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Myc Structure and Function

  • Chapter
Oncogenes as Transcriptional Regulators

Part of the book series: Progress in Gene Expression ((PRGE))

Abstract

Functional analysis of Myc continues to strengthen connections to trans-criptional regulation. CTD interactions are growing in complexity, but, at a broad level of understanding, the new results reaffirm the role of this region in controlling DNA recognition. One should expect additional progress in defining b/HLH/LZ partners for both Myc and Max, as well as a dissection of higher order interactions between partner complexes and other transcription factors. The NTD has only begun to be examined mechanistically. Transactivation and repression domains have been roughly parsed, with repression turning out to play a critical role (perhaps the most important one) in cancer cells. Mechanisms should begin to emerge as several new NTD binding proteins are analyzed. These directions are exciting because they may also shed light on the persistent issues concerning nontranscriptional roles. Long a “citadel of incomprehensibility” (Lüscher et al, 1990), Myc is finally yielding answers to long-standing questions. For those interested in basic mechanisms and cancer, answers to current questions are likely to be both interesting and important.

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Authors
  1. George C. Prendergast
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  1. Dept. of Biotechnology, Institut Pasteur, 28, rue du Dr. Roux, F-75724, Paris Cedex 15, France

    M. Yaniv

  2. CNRS UMR 146 Institut Curie, Section de Recherche, Centre Universitaire, F-91405, Orsay, France

    J. Ghysdael

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Prendergast, G.C. (1997). Myc Structure and Function. In: Yaniv, M., Ghysdael, J. (eds) Oncogenes as Transcriptional Regulators. Progress in Gene Expression. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8889-9_1

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  • DOI: https://doi.org/10.1007/978-3-0348-8889-9_1

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