Abstract
Arterial blood pressure is maintained by the tonic vasomotor activity of sympathetic preganglionic neurons which are located in the intermediolateral cell column of the thoracic and lumbar spinal cord. Supraspinal inputs are critical in maintaining the activity of SPN. The medulla and pons have been recognized as essential for maintaining tonic sympathetic activity since the late 1800’s when experiments showed that transection of the brain stem caudal to the inferior colliculus failed to lower blood pressure. Transections more caudally produced increasingly greater falls in blood pressure. Reductions in blood pressure reached a maximum with transections at the level of the obex (see ref [1] for historical review). A major goal of central autonomic research has been to identify the descending neuronal pathways which project to SPN and to determine the neurotransmitters contained within these pathways (see ref [2–6] for review). Neuroanatomical and immunocytochemical techniques have been used to identify chemically specific pathways between areas thought to be important in central autonomic regulation. This information combined with experiments utilizing sophisticated electrophysiological and pharmacological analysis have begun to elucidate the role of these pathways in central autonomic regulation and to determine the functional significance of putative neurotransmitters contained within these pathways. This review describes recent developments which have had a major influence on our understanding of the central neurotransmitters involved in the regulation of sympathetic nerve discharge.
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References
G. L. Gebber: Brainstem systems involved in cardiovascular regulation. In: W.C. Randall (Ed.): Nervous control of cardiovascular function. Oxford: Oxford University Press, 1984: 346–368.
R.B. McCall: Effects of putative neurotransmitters on sympathetic preganglionic neurons. In: R.M. Berne (Ed.): Annual Reviews of Physiology, vol. 50. Palo Alto: Annual Reviews Inc., 1988: 553–564.
P.G. Guyenet: Role of the ventral medulla oblongata in blood pressure regulation. In: A.D. Loewy and K.M. Spyer (Eds.): Central Regulation of Autonomic Functions, Oxford: Oxford Univ. Press, 1990, 145–167.
R.B. McCall: Role of neurotransmitters in the central regulation of the cardiovascular system. In: E. Jucker (Ed.): Prog. Drug Res. Basel: Birkhäuser Verlag, 1990; 25–84.
R.A.L. Dampney: Functional organization of central pathways regulating the cardiovascular system. Physiol. Rev. 1994: 74, 323–364.
R.A.L. Dampney: The subretrofacial vasomotor nucleus: anatomical, chemical and pharmacological properties and role in cardiovascular regulation. Prog. in Neuro-biol. 1994; 42: 197–227.
J.B. Cabot: Sympathetic preganglionic neurons: cytoarchitecture, ultrastructure, and biophysical properties. In: A.D. Loewy and K.M. Spyer (Eds.): Central Regulation of Autonomic Functions, Oxford: Oxford Univ. Press, 1990, 22–34.
J.H. Coote: The organization of cardiovascular neurons in the spinal cord. Rev. Physiol Biochem. Pharmacol. 1988; 160: 13–35.
C.G. Charlton and C.J. Helke: Substance P-containing medullary projections to the intermediolateral cell column: Identification with retrogradely transported rhoda-mine-labeled latex microspheres and immunohistochemistry. Brain Res. 1987; 418: 245–254.
C.J. Helke, S.C. Sayson, J.R. Keeler and C.G. Charlton: Thyrotropin-releasing hor-mone-immunoreactive neurons project from the ventral medulla to the intermediolateral cell column: partial coexistence with serotonin. Brain Res. 1986; 381: 1–7.
A.D. Loewy: Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat. Brain Res. 1981; 222: 129–133.
A.D. Loewy and S. McKellar: Serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat. Brain Res. 1981; 211: 146–152.
M. Miura, T. Onai and K. Takayama: Projections of the upper structure to the spinal cardioacceleratory center in cats: an HRP study using a new microinjection method. J. Auton. Nerv. Syst. 1983; 7: 119–140.
C.A. Sasek and C.J. Heike: Enkephalin-immunoreaetive neuronal projections from the medulla oblongata to the intermediolateral cell column-relationship to substance P-immunoreactive neurons. J. Comp. Neurol. 1989; 287: 484–494.
Z.Q. Ding, Y.-W. Li, S.L. Wesselingh and W.W. Blessing: Transneuronal labelling of neurons in rabbit brain after injection of Herpes simplex virus type 1 into the renal nerve. J. Auton. Nerv. Syst. 1993; 42: 23–31.
A.S. Jansen, D.G. Farwell and A.D. Loewy: Specificity of Pseudorabies virus as a retrograde marker of sympathetic preganglionic neurons: implications for transneuronal labeling studies. Brain Res. 1993; 617: 103–112.
A.M. Strack, W.B. Sawyer, J.H. Hughes, K.B. Platt and A.D. Loewy: A general pattern of CNS innervation of the sympathetic outflow demonstrated by transneuro-nal Pseudorabies viral infections. Brain Res. 1989; 491: 156–162.
A.M. Strack, W.B. Sawyer, K.B. Platt and A.D. Loewy: CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labeling with Pseudorabies virus. Brain Res. 1989; 491: 274–296.
S.L. Wesselingh, Y.W. Li and W.W. Blessing: PNMT-containing neurons in the rostral medulla oblongata (C1, C3 groups are transneuronally labelled after injection of herpes simplex virus type 1 into the adrenal gland. Neurosci. Lett. 1989; 106: 99–104.
P. Carrive, R. Bandler and R.A.L. Dampney: Anatomical evidence that hypertension associated with the defence reaction in the cat is mediated by a direct projection from a restricted portion of the midbrain periaqueductal grey to the subretro-facial nucleus of the medulla. Brain Res. 1988; 460: 339–345.
R.A.L. Dampney, J. Czachurski, K. Dembowsky, A.K. Goodchild and H. Seller: Afferent connections and spinal projections of the vasopressor region in the rostral ventrolateral medulla of the cat. J. Auton. Nerv. Syst. 1987; 20: 73–86.
R.A.L. Dampney, A.K. Goodchild, L.G. Robertson and W. Montgomery: Role of ventrolateral medulla in vasomotor regulation: a correlative anatomical and physiological study. Brain Res. 1982; 249: 223–235.
C.A. Ross, D.A. Ruggiero and D.J. Reis: Projections from the nucleus tractus soli-tarii to the rostral ventrolateral medulla. J. Comp. Neurol. 1985; 242: 511–534.
K. Takayama, J. Okada and M. Muira: Evidence that neurons of the central amygdaloid nucleus directly project to the site concerned with circulatory and respiratory regulation in the ventrolateral nucleus of the cat — a WGA-HRP study. Neurosci. Lett. 1990; 109: 241–246.
A.M. Allen and P.G. Guyenet: Alpha 2-adrenoceptor-mediated inhibition of bulbospinal barosensitive cells of rat rostral medulla. Am. J. Physiol. 1993; 265: R1065–R1075.
N. Koshiya, D.H. Huangfu and P.G. Guyenet: Ventrolateral medulla and sympathetic chemoreflex in the rat. Brain Res. 1993; 609: 174–184.
S.K. Agarwal and F.R. Calaresu: Monosynaptic connection from caudal to rostral ventrolateral medulla in the baroreceptor reflex pathway. Brain Res. 1991; 555: 70–74.
M.E. Clement and R.B. McCall: Impairment of baroreceptor reflexes following kainic acid lesions of the lateral tegmental field. Brain Res. 1993; 618: 328–332.
C. Dean and J.H. Coote: A ventromedullary relay involved in the hypothalamic and chemoreceptor activation of sympathetic postganglionic neurones to skeletal muscle, kidney and splanchnic area. Brain Res. 1986; 377: 279–285.
A.R. Granata, D.A. Ruggiero, D.H. Park, T.H. Joh and D.J. Reis: Lesions of epinephrine neurons in the rostral ventrolateral medulla abolish the vasodepressor components of baroreflex and cardiopulmonary reflex. Hypertension 1983; 5: V80–V84.
A.R. Granata, D.A. Ruggiero, D.H. Park, T.H. Joh and D.J. Reis: Brain stem area with Cl epinephrine neurons mediates baroreflex vasodepressor responses. Am. J. Physiol. 1985; 248: H547–H567.
R.M. McAllen: Mediation of fastigial pressor response and a somatosympathetic reflex by ventral medullary neurones in the cat. J. Physiol. 1985; 368: 423–433.
R.L. Stornetta, S.F. Morrison, D.A. Ruggiero and D.J. Reis: Neurons of rostral ventrolateral medulla mediate somatic pressor reflex. Am. J. Physiol. 1989; 256: R448–R462.
A.M. Strack, W.B. Sawyer, L.M. Marubio and A.D. Loewy: Spinal origin of sympathetic preganglionic neurons in the rat. Brain Res. 1988; 455: 187–191.
M.B. Hancock: Separate populations of lumbar preganglionic neurons identified with the retrograde transport of HRP and 4,6-diamidine-phenylindole (DAPI). J. Auton. Nerv. Syst. 1982; 5:135–143.
Y.-W. Li, Z.Q. Ding, S.I. Wesselingh and W.W. Blessing: Renal and adrenal sympathetic preganglionic neurons in rabbit spinal cord-tracing with herpes simplex virus. Brain Res. 1992; 573: 147–152.
J.L. Henry and F.R. Calaresu: Topography and numerical distribution of neurons of the thoraco-lumbar intermediolateral nucleus. J. Comp. Neurol. 1972; 144: 205–214.
B.J. Oldfield and E.M. McLachlan: An analysis of the sympathetic preganglionic neurons projecting from the upper thoracic spinal roots of the cat. J. Comp. Neurol. 1981; 196: 329–346.
T.A. Rando, C.W. Bowers and R.E. Zigmond: Localization of neurons in the rat spinal cord which project to the superior cervical ganglion. J. Comp. Neurol. 1981; 196: 73–83.
S.J. Bacon and A.D. Smith: Preganglionic sympathetic neurones innervating the rat adrenal medulla: immunocytochemical evidence of synaptic input from nerve terminals containing substance P, GABA or 5-hydroxytryptamine. J. Auton. Nerv. Syst. 1988; 24: 97–122.
C.J. Forehand: Morphology of sympathetic preganglionic neurons in the neonatal rat spinal cord-an intracellular horseradish peroxidase study. J. Comp. Neurol. 1990; 298: 334–342.
P.L. Vera, B.E. Hurwitz and N. Schneiderman: Sympathoadrenal preganglionic neurons in the adult rabbit send their dendrites into the contralateral hemicord. J. Auton. Nerv. Syst. 1990; 30: 193–198.
T.L. Krukoff: Coexistence of neuropeptides in sympathetic preganglionic neurons of the cat. Peptides 1987; 8: 109–112.
T.L. Krukoff, J. Ciriello and F.R. Calaresu: Segmental distribution of peptide-and 5-HT-like immunoreactivity in nerve terminals and fibers of the thoracolumbar sympathetic nuclei of the cat. J. Comp. Neurol. 1985; 240: 103–116.
R.B. McCall: Serotonergic excitation of sympathetic preganglionic neurons: a micro-iontophoretic study. Brain Res. 1983; 289: 121–127.
L.C. Weaver and R.D. Stein: Effects of spinal cord transection on sympathetic discharge in decerebrate-unanesthetized cats. Am. J. Physiol. 1989; 257: R1506–R1511.
J.H. Coote and D.R. Westbury: Intracellular recordings from sympathetic preganglionic neurones. Neurosci. Lett. 1979; 15: 171–176.
K. Dembowsky, J. Czachurski and H. Seller: An intracellular study of the synaptic input to sympathetic preganglionic neurones of the third thoracic segment of the cat. J. Auton. Nerv. Syst. 1985; 13: 201–244.
E.M. McLachlan and G.D.S. Hirst: Some properties of preganglionic neurons in upper thoracic spinal cord of the cat. J. Neurophysiol. 1980; 43: 1251–1265.
I.J. Llewellyn-Smith, K.D. Phend, J.B. Minson, P.M. Pilowsky and J.P. Chalmers: Glu-tamate-immunoreactive synapses on retrogradely-labelled sympathetic preganglionic neurons in rat thoracic spinal cord. Brain Res. 1992; 581: 67–80.
S.F. Morrison, I. Callaway, T.A. Milner and D.J. Reis: Glutamate in the spinal sympathetic intermediolateral nucleus: localization by light and electron microscopy. Brain Res. 1989; 503: 5–15.
S.F. Morrison, P. Ernsberger, T.A. Milner, J. Callaway, A. Gong and D.J. Reis: A glutamate mechanism in the intermediolateral nucleus mediates sympathoexcitatory responses to stimulation of the rostral ventrolateral medulla. In: J. Ciriello, M. M. Caverson and C. Polosa (Eds.): Central Neural Organization of Cardiovascular Control. Progress in Brain Research. Amsterdam: Elsevier, 1989: vol. 81, 159–169.
N. Bogan, A. Mennone and J.B. Cabot: Light microscopic and ultrastructural localization of GABA-like immunoreactive input to retrogradely labeled sympathetic preganglionic neurons. Brain Res. 1989; 505: 257–270.
T. Chiba and R. Semba: Immuno-electron microscopic studies on the gamma-ami-nobutyric acid and glycine receptor in the intermediolateral nucleus of the thoracic spinal cord of rats and guinea pigs. J. Auton. Nerv. Syst. 1991; 36: 173–182.
J.B. Cabot, V. Alessi and A. Bushneil: Glycine-like immunoreactive input to sympathetic preganglionic neurons. Brain Res. 1992; 571: 1–18.
