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Migräne und andere Kopfschmerzen

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Neurologische Erkrankungen in der Schwangerschaft

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Kopfschmerzen gehören mit zu den häufigsten Beschwerden, über die Patienten klagen. Die Lebenszeitprävalenz von Kopfschmerzen beträgt an die 99% (Rasmussen et al. 1991). Mit Abstand die beiden häufigsten Kopfschmerzformen sind der Kopfschmerz vom Spannungstyp und die Migräne. Das Spektrum der Kopfschmerzerkrankungen ist groß; es reicht vom harmlosen selbstlimitierenden Symptom bis hin zur lebensbedrohlichen Erkrankung. Die richtige Einordnung und Einschätzung des Symptoms Kopfschmerz ist deswegen außerordentlich wichtig. Aber auch als Symptom einer ungefährlichen Erkrankung kann Kopfschmerz die Betroffenen im alltäglichen Leben beeinträchtigen, sie sogar völlig außer Funktion setzen.

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Literatur

  • American Academy of Pediatrics Committee on Drugs (1994) The transfer of drugs and other chemicals into human milk. Pediatrics 93: 137–150

    Google Scholar 

  • Aubé M (1999) Migraine in pregnancy. Neurology 53[Suppl] 1: 26–28

    Google Scholar 

  • Bousser MG (1999) Migraine, female hormones, and stroke. Cephalalgia 19: 75–79

    Article  PubMed  CAS  Google Scholar 

  • Bousser MG, Chiras J, Bories J et al. (1985) Cerebral venous thrombosis — a review of 38 cases. Stroke 16: 199–213

    PubMed  CAS  Google Scholar 

  • Bousser MG, Massiou H (1993) Migraine in the reproductive cycle. In: Olesen J, Tfelt-Hansen P, Welch KMA (eds) The headaches. Raven Press, New York, pp 413–419

    Google Scholar 

  • Briggs GG, Freeman RK, Yaffe SJ (eds) (2002) Drugs in pregnancy and lactation. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  • Bulens C, de Vries WAEJ, van Crevel H (1979) Benign intracranial hypertension. J Neurol Sci 40: 147–157

    Article  PubMed  CAS  Google Scholar 

  • Cantu C, Barinagarrementeria F (1993) Cerebral venous thrombosis associated with pregnancy and puerperium. Stroke 24: 1880–1884

    PubMed  CAS  Google Scholar 

  • Chancellor AM, Wroe SJ, Cull RE (1990) Migraine occuring for the first time in pregnancy. Headache 30: 224–227

    Article  PubMed  CAS  Google Scholar 

  • Cogan R, Spinnato JA (1986) Pain and discomfort thresholds in late pregnancy. Pain 27: 63–68

    Article  PubMed  CAS  Google Scholar 

  • Cupini LM, Matteis M, Troisi E, Calabresi P, Bernardi G, Silvestrini M (1995) Sex-hormone-related events in migrainous females. A clinical comparative study between migraine with aura and migraine without aura. Cephalalgia 15: 140–144

    Article  PubMed  CAS  Google Scholar 

  • Dandy WE (1937) Intracranial pressure without brain tumour. Ann Surg 106: 492–513

    PubMed  CAS  Google Scholar 

  • Davies PTG, Eccles NK, Steiner TJ, Leathard HL, Rose FC (1989) Plasma estrogen, progesterone and sex-hormone binding globulin levels in the pathogenesis of migraine. Cephalalgia 9[Suppl] 10: 143

    Google Scholar 

  • Dawson-Basoa MB, Gintzler AR (1993) 17-Beta-estradiol and progesterone modulate an intrinsic opioid analgesic system. Brain Res 601: 241–245

    Article  PubMed  CAS  Google Scholar 

  • De Bruijn SFTM, Stam J, Kapelle IJ for the CVST Study Group (1996) Thunderclap headache as the first symptom of cerebral venous sinus thrombosis. Lancet 348: 1623–1625

    Article  PubMed  Google Scholar 

  • De Fusco M, Marconi R, Silvestri L, Atorino L, Rampoldi L, Morgante L, Ballabio A, Aridon P, Casari G (2003) Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type2. Nat Genet 33(2): 192–196

    Article  PubMed  CAS  Google Scholar 

  • Dichgans M, Freilinger T, Eckstein G, Babini E, Lorenz-Depiereux B, Biskup S, Ferrari MD, Herzog J, van den Maagdenberg AM, Pusch M, Strom TM (2005) Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 366(9483): 371–377

