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Number of Trocars, Types of Dissection, Exploration of Bile Duct, Drainage and Analgesia

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Laparoscopic Cholecystectomy

Abstract

Laparoscopic cholecystectomy is a gold standard, but at this time several aspects of technique are not homogeneous and there are many differences in terms of indications, instruments, technologies involved, surgical techniques employed. So we decide to examine specifically the literature about five main topics, trying to solve some concern existing about.

Standard laparoscopic cholecystectomy is mainly done by using four trocars. With increasing surgeon experience, laparoscopic cholecystectomy has undergone many refinements including reduction in port size and number. It has been argued that the fourth trocar may not be necessary, and laparoscopic cholecystectomy can be performed safely without using it.

The occlusion of the cystic duct is one of the main steps of laparoscopic cholecystectomy. Usually it has been done by metal clips, but it could be done by several methods (absorbable clips, clipless with ultrasonic dissector, with stapler and so on). Currently, monopolar electrosurgical energy is the most commonly used energy undertaken for dissection of the liver bed. However, its application is associated with numerous risks, such as biliary compilations and thermal injuries.

Intraoperative cholangiography (IOC) was performed for first time by Mirizzi in 1931 during open cholecystectomy in a female patient with gallbladder hydrops (Mirizzi, Comunicación en la Sociedad de Cirugía de Buenos Aires, 1932; Mirizzi, Surg Gynecol Obstet 65:702–710, 1937). Since then, IOC has been advocated to reduce the risk of biliary injuries and of retained stones in the common bile duct (CBD). Drains are used after laparoscopic cholecystectomy to prevent abdominal collections and to help the surgeon in the management of bleeding and biliary injuries. However, drain use may increase infective complications and delay discharge. The value of surgical drainage in laparoscopic cholecystectomy is an issue that is not resolved clearly.

Postoperative pain has been an important limiting factor for ambulatory LC. To date, the exact mechanism of pain has not been clarified. The use of intraperitoneal local anesthetics as the use of a local anesthetic applied to the port wounds provide some benefit in pain reduction but their results are controversial. The origin of pain after laparoscopic cholecystectomy is multifactorial with pain arising from the incision sites (somatic pain), from the gallbladder bed (visceral pain) and as a consequence of a pneumoperitoneurn.

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References

  1. Shaoliang S, Kehu Y, Mingtai G, Xiaodong H, Jinhui T, Bin M (2009) Three-port versus four-port laparoscopic cholecystectomy: meta-analysis of randomized clinical trials. World J Surg 33:1904–1908

    Article  Google Scholar 

  2. Trichak S (2003) Three-port vs standard four-port laparoscopic cholecystectomy. A prospective randomized study. Surg Endosc 17:1434–1436

    Article  CAS  PubMed  Google Scholar 

  3. Manoj K, Chandra SA, Rakesh KG (2007) Three-port versus standard four-port laparoscopic cholecystectomy: a randomized controlled clinical trial in a Community-Based Teaching Hospital in Eastern Nepal. JSLS 11:358–362

    Google Scholar 

  4. Celal C, Omer RT, Ibrahim B, Mahmut B (2007) Three-port versus four-port laparoscopic cholecystectomy. Hepatogastroenterology 54:15–16

    Google Scholar 

  5. Dhafir A, Nariman H, Abu BR, McMahon D, Dermot JH (2007) Three-port versus four-port laparoscopic cholecystectomy in acute and chronic cholecystitis. BMC Surg 7:8

    Article  Google Scholar 

  6. Yeh CN, Jan YY, Liu NJ, Yeh TS, Chen MF (2004) Endo-GIA for ligation of dilated cystic duct during laparoscopic cholecystectomy: an alternative, novel and easy method. J Laparoendosc Adv Surg Tech A 14:153–157

    Article  PubMed  Google Scholar 

  7. Eikermann M, Siegel R, Broeders I, Dziri C, Fingerhut A, Gutt C, Jaschinski T, Nassar A, Paganini AM, Pieper D, Targarona E, Schrewe M, Shamiyeh A, Strik M, Neugebauer EAM (2012) Prevention and treatment of bile duct injuries during laparoscopic cholecystectomy: the clinical practice guidelines of the European Association for Endoscopic Surgery (EAES). Surg Endosc 26:3003–3039