T. Chiba and S. Masuko: Direct synaptic contacts of catecholamine axons on the preganglionic sympathetic neurons in the rat thoracic spinal cord. Brain Res. 1986; 380: 405–408.
T. Chiba and S. Masuko: Synaptic structure of the monoamine and peptide nerve terminals in the intermediolateral nucleus of the guinea pig thoracic spinal cord. J. Comp. Neurol. 1987; 262: 242–255.
H. Bernstein-Goral and M.C. Bohn: Phenylethanolamine N-methyltransferase-immunoreactive terminals synapse on adrenal preganglionic neurons in the rat spinal cord. Neuroscience 1989; 32: 521–537.
T.A. Milner, S.F. Morrison, C. Aboate and D.J. Reis: Phenylethanolamine N-methyl-transferase-containing terminals synapse directly on sympathetic preganglionic neurons in the rat. Brain Res. 1988; 448: 205–222.
T. Chiba: Direct synaptic contacts of 5-hydroxytryptamine-, neuropeptide Y-, and somatostatin-immunoreactive nerve terminals on the preganglionic sympathetic neurons of the guinea pig. Neurosci. Lett. 1989; 105: 281–286.
P. Poulat, L. Marlier, N. Rajaofetra and A. Privat: 5-hydroxytryptamine, substance P and thyrotropin-releasing hormone synapses in the intermediolateral cell column of the rat thoracic spinal cord. Neurosci. Lett. 1992; 136: 19–22.
P.L. Vera, V.R. Holets and K.E. Miller: Ultrastructural evidence of synaptic contacts between substance-P-immunoreactive, enkephalin-immunoreactive, and serotonin-immunoreactive terminals and retrogradely labeled sympathetic preganglionic neurons in the rat-a study using a double-peroxidase procedure. Synapse 1990; 6: 221–229.
P. Pilowsky, I.J. Llewellyn-Smith, J. Lipski and J. Chalmers: Substance P immunoreactive boutons form synapses with feline sympathetic preganglionic neurons. J. Comp. Neurol. 1992; 320: 121–135.
I.J. Llewellyn-Smith, J.B. Minson, D.A. Morilak, J.R. Oliver and J.P. Chalmers: Neuropeptide Y-immunoreactive synapses in the intermediolateral cell column of rat and rabbit thoracic spinal cord. Neurosci. Lett. 1990; 108: 243–248.
Y.-W. Li, Z.Q. Ding, S.L. Wesselingh and W.W. Blessing: Renal sympathetic preganglionic neurons demonstrated by herpes simplex virus transneuronal labelling in the rabbit: close apposition of neuropeptide Y-immunoreactive terminals. Neuroscience 1993; 53: 1143–1152.
P.G. Galabov: Ultrastructural localization of angiotensin II-like immunoreactivity in the vegetative networks of the spinal cord of the guinea pig. J. Auton. Nerv. Syst. 1992; 40: 215–222.
N.M. Appel and R.P. Elde: The intermediolateral cell column of the thoracic spinal cord is comprised of target-specific subnuclei: evidence from retrograde transport studies and immunohistochemistry. J. Neurosci. 1988; 8: 1767–1775.
R.B. McCall and M.E. Clement: Identification of serotonergic and sympathetic neurons in medullary raphe nuclei. Brain Res. 1989; 477: 172–182.
R.B. McCall and M.E. Clement: Role of serotonin 1A and serotonin2 receptors in the central regulation of the cardiovascular system. Pharmacol. Rev. 1994; 46: 231–243.
C.A. Fornai and B.L. Jacobs: Physiological and behavioral correlates of serotonergic single-unit activity. In: N.N. Osborne and M. Hamon (Eds.): Neuronal serotonin, Chichester: John Wiley and Sons Ltd., 1988.
H. Inokuchi, M. Yoshimura, C. Polosa and S. Nishi: Adrenergic receptors (α1 and α2) modulate different potassium conductances in sympathetic preganglionic neurons. Can. J. Physiol. Pharmacol. 1992; 70: S92–S97.
S.B. Backman and J.L. Henry: Effects of substance P and thyrotropin-releasing hormone on sympathetic preganglionic neurones in the thoracic intermediolateral nucleus of the cat. Can J Physiol Pharmacol. 1983; 62: 248–251.
M.P. Gilbey, K.E. McKenna and L.P. Schramm: Effects of substance P on sympathetic preganglionic neurones. Neurosci Lett. 1983; 41: 157–159.
R.B. McCall: Serotonergic excitation of sympathetic preganglionic neurons: a micro-iontophoretic study. Brain Res. 1983; 289: 121–127.
S. Nishi, M. Yoshimura and C. Polosa: Synaptic potentials and putative transmitter actions in sympathetic preganglionic neurons. In: J. Ciriello, F.R. Calaresu, L.P. Renaud and C. Polosa (Eds.): Organization of the autonomic nervous system: central and peripheral mechanisms. New York: Alan Liss Inc. 1987; 15–26.
H. Inokuchi, M. Yoshimura, S. Yamada, C. Polosa and S. Nishi: Fast excitatory postsynaptic potentials and the responses to excitant amino acids of sympathetic preganglionic neurons in the slice of the cat spinal cord. Neuroscience 1992; 46: 657–667.
P.G. Guyenet, M.-K. Sun and D.L. Brown: Role of GABA and excitatory amino-acids in medullary baroreflex pathway. In: J. Ciriello, F.R. Calaresu, L.P. Renaud, and C. Polosa (Eds.): Organization of the autonomic nervous system: central and peripheral mechanisms. New York: Alan Liss Inc. 1987; 215–225.
J. Minson, P. Pilowsky, I.J. LLewellyn-Smith, T. Kaneko, V. Kapoor and J.P. Chalmers: Glutamate in spinally projecting neurons of the rostral ventral medulla. Brain Res. 1991; 555: 326–331.
O. Johansson, T. Hokfelt and B. Pernow et al.: Immunohistochemical support for three putative transmitters in one neuron: co-existence of 5-hydroxytryptamine, substance P and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord. J. Neurosci. 1981; 6: 1857–1881.
R.B. McCall and G.K. Aghajanian: Serotonergic facilitation of facial motoneuron excitation. Brain Res. 1979; 169: 11–27.
D.I. Lewis and J.H. Coote: Excitation and inhibition of rat sympathetic preganglionic neurones by catecholamines. Brain Res. 1990; 530: 229–234.
H. Inokuchi, M. Yoshimura, A. Trzebski, C. Polosa and S. Nishi: Fast inhibitory postsynaptic potentials and responses to inhibitory amino acids of sympathetic preganglionic neurons in the adult cat. J. Auton. Nerv. Syst. 1992; 41: 53–60.
R.B. McCall, G.L. Gebber and S.M. Barman: Spinal interneurons in the barorecep-tor reflex arc. Am. J. Physiol. 1977; 232: H657–H665.
S.B. Backman and J.L. Henry: Effects of GABA and glycine on sympathetic preganglionic neurons in the upper thoracic intermediolateral nucleus of the cat. Brain Res. 1983; 277: 365–369.
F.J. Gordon: Spinal GABA receptors and central cardiovascular control. Brain Res. 1985; 328: 165–169.
D. Blottner and H.G. Baumgarten: Nitric oxide synthetase (NOS)-containing sympathoadrenal cholinergic neurons of the rat IML cell column: evidence from histochemistry, immunohistochemistry, and retrograde labeling. J. Comp. Neurol. 1992; 316: 45–55.
J.A. Gaily, P.R. Montague, G.N. Reeke and G.M. Edelman: The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system. Proc. Natl. Acad. Sci. 1990; 87: 3547–3551.
J. Garthwaite: Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci. 1991; 14: 60–67.
C.A. Ross, D.A. Ruggerio, D.H. Park, et al.: Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing Cl adrenaline neurons on arterial pressure, heart rate and plasma catecholamines and vasopressin. J. Neurosci. 1984; 4: 474–494.
R.A.L. Dampney, A.K. Goodchild, L.G. Robertson and W. Montgomery: Role of ventrolateral medulla in vasomotor regulation: a correlative anatomical and physiological study. Brain Res. 1982; 249: 223–235.
P.J. Gad, W.P. Norman, A.M.T. Da Salve and R.A. Gills: Cardiorespiratory effects produced by microinjecting L-glutamic acid into medullary nuclei associated with the ventral surface of the feline medulla. Brain Res. 1986; 381: 281–288.
R.N. Willette, P.P. Barcas, A.J. Krieger and H.N. Sapru: Vasopressor and depressor areas in the rat medulla: identification by microinjection of L-glutamate. Neurophar-macol. 1983; 22: 1071–1079.
R.N. Willette, S. Punnen-Grandy, A.J. Krieger, H.N. Sapru: Differential regulation of regional vascular resistance by the rostral and caudal ventrolateral medulla in the rat. J. Auton. Nerv. Syst. 1987; 18: 143–151.
W. Feldberg and P.G. Guertzenstein: A vasodepressor effect of pentobarbitone sodium. J. Physiol. 1972; 224: 83–103.
P.G. Guertzenstein and A. Silver: Fall in blood pressure from discrete regions of the ventral surface of the medulla by glycine and lesions. J. Physiol. 1974; 242: 489–503.
R.A. Dampney and E.A. Moon: Role of ventrolateral medulla in vasomotor response to cerebral ischemia. Am. J. Physiol. 1980; 239: H349–H358.
E.E. Benarroch, A.R. Granata, D. Ruggiero, D.H. Park and D.J. Reis: Neurons of the Cl area mediate cardiovascular responses initiated form the ventral medullary surface. Am J Physiol. 1986; 250: R932–R945.
S.M. Barman and G.L. Gebber: Basis for the naturally occurring activity of rostral ventrolateral medullary sympathoexcitatory neurons. In: J. Ciriello, M.M. Caverson and C. Polosa (Eds.): Central Neuronal Organization of Cardiovascular Control. Progress in Brain Research. Amsterdam: Elsevier, 1989: vol. 81, 117–129.
S.M. Barman and G.L. Gebber: Axonal projection patterns of ventrolateral medul-lospinal sympathoexcitatory neurons. J. Neurophysiol. 1985; 53: 1551–1566.
D.L. Brown and P.G. Guyenet: Cardiovascular neurons of brainstem with projections to spinal cord. Am. J. Physiol. 1984; 247: R1009–R1016.
P.G. Guyenet and D.L. Brown: Nucleus paragigantocellularis lateralis and lumbar sympathetic discharge in the rat. Am. J. Physiol. 1986; 250: R1081–R1094.
R.M. McAllen: Identification and properties of subretrofacial bulbospinal neurones: a descending cardiovascular pathway in the cat. J. Auton. Nerv. Syst. 1986; 17: 151–164.
R.B. McCall: Lack of involvement of GABA in baroreceptor-mediated sympathoin-hibition. Am. J. Physiol. 1986; 253: R1065–R1073.
R.B. McCall: GABA-mediated inhibition of sympathoexcitatory neurons by midline medullary stimulation. Am. J. Physiol. 1988; 255: R605–R615.
M.-K. Sun and P.G. Guyenet: GABA-mediated baroreceptor inhibition of reticulospinal neurons. Am. J. Physiol. 1985; 249: R672–R680.
S.M. Barman and G.L. Gebber: Lateral tegmental field neurons play a permissive role in governing the 10-Hz rhythm in sympathetic nerve discharge. Am. J. Physiol. 1993; 265: R1006–R1013.
S.M. Barman, G.L. Gebber and S. Zhong: The 10-Hz rhythm in sympathetic nerve discharge. Am. J. Physiol. 1992; 262: R1006–1014.
S.M. Barman, H.S. Orer and G.L. Gebber: Caudal ventrolateral medullary neuron are elements of the network responsible for 10-Hz rhythm in sympathetic nerve discharge. J. Neurophysiol. 1994; 72: 106–120.
S.M. Barman and G.L. Gebber: Rostral ventrolateral medullary and caudal medullary raphe neurons with activity correlated to the 10-Hz rhythm in sympathetic nerve discharge. J. Neurophysiol. 1992; 68: 1535–1547.
S. Zhong, S.M. Barman and G.L. Gebber: Effects of brain stem lesions on 10-Hz and 2-to 6-Hz rhythms in sympathetic nerve discharge. Am. J. Physiol. 1992; 262: R1015–R1024.
S.M. Barman and G.L. Gebber: Lateral tegmental field neurons of cat medulla: a source of basal activity of ventrolateral medullospinal sympathoexcitatory neurons. J. Neurophysiol. 1987; 57: 1410–1424.
D.L. Brown and P.G. Guyenet: Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats. Circ. Res. 1985; 56: 359–369.
R.M. McAllen: Actions of carotid chemoreceptors on subretrofacial bulbospinal neurons in the cat. J. Auton. Nerv. Syst. 1992; 40: 181–188.
S.F. Morrison and D.J. Reis: Reticulospinal vasomotor neurons in the RVL mediate the somatosympathetic reflex. Am. J. Physiol. 1989; 256: R1084–R1097.
Y. Saeki, N. Terui and M. Kumada: Participation of ventrolateral medullary neurons in the renal-sympathetic reflex in rabbits. Jpn. J. Physiol. 1988; 38: 267–281.
L. Salve-Carvalho, J.F.R. Paton, G.E. Goldsmith and K.M. Spyer: The effects of electrical stimulation of lobule IXb of the posterior cerebellar vermis on neurones within the rostral ventrolateral medulla in the anaesthetized cat. J. Auton. Nerv. Syst. 1991; 36: 97–106.
M.-K. Sun: Medullospinal vasomotor neurones mediate hypotension from stimulation of prefrontal cortex. J. Auton. Nerv. Syst. 1992; 38: 209–218.
M.-K. Sun and K.M. Spyer: Responses of rostroventrolateral medulla spinal vasomotor neurones to chemoreceptor stimulation in rats. J. Auton. Nerv. Syst. 1991; 33: 79–84.
M.-K. Sun and K.M. Spyer: GABA-mediated inhibition of medullary vasomotor neurones by area postrema stimulation in rats. J. Physiol. 1991; 436: 669–684.
M.-K. Sun and K.M. Spyer: Nociceptive inputs into rostral ventrolateral medulla spinal vasomotor neurones in rats. J. Physiol. 1991; 436: 685–700.
A.J.M. Verberne and P.G. Guyenet: Midbrain central gray-influence on medullary sympathoexcitatory neurons and the baroreflex in rats. Am J. Physiol. 1992; 263: R24–R33.
M.A. Vizzard, A. Standish and W.S. Ammons: Renal afferent input to the ventrolateral medulla of the cat. Am J. Physiol. 1992; 263: R412–R422.
B.J. Yates, Y. Yamagata and P.S. Bolton: The ventrolateral medulla of the cat mediates vestibulosympathetic reflexes. Brain Res. 1991; 552: 265–272.
B.J. Yates, Y. Goto and P.S. Bolton: Responses of neurons in the rostral ventrolateral medulla of the cat to natural vestibular stimulation. Brain Res. 1993; 601: 255–264.
D.F. Cechetto and S.J. Chen: Hypothalamic and cortical sympathetic responses relay in the medulla of the rat. Am. J. Physiol. 1992; 263: R544–R552.
R.A.L. Dampney: Brain stem mechanisms in the control of arterial pressure. Clin Exp. Hypertens. 1981; 3: 379–393.
A.F. Sved, D.L. Mancini, J.C. Graham, A.M. Schreihofer and G.E. Hoffman: PNMT-containing neurons of the Cl cell group express c-fos in response to changes in baro-receptor input. Am. J. Physiol. 1994; 266: R361–R367.
S.F. Morrison, T. A. Milner and D.J. Reis: Reticulospinal vasomotor neurons of the rat rostral ventrolateral medulla: relationship to sympathetic nerve activity and the C1 adrenergic cell group. J. Neurosci. 1988; 8: 1286–1301.
J.R. Haselton and P.G. Guyenet: Electrophysiological characterization of putative Cl adrenergic neurons in the rat. Neuroscience 1989; 30: 199–214.
M.-K. Sun, J.T. Hackett and P.G. Guyenet: Sympathoexcitatory neurons of rostral ventrolateral medulla exhibit pacemaker properties in the presence of a glutamate-receptor antagonist. Brain Res. 1988; 438: 23–40.
M.-K. Sun, B.S. Young, J.T. Hackett and P.G. Guyenet: Rostral ventrolateral medullary neurons with intrinsic pacemaker properties are not catecholaminergic. Brain Res. 1988; 451: 345–349.
I. M. Kangraga and A.D. Loewy: Whole-cell patch-clamp recordings from visualized bulbospinal neurons in the brainstem slices. Brain Res. 1994; 641: 181–190.
D.J. Reis, C. Ross, A. R. Granata and D.A. Ruggiero: Role of Cl area of rostroven-trolateral medulla in cardiovascular control. In: J.P. Buckley and D.M. Ferrario (Eds.): Brain peptides and catecholamines in cardiovascular regulation. New York: Raven Press, 1987; 1–14.
C.A. Ross, D.A. Ruggiero, T.H. Joh, D.H. Park and D.J. Reis: Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons. J. Comp. Neurol. 1984; 228: 168–185.
D.C. Tucker, C.B. Saper, D.A. Ruggiero and D.J. Reis: Organization of central adrenergic pathways: I. Relationships of ventrolateral medullary projections to the hypothalamus and spinal cord. J. Comp. Neurol. 1987; 259: 591–603.
J.W. Poison, G.M. Halliday, R.M. McAllen, M.J. Coleman and R.A.L. Dampney: Ros-trocaudal differences in morphology and neurotransmitter content of cells in the subretrofacial vasomotor nucleus. J. Auton. Nerv. Syst. 1992; 38: 117–138.
D.A. Ruggiero, S.L. Cravo, V. Arango and D.J. Reis: Central control of the circulation by the rostral ventrolateral reticular nucleus-anatomical substrates. In: J. Ciriello, M.M. Caverson and C. Polosa (Eds.): Central Neural Organization of Cardiovascular Control. Progress in Brain Research. Amsterdam: Elsevier, 1989: vol. 81, 49–79.
M.E. Clement and R.B. McCall: Effects of Clonidine on sympathoexcitatory neurons in the rostral ventrolateral medulla. Brain Res. 1991; 550: 353–357.
P.G. Guyenet and J.B. Cabot: Inhibition of sympathetic preganglionic neurons by catecholamines and Clonidine: mediation by an adrenergic receptor. J. Neurosci. 1981; 1: 908–917.
P.G. Guyenet and R.L. Stornetta: Inhibition of sympathetic preganglionic discharges by epinephrine and α-methylepinephrine. Brain Res. 1982; 235: 271–283.
K. Kadzielawa: Inhibition of the activity of sympathetic preganglionic neurones and neurones activated by visceral afferents, by alpha-methylnoradrenaline and endogenous catecholamines. Neuropharmacol. 1983; 22: 3–17.
A.V. Seybold and R.P. Elde: Receptor autoradiography in thoracic spinal cord: correlation of neurotransmitter binding sites with sympathoadrenal neurons. J. Neurosci. 1984; 4: 2533–2542.
T. Miyazaki, J.H. Coote and N.J. Dun: Excitatory and inhibitory effects of epinephrine on neonatal rat sympathetic preganglionic neurons in vitro. Brain Res. 1989; 497: 108–116.
C. Sangdee and D.N. Franz: Evidence for inhibition of sympathetic preganglionic neurons by bulbospinal epinephrine pathways. Neurosci. Lett. 1983; 37: 167–173.
G.A. Head and P.R.C. Howe: Effects of 6-hydroxydopamine and the PNMT inhibitor LY134046 on pressor responses to stimulation of the subretrofacial nucleus in anaesthetized stroke-prone spontaneously hypertensive rats. J. Auton. Nerv. Syst. 1987; 18: 213–224.
A.F. Sved: PNMT-containing catecholaminergic neurons are not necessarily adrenergic. Brain Res. 1989; 481: 113–118.
T. Kubo and M. Kihara: Evidence of N-methyl-D-aspartate receptor-mediated modulation of the aortic baroreceptor reflex in the rat nucleus tractus solitarii. Neurosci. Lett. 1988; 87: 69–74.
D. Haungfu, L.J. Hwang, T. A. Riley and P.G. Guyenet: Role of serotonin and catecholamines in sympathetic responses evoked by stimulation of rostral medulla. Am. J. Physiol. 1994; 266: R338–R352.
M.K. Bazil and F.J. Gordon: Effect of blockade of spinal NMDA receptors on sym-pathoexcitation and cardiovascular responses produced by cerebral ischemia. Brain Res. 1991; 555: 149–152.
K. Sundara and H. Sapru: NMDA receptors in the intermediolateral column of the spinal cord mediate sympathoexcitatory cardiac responses elicited from the ventrolateral medullary pressor area. Brain Res. 1991; 544: 33–41.
A.R. Granata and H.T. Chang: Relationship of calbindin D-28k with afferent neurons to the rostral ventrolateral medulla in the rat. Brain Res. 1994; 645: 265–277.
T.A. Milner, V.M. Pickel, S.F. Morrison and D.J. Reis: Adrenergic neurons in the rostral ventrolateral medulla: ultrastructure and synaptic relations with other transmitter-identified neurons. In: J. Ciriello, M.M. Caverson and C. Polosa (Eds.): Central Neural Organization of Cardiovascular Control. Progress in Brain Research. Amsterdam: Elsevier, 1989: vol. 81, 29–47.
M.-K. Sun and P.G. Guyenet: Arterial baroreceptor and vagal inputs to sympathoexcitatory neurons in rat medulla. Am. J. Physiol. 1986; 252: R699–R709.
M.-K. Sun and P.G. Guyenet: Hypothalamic glutamatergic input to medullary sympathoexcitatory neurons in rats. Am. J. Physiol. 1986; 251: R798–R810.
V. Kapoor, D. Nakahara, R.J. Blood and J.P. Chalmers: Preferential release of neu-roactive amino acids from the ventrolateral medulla of the rat in vivo as measured by microdialysis. Neuroscience 1990; 37: 187–191.
V. Kapoor, V.J. Minson and J.P. Chalmers: Ventral medulla stimulation increases blood pressure and spinal cord amino acid release. NeuroReport 1992; 3: 55–58.
T.P. Abrahams, P.J. Hornby, K. Chen, A.M. da Silva and R.A. Gills: The non-NMDA subtype of excitatory amino acid receptor plays the major role in control of cardiovascular function by the subretrofacial nucleus in cats. J. Pharmacol. Exp. Therap. 1994; 270: 424–432.
Z.J. Gieroba and W.W. Blessing: Blockade of excitatory amino acid receptors in the ventrolateral medulla does not abolish the cardiovascular actions of L-glutamate. Naunyn Schmied. Arch. Pharmacol. 1993; 347: 66–72.
P.G. Guyenet, T.M. Filtz and S.R. Donaldson: Role of excitatory amino acids in rat vagal and sympathetic baroreflexes. Brain Res. 1987; 407: 272–284.
R.A. Gills, I.J. Namath, C. Easington, T.P. Abrahams, A. Guidotti, J.A. Quest, P. Hamosh and A.M. Taveira-daSilva: Drug interaction with gamma-aminobutyric acid/benzodiazepine receptors at the ventral surface of the medulla results in pronounced changes in cardiorespiratory activity. J. Pharmacol. Exp. Therap. 1989; 248: 863–870.
R.A.L. Dampney, W.W. Blessing and E. Tan: Origin of tonic GABAergic inputs to vasopressor neurons in the subretrofacial nucleus of the rabbit. J. Auton. Nerv. Syst. 1988; 24: 227–239.
T. Kubo and M. Kihara: Studies on GABAergic mechanisms responsible for cardiovascular regulation in the rostral ventrolateral medulla of the rat. Arch. Int. Phar-macodyn. Ther. 1987; 285: 277–287.
M.-K. Sun and P.G. Guyenet: GABA-mediated baroreceptor inhibition of reticulospinal neurons. Am. J. Physiol. 1985; 249: R672–R680.
R.N. Willette, P.P. Barcas, A.J. Krieger and H.N. Sapru: Endogenous GABAergic mechanisms in the medulla and the regulation of blood pressure. J. Pharmacol. Exp. Therap. 1984; 230: 34–39.
A.J.M. Verberne and P.G. Guyenet: Medullary pathway of the Bezold-Jarisch reflex in the rat. Am. J. Physiol. 1992; 263: R1190–R1202.
M. Amano and T. Kubo: Involvement of both GABAA and GABAB receptors in tonic inhibitory control of blood pressure at the rostral ventrolateral medulla of the rat. Naunyn Schmied. Arch. Pharmacol. 1993; 348: 146–153.
Y.-W. Li and P.G. Guyenet: Neuronal inhibition by a GABAB receptor agonist in the rostral ventrolateral medulla of the rat. Am. J. Physiol. 1995; 268: R428–R437.
R.B. McCall and S.J. Humphrey: Evidence for GABA mediation of sympathetic inhibition evoked from midline medullary depressor sites. Brain Res. 1985; 339: 356–361.
D.A. Ruggiero, M.P. Meeley, M. Anwar and D.J. Reis: Newly identified GABAergic neurons in regions of the ventrolateral medulla which regulate blood pressure. Brain Res. 1985; 339: 171–177.
M. Kihara and T. Kubo: Immunocytochemical localization of GABA containing neurons in the ventrolateral medulla oblongata of the rat. Histochem. 1989; 91: 309–314.
H.W.M. Steinbusch: Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 1981; 6: 557–618.
K.B. Thor, A. Blitz-Siebert and C.J. Helke: Discrete localization of high-density 5-HT1A binding sites in the midline raphe and parapyramidal region of the ventral medulla oblongata of the rat. Neurosci. Lett. 1990; 108: 249–254.
R.A. Gills, K.J. Hill, J.S. Kirby, J.A. Quest, P. Hamosh, W.P. Norman and K.J. Kellar: Effect of activation of central nervous system serotonin1A receptors on cardiorespiratory function. J. Pharmacol. Exp. Therap. 1989; 248: 851–857.
T.A. Lovick: Systemic and regional haemodynamic responses to microinjection of 5-HT agonists in the rostral ventrolateral medulla in the rat. Neurosci. Lett. 1989; 107: 157–161.
A. Nosjean and P.G. Guyenet: Role of the ventrolateral medulla in the sympatholytic effect of 8-OH DPAT in rats. Am. J. Physiol. 1991; 260: R600–R609.
A.K. Mandai, K.J. Kellar, and R.A. Gills: The subretrofacial nucleus: a major site of action for the cardiovascular effects of 5-HT1A and 5-HT2 agonist drugs. In: J.R. Fozard and P.R. Saxena (Eds.): Serotonin: Molecular Biology, Receptors and Functional Effects, Birkhäuser Verlag, Basel, 1991; 289–299.
K.A. King and J.R. Holtman: Characterization of the effects of activation of ventral medullary serotonin receptor subtypes on cardiovascular activity and respiratory motor outflow to the diaphragm and larynx. J. Pharmacol. Exp Therap. 1990; 252: 665–674.
M. Laubie, M. Drouillat, H. Dabire, C. Cherqui and H. Schmitt: Ventrolateral medullary pressor area: site of hypotensive and sympatho-inhibitory effects of 8-OH DPAT in anesthetized dogs. Eur. J. Pharmacol. 1989; 160: 385–394.
M.E. Clement and R.B. McCall: Studies on the site and mechanism of the sympatholytic action of 8-OH DPAT. Brain Research 1990; 525: 232–241.
D.I. Lewis and J.H. Coote: The actions of 5-hydroxytryptamine on the membrane of putative sympatho-excitatory neurones in the rostral ventrolateral medulla of the adult rat in vitro. Brain Research 1993; 609: 103–109.
W.H. Wang and T.A. Lovick: Inhibitory serotonergic effects on rostral ventrolateral medullary neurons. Pflugers Arch. 1992; 422: 93–97.
E.J. Mah and K.A. Cunningham: Electrophysiological studies of the serotonergic (5-HT) modulation of glutamate-evoked activity in amygdala neurons. Neurosci. Abst. 1993; 19: 1554.
A.K. Mandal K.J. Kellar, W.P. Norman and R.A. Gills: Stimulation of serotonin2 receptors in the ventrolateral medulla of the cat results in nonuniform increases in sympathetic outflow. Circ. Res. 1990; 67: 1267–1280.
C. Vayssettes-Courchay, F. Bouysset, T.J. Verbeuren, M. Laubie and H. Schmitt: Qui-pazine-induced hypotension in anaesthetized cats is mediated by central and peripheral 5-HT2 receptors: role of the ventrolateral pressor area. Europ. J. Pharmacol. 1991; 192: 389–395.
M.E. Clement and R.B. McCall: Studies on the site and mechanism of the sympa-thoexcitatory action of 5-HT2 agonists. Brain Res. 1990; 515: 299–302.
Y. Yasui, D.F. Cechetto and C.B. Saper: Evidence for a cholinergic projection from the pedunculopontine tegmental nucleus to the rostral ventrolateral medulla in the rat. Brain Res. 1990; 517: 19–24.
S.B. Lee, S.Y. Kim and K.W. Sung: Cardiovascular regulation by cholinergic mechanisms in rostral ventrolateral medulla of spontaneously hypertensive rats. Eur. J. Pharmacol. 1991; 205: 117–123.
K. Sundaram and J. Sapru: Cholinergic nerve terminals in the ventrolateral medullary pressor area: pharmacological evidence. J. Auton. Nerv. Syst. 1988; 22: 221–228.
R.N. Willette, S. Punnen, A.J. Krieger and H.N. Sapru: Cardiovascular control by cholinergic mechanisms in the rostral ventrolateral medulla. J. Pharmacol. Exp. Therap. 1984; 231:457–463.
R. Giuliano, D.A. Ruggiero, S.F. Morrison, P. Ernsberger and D.J. Reis: Cholinergic regulation of arterial pressure by the Cl area of the rostral ventrolateral medulla. J. Neurosci. 1989; 9: 923–942.
K. Sundaram and H. Sapru: Cholinergic nerve terminals in the ventrolateral medullary pressor area: pharmacological evidence. J. Auton. Nerv. Syst. 1988; 22: 221–228.
H. Sapru: Cholinergic mechanisms subserving cardiovascular function in the medulla and spinal cord. Prog. Brain Res. 1989; 81: 171–179.
S.P. Arneric, R. Giuliano, P. Ernsberger, M.D. Underwood and D.J. Reis: Synthesis, release and receptor binding of acetylcholine in the Cl area of the rostral ventrolateral medulla: contributions in regulating arterial pressure. Brain Res. 1990; 511: 98–112.
H.S. Orer, S.M. Barman, S. Zhong and G.L. Gebber: A modulatory role of central cholinergic transmission in control of the 10-Hz rhythm in sympathetic nerve discharge. Brain Res. 1994; 661: 283–288.
D.A. Morilak, P. Somogyi, R.A.J. McIlhinney and J.P. Chalmers: An enkephalin-con-taining pathway from nucleus tractus solitarius to the pressor area of the rostral ventrolateral medulla of the rabbit. Neuroscience 1989; 31: 187–194.
S. Punnen, R. Willette, A.J. Krieger and H.N. Sapru: Cardiovascular response to injections of enkephalin in the pressor area of the ventrolateral medulla. Neuropharma-col. 1984, 23: 939–946.
H.N. Sapru, S. Punnen and R.N. Willette: Role of enkephalins in ventrolateral medullary control of blood pressure. In: J.P. Buckley and C.M. Ferrano (Eds.): Brain Peptides and Catecholamines in Cardiovascular Regulation. New York: Raven, 1987; 153–167.
M.-K. Sun and P.G. Guyenet: Effects of vasopressin and other neuropeptides on rostral medullary sympathoexcitatory neurons in vitro. Brain Res. 1989; 492: 261–270.
R.W. Urbanski, J. Murugaian, A. Krieger and H.N. Sapru: Cardiovascular effects of substance P receptor stimulation in the ventrolateral medullary pressor and depressor areas. Brain. Res. 1989; 491: 383–389.
R.E. Gomez, M.A. Cannata, T.A. Milner, M. Anwar, D.J. Reis and D.A. Ruggiero: Vasopressinergic mechanisms in the nucleus reticularis lateralis in blood pressure control. Brain Res. 1993; 604: 90–105.
A.M. Allen, S.Y. Chai, P.M. Sexton, S.J. Lewis, A.J.M. Verberne, B. Jarrott, W.J. Louis, J. Clevers, M.J. McKinley, G. Paxinos and F.A.O. Mendelsohn: Angiotensin II receptors and angiotensin converting enzyme in the medulla oblongata. Hypertension 1987; 9 Suppl.: III198–III205.
A.M. Allen, R.A.L. Dampney and F.A.O. Mendelsohn: Angiotensin receptor binding and pressor effects in cat subretrofacial nucleus. Am J. Physiol. 1988; 255: H1011–H1017.
R.W. Lind, L.W. Swanson and D. Ganten: Organization of angiotensin immunoreac-tive cells and fibers in the rat central nervous system. Neuroendocrinology 1985; 40: 2–24.
G.P. Aldred, S.Y. Chai, K.-F. Song, J.-L Zhuo, D. MacGregor and F.A.O. Mendelsohn: Distribution of angiotensin receptor subtypes in the rabbit brain. Regul. Peptides 1993; 21: 119–130.
K.-F. Song, A.M. Allen, G. Paxinos and F.A.O. Mendelsohn: Mapping of angiotensin receptor subtype heterogeneity in rat brain. J. Comp. Neurol. 1992; 316: 467–484.
S. Sasaki and R.A. Dampney: Tonic cardiovascular effects of angiotensin II in the ventrolateral medulla. Hypertension 1990; 15: 274–283.
H. Muratani, C.M. Ferrano and D.B. Averill: Ventrolateral medulla in spontaneously hypertensive rats-role of angiotensin II. Am J. Physiol. 1993; 264: R388–R395.
S. Sasaki, Y.W. Li and R.A. Dampney: Comparison of the pressor effects of angiotensin II and III in the rostral ventrolateral medulla. Brain Res. 1993; 600: 335–338.
Y.-W. Li, J.W. Poison and R.A. Dampney: Angiotensin II excites vasomotor neurons but not respiratory neurons in the rostral and caudal ventrolateral medulla. Brain Res. 1992; 577: 161–164.
Y.-W. Li and P.G. Guyenet: Neuronal excitation by angiotensin II in the rostral ventrolateral medulla of the rat in vitro. Am J. Physiol. 1995; 268: R272–R277.
R.M. Bowker, K.N. Westlund, M.C. Sullivan, J.F. Wilber and J.D. Coulter: Descending serotonergic, peptidergic and cholinergic pathways from the raphe nuclei: a multiple transmitter complex. Brain Res. 1983; 288: 33–48.
N.M. Appel, M.W. Wessendorf and R.P. Elde: Thyrotropin-releasing hormone in spinal cord: coexistence with serotonin and with substance P in fibers and terminals apposing identified preganglionic sympathetic neurons. Brain Res. 1987; 415: 137–143.
D.E. Millhorn, T. Hokfelt, K. Serogy, W. Oertel, A.A.J. Verhofstad and J.-Y. Wu: Immu-nohistochemical evidence for colocalization of g-aminobutyric acid and serotonin in neurons of the ventral medulla oblongata projecting to the spinal cord. Brain Res. 1987; 410:179–185.
C.J. Helke, K.B. Thor and D.A. Sasek: Chemical neuroanatomy of the parapyrami-dal region of the ventral medulla in the rat. In: J. Ciriello, M.M. Caverson and C. Polosa (Eds.): Central Neural Organization of Cardiovascular Control. Progress in Brain Research. Amsterdam: Elsevier, 1989: vol. 81, 177–188.
P.R.C. Howe, D.M. Kuhn, J.B. Minson, B.H. Stead and J.P. Chalmers: Evidence for a bulbospinal serotonergic pressor pathway in the rat brain. Brain Res. 1983; 270: 29–36.
G.A. Head and P.R.C. Howe: Effects of 6-hydroxydopamine and the PNMT inhibitor LY134046 on pressor responses to stimulation of the subretrofacial nucleus in anaesthetized stroke-prone spontaneously hypertensive rats. J. Auton. Nerv. Syst. 1987; 18: 213–224.
J.B. Minson, J.P. Chalmers, A.C. Caon and B. Renaud: Separate areas of rat medulla oblongata with populations of serotonin-and adrenaline-containing neurons alter blood pressure after L-glutamate stimulation. J. Auton. Nerv. Syst. 1987; 19: 39–50.
M.W. Wessendorf and R. Elde: The coexistence of serotonin-and substance P-like immunoreactivity in the spinal cord of the rat as shown by immunofluorescent double labeling. J. Neurosci. 1987; 7: 3252–3263.
C.J. Helke, J.J. Neil, V.J. Massari and A.D. Loewy: Substance P neurons project from the ventral medulla to the intermediolateral cell column in the rat. Brain Res. 1982; 243: 147–152.
B.M. Davis, J.E. Krause, J.F. McKelry and J.B. Cabot: Effects of spinal lesions on substance P levels in the rat sympathetic preganglionic cell column: evidence for local spinal regulation. Neurosci. 1984; 13: 1311–1326.
S.B. Backman and J.L. Henry: Effects of substance P and thyrotropin-releasing hormone on sympathetic preganglionic neurones in the thoracic intermediolateral nucleus of the cat. Can. J. Physiol. Pharmacol. 1983; 62: 248–251.
M.P. Gilbey, K.E. McKenna and L.P. Schramm: Effects of substance P on sympathetic preganglionic neurones. Neurosci Lett. 1983; 41: 157–159.
S.B. Backman, H. Sequeiramartinho and J.L. Henry: Adrenal versus nonadrenal sympathetic preganglionic neurones in the lower thoracic intermediolateral nucleus of the cat: effects of serotonin, substance P, and thyrotropin-releasing hormone. Can. J. Physiol. Pharmacol. 1990; 68: 1108–1118.
N.J. Dun and N. Mo: In vitro effects of substance P on neonatal rat sympathetic preganglionic neurones. J. Physiol. 1988; 399: 321–334.
C.J. Helke, E.T. Phillip and J.T. ONeil: Regional peripheral and CNS hemodynamic effects of intrathecal administration of a substance P receptor agonist. J. Auton. Nerv. Syst. 1987; 21: 1–7.
A.P.M. Yusof and J.H. Coote: The action of a substance P antagonist on sympathetic nerve activity in the rat. Neurosci Lett. 1987; 75: 329–333.
J.R. Keeler, C.G. Charlton and C.J. Helke: Cardiovascular effects of spinal cord substance P: studies with a stable receptor agonist. J. Pharmacol. Exp.Therap. 1985; 233: 755–760.
K. Yashpal, S. Gauthier and J.L. Henry: Substance P given intrathecally at the spinal T9 level increases arterial pressure and heart rate in the rat. J. Auton. Nerv. Syst. 1987; 18: 93–103.
A.D. Loewy and W.B. Sawyer: Substance P antagonist inhibit vasomotor responses elicited from ventral medulla in rat. Brain Res. 1982; 245: 379–383.
Y. Takano, J.E. Martin, S.E. Leeman and A.D. Loewy: Substance P immunoreactiv-ity released from spinal cord after kainic acid excitation of the ventral medulla oblongata: a correlation with increases in blood pressure. Brain Res. 1984; 291: 168–172.
J.R. Keeler and C.J. Helke: Spinal cord substance P mediates bicuculline-induced activation of cardiovascular responses from the ventral medulla. J. Auton. Nerv. Syst. 1985; 13: 19–33.
T. Hokfelt, S. Vincent, L. Hellsten, et al.: Immunohistochemical evidence for a “neurotoxic” action of (D-Pro2,D-Trp7.9) substance P, an analogue with substance P antagonistic activity. Acta Physiol. Scand. 9181; 113: 571–573.
C. Post, J.-A. Karlsson, F.G. Butterworth, C.G.A. Persson and G.R. Strichartz: Local anaesthetic effects of substance P (SP) analogues in vitro. In: C.C. Jordan and P. Oehme (Eds.): Substance P: metabolism and biological activity. London, Taylor and Francis, 1985; 227–241.
B.F. Cox, R.L. Schelper, F.M. Faraci and M.J. Brody: Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists. Exp. Brain Res. 1988; 70: 61–72.
