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Small G Proteins: Arf Family GTPases in Vesicular Transport

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Ras Superfamily Small G Proteins: Biology and Mechanisms 2

Abstract

Small GTP-binding proteins of the ADP-ribosylation factor (Arf) family are key components of trafficking vesicles. In the past three decades a number of vesicular carriers, whose formation depends on members of the Arf family were identified, and general molecular mechanisms how these transport carriers form and operate were established. Here we describe discovery and roles of the Arf-dependent carriers of the early secretory pathway, the COPI and COPII vesicles. We will discuss their function with regard to molecular mechanisms in coat recruitment, selection of cargo proteins, vesicle membrane budding/scission, and vesicle uncoating.

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Acknowledgements

The work lab of FTW was supported by the German Research Council SFB638 project A10 and A16. We would like to apologise to all colleagues whose work could not be cited due to space limitation.

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  1. Heidelberg University Biochemistry Center (BZH), University of Heidelberg, Im Neuenheimer Feld 328, 69120, Heidelberg, Germany

    Frank Adolf & Felix T. Wieland

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  1. Frank Adolf
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  2. Felix T. Wieland
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Correspondence to Felix T. Wieland .

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  1. Max-Planck-Institute of Molecular Physiology, Dortmund, Nordrhein-Westfalen, Germany

    Alfred Wittinghofer

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Adolf, F., Wieland, F.T. (2014). Small G Proteins: Arf Family GTPases in Vesicular Transport. In: Wittinghofer, A. (eds) Ras Superfamily Small G Proteins: Biology and Mechanisms 2. Springer, Cham. https://doi.org/10.1007/978-3-319-07761-1_9

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