    Article  CAS  PubMed  Google Scholar 

  8. Liu Y, Ji B, Wang Y, Wang G (2012) Hem-o-lok clip found in common bile duct after laparoscopic cholecystectomy and common bile duct exploration: a clinical analysis of 8 cases. Int J Med Sci 9(3):225–227

    Article  PubMed Central  PubMed  Google Scholar 

  9. Rohatgi A, Widdison AL (2006) An audit of cystic duct closure in laparoscopic cholecystectomies. Surg Endosc 20:875–877

    Article  CAS  PubMed  Google Scholar 

  10. Yano H, Okada K, Kinuta M, Nakano Y, Tono T, Matsui S, Iwazawa T, Kanoh T, Monden T (2003) Efficacy of absorbable clips compared with metal clips for cystic duct ligation in laparoscopic cholecystectomy. Surg Today 33:18–23

    Article  PubMed  Google Scholar 

  11. Jongsiri N (2009) How to secure cystic duct ligation for laparoscopic cholecystectomy – back to simple basic. Thai J Surg 30:29–33

    Google Scholar 

  12. Gurusamy KS, Bong JJ, Fusai G, Davidson BR (2010) Methods of cystic duct occlusion during laparoscopic cholecystectomy (review). In: The Cochrane collaboration. John Wiley & Sons UK

    Google Scholar 

  13. Katri KM, Bessa SB, Elnagah GA, El-Kayal E-SA (2012) Is monopolar electrocautery safe and effective for control of the cystic artery during laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A 22:557–560

    Article  PubMed  Google Scholar 

  14. Kavlakoglu B, Pekcici R, Ora S (2010) Verification of clipless closure of cystic duct by harmonic scalpel. J Laparoendosc Adv Surg Tech A 20:591–595

    Article  PubMed  Google Scholar 

  15. Jain SK, Tanwar R, Kaza RC, Agarwal PN (2011) A prospective, randomized study of comparison of clipless cholecystectomy with conventional laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A 21:203–208

    Article  PubMed  Google Scholar 

  16. Cengiz Y, Dalenback J, Edlund G, Israelsson LA, Janes A, Moller M, Thorell A (2010) Improved outcome after laparoscopic cholecystectomy with ultrasonic dissection: a randomized multicenter trial. Surg Endosc 24:624–630

    Article  PubMed  Google Scholar 

  17. Mahabaleshwar V, Kaman L, Iqbal J, Singh R (2012) Monopolar electrocautery versus ultrasonic dissection of the gallbladder from the gallbladder bed in laparoscopic cholecystectomy: a randomized controlled trial. Can J Surg 51:1–10

    Google Scholar 

  18. Alaa A, Redwan MD (2010) Single-working-instrument, double-trocar, clipless cholecystectomy using harmonic scalpel: a feasible, safe, and less invasive technique. J Laparoendosc Adv Surg Tech A 20:597–603

    Article  Google Scholar 

  19. Catena F, Ansaloni L, Di Saverio S, Gazzotti F, Coccolini F, Pinna AD (2009) Prospective analysis of 101 consecutive cases of laparoscopic cholecystectomy for acute cholecystitis operated with harmonic scalpel. Surg Laparosc Endosc Percutan Tech 19(4):312–316

    Article  PubMed  Google Scholar 

  20. Cengiz Y, Janes A, Grehn A, Israelsson LA (2005) Randomized clinical trial of traditional dissection with electrocautery versus ultrasonic fundus-first dissection in laparoscopic cholecystectomy. Br J Surg 92:810–813

    Article  CAS  PubMed  Google Scholar 

  21. Huscher CGS, Lirici MM, Di Paola M, Crafa F, Napolitano C, Mereu A, Recher A, Corradi A, Amini M (2003) Laparoscopic cholecystectomy by ultrasonic dissection without cystic duct and artery ligature. Surg Endosc 17:442–451

    Article  CAS  PubMed  Google Scholar 

  22. Xiong J, Altaf K, Huang W, Javed MA, Mukherjee R, Mai G, Hu W, Sutton R, Liu X (2012) A meta-analysis of randomized clinical trials that compared ultrasonic energy and monopolar electrosurgical energy in laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A 22:768–777

    Article  PubMed  Google Scholar 

  23. Mirizzi PL (1932) La colangiografía durante las operaciones de las vías biliares. Comunicación en la Sociedad de Cirugía de Buenos Aires. 5 de octubre de 1932

    Google Scholar 

  24. Mirizzi PL (1937) Operative cholangiography. Surg Gynecol Obstet 65:702–710

    Google Scholar 

  25. Sajid MS, Leaver C, Haider Z, Worthington T, Karanjia N, Singh KK (2012) Routine on-table cholangiography during cholecystectomy: a systematic review. Ann R Coll Surg Engl 94(6):375–380

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Hauer-Jensen M, Kåresen R, Nygaard K et al (1986) Consequences of routine preoperative cholangiography during cholecystectomy for gallstone disease: a prospective, randomized study. World J Surg 10:996–1002

    Article  CAS  PubMed  Google Scholar 

  27. Soper NJ, Dunnegan DL (1992) Routine versus selective intra-operative cholangiography during laparoscopic cholecystectomy. World J Surg 16:1133–1140

    Article  CAS  PubMed  Google Scholar 

  28. Nies C, Bauknecht F, Groth C et al (1997) Intraoperative cholangiography as a routine method? A prospective, controlled, randomized study. Chirurg 68:892–897

    Article  CAS  PubMed  Google Scholar 

  29. Khan OA, Balaji S, Branagan G et al (2011) Randomized clinical trial of routine on table cholangiography during laparoscopic cholecystectomy. Br J Surg 98:362–367

    Article  CAS  PubMed  Google Scholar 

  30. Ford JA, Soop M, Du J, Loveday BP, Rodgers M (2012) Systematic review of intraoperative cholangiography in cholecystectomy. Br J Surg 99(2):160–167

    Article  CAS  PubMed  Google Scholar 

  31. Amott D, Webb A, Tulloh B (2005) Prospective comparison of routine and selective operative cholangiography. ANZ J Surg 75:378–382

    Article  PubMed  Google Scholar 

  32. Tusek D, Hufschmidt M, Raguse T (1997) Value of intraoperative laparoscopic cholangiography. Zentralbl Chir 122:153–156

    CAS  PubMed  Google Scholar 

  33. Hauer-Jensen M, Karesen R, Nygaard K, Solheim K, Amlie EJ, Havig O et al (1993) Prospective randomized study of routine intraoperative cholangiography during open cholecystectomy: long-term follow-up and multivariate analysis of predictors of choledocholithiasis. Surgery 113:318–323

    CAS  PubMed  Google Scholar 

  34. Murison MS, Gartell PC, McGinn FP (1993) Does selective preoperative cholangiography result in missed common bile duct stones? J R Coll Surg Edinb 38:220–224

    CAS  PubMed  Google Scholar 

  35. Sharma AK, Cherry R, Fielding JW (1993) A randomised trial of selective or routine on-table cholangiography. Ann R Coll Surg Engl 75:245–248

    CAS  PubMed Central  PubMed  Google Scholar 

  36. Buddingh KT, Nieuwenhuijs VB, van Buuren L, Hulscher JB, de Jong JS, van Dam GM (2011) Surg Endosc 25(8):2449–2461

    Article  PubMed Central  PubMed  Google Scholar 

  37. Hobbs MS, Mai Q, Knuiman MW, Fletcher DR, Ridout SC (2006) Surgeon experience and trends in intraoperative complications in laparoscopic cholecystectomy. Br J Surg 93:844–853