C.J. Helke and E.T. Phillips: Substance P antagonist-induced spinal cord vasoconstriction: effects of thyrotropin-releasing hormone and substance P agonists. Peptides 1988; 9: 1307–1315.
D.N. Franz, B.D. Hare and K.L. McCloskey: Spinal sympathetic neurons: possible sites of opiate-withdrawal suppression by Clonidine. Science 1982; 215: 11643–11645.
C.W. Xie, J. Tang and J.S. Han: Clonidine stimulates the release of dynorphin in the spinal cord of the rat: a possible mechanism for its depressor effects. Neurosci Lett. 1986; 65: 224–228.
K.E. McKenna and L.P. Schramm: Mechanisms mediating the silent period. Studies in the isolated spinal cord of the neonatal rat. Brain Res. 1985; 329: 233–240.
K. Amendt, J. Czachurski, K. Dembowsky and H. Seller: Bulbospinal projections to the intermediolateral cell column: a neuroanatomical study. J. Auton. Nerv. Syst. 1979; 1:103–117.
S.C. Wang and S.W. Ranson: Autonomic responses to electrical stimulation of the lower brain stem. J Comp Neurol. 1939; 71: 437–455.
R.B. McCall and L.T. Harris: Role of serotonin and serotonin receptor subtypes in the central regulation of blood pressure. In: R.H. Rech and G.A. Gudelsky (Eds.): 5-HT agonists as psychoactive drugs, Ann Arbor: NPP Books, 1988; 1433–1162.
R.B. McCall: Role of serotonin in the regulation of sympathetic nerve discharge. In P. Saxena, D.I. Wallis, W. Wouters and P. Bevan (Eds.): Cardiovascular Pharmacology of 5-hydroxytryptamine: prospective therapeutic applications. Dordrecht: Kluwer Academic Publishers, 1990, 271–283.
J.R. Adair, B.L. Hamilton, K.A. Scappaticci, C.J. Helke and R.A. Gills: Cardiovascular responses to electrical stimulation of the medullary raphe area of the cat. Brain Res. 1977; 128: 141–145.
R.B. McCall: Evidence for a serotonergically mediated sympathoexcitatory response to stimulation of medullary raphe nuclei. Brain Res. 1984; 311: 131–139.
S.E. Morrison and G.L. Gebber: Classification of raphe neurons with cardiac-related activity. Am. J. Physiol. 1982; 243: R49–R59.
S.F. Morrison and G.L. Gebber: Raphe neurons with sympathetic-related activity: baroreceptor responses and spinal connections. Am. J. Physiol. 1984; 246: R338–R348.
M.D. Hirsch and C.J. Helke: Bulbospinal thyrotropin-releasing hormone projections to the intermediolateral cell column: a double fluorescence immunohistochemical-retrograde tracing study in the rat. Neuroscience 1988; 25: 625–638.
R.B. Lynn, M.S. Kreider and R.R. Miselis: Thyrotropin-releasing hormone-immu-noreactive projections to the dorsal motor nucleus and the nucleus of the solitary tract of the rat. J. Comp. Neurol. 1991; 311: 271–288.
S.F. Morrison: Raphe pallidus excites a unique class of sympathetic preganglionic neurons. Am. J. Physiol. 1993; 265: R82–R89.
G.K. Aghajanian and R.Y. Wang: Physiology and pharmacology of central serotonergic neurons. In: M.A. Lipton, A. DiMascio and K.F. Killam (Eds.): Psychophar-macology: A generation of progress, Raven Press, New York, 1978; 171–183.
W.C. DeGroat and R.W. Ryall: An excitatory action of 5-hydroxytryptamine on sympathetic preganglionic neurons. Exp Brain Research 1967; 3: 299–305.
D.I. Lewis, E. Sermasi and J.H. Coote: Excitatory and indirect inhibitory actions of 5-hydroxytryptamine on sympathetic preganglionic neurones in the neonate rat spinal cord in vitro. Brain Res. 1993; 610: 267–275.
K.B. Thor, S. Mickolaus and C.J. Helke: Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B, and 5-hydroxytryptaminelC/2 binding sites in the rat spinal cord. Neuroscience 1993; 55: 235–252.
A.P.M. Yusoff and J.H. Coote: Excitatory and inhibitory actions of intrathecally administered 5-hydroxytryptamine on sympathetic nerve activity in the rat. J. Auton. Nerv. Syst. 1988; 222: 229–236.
R.B. McCall and S.J. Humphrey: Involvement of serotonin in the central regulation of blood pressure: evidence for a facilitating effect on sympathetic nerve activity. J. Pharmacol. Exp.Therap. 1982; 222: 94–102.
R.B. McCall and L.T. Harris: Characterization of the central sympathoinhibitory action of ketanserin. J. Pharmacol. Exp.Therap. 1987; 241: 736–740.
A.G. Ramage: The effects of ketanserin, methysergide and LY 53857 on sympathetic nerve activity. Eur. J. Pharmacol. 1985; 113: 295–303.
A.G. Ramage: Are drugs that act both on serotonin receptors and α1-adrenoceptors more potent hypotensive agents than those that act only on α1adrenoceptors? J. Cardiovasc. Pharmacol. 1988; 11: S30–S34.
R.B. McCall, M.E. Clement and L.T. Harris: Studies on the mechanism of the sympatholytic effect of 8-OH DPAT: lack of correlation between inhibition of serotonin neuronal firing and sympathetic activity. Brain Res. 1989; 501: 73–83.
K.B. Thor, A. Blitz-Siebert and C.J. Helke: Autoradiographic localization of 5-HT1 binding sites in the medulla oblongata of the rat. Synapse 1992; 10: 185–205.
B. Valenta and E. Singer: Hypotensive effects of 8-hydroxy-2-(di-n-propyl-amino) tetralin and 5-methylurapidil following stereotaxic microinjection into the ventral medulla of the rat. Br. J. Pharmacol. 1990; 99: 713–720.
C.I. Helke, C.H. McDonald and E.T. Philips: Hypotensive effects of 5-HT(1A) receptor activation-ventral medullary sites and mechanisms of action in the rat. J. Auton. Nerv. Syst. 1993; 42: 177–188.
A.G. Ramage and S.J. Wilkinson: Evidence that different regional sympathetic outflows vary in their sensitivity to the sympathoinhibitory actions of putative 5-HT1A and α2 adrenoceptor agonists in anaesthetized cats. Br. J. Pharmacol. 1989; 98: 1157–1164.
A.G. Ramage, M.E. Clement and R.B. McCall: 8-OH DPAT-induced inhibition of renal sympathetic nerve activity and serotonin neuronal firing. Eur. J. Pharmacol. 1992; 219:165–167.
H.S. Orer, M.E. Clement, S.M. Barman, S. Zhong, G.L. Gebber and R.B. McCall: The role of serotonergic neurons in the maintenance of the 10-Hz rhythm in sympathetic nerve discharge. Am. J. Physiol. 1995; in press.
C.E. Byrum, R. Stornetta and P.G. Guyenet: Electrophysiological properties of spi-nally-projecting A5 noradrenergic neurons. Brain Res. 1984; 303: 15–29.
C.E. Byrum and P.G. Guyenet: Afferent and efferent connections of the A5 noradrenergic cell group in the rat. J. Comp. Neurol. 1987; 261: 529–542.
P.G. Guyenet: Central noradrenergic neurons: the autonomic connection. Prog. Brain Res. 1991; 88: 365–380.
M.L. Woodruff, R.H. Baisden, D.L. Whittington and J.E. Kelly. Inputs to the pontine A5 noradrenergic cell group: a horseradish peroxidase study. Exp. Neurol. 1986; 94: 762–778.
D. Huangfu, N. Koshiya and P.G. Guyenet: A5 noradrenergic unit activity and sympathetic nerve discharge in rats. Am J. Physiol. 1991; 267: R393–R402.
D.L. Rosin, D. Zheng, R.L. Stornetta, F.R. Norton, T. Riley, M.D. Okusa, P.G. Guyenet and K.R. Lynch: Immunohistochemical localization of alpha 2A-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat. Neuroscience 1993; 56: 139–155.
P.G. Guyenet, R.L. Stornetta, T. Riley, F.R. Norton, D.L. Rosin and K.R. Lynch: Alpha 2A-adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating spinal cord. Brain Res. 1994; 638: 285–294.
G.K. Aghajanian, J.M. Cedarbaum and R.Y. Wang: Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons. Brain Res. 1977; 136: 570–577.
B. Astier and G. Aston-Jones: Electrophysiological evidence for medullary adrenergic inhibition of rat locus coeruleus neurons. Soc. Neurosci. Abstr. 1989, 15: 1012.
R. Andrade and G.K. Aghajanian: Single cell activity in the noradrenergic A5 region: Response to drugs and peripheral manipulations of blood pressure. Brain Res. 1982; 242: 125–135.
P.G. Guyenet: Baroreceptor-mediated inhibition of A5 noradrenergic neurons. Brain Res. 1984; 303: 31–40.
N. Koshiya and P.G. Guyenet: A5 noradrenergic neurons and the carotid sympathetic chemoreflex. Am. J. Physiol. 1994; 267: R519–R526.
A.D. Loewy et al.: Electrophysiological evidence that the A5 cateeholaminergie cell group is a vasomotor center. Brain Res. 1979; 178: 196–200.
J.J. Neil and A.D. Loewy: Decreases in blood pressure in response to L-glutamate microinjections in the A5 catecholamine cell group. Brain Res. 1982; 241: 271–278.
A.D. Loewy, L. Marson, D. Parkinson, M.A. Perry and W.B. Sawyer: Descending noradrenergic pathways involved in the A5 depressor response. Brain Res. 1986; 386: 313–324.
M.L. Woodruff, R.H. Baisden and D.L. Whittington: Effects of electrical stimulation of the pontine A5 cell group on blood pressure and heart rate in the rabbit. Brain Res. 1986; 379: 10–23.
K.A. Stanek, J.J. Neil, W.B. Sawyer and A.D. Loewy: Changes in regional blood flow and cardiac output after L-glutamate stimulation of A5 cell group. Am. J. Physiol. 1984; 246: H44–H51.
D. Huangfu, L.J. Hwang, T.A. Riley and P.G. Guyenet: Splanchnic nerve response to A5 area stimulation in rats. Am. J. Physiol. 1992; 263: R437–R446.
R.L. Stornetta, P.G. Guyenet and R. McCarty: Modulation of autonomic outflow by pontine A5 noradrenergic neurons. In: K. Nakamura (Ed.): Brain and blood pressure control, Utrecht, Elsevier Science Publishers, 1986; 23–28.
J.H. Coote, V.H. Macleod, S. Fleetwood-Walker and M.P. Gilbey: The response of individual sympathetic preganglionic neurones of microelectrophoretically applied endogenous monoamines. Brain Res. 1981; 215: 1135–1145.
R.B. McCall and M.R. Schuette: Evidence for an alpha-1 receptor-mediated central sympathoinhibitory action of ketanserin. J. Pharmacol. Exp.Therap. 1984; 228: 704–710.
R.B. McCall and S.J. Humphrey: Evidence for a central depressor action of postsynaptic alpha-1 adrenergic antagonists. J. Auton. Nerv. Syst. 1981; 3: 9–23.
G.K. Aghajanian and M.A. Rogawski: The physiological role of a-adrenoceptors in the CNS: new concepts from single-cell studies.Trends in Pharmacol. Sciences 1983; 4: 315–317.
H. Shi, D.I. Lewis and J.H. Coote: Effects of activating spinal alpha-adrenorecep-tors on sympathetic nerve activity in the rat. J. Auton. Nerv. Syst. 1988; 23: 69–78.
B.D. Hare, R.J. Neuymayr and D.N. Franz: Opposite effects of L-dopa and 5-HTP on spinal sympathetic reflexes. Nature 1972; 239: 336–337.
R.C. Ma and N.J. Dun: Norepinephrine depolarizes lateral horn cells of neonatal rat spinal cord in vitro. Neurosci Lett. 1985; 60: 163–168.
M. Yoshimura, C. Polosa and S. Nishi: Noradrenaline modifies sympathetic preganglionic neuron spike and afterpotential. Brain Res. 1986; 362: 370–374.
M. Yoshimura, C. Polosa and S. Nishi: Noradrenaline induces rhythmic bursting in sympathetic preganglionic neurons. Brain Res. 1987; 420: 147–151.
M. Yoshimura, C. Polosa and S. Nishi: Slow IPSP and the noradrenaline-induced inhibition of the cat sympathetic preganglionic neuron in vitro. Brain Res. 1987; 419: 383–386.
H.S. Orer, S. Zhong, S.M. Barman and G.L. Gebber: Differential control of 10-Hz and 2-to 6-Hz sympathetic nerve discharge by central adrenergic neurons. Am. J. Physiol., 1995; in press.
L.W. Swanson: Immunohistochemical evidence for a neurophysin-containing autonomic pathway arising in the paraventricular nucleus of hypothalamus. Brain Res. 1977; 128: 346–353.
L.W. Swanson and S. McKellar: The distribution of oxytocin-and neurophysin-stained fibers in the spinal cord of the rat and monkey. J. Comp. Neurol. 1979; 188: 87–106.
W.E. Armstrong, S. Warach, G.I. Hatton and T.H. McNeil: Subnuclei in the rat hypothalamic paraventricular nucleus: a cytoarchitectural, horseradish peroxidase and immunocytochemical analysis. Neuroscience 1980; 5: 1931–1958.
Y. Hosoya, Y. Sugiura, N. Okado, A.D. Loewy and K. Kohno: Descending input from the hypothalamic paraventricular nucleus to sympathetic preganglionic neurons in the rat. Exp. Brain Res. 1991; 85: 10–20.
L.W. Swanson and H.G.J.M. Kuypers: The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J. Comp. Neurol. 1980; 194: 555–570.
M.V. Sofroniew: Vasopressin and oxytocin in the mammalian brain and spinal cord. Trends in Neurosci. 1983; 5: 467–472.
M.J. Brody, T.P. O’Neill and J.P. Porter: Role of paraventricular and arcuate nuclei in cardiovascular regulation. In: Magro A., Oswald W., Reis D., Vanhoutte P. (Eds.): Central and peripheral mechanisms of cardiovascular regulation, New York: Plenum Press, 1986; 443–464.
H. Kannan and H. Yamashita: Connections of neurons in the region of the nucleus tractus solitarius with the hypothalamic paraventricular nucleus: their possible involvement in neural control of the cardiovascular system. Brain Res. 1985; 329: 205–212.
M.M. Caverson, J. Ciriello and F.R. Calaresu: Paraventricular nucleus of the hypothalamus: an electrophysiological investigation of neurons projecting directly to inter-mediolateral nucleus in the cat. Brain Res. 1984; 305: 380–383.
T.A. Lovick and J.H. Coote: Electrophysiological properties of paraventriculo-spi-nal neurones in the rat. Brain Res. 1988; 454: 123–130.
H. Yamashita, K. Inenaga and K. Koizumi: Possible projections from regions of paraventricular and supraoptic nuclei to the spinal cord: electrophysiological studies. Brain Research 1984; 296: 373–378.
T. Segura, E.M. Hasser, R.E. Shade and J.R. Haywood: Evidence of an endogenous forebrain GABAergic system capable of inhibiting baroreceptor-mediated vasopressin release. Brain Res. 1989; 499: 53–62.
D.S. Martin, T. Segura and J.R. Haywood: Cardiovascular responses to bicuculline in the paraventricular nucleus of the rat. Hypertension 1991; 18: 48–55.
D.S. Martin and J.R. Haywood: Hemodynamic responses to paraventricular nucleus disinhibition with bicuculline in conscious rats. Am J. Physiol. 1993; 265: H1727–H1733.
M.P. Gilbey, J.H. Coote, S. Fleetwood-Walker and D.F. Peterson: The influence of the paraventriculo-spinal pathway, and oxytocin and vasopressin on sympathetic preganglionic neurones. Brain Res. 1982: 251: 283–290.
J.P. Porter and M.J. Brody: Neural projections from paraventricular nucleus that subserve vasomotor functions. Am. J. Physiol. 1985; 248: R271–R281.
H. Yamashita, H. Kannan, M. Kasal and T. Osaka: Decrease in blood pressure by stimulation of the rat hypothalamic paraventricular nucleus with L-glutamate or weak current. J. Auton. Nerv. Syst. 1987; 19: 229–234.
A.J. Gelsema, M.J. Roe and F.R. Calaresu: Neurally mediated cardiovascular responses to stimulation of cell bodies in the hypothalamus of the rat. Brain Res. 1989; 482: 67–77.
H. Kannan, Y. Hayashida and H. Yamashita: Increase in sympathetic outflow by paraventricular nucleus stimulation in awake rats. Am J. Physiol. 1989; 256: R1325–R1330.
T. Katafuchi, Y. Omura and M. Kurosawa: Effects of chemical stimulation of paraventricular nucleus on adrenal and renal nerve activity in rats. Neurosci. Lett. 1988; 86: 195–200.
V. Holets and R. Elde: The differential distribution and relationship of serotonergic and peptidergic fibers to sympathoadrenal neurons in the intermediolateral cell column of the rat: a combined retrograde axonal transport and immunofluorescence study. Neuroscience 1982; 7: 1155–1174.
J. Ciriello and F.R. Calaresu: Role of paraventricular and supraoptic nuclei in central cardiovascular regulation in the cat. Am. J. Physiol. 1980; 239: R137–R142.
S.B. Backman and J.L. Henry: Effects of oxytocin and vasopressin on thoracic sympathetic preganglionic neurons in the cat. Brain Res. Bull. 1984; 13: 679–684.
R.C. Ma and N.J. Dun: Vasopressin depolarizes lateral horn cells of the neonatal rat spinal cord in vitro. Brain Res. 1985; 348: 36–43.
J.P. Porter and M.J. Brody: The paraventricular nucleus and cardiovascular regulation: role of spinal vasopressinergic mechanisms. J. Hyperten. 1986; 4(suppl. 3): S181–S184.
K.M. Spyer: Central nervous mechanisms contributing to cardiovascular control. J. Physiol. 1994; 474: 1–19.
M.J. Brody: Central nervous system mechanisms of arterial pressure regulation. Federation Proc. 1986; 45: 2700–2706.
P. Sleight: Arterial baroreceptors and hypertension, Oxford: Oxford Univ. Press, 1980.
A. Malliani: Cardiovascular sympathetic afferent fibres. Rev. Physiol. Biochem. Pharmacol. 1982; 94: 11–75.
A. Sato and R.F. Schmidt: Somatosympathetic reflexes: afferent fibres, central pathways, discharge characteristics. Physiol. Rev. 1973; 53: 916–947.
J. Ciriello: Brainstem projections of aortic baroreceptor afferent fibers in the rat. Neurosci. Lett. 1983; 36: 37–42.
S. Donoghue, R.B. Fielder, D. Jordan and K.M. Spyer: The central projections of carotid baroreceptors and chemoreceptors in the cat: a neurophysiological study. J. Physiol. 1984; 347: 391–411.
S. Donoghue, M. Garcia, D. Jordan and K.M. Spyer: Identification and brainstem projections of aortic baroreceptor afferent neurones in nodose ganglia of cats and rabbits. J. Physiol. 1982; 322: 337–352.
J.H. Wallach and A.D. Loewy: Projections of the aortic nerve to the nucleus tractus solitarius in the rabbit. Brain Res. 1980; 188: 247–251.
J.C.W. Finley and D.M. Katz: The central organization of carotid body afferent projections to the brainstem of the rat. Brain Res. 1992; 572: 108–116.
J. Ciriello, A.W. Hrycyshyn and F.R. Calaresu: Horseradish peroxidase study of brain stem projections of carotid sinus and aortic depressor nerves in the cat. J. Auton. Nerv. Syst. 1981; 4: 43–61.
G.D. Housley, R.L. Martin-Body, N.J. Dawson and J.D. Sinclair: Brain stem projections of the glossopharyngeal nerve and its carotid sinus branch in the rat. Neuroscience 1987; 22: 237–250.
S. Donoghue, R.B. Felder, M.P. Gilbey, D. Jordan and K.M. Spyer: Post-synaptic activity evoked in the nucleus tractus solitarius by carotid sinus and aortic nerve afferents in the cat. J. Physiol. 1985; 360: 261–273.
H. Ichikawa, A. Rabchevsky and C.J. Helke: Presence and coexistence of putative neurotransmitters in carotid sinus baro-and chemoreceptor afferent neurons. Brain Res. 1993; 611: 67–74.
R.M. Sykes, K.M. Spyer and P. N. Izzo: Central distribution of substance P, calcitonin gene-related peptide and 5-hydroxytryptamine in vagal sensory afferents in the rat dorsal medulla. Neuroscience 1994; 59: 195–210.
W.T. Taiman, M.H. Perrone and D.J. Reis: Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Science 1980; 209: 813–815.
W.T. Taiman, A.R. Granata and D.J. Reis: Glutamatergic mechanisms in the nucleus tractus solitarius in blood pressure control. Fed Proc. 1984; 43: 39–44.
A.R. Granata and D.J. Reis: Release of [3H]L-glutamine acid (L-Glu) and [3H]D-aspartic acid (D-Asp) in the area of nucleus tractus solitarius in vivo produced by stimulation of the vagus nerve. Brain Res. 1983; 259: 77–93.
M.P. Meeley, M.D. Underwood, W.T. Taiman and D.J. Reis: Content and in vitro release of endogenous amino acids in the area of the nucleus of the solitary tract of the rat. J. Neurochem. 1989; 53: 1807–1817.
W.T. Taiman, M.H. Perrone, P. Scher, S. Kwo and D.J. Reis: Antagonism of the baroreceptor reflex by glutamate diethyl ester, an antagonist to L-glutamate. Brain Res. 1981; 217: 186–191.
S.J. Humphrey and R.B. McCall: Evidence that L-glutamic acid mediates baroreceptor function in the cat. Clin exp Hyperten. 1984; 6: 1311–1329.
B.D. Miller and R.B. Felder: Excitatory amino acid receptors intrinsic to synaptic transmission in nucleus tractus solitarii. Brain Res. 1988; 456: 333–343.
F.J. Gordon and C. Leone: Non-NMDA receptors in the nucleus of the tractus solitarius play the predominant role in mediating aortic baroreceptor reflexes. Brain Res. 1991; 568: 319–322.
M.C. Andersen and M.Y. Yang: Non-NMDA receptors mediate sensory afferent synaptic transmission in medial nucleus tractus solitarius. Am. J. Physiol. 1990; 259: H1307–H1311.
H. Ohta and W.T. Taiman: Both NMDA and non-NMDA receptors in the NTS participate in the baroreceptor reflex in rats. Am. J. Physiol. 1994; 267: R1065–R1070.
A. Vardhan, A. Kachroo and H.N. Sapru: Excitatory amino acid receptors in the nucleus tractus solitarius mediate the responses to the stimulation of cardio-pulmonary vagal afferent C fiber endings. Brain Res. 1993; 618: 23–31.
A. Vardhan, A. Kachroo and H.N. Sapru: Excitatory amino acid receptors in commissural nucleus of the NTS mediate carotid chemoreceptor responses. Am J. Physiol. 1993; 264: R41–R50.
W.T. Taiman: Kynurenic acid microinjected into the nucleus tractus solitarius of rat blocks the arterial baroreflex but not responses to glutamate. Neurosci. Lett. 1989; 102: 247–252.
A.F. Sved and M.G. Backes: Neuroanatomical evidence that vagal afferent nerves do not possess a high affinity uptake system for glutamate. J. Auton. Nerv. Syst. 1992; 38: 219–229.
A.F. Sved and J.T. Curtis: Amino acid neurotransmitters in nucleus tractus solitarius: an in vivo microdialysis study. J. Neurochem. 1993; 61: 2089–2098.
V.M. Pickel, J. Chan and T.A. Milner: Cellular substrates for interactions between neurons containing phenylethanolamine N-methyltransferase and GABA in the nuclei of the solitary tracts. J. Comp. Neurol. 1989; 286: 243–259.
W.W. Blessing: Distribution of glutamate decarboxylase-containing neurons in rabbit medulla oblongata with attention to intramedullary and spinal projections. Neuroscience 1990; 37: 171–185.
P.N. Izzo, R.M. Sykes and K.M. Spyer: gamma-Aminobutyric acid immunoreactive structures in the nucleus tractus solitarius: a light and electron microscopic study. Brain Res. 1992; 591: 69–78.
J.M. Catelli, W.J. Giakas and A.F. Sved: GABAergic mechanisms in nucleus tractus solitarius alter blood pressure and vasopressin release. Brain Res. 1987; 403: 279–289.
T. Kubo and M. Kihara: Evidence for gamma-aminobutyric acid receptor-mediated modulation of the aortic baroreceptor reflex in the nucleus tractus solitarii of the rat. Neurosci Lett. 1988; 89: 156–160.
J.C. Sved and A.E. Sved: Cardiovascular responses elicited by gamma-aminobutyric acid in the nucleus tractus solitarius: evidence for action at the GABAB receptor. Neuropharmacol. 1989; 28: 515–520.
P.A. Brooks, S.R. Glaum, R.J. Miller and K.M. Spyer: The actions of baclofen on neurones and synaptic transmission in the nucleus tractus solitarii of the rat in vitro. J. Physiol. 1992; 457: 115–129.
A.E. Sved and J.C. Sved: Endogenous GABA acts on GABAB receptors in nucleus tractus solitarius to increase blood pressure. Brain Res. 1990; 526: 235–240
A.E. Sved and K. Tsukamoto: Tonic stimulation of GABAB receptors in the nucleus tractus solitarius modulates the baroreceptor reflex. Brain Res. 1992; 592: 37–43.
P.N. McWilliam and S.L. Shepheard: A GABA-mediated inhibition of neurones in the nucleus tractus solitarius of the cat that respond to electrical stimulation of the carotid sinus nerve. Neurosci. Lett. 1988; 94: 321–326.
T. Kubo and M. Kihara: Evidence for the presence of GABAergic and glycine-like systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat. Neurosci Lett. 1987; 74: 331–336.
J.H. Coote, S.M. Hilton and A.W. Zbrozyna: The pontomedullary area integrating the defence reaction in the cat and its influence on muscle blood flow. J. Physiol. 1973; 229: 257–274.
S.W. Mifflin, K.M. Spyer and D.J. Withington-Wray: Baroreceptor inputs to the nucleus tractus solitarius in the cat; modulation by the hypothalamus. J. Physiol. 1988; 399: 369–387.
P.N. Izzo, R.M. Sykes and K.M. Spyer: γ-aminobutyric acid immunoreactive structures in the nucleus tractus solitarius: A light and electron microscopic study. Brain Res. 1992; 591: 69–79.
J.F.R. Paton and K.M. Spyer: Cerebellar cortical regulation of circulation. News in Physiol. Sci. 1992; 7: 124–129.
P.M. McWilliam, T. Yang and L.X. Chen: Changes in the baroreceptor reflex at the start of muscle contraction in the decerebrate cat. J. Physiol. 1991; 436: 549–558.