    Article  PubMed  CAS  Google Scholar 

  • Digre KB, Varner MW, Corbett JJ (1984) Pseudotumor cerebri and pregnancy. Neurology 34: 721–729

    PubMed  CAS  Google Scholar 

  • Eccles NK, Leathard HL (1984) Effects of 17 beta-oestradiol and progesterone on human vascular reactivity. The migraine trust. 5th International Symposium, London

    Google Scholar 

  • Edelson RN (1985) Menstrual migraine and other hormonal aspects of migraine. Headache 25: 376–379

    Article  PubMed  CAS  Google Scholar 

  • Epstein MT, Hockaday JM, Hockaday TDR (1975) Migraine and reproductive hormones throughout the menstrual cycle. Lancet 1: 543–548

    Article  PubMed  CAS  Google Scholar 

  • Ertresvåg JM, Zwart JA, Helde G, Johnsen HJ, Bovin G (2005) Headache and transient focal neurological symptoms during pregnancy, a prospective cohort. Acta Neurol Scand 111: 233–237

    Article  PubMed  Google Scholar 

  • Evans RW, Friedman DI (2000) The management of pseudotumor cerebri during pregnancy. Headache 40: 495–497

    Article  PubMed  CAS  Google Scholar 

  • Facchinetti F, Sances G, Borella P, Genazzani AR, Nappi G (1991) Magnesium prophylaxis of menstrual migraine. Effects of intracellular magnesium. Headache 31: 298–301

    Article  PubMed  CAS  Google Scholar 

  • Facchinetti F, Martignoni E, Nappi G, Fioroni L, Sances G, Genazzani AR (1989) Premenstrual failure of α adrenergic stimulation on hypothalamus-pituitary responses in menstrual migraine. Psychosom Med 51: 550–558

    PubMed  CAS  Google Scholar 

  • Feniuk W, Humphrey PP, Perren MJ (1989) GR43175 does not share the complex pharmacology of ergots. Cephalalgia [Suppl] 9: 35–39

    PubMed  Google Scholar 

  • Fiore M, Shields KE, Santanello N, Goldberg MR (2005) Exposure to rizatriptan during pregnancy: post-marketing experience up to 30 June 2004. Cephalalgia 25: 685–688

    Article  PubMed  CAS  Google Scholar 

  • Fox AW, Chambers CD, Anderson PO, Diamond ML, Spierings LH (2002) Evidence-based assessment of pregnancy outcome after sumatriptan exposure. Headache 42: 8–15

    Article  PubMed  Google Scholar 

  • Gerhard M, Creager MA (1996) Estrogen and vascular reactivity. In: Sowers JR (ed) Endocrinology of the vasculature. Humana Press, Totowa, pp 67–78

    Google Scholar 

  • Gintzler AR (1980) Endorphin-mediated increases in pain threshold during pregnancy. Science 210: 193–195

    Article  PubMed  CAS  Google Scholar 

  • Goadsby PJ, Edvinsson L, Ekman R (1990) Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 28: 183–187

    Article  PubMed  CAS  Google Scholar 

  • Goadsby PJ, Knight YE, Hoskin KL (1997) Stimulation of the greater occipital nerve increases matabolic activity in the trigeminal nucleus caudalis and cervical dorsal horn of the cat. Pain 73: 23–28

    Article  PubMed  CAS  Google Scholar 

  • Göbel H, Petersen-Braun M, Soyka D (1994) The epidemiology of headache in Germany. Cephalalgia 14: 97–106

    Article  PubMed  Google Scholar 

  • Granella F, Sances G, Zanferrari C, Costa A, Martignoni E, Manzoni GC (1993) Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women. Headache 33: 385–389

    Article  PubMed  CAS  Google Scholar 

  • Granella F, Sances G, Pucci E, Nappi RE, Ghiotto N, Nappi G (2000) Migraine with aura and reproductive life events: a case control study. Cephalalgia 20: 701–707

    Article  PubMed  CAS  Google Scholar 

  • Haan J, Terwindt GM, Ferrari MD (1997) Genetics of migraine. Neurologic Clin 15: 43–60

    Article  CAS  Google Scholar 

  • Hannington E, Jones RJ, Amess JAL (1982) Platelet aggregation in response to 5HAT in migraine patients taking oral contraceptives. Lancet 1: 967–968

    Article  Google Scholar 

  • Hardebo JE, Edvinsson L. Reduced sensitivity to alpha-and beta-adrenergic receptor agonists of intra-and extracranial vessels during pregnancy: relevance to migraine (1977) Acta Neurol Scand [Suppl] 64: 204–205