    Article  CAS  PubMed  Google Scholar 

  38. Flum DR, Dellinger EP, Cheadle A, Chan L, Koepsell T (2003) Intraoperative cholangiography and risk of common bile duct injury during cholecystectomy. JAMA 289:1639–1644

    Article  PubMed  Google Scholar 

  39. Flum DR, Koepsell T, Heagerty P, Sinanan M, Dellinger EP (2001) Common bile duct injury during laparoscopic cholecystectomy and the use of intraoperative cholangiography: adverse outcome or preventable error? Arch Surg 136:1287–1292

    Article  CAS  PubMed  Google Scholar 

  40. Waage A, Nilsson M (2006) Iatrogenic bile duct injury: a population-based study of 152, 776 cholecystectomies in the Swedish Inpatient Registry. Arch Surg 141:1207–1213

    Article  PubMed  Google Scholar 

  41. Z’graggen K, Wehrli H, Metzger A, Buehler M, Frei E, Klaiber C (1998) Complications of laparoscopic cholecystectomy in Switzerland. A prospective 3-year study of 10, 174 patients. Swiss Association of Laparoscopic and Thoracoscopic Surgery. Surg Endosc 12:1303–1310

    Article  PubMed  Google Scholar 

  42. Giger U, Ouaissi M, Schmitz SF, Krahenbuhl S, Krahenbuhl L (2011) Bile duct injury and use of cholangiography during laparoscopic cholecystectomy. Br J Surg 98(3):391–396

    Article  CAS  PubMed  Google Scholar 

  43. Törnqvist B, Strömberg C, Persson G, Nilsson M (2012) Effect of intended intraoperative cholangiography and early detection of bile duct injury on survival after cholecystectomy: population based cohort study. BMJ 11:345

    Google Scholar 

  44. Ragulin-Coyne E, Witkowski ER, Chau Z, Ng SC, Santry HP, Callery MP, Shah SA, Tseng JF (2013) Is routine intraoperative cholangiogram necessary in the twenty-first century? A national view. J Gastrointest Surg 17(3):434–442

    Article  PubMed  Google Scholar 

  45. Nuzzo G, Giuliante F, Giovannini I, Ardito F, D’Acapito F, Vellone M, Murazio M, Capelli G (2005) Bile duct injury during laparoscopic cholecystectomy: results of an Italian national survey on 56 591 cholecystectomies. Arch Surg 140(10):986–992

    Article  PubMed  Google Scholar 

  46. Regöly-Mérei J, Ihász M, Szeberin Z, Sándor J, Máté M (1998) Biliary tract complications in laparoscopic cholecystectomy. A multicenter study of 148 biliary tract injuries in 26,440 operations. Surg Endosc 12(4):294–300

    Article  PubMed  Google Scholar 

  47. Metcalfe MS, Ong T, Bruening MH, Iswariah H, Wemyss-Holden SA, Maddern GJ (2004) Is laparoscopic intraoperative cholangiogram a matter of routine? Am J Surg 187:475–481

    Article  PubMed  Google Scholar 

  48. Sheffield KM, Riall TS, Han Y, Kuo YF, Townsend CM Jr, Goodwin JS (2013) Association between cholecystectomy with vs without intraoperative cholangiography and risk of common duct injury. JAMA 310(8):812–820

    Article  CAS  PubMed  Google Scholar 

  49. Ludwig K, Bernhardt J, Steffen H, Lorenz D (2002) Contribution of intraoperative cholangiography to incidence and outcome of common bile duct injuries during laparoscopic cholecystectomy. Surg Endosc 16(7):1098–1104

    Article  CAS  PubMed  Google Scholar 

  50. Overby DW, Apelgren KN, Richardson W, Fanelli R, Society of American Gastrointestinal and Endoscopic Surgeons (2010) SAGES guidelines for the clinical application of laparoscopic biliary tract surgery. Surg Endosc 24(10):2368–2386

    Article  PubMed  Google Scholar 

  51. Gurusamy KS, Samraj K, Mullerat P, Davidson BR (2007) Routine abdominal drainage for uncomplicated laparoscopic cholecystectomy. Cochrane Database Syst Rev (4):CD006004

