Abstract
Introduction During both acute and chronic inflammatory processes profound physiological adaptations are triggered in an attempt to limit tissue damage and remove the pathogenic insult. Such mechanisms include local and systemic vasodilatation, pyresis and the activation of the immune system. These changes are regulated by a number of diverse mediators such as cytokines, bacterial products, (neuro)peptides and eicosanoids. Moreover, the considerable advances in the understanding of the role of nitric oxide (NO) as an inter- and intra- cellular messenger molecule have also established that NO plays an important role as a mediator of inflammation.
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Hobbs, A.J., Moncada, S. (1999). Inducible nitric oxide synthase and inflammation. In: