceutical Sciences and Technology, Mumbai, India

    Padma V. Devarajan

  2. National Institute of Pharmaceutical Education and Research (NIPER), Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, Mohali, Punjab, India

    Sanyog Jain

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Agrawal, U., Sharma, R., Vyas, S.P. (2015). Targeted Drug Delivery to the Mitochondria. In: Devarajan, P., Jain, S. (eds) Targeted Drug Delivery : Concepts and Design. Advances in Delivery Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-11355-5_7

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