    Google Scholar 

  52. Neugebauer E, Troidl H, Kum CK, Eypasch E, Miserez M, Paul A (1995) The E.A.E.S. Consensus Development Conferences on laparoscopic cholecystectomy, appendectomy, and hernia repair. Consensus statements–September 1994. The Educational Committee of the European Association for Endoscopic Surgery. Surg Endosc 9(5):550–563

    CAS  PubMed  Google Scholar 

  53. Picchio M, De Angelis F, Zazza S, Di Filippo A, Mancini R, Pattaro G, Stipa F, Adisa AO, Marino G, Spaziani E (2012) Drain after elective laparoscopic cholecystectomy. A randomized multicentre controlled trial. Surg Endosc 26(10):2817–2822, epub 27 Apr 2012

    Article  PubMed  Google Scholar 

  54. El-Labban G, Hokkam E, El-Labban M, Saber A, Heissam K, El-Kammash S (2012) Laparoscopic elective cholecystectomy with and without drain: a controlled randomised trial. J Minim Access Surg 8(3):90–92

    Article  PubMed Central  PubMed  Google Scholar 

  55. Tzovaras G, Liakou P, Fafoulakis F, Baloyiannis I, Zacharoulis D, Hatzitheofilou C (2009) Is there a role for drain use in elective laparoscopic cholecystectomy? A controlled randomized trial. Am J Surg 197:759–763

    Article  PubMed  Google Scholar 

  56. Uchiyama K, Tani M, Kawai M, Terasawa H, Hama T, Yamaue H (2007) Clinical significance of drainage tube insertion in laparoscopic cholecystectomy: a prospective randomized controlled trial. J Hepatobiliary Pancreat Surg 14(6):551–556, epub 30 Nov 2007

    Article  PubMed  Google Scholar 

  57. Ruiz-Tovar J, Ortega I, Santos J, Sosa L, Armañanzas L, Diez Tabernilla M, Calero A, Arroyo A, Oliver I, García S, Calpena R (2012) Is there any indication for inserting a drain in elective laparoscopic cholecystectomy? Cir Esp 90(5):318–321

    Article  PubMed  Google Scholar 

  58. Hawasli A, Brown E (1994) The effect of drains in laparoscopic cholecystectomy. J Laparoendosc Surg 4:393–398

    Article  CAS  PubMed  Google Scholar 

  59. Boddy AP, Mehta S, Rhodes M (2006) The effect of intraperitoneal local anesthesia in laparoscopic cholecystectomy: a systematic review and meta-analysis. Anesth Anal 103:682–688

    Article  CAS  Google Scholar 

  60. Kahokehr A, Sammour T, Soop M, Hill AG (2010) Intraperitoneal use of local anesthetic in laparoscopic cholecystectomy: systematic review and meta-analysis of randomized controlled trials. Review article. J Hepatobiliary Pancreat Sci 17:637–656

    Article  PubMed  Google Scholar 

  61. Gupta A (2005) Local anaesthesia for pain relief after laparoscopic cholecystectomy–a systematic review. Best Pract Res Clin Anaesthesiol 19(2):275–292

    Article  CAS  PubMed  Google Scholar 

  62. Bisgaard T (2006) Analgesic treatment after laparoscopic cholecystectomy. A critical assessment of the evidence. Review article. Anaesthesiology 104(4):835–846

    Article  Google Scholar 

  63. Bisgaard T, Klarskov B, Kristiansen VB, Callesen T, Schulze S, Kehlet H, Rosenberg J (1999) Multi-regional local anesthetic infiltration during laparoscopic cholecystectomy in patients receiving prophylactic multi-modal analgesia: a randomized, double-blinded, placebo-controlled study. Anesth Anal 89(4):1017–1024

    CAS  Google Scholar 

  64. Nicolau AE et al (2008) Multimodal analgesia in elective laparoscopic cholecystectomy. A double-blind randomized controlled trial. Chirurgia 103(5):547–551

    CAS  PubMed  Google Scholar 

  65. Kehlet H, Gray AW, Bonnet F, Camu F, Fischer HB, McCloy RF, Neugebauer EA, Puig MM, Rawal N, Simanski CJ (2005) A procedure-specific systematic review and consensus recommendations for postoperative analgesia following laparoscopic cholecystectomy. Surg Endosc 19(10):1396–1415

    Article  CAS  PubMed  Google Scholar 

  66. Ahn Y et al (2011) A systematic review of interventions to facilitate ambulatory laparoscopic cholecystectomy. Review article. HPB (Oxford) 13:677–686

    Article  Google Scholar 

  67. Pasqualucci A, De Angelis V, Contardo R, Colò F, Terrosu G, Donini A, Pasetto A, Bresadola F (1996) Preemptive analgesia: intraperitoneal local anesthetic in laparoscopic cholecystectomy. A randomized, double blind, placebo-controlled study. Anesthesiology 85:11–20

    Article  CAS  PubMed  Google Scholar 

  68. Donatsky AM, Bjerrum F, Gogenur I (2013) Intraperitoneal instillation of saline and local anesthesia for prevention of shoulder pain after laparoscopic cholecystectomy: a systematic review. Surg Endosc 27:2283–2292

    Article  PubMed  Google Scholar 

  69. Karaaslan D, Sivaci RG, Akbulut G, Dilek ON (2006) Preemptive analgesia in laparoscopic cholecystectomy: a randomized controlled study. Pain Pract 6(4):237–241

    Article  PubMed  Google Scholar 

  70. Kahoehr A et al (2011) Systematic review and meta-analysis of intraperitoneal local anaesthetic for pain reduction after laparoscopic gastric procedures. Br J Surg 98:29–36

    Article  Google Scholar 

  71. Hudcova J, McNicol E, Quah C, Lau J, Carr DB (2006) Patient controlled opioid analgesia versus conventional opioid analgesia for postoperative pain. Cochrane Database Syst Rev (4): 71:1–10. CD003348

    Google Scholar 

  72. Gurusamy KS (2009) Low pressure versus standard pressure pneumoperitoneum in laparoscopic cholecystectomy. Cochrane Database Syst Rev (2):1–12. CD006930

    Google Scholar 

  73. Alkhamesi NA, Peck DH, Lomax D, Darzi AW (2007) Intraperitoneal aerosolization of bupivacaine reduces postoperative pain in laparoscopic surgery: a randomized prospective controlled double-blinded clinical trial. Surg Endosc 21(4):602–606

    Article  CAS  PubMed  Google Scholar 

  74. Hasaniya NW, Zayed FF, Faiz H, Severino R (2001) Preinsertion local anesthesia at the trocar site improve perioperative pain and decreases costs of laparoscopic cholecystectomy. Surg Endosc 15(9):962–964

    Article  CAS  PubMed  Google Scholar 

  75. El-Dawlatly AA, Turkistani A, Kettner SC, Machata AM, Delvi MB, Thallaj A, Kapral S, Marhofer P (2007) Ultrasound-guided transversus abdominis plane block: description of a new technique and comparison with conventional systemic analgesia during laparoscopic cholecystectomy. Surg Endosc 21(4):602–606

    Article  Google Scholar 

  76. Abdallah FW, Chan VW, Brull R (2012) Transversus abdominis plane block: a systematic review. Reg Anesth Pain Med 37(2):193–209

    Article  CAS  PubMed  Google Scholar 

  77. Ortiz J et al (2012) Bilateral transversus plane block does not decrease postoperative pain after laparoscopic cholecystectomy when compared with local anesthetic infiltration of trocar insertion sites. Reg Anesth Pain Med 37(2):188–192

    Article  CAS  PubMed  Google Scholar 

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Maida, P. et al. (2014). Number of Trocars, Types of Dissection, Exploration of Bile Duct, Drainage and Analgesia. In: Agresta, F., Campanile, F., Vettoretto, N. (eds) Laparoscopic Cholecystectomy. Springer, Cham. https://doi.org/10.1007/978-3-319-05407-0_6

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