    Google Scholar 

  • Headache Classification Committee of the International Headache Society (2004) The international classification of headache disorders. Cephalalgia 24[Suppl] 1: 1–136

    Google Scholar 

  • Hoskin KL, Zagami A, Goadsby PJ (1999) Stimulation of the middle meningeal artery leads to bilateral Fos expression in the trigeminocervical: a comparative study of monkey and cat. J Anat 194: 579–588

    Article  PubMed  CAS  Google Scholar 

  • Källén B, Lygner PE (2001) Delivery outcome in women who used drugs for migraine during pregnancy with special reference to sumatriptan. Headache 41: 351–356

    Article  PubMed  Google Scholar 

  • Kelman L (2004) Women’s issues of migraine in tertiary care. Headache 44: 2–7

    Article  PubMed  Google Scholar 

  • Kerr FWL (1961) A mechanism to account for frontal headache in cases of posterior-fossa tumours. J Neurosurg 18: 605–609

    PubMed  CAS  Google Scholar 

  • Kittner SJ, Stern BJ, Feeser BR, Hebel JR, Nagey DA, Buchholz DW, Earley CJ, Johnson CJ, Macko RF, Sloan MA, Wityk RJ, Wozniak MA (1996) Pregnancy and the risk of stroke. N Engl J Med 335: 768–774

    Article  PubMed  CAS  Google Scholar 

  • Kopfschmerzklassifikationskomitee der International Headache Society (2003) Die internationale Klassifikation von Kopfschmerzen. Nervenheilkunde 22: 531–670

    Google Scholar 

  • Kraus AM (1975) Congenital cataract and maternal steroid injection. J Pediatr Ophthalmol 12: 107–108

    Google Scholar 

  • Kudrow L (1975) The relationship of headache frequency to hormone dose in migraine. Headache 15: 36–49

    Article  PubMed  CAS  Google Scholar 

  • Labbok MH, Hight-Laukaran V, Peterson AE, Fletcher V, von Hertzen H, van Look PF (1997) Multicenter study of the lactational amenorrhea Method (LAM): I. Efficacy, duration, and implications for clinical application. Contraception 55: 327–336

    Article  PubMed  CAS  Google Scholar 

  • Lance JW, Anthony M (1966) Some clinical aspects of migraine. A prospective survey of 500 patients. Arch Neurol 15: 356–361

    PubMed  CAS  Google Scholar 

  • Linn FHH, Rinkel GJE, Algra A, van Gijn J (2000) The notion of „warning leaks“ in subarachnoid hemorrhage: are such patients in fact admitted with a rebleed? J Neurol Neurosurg Psychiatry 68: 332–336

    Article  PubMed  CAS  Google Scholar 

  • Loder E (2003) Safety of sumatriptan in pregnancy: a review of the data so far. CNS Drugs 17(1): 1–7

    Article  PubMed  CAS  Google Scholar 

  • Maggioni F, Alessi C, Maggino T, Zanchin G. Headache during pregnancy (1997) Cephalalgia 17: 765–769

    Article  PubMed  CAS  Google Scholar 

  • Manzoni GC, Micieli G, Granella F, Martignoni E, Farina S, Nappi G (1988) Cluster headache in women: clinical findings and relationship with reproductive life. Cephalalgia 8: 37–44

    Article  PubMed  CAS  Google Scholar 

  • Marcus DA, Scharff L, Turk D (1999) Longitudinal prospective study of headache during pregnancy and postpartum. Headache 39: 625–632

    Article  PubMed  CAS  Google Scholar 

  • Martignoni E, Sance SG, Nappi G (1987) Significance of hormonal changes in migraine and cluster headache. Gynecol Endocrinol 1: 295–319

    PubMed  CAS  Google Scholar 

  • Martin VT, Behbehani M (2006) Ovarian Hormones and migraine headache: understanding mechanisms and pathogenesis — Part 1. Headache 46: 3–23

    Article  PubMed  Google Scholar 

  • Martin VT, Behbehani M (2006) Ovarian Hormones and migraine headache: understanding mechanisms and pathogenesis — Part 2. Headache 46: 365–386

    Article  PubMed  Google Scholar 

  • McGregor EA, Chia H, Vohrad RC, Wilkinson M (1990) Migraine and menstruation: a pilot study. Cephalalgia 10: 305–310

