Abstract
Lipid particulates as the name suggests are a breed of novel delivery systems consisting of lipids or lipid based excipients as its major components. Functionalized lipid particulates are designed preferably by incorporation of specific lipid based excipients which can confer targeting ability. The chapter focuses on functionalized lipid particulates like passively targeted liposomes via PEGylation; actively targeted liposomes functionalized via use of monoclonal antibodies, carbohydrates, charged lipids, or other type of targeting ligands; solid lipid nanoparticles and nanostructured lipid carriers functionalized with a targeting ligand; cationic emulsions and other functionalized lipid systems.
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Acknowledgments
Ankitkumar S. Jain is thankful to Amrut Mody Research Fund (AMRF), Mumbai, India and University Grants Commission (UGC), New Delhi, India for financial assistance. Sanket M. Shah is thankful to Indian Council of Medical Research (ICMR), New Delhi, India for financial assistance. We would also like to extend our acknowledgement to Mukul Ashtikar, Frank Steiniger, Jana Thamm, and Prof. Alfred Fahr from Friedrich Schiller University, Jena, Germany for expertise and support in investigating the vesicular structure of LeciPlex, as a part of Indian Council of Medical Research ICMR–Bundesministerium für Bildung und Forschung BMBF funded project.
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Nagarsenker, M.S., Jain, A.S., Shah, S.M. (2015). Functionalized Lipid Particulates in Targeted Drug Delivery. In: Devarajan, P., Jain, S. (eds) Targeted Drug Delivery : Concepts and Design. Advances in Delivery Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-11355-5_13
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