D. Riche, J. De Pommery and D. Menetrey: Neuropeptides and catecholamines in efferent projections of the nuclei of the solitary tract in the rat. J. Comp. Neurol. 1990; 293: 399–424.
P.R.C. Howe: Blood pressure control by neurotransmitters in the medulla oblongata and spinal corD. J. Auton. Nerv. Syst. 1985; 12: 95–115.
P.D. Feldman and H.C. Moises: Adrenergic responses of baroreceptive cells in the nucleus tractus solitarii of the rat: a microiontophoretic study. Brain Res. 1987; 420: 351–361.
P.D. Feldman and H.C. Moises: Electrophysiological evidence for alpha 1-and alpha 2-adrenoceptors in solitary tract nucleus. Am. J. Physiol. 1988; 254: H756–H762.
A.F. Sved, K. Tsukamoto and A.M. Schreihofer: Stimulation of alpha 2-adrenergic receptors in nucleus tractus solitarius is required for the baroreceptor reflex. Brain Res. 1992; 576: 297–303.
D.J. Reis, T.H. Joh, M.A. Nathan, B. Renaud, D.W. Snyder and W.T. Taiman: Nucleus traetus solitarii: catecholaminergic innervation in normal and abnormal control of arterial pressure. In: P. Myer and H. Schmitt (Eds.): Nervous system and hypertension, Toronto: Wiley-Flammarion, 1979; 147–164.
K.B. Thor and C.J. Helke: Serotonin and substance P colocalization in medullary projections to the nucleus tractus solitarius: dual color immunohistochemistry combined with retrograde tracing. J. Chem. Neuroanat. 1989; 2: 139–148.
W. A. Wolf, D.M. Kuhn and W. Lovenberg: Blood pressure responses to local application of serotonergic agents in the nucleus tractus solitarii. Europ. J. Pharmacol. 1981; 69:291–299.
D.A. Carter and S.L. Lightman: Cardio-respiratory actions of substance P, TRH and 5-HT in the nucleus tractus solitarius of rats: evidence for functional interactions of neuropeptides and amine neurotransmitters. Neuropeptides 1985; 6: 425–436.
R. Laguzzi, D.J. Reis and W.T. Taiman: Modulation of cardiovascular and electro-cortical activity through serotonergic mechanisms in the nucleus tractus solitarius of the rat. Brain Research 1984; 304: 321–328.
A. Shvaloff and R. Laguzzi: Serotonin receptors in the rat nucleus tractus solitarii and cardiovascular regulation. Eur. J. Pharmacol. 1986; 132: 283–288.
K.B. Thor, A. Blitz-Siebert and C.J. Helke: Autoradiographic localization of 5HT1 binding sites in autonomic areas of the rat dorsomedial medulla oblongata. Synapse 192; 10: 217–227.
S.R. Glaum, P.A. Brooks, K.M. Spyer and R.J. Miller: 5-Hydroxytryptamine-3 receptors modulate synaptic activity in the rat nucleus tractus solitarius in vitro. Brain Res. 1992; 589: 62–68.
W.T. Taiman and S.J. Lewis: Altered cardiovascular responses to glutamate and acetylcholine microinjected into the nucleus tractus solitarii of the SHR. Clin. Exp. Hyperten. 1991; 13: 661–668.
H.N. Sapru: Cholinergic mechanisms subserving cardiovascular function in the medulla and spinal cord. Prog. Brain Res. 1989; 81: 171–179.
K. Tsukamoto, M. Yin and A.F. Sved: Effect of atropine injected into the nucleus tractus solitarius on the regulation of blood pressure. Brain Res. 1994; 648: 915.
W.T. Taiman and S.C. Robertson: Glycine, like glutamate, microinjected into the nucleus tractus solitarii of rat decreases arterial pressure and heart rate. Brain Res. 1989; 477: 7–13.
M.D. Cassell, L. Roberts and W.T. Taiman: Glycine-containing terminals in the rat dorsal vagal complex. Neuroscience 1992; 50: 907–920.
W.T. Taiman, J.M. Colling and S.C. Robertson: Glycine microinjected into nucleus tractus solitarii of rat acts through cholinergic mechanisms. Am. J. Physiol. 1991; 260: H1326–H1331.
H. Matsuguchi, F.M. Sharabi, F.J. Gordon, A.K. Johnson and P.G. Schmid: Blood pressure and heart rate responses to microinjection of vasopressin into the nucleus tractus solitarius region of the rat. Neuropharmacol. 1982; 21: 687–693.
K.A. King and C.C. Pang: Cardiovascular effects of injections of vasopressin into the nucleus tractus solitarius in conscious rats. Brit. J. Pharmacol. 1987; 90: 531–536.
Q.J. Pittman and L.G. Franklin: Vasopressin antagonist in nucleus tractus solitar-ius/vagal area reduces pressor and tachycardia responses to paraventricular nucleus stimulation in rats. Neurosci. Lett. 1985; 56: 155–160.
V.J. Massari, P.J. Hornby, E.K. Friedman, T.A. Milner, R.A. Gills and P.J. Gad: Distribution of neuropeptide Y-like immunoreactive perikarya and processes in the medulla of the cat. Neurosci. Lett. 1990; 115: 37–42.
V.M. Pickel, J. Chan and V.J. Massari: Neuropeptide Y-like immunoreactivity in neurons of the solitary tract nuclei: vesicular localization and synaptic input from GABAergic terminals. Brain Res. 1989; 476: 265–278.
C.J. Tseng, R. Mosqueda-Garcia, M. Appalsamy and D. Robertson: Cardiovascular effects of neuropeptide Y in rat brainstem nuclei. Circ. Res. 1989; 64: 55–61.
L. Grundemar, C. Wahlestedt and D.J. Reis: Long-lasting inhibition of the cardiovascular responses to glutamate and the baroreceptor reflex elicited by neuropeptide Y injected into the nucleus tractus solitarius of the rat. Neurosci. Lett. 1991; 122: 135–139.
L. Grundemar, C. Wahlestedt and D.J. Reis: Neuropeptide Y acts at an atypical receptor to evoke cardiovascular depression and to inhibit glutamate responsiveness in the brainstem J. Pharmacol. Exp.Therap. 1991; 258: 633–638.
D.B. Averil, D.I. Diz, K.L. Barnes and C.M. Ferrano: Pressor responses of angiotensin II microinjected into the dorsomedial medulla of the dog. Brain Res. 1987; 414: 294–300.
R. Casto and M.I. Phillips: Neuropeptide action in nucleus tractus solitarius: angiotensin specificity and hypertensive rats. Am. J. Physiol. 1985; 249: R341–R347.
R. Rettig, D.P. Healy and M.P. Printz: Cardiovascular effects of microinjections of angiotensin II into the nucleus tractus solitarii. Brain Res.l986; 364: 233–240.
M.J. Campagnole-Santos, D.I. Diz and C.M. Ferrano: Baroreceptor reflex modulation by angiotensin II at the nucleus tractus solitarii. Hypertension 1988; 11: 167–171.
M. A. Petty and W. de-Jong: Enkephalins induce a centrally mediated rise in blood pressure in rats. Brain Res. 1983; 260: 322–325.
M. A. Petty and W. de-Jong: Cardiovascular effects of β-endorphin after microinjection into the nucleus tractus solitarii of the anaesthetized rat. Europ. J. Pharmacol. 1982; 81: 449–457.
L.Y. Koda, N. Ling, R. Benoit, S.G. Madamba and C. Bakhit: Blood pressure following microinjection of somatostatin related peptides into the rat nucleus tractus solitarii. Europ. J. Pharmacol. 1985; 113: 425–430.
M. Vallejo, S. Lightman and I. Marshall: Central cardiovascular effects of calcitonin gene related peptide: interaction with noradrenaline in the nucleus tractus solitarius of rats. Exp. Brain Res. 1988; 70: 221–224.
F.R. Calaresu and C.P. Yardley: Medullary basal sympathetic tone. In: R.M. Berne (Ed.): Annual reviews of physiology, vol 50. Palo Alto: Annual Reviews Inc., 1988; 511–524.
W.W. Blessing and D.J. Reis: Inhibitory cardiovascular function of neurons in the caudal ventrolateral medulla of the rabbit: relationship to the area containing A1 noradrenergic cells. Brain Res. 1982; 253:161–171.
T.A. Day, A. Ro and L.P. Renaud: Depressor area within caudal ventrolateral medulla of the rat does not correspond to the A1 catecholamine cell group. Brain Res. 1983; 279: 299–302.
W.W. Blessing and D.J. Reis: Evidence that GABA-and glycine-like inputs inhibit vasodepressor neurons in the caudal ventrolateral medulla of the rabbit. Neurosci. Lett. 1983; 37: 57–62.
R.N. Willette, A.J. Krieger, P.P. Barcas and H.N. Sapru: Medullary-aminobutyric acid (GABA) receptors and the regulation of blood pressure in the rat. J. Pharmacol. Exp.Therap. 1983; 226: 893–899.
J.S. Schwaber: Neuroanatomical substrates of cardiovascular and emotional-auto-nomic regulation. In: A. Magro, W. Osswald, DJ. Reis and P. Vanhoutte (Eds.): Central and peripheral mechanisms of cardiovascular regulation, New York: Plenum Press, 1986; 353–384.
S.K. Agarwal, A.J. Gelsema and F.R. Calaresu: Inhibition of rostral VLM by baror-eceptor activation is relayed through caudal VLM. Am. J. Physiol. 1990; 258: R1271–R1278.
F.J. Gordon: Aortic baroreceptor reflexes are mediated by NMDA receptors in caudal ventrolateral medulla. Am. J. Physiol. 1987; 252: R628–R633.
Y.-W. Li and W.W. Blessing: Localization of vasodepressor neurons in the caudal ventrolateral medulla in the rabbit. Brain Res. 1990; 517: 57–63.
Z.J. Gieroba, Y.-W. Li and W.W. Blessing: Characteristics of caudal ventrolateral medullary neurons antidromically activated from rostral ventrolateral medulla in the rabbit. Brain Res. 1992; 582: 196–207.
I. Jeske, S.F. Morrison, S.L. Cravo and D.J. Reis: Identification of baroreceptor reflex interneurons in the caudal ventrolateral medulla. Am. J. Physiol. 1993; 264: R169–R178.
N. Terui, N. Masuda, Y. Saeki and M. Kumada: Activity of barosensitive neurons in the caudal ventrolateral medulla that send axonal projections to the rostral ventrolateral medulla in rabbits. Neurosci. Lett. 1990; 118: 211–214.
S.L. Cravo, S.F. Morrison and D.J. Reis: Differentiation of two cardiovascular regions within caudal ventrolateral medulla: Am. J. Physiol. 1991; 261: R985–R994.
Y.-W. Li, Z.J. Gieroba, R.M. McAllen and W.W. Blessing: Neurons in rabbit caudal ventrolateral medulla inhibit bulbospinal barosensitive neurons in rostral medulla. Am J. Physiol. 1991; 261: R44–R51.
Y.-W Li, S.L. Wesselingh and W.W. Blessing: Projections from rabbit caudal medulla to C1 and A5 sympathetic premotor neurons, demonstrated with phaseolus leucoag-glutinin and herpes simplex virus. J. Comp. Neurol. 1992; 317: 379–395.
Y.-W. Li and R.A. Dampney: Expression of c-fos protein in the medulla oblongata of conscious rabbits in response to baroreceptor activation. Neurosci. Lett. 1992; 144: 70–74.
K.A. Yamada, R.M. McAllen and A.D. Loewy: GABA antagonists applied to the ventral surface of the medulla oblongata block the baroreceptor reflex. Brain Res. 1984; 297: 175–180.
S.J. Humphrey and R.B. McCall: Evidence for τ-aminobutyric acid mediation of the sympathetic nerve inhibitory response to vagal afferent stimulation. J. Pharmacol. Exp. Therap. 1985; 234: 288–297.
W.W. Blessing and J.O. Willoughby: Depressor neurons in rabbit caudal medulla do not transmit the baroreceptor-vasomotor reflex. Am. J. Physiol. 1987; 253: H777–H786.
S.L. Cravo and S.F. Morrison: The caudal ventrolateral medulla is a source of tonic sympathoinhibition. Brain Res. 1993; 621: 133–136.
W.W. Blessing and Y.-W. Li: Inhibitory vasomotor neurons in the caudal ventrolateral region of the medulla oblongata. Prog. Brain Res. 1989; 81: 83–97.
A.R. Granata, Y. Numao, M. Kumada and D.J. Reis: A1 noradrenergic neurons ton-ically inhibit sympathoexcitatory neurons of C1 area in rat brainstem. Brain Res. 1986; 377: 127–146.
H. Kaba, H. Saito, K. Otsuka, K. Seto and M. Kawakami: Effects of estrogen on the excitability of neurons projecting from the noradrenergic A1 region to the preoptic and anterior hypothalamic area. Brain Res. 1983; 274: 156–159.
H. Kaba, H. Saito, K. Otsuka and K. Seto: Ventrolateral medullary neurons projecting to the medial preoptic-anterior hypothalamic area through the medial forebrain bundle: An electrophysiological study in the rat. Exp. Brain Res. 1986; 63: 369–374.
H. Yamashita, H. Kannan and Y. Ueta: Involvement of caudal ventrolateral medulla in mediating visceroreceptive information to the hypothalamic paraventricular nucleus. In: J. Ciriello, M.M. Caverson and C. Polosa (Eds.): Central Neural Organization of Cardiovascular Control. Progress in Brain Research. Amsterdam: Elsevier, 1989: vol 81, 293–302.
R.M. McAllen and W.W. Blessing: Neurons (presumably A1 cells) projecting from the caudal ventrolateral medulla to the region of the supraoptic nucleus respond to baroreceptor inputs in the rabbit. Neurosci. Lett. 1987; 73: 247–252.
D.A. Thrivikraman, D.A. Bereiter and D.S. Gann: Catecholamine activity in paraventricular hypothalamus after hemorrhage in cats. Am. J. Physiol. 1989; 257: H370–H376.
L. Quitin, J.-Y. Gillon, M. Ghigone, B. Renaud and J.-F. Pujol: Baroreflex-linked variations of catecholamine metabolism in the caudal ventrolateral medulla: An ‘in vivo’ electrochemical study. Brain Res. 1987; 425: 319–336.
M. Elam: On the Physiological Regulation of Brain Norepinephrine Neurons in Rat Locus Coeruleus. Kompendietryckeriet, Kallered, Goteberg, Sweden.
W.W. Blessing, C.B. Jaeger, D.A. Ruggiero and D.J. Reis: Hypothalamic projections of medullary catecholamine neurons in the rabbit: a combined catecholamine fluorescence and HRP transport study. Brain Res.Bull. 1982; 9: 279–286.
P.E. Sawchenko and L.W. Swansom: The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat. Brain Res. Rev. 1982; 4: 275–325.
E. Mills and S.C. Wang: Liberation of antidiuretic hormone: location of ascending pathways. Am. J. Physiol. 1964; 207: 1399–1404.
W. Feldberg and S.M. Rocha: Vasopressin release produced in anaesthetized cats by antagonists of GABA abd glycine. Brit. J. Pharmacol. 1978; 62: 99–106.
W.W. Blessing and J.O. Willoughby: Inhibiting the rabbit caudal ventrolateral medulla prevents baroreceptor-initiated secretion of vasopressin. J. Physiol. 1985; 367: 253–265.
Z.J. Gieroba, M.J. Fullerton, J.W. Funder and W.W. Blessing: Medullary pathways for adrenocorticotropic hormone and vasopressin secretion in rabbits. Am. J. Physiol. 1992; 262: R1047–R1056.
W.W. Blessing and J.O. Willoughby: Excitation of neuronal function in rabbit caudal ventrolateral medulla elevates plasma vasopressin. Neurosci Lett. 1985; 58: 189–194.
A. Benetos, I. Gavras and H. Gavras: Norepinephrine applied in the paraventricular hypothalamic nucleus stimulates vasopressin release. Brain Res. 1986; 381: 322–326.
T.A. Day, A.V. Ferguson and L.P. Renaud: Facilitatory influence of noradrenergic afferents on the excitability of rat paraventricular nucleus neurosecretory cells. J. Physiol. 1984; 355: 237–249.
T.A. Day and L.P. Renaud: Electrophysiological evidence that noradrenergic afferents selectively facilitate the activity of supraoptic vasopressin neurons. Brain Res. 1984; 303: 233–240.
B.J. Davis, M.L. Blain, J.R. Sladek and C.D. Sladek: Effects of lesions of hypothalamic catecholamines on blood pressure, fluid balance, vasopressin and renin in the rat. Brain Res. 1987; 405: 1–15.
J. Tanaka, H. Kaba, H. Saito and K. Seto: Inputs from the A1 noradrenergic region to hypothalamic paraventricular neurons in the rat. Brain Res. 1985; 355: 368–371.
J.C.R. Randle, C.W. Bourque and L.R. Renaud: α-Adrenergic activation of rat hypothalamic supraoptic neurons maintained in vitro. Brain Res. 1984; 307: 374–378.
T. Imaizumi, A.R. Granata, E.E. Benarroch, A.F. Sved and D.J. Reis: Contributions of arginine vasopressin and the sympathetic nervous system to fulminating hypertension after destruction of neurons of caudal ventrolateral medulla in the rat. J. Hyperten. 1985; 3: 491–501.
J. Minson, J. Chalmers, V. Kapoor, M. Cain and A. Caon: Relative importance of sympathetic nerves and of circulating adrenaline and vasopressin in mediating hypertension after lesions of the caudal ventrolateral medulla in the rat. J. Hyperten. 1986; 4: 273–281.
J. Ciriello, M.M. Caverson and C. Polosa: Function of the ventrolateral medulla in the control of the circulation. Brain Res. Rev. 1986; 111: 359–391.
Y.I. Kim, C.A. Dudley and R.L. Moss: Inhibitory effect of norepinephrine on the single-unit activity of caudally projecting paraventricular neurons. Synapse 1989; 3: 213–224.
H. Yamashita, R.E.J. Dyball, K. Inenaga and K. Kannan: The effects of noradrenaline on supraoptic and paraventricular cells of mice in vitro. In: J. Ciriello, F.R. Calaresu, L.P. Renaud and C. Polosa (Eds.): Organization of the autonomic nervous system: central and peripheral mechanisms. New York: Alan Liss Inc. 1987; 417–423.
A.J. Silverman, Y.A. Hou and B.J. Oldfield: Ultrastructural identification of noradrenergic nerve terminals and vasopressin-containing neurons of the paraventricular nucleus in the same thin section. J. Histochem. Cytochem. 1983; 31: 1151–1156.
S.C. Wang and S.W. Ranson: Autonomic responses to electrical stimulation of the lower brain steM. J. Comp. Neurol. 1939; 71: 437–455.
D.M. Farlow, A.K. Goodchild and R.A. Dampney: Evidence that vasomotor neurons in the rostral ventrolateral medulla project to the spinal sympathetic outflow via the dorsomedial pressor area. Brain Res. 1984; 298: 313–320.
M. Kumada, R.A. Dampney and D.J. Reis: Profound hypotension and abolition of the vasomotor component of the cerebral ischemic response produced by restricted lesions of medulla oblongata: relationship to the so-called tonic vasomotor center. Circ. Res. 1979; 45: 63–70.
M.E. Clement and R.B. McCall: Lateral tegmental field involvement in the central sympathoinhibitory action of 8-OH DPAT. Brain Res. 1993; 612: 78–84.
C. Vayssettes-Courchay, F. Bouysset, T.J. Verbeuren, H. Schmitt and M. Laubie: Cardiovascular effects of microinjections of quipazine into nuclei of the medulla-oblon-gata in anaesthetized cats-comparison with L-glutamate. Eur. J. Pharmacol. 1992; 211:243–250.
M.E. Clement and R.B. McCall: Evidence that the lateral tegmental field plays an important role in the central sympathoinhibitory action of 8-OH-DPAT. Brain Res. 1992; 587: 115–122.
G.L. Gebber and S.M. Barman.: Lateral tegmental field neurons of cat medulla: a potential source of basal sympathetic discharge. J. Neurophysiol. 1985; 54: 1498–1512.
Y. Hirooka, J. W. Poison and R. A. Dampney: Pressor response from rostral dorsomedial medulla is mediated by excitatory amino acid receptors in rostral VLM. Am. J. Physiol. 1994; 267: R309–R315.
P.L. McGeer and E.G. McGeer: Kainic acid: the neurotoxic breakthrough. CRC Crit. Rev. Toxicol. 1982; 10: 1–26.
C. Vayssettes-Courchay, F. Bouysset, T.J. Verbeuren and M. Laubie: Role of the lateral tegmental field in the central sympatho-inhibitory effect of 8-hydroxy-2-(di-n-propylamino)tetralin in the cat. Europ. J. Pharmacol. 1993; 236: 121–130.
M.E. Clement and R.B. McCall: Lateral tegmental field involvement in the central sympathoinhibitory action of 8-OH DPAT. Brain Res. 1993; 612: 78–84.
C. Vayssettes-Courchay, F. Bouysset, T.J. Verbeuren and M. Laubie: Role of the nucleus tractus solitarii and the rostral depressive area in the sympatholytic effect of 8-hydroxy-2-(di-n-propylamino)tetralin in the cat. Europ. J. Pharmacol. 1993; 242: 37–45.
D. Bieger and D. A. Hopkins: Viscerotopic representation of the upper alimentary tract in the medulla oblongata in the rat: the nucleus ambiguus. J. Comp. Neurol. 1987; 262: 546–562.
D.A. Hopkins and J.A. Armour: Medullary cells of origin of physiologically identified cardiac nerves in the dog. Brain Res. Bull. 1982; 8: 359–365.
P.N. Izzo, J. Deuchars and K.M. Spyer: Localization of cardiac vagal preganglionic motoneurones in the rat-immunocytochemical evidence of synaptic inputs containing 5-hydroxytryptamine. J. Comp. Neurol. 1993; 327: 572–583.
S. Nosaka, T. Yamamoto and K. Yasunaga: Localization of vagal cardioinhibitory preganglionic neurons within rat brainstem. J. Comp. Neurol. 1979; 186: 79–92.
D.M. Plecha, W.C. Randall, G.S. Geis and R.D. Wurster: Localization of vagal preganglionic somata controlling sinoatrial and atrioventricular nodes. Am. J. Physiol. 1988; 255: R703–R708.
S.K. Agarwal and F.R. Calaresu: Electrical stimulation of nucleus tractus solitarius excites vagal preganglionic cardiomotor neurons of the nucleus ambiguus in rats. Brain Res. 1992; 574: 320–324.
A.D. Loewy and H. Burton: Nuclei of the solitary tract: efferent projections to the lower brainstem and spinal cord of the cat. J. Comp. Neurol. 1978; 181: 421–450.
S.L. Stuesse and S.E. Fish: Projections to the cardioinhibitory region of the nucleus ambiguus of rat. J. Comp. Neurol. 1984; 229: 271–278.
M.P. Gilbey, D. Jordan, D.W. Richter and K.M. Spyer: Synaptic mechanisms involved in the inspiratory modulation of the vagal cardioinhibitory neurons in the cat. J. Physiol. 1984; 356: 65–78.
A. Pazos and J.M. Palacios: Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 1985; 346: 205–230
S. Manaker and H.M. Verderame: Organization of serotonin 1A and 1B receptors in the nucleus of the solitary tract. J. Comp. Neurol. 1990; 301: 535–553.
M.R. Dashwood, M.P. Gilbey, D. Jordan and A.G. Ramage: Autoradiographic localization of 5-HT1A binding sites in the brain stem of the cat. Br. J. Pharmacol. 1988; 94: 386 P.
K. Gradin, A. Pettersson, T. Hedner and B. Persson: Acute administration of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective 5-HT receptor agonist in Sprague-Dawley rat and the spontaneously hypertensive rat. J. Neural Transm. 1985; 62: 305–319.
A.G. Ramage and J.R. Fozard.: Evidence that the putative 5-HT1A receptor agonists 8-OH DPAT and ipsapirone have a central hypotensive action that differs from that of Clonidine in anaesthetized cats. Europ J Pharmacol. 1987; 138: 179–191.
A.G. Ramage, W. Wouters and P. Bevan: Evidence that the novel antihypertensive agent, flesinoxan, causes differential sympathoinhibition and also increases vagal tone by a central action, Europ. J. Pharmacol. 1988; 151: 373–379.
J.H. Coote: The central antihypertensive action of 5-hydroxytryptamine: the location of site of action. In: R.R. Saxena, D.I. Wallis, W. Wouters and P. Bevan (Eds.): Cardiovascular Pharmacology of 5-Hydroxytryptamine. Kluwer Academic Publishers, Dordrecht, 1990, 259–270.
P. N. Izzo, D. Jordan and A.G. Ramage: Anatomical and pharmacological evidence supporting the involvement of serotonin in the central control of cardiac vagal moto-neurones in the anaesthetized cat. J. Physiol. 1988; 406: 19P.
D.W. Dalton, W. Feniuk and P.P.A. Humphrey: An investigation into the mechanisms of the cardiovascular effects of 5-hydroxytryptamine in conscious normotensive and Doca-salt hypertensive rats. J. Auton. Nerv. Syst. 1986; 6: 219–229.
S.C.E. Sporton, S.L. Shepheard, D. Jordan and A.G. Ramage: Microinjections of 5-HT1A agonists into the dorsal motor vagal nucleus produce a bradycardia in the aten-olol-pretreated anaesthetized rat. Brit. J. Pharmacol. 1991; 104: 466–470.
R.B. McCall, N. A. Escandon, L.T. Harris and M.E. Clement: Tolerance development to the vagal-mediated bradycardia produced by 5-HT1A receptor agonists. J. Pharmacol. Exp.Therap. 1994; 271: 776–781.
J.M. De Voogd and G. Prager: Early clinical experience with flesinoxan, a new selective 5-HT1A receptor agonist. In: P.R. Saxena, D.I. Wallis, W. Wouters and P. Bevan (Eds.): Cardiovascular Pharmacology of 5-Hydroxytryptamine. Kluwer Academic Publishers, Dordrecht, 1990, 259–270.
R.G. Bogle, J.G. Pires and A.G. Ramage: Evidence that central 5-HT1A receptors play a role in the von Bezold-Jarisch reflex in the rat. Br. J. Pharmacol. 1990; 100: 757–760.
H.A. Futuro-Neto, J.G. Pires, M.P. Gilbey and A.G. Ramage: Evidence for the ability of central 5-HT1A receptors to modulate the vagal bradycardia induced by stimulating the upper airways of anesthetized rabbits with smoke. Brain Res. 1993; 629: 349–354.
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McCall, R.B. (1996). Neurotransmitters involved in the central regulation of the cardiovascular system. In: Jucker, E. (eds) Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques, vol 46. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8996-4_2
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