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Regulation of Neutrophil Proteinases

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Molecular Biology of the Lung

Part of the book series: espiratory harmacology and harmacotherapy ((RPP))

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Abstract

Proteinases play a central role in the degradation of proteins by hydrolyzing peptide bonds. Originally thought to fulfill primarily digestive functions, it now is believed that these enzymes are the principal regulators of a multitude of crucial and diverse physiologic processes and have a central role in pathologic tissue destruction of many organs. Their role in tissue destruction has been investigated in the greatest detail in the lungs, especially in relationship to the pathogenesis of emphysema. Recent investigations suggest prominent roles for proteinases in growth and development and in intracellular signaling.

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  1. Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA

    Anne B. Sturrock & John R. Hoidal

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  1. Anne B. Sturrock
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  1. Department of Respiratory Medicine, University Hospital Birmingham, Edgbaston, Birmingham, B15 2TH, UK

    Robert A. Stockley

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Sturrock, A.B., Hoidal, J.R. (1999). Regulation of Neutrophil Proteinases. In: Stockley, R.A. (eds) Molecular Biology of the Lung. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8831-8_6

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  • DOI: https://doi.org/10.1007/978-3-0348-8831-8_6

  • Publisher Name: Birkhäuser, Basel

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