    Article  Google Scholar 

  • Mendonca LL, Khamashta MA, Nelson-Piercy C, Hunt BJ, Hughes GR (2000) Non-steriodal anti-inflammatory drugs as a possible cause for reversible infertility. Rheumatology 39: 880–882

    Article  PubMed  CAS  Google Scholar 

  • Merikangas KR, Angst J, Isler H (1990) Migraine and psychopathology. Results of the Zurich cohort study of young adults. Arch Gen Psychiatry 47: 849–853

    PubMed  CAS  Google Scholar 

  • Moskowitz MA, Buzzi MG, Sakas D (1989) Pain mechanisms underlying vascular headache. Rev Neurol 145: 181–193

    PubMed  CAS  Google Scholar 

  • Mueller L (2000) Predictability of exogenous hormone effect on subgroups of migrainers. Headache 40: 189–193

    Article  PubMed  CAS  Google Scholar 

  • Nattero G, Allais G, De Lorenzo C et al. (1989) Relevance of prostaglandins in true menstrual migraine. Headache 29: 232–238

    Google Scholar 

  • Neri I, Granella F, Nappi R (1993) Characteristics of headache at menopause. Nature 17: 31–37

    CAS  Google Scholar 

  • Ophoff RA, Terwindt GM, Vergouwe MN, Eijk RV, Oefner PJ, Hoffman SMG, Lamerdin JE, Mohrenweiser HW, Bulman DE, Ferrari M, Haan J, Lindhout D, Ommen G-JBv, Hofker MH, Ferrari MD, Frants RR (1996) Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 87: 543–552

    Article  PubMed  CAS  Google Scholar 

  • O’Quinn S, Ephross SA, Williams V, Davis RL, Gutterman DL, Fox AW (1999) Pregnancy and perinatal outcomes in migraineurs using sumatiptan: a prospective study. Arch Gynecol Obstet 263: 7–12

    Article  PubMed  CAS  Google Scholar 

  • Peikert A, Wilimzig C, Köhne-Volland R (1996) Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebocontrolled and double-blind randomized study. Cephalalgia 16: 257–263

    Article  PubMed  CAS  Google Scholar 

  • Petzold GC, Dreier JP, Einhäupl KM, Arnold G (2003) Cluster-like headache time-locked to the menstrual cycle. Neurology 60: 1049

    PubMed  Google Scholar 

  • Pfaffenrath V, Wessely P, Meyer C, Isler HR, Evers S, Grotemeyer KH, Taneri Z, Soyka D, Göbel H, Fischer M (1996) Magnesium in the prophylaxis of migraine — a double-blind placebo controlled study. Cephalalgia 16: 436–440

    Article  PubMed  CAS  Google Scholar 

  • Pfaffenrath V, Rehm M (1998) Migraine in pregnancy: what are the safest treatment options? Drug Saf 19(5): 383–388

    Article  PubMed  CAS  Google Scholar 

  • Rasmussen BK, Jensen R, Schroll M, Olesen J (1991) Epidemiology of headache in a general population — a prevalence study. J Clin Epidemiol 44: 1147–1157

    Article  PubMed  CAS  Google Scholar 

  • Rasmussen BK (1993) Migraine and tension-type headache in a general population: precipitating factors, female hormones, sleep pattern and relation to lifestyle. Pain 53(1): 65–72

    Article  PubMed  CAS  Google Scholar 

  • Ratinahirana H, Darbois Y, Bousser MG (1990) Migraine and pregnancy: a prospective study in 703 women after delivery. Neurology 40[Suppl] 1: 437

    Google Scholar 

  • Reiff-Eldridge R, Heffner CR, Ephross SA, Tennis PS, White AD, Andrews EB (2000) Monitoring pregnancy outcomes after prenatal drug exposure through prospective pregnancy registries: a pharmaceutical company commitment. Am J Obstet Gynecol 40: 20–24

    Google Scholar 

  • Sances G, Granella F, Nappi RE, Fignon A, Ghiotto N, Polatti F, Nappi G (2003) Course of migraine during pregnancy and postpartum: a prospective study. Cephalalgia 23: 197–205

    Article  PubMed  CAS  Google Scholar 

  • Scharff L, Marcus DA, Turk DC (1997) Headache during pregnancy in the postpartum: a prospective study. Headache 37: 203–210

    Article  PubMed  CAS  Google Scholar 

  • Shapiro S, Yee R, Brown H (1995) Surgical management of pseudotumor cerebri in pregnancy: case report. Neurosurgery 37: 829–831

    Article  PubMed  CAS  Google Scholar 

  • Sharshar T, Lamy C, Mas JL (1995) Incidence and causes of strokes associated with pregnancy and puerperium Stroke 26: 930–936

    PubMed  CAS  Google Scholar 

  • Shuhaiber S, Pastuszak A, Schick B, Matsui D, Spivey G, Brochu J, Koren G (1998) Pregnancy outcome following first trimester exposure to sumatriptan. Neurology 51: 581–583

    PubMed  CAS  Google Scholar 

  • Sicuteri F (1980) Opioids, pregnancy and the disappearance of headache. Headache 20: 220–221

    Article  PubMed  CAS  Google Scholar 

  • Silberstein SD, Merriam GR (1991) Estrogens, progestins, and headache. Neurology 41: 775–793

    Google Scholar 

  • Silberstein SD (1996) Sex hormones and headache. In: Clifford-Rose F (ed) Towards migraine 2000. Elsevier, Amsterdam, pp 201–218

    Google Scholar 

  • Silberstein SD (2001) Headache and female hormones: what you need to know. Curr Opin Neurol 14: 323–333

    Article  PubMed  CAS  Google Scholar 

  • Simolke GA, Cox SM, Cunningham FG (1991) Cerebrovascular accidents complicating pregnancy and the puerperium. Obstet Gynecol 78: 37–42

    PubMed  CAS  Google Scholar 

  • Sommerville BW (1972a) The role of estradiol withdrawal in the etiology of menstrual migraine. Neurology 22: 355–365

    Google Scholar 

  • Sommerville BW (1972b) A study of migraine in pregnancy. Neurology 22: 824–828

    Google Scholar 

  • Sommerville BW (1975) Estrogen withdrawal migraine. Duration of exposure required and attempted prophylaxis by premenstrual estrogen administration. Neurology 25: 239–244

    Google Scholar 

  • Stone S, Khamashta MA, Nelson-Piercy C (2002) Nonsteroidal anti-inflammatory drugs and reversible female infertility: is there a link. Drug Saf 25: 545–551

    Article  PubMed  CAS  Google Scholar 

  • Uknis A, Silberstein SD (1991) Review article: migraine and pregnancy. Headache 31: 372–374

    Article  PubMed  CAS  Google Scholar 

  • Von Wald T, Walling AD (2002) Headache during pregnancy. Obstet Gynecol Surv 57: 179–185

    Article  Google Scholar 

  • Wainscott G, Sullivan FM, Volans GN, Wilkinson M (1978) The outcome of pregnancy in women suffering from migraine. Postgrad Med J 54: 98–102

    PubMed  CAS  Google Scholar 

  • Weiller C, May A, Limmroth V, Jüptner M, Kaube H, van Schayck R, Coenen HH, Diener HC (1995) Brain stem activation in spontaneous human migraine attacks. Nature Med 1: 658–660

    Article  PubMed  CAS  Google Scholar 

  • Wessely P, Wöber C (Herausgeber) (2003) Behandlung von Kopf-und Gesichtsschmerzen. Therapieempfehlungen der Österreichischen Kopfschmerzgesellschaft. Facultas, Wien

    Google Scholar 

  • Whitty CWM, Hockaday JM, Whitty MM (1966) The effect of oral contraceptives on migraine. Lancet 1: 856–859

    Article  PubMed  CAS  Google Scholar 

  • Wiebers D (1985) Ischemic cerebrovascular complications of pregnancy. Arch Neurol 42: 1106–1113

    PubMed  CAS  Google Scholar 

  • Wright DS, Patel MK (1986) Focal migraine and pregnancy. BMJ 293: 1557–1558

    Article  PubMed  CAS  Google Scholar 

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  1. Neurologische Abteilung, Regionalkrankenhaus Bozen, Lorenz-Böhler-Str. 5, I-39100, Bozen, Italien

    Gabriele Johanna Sixt (OÄ Dr. med. univ.)

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  1. Universitätsklinik für Neurologie, Innsbruck, Österreich

    Thomas Berger  & Gerhard Luef  & 

  2. Universitätsklinik für Frauenheilkunde, Innsbruck, Österreich

    Christoph Brezinka

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Sixt, G.J. (2007). Migräne und andere Kopfschmerzen. In: Berger, T., Luef, G., Brezinka, C. (eds) Neurologische Erkrankungen in der Schwangerschaft. Springer, Vienna. https://doi.org/10.1007/978-3-211-69357-5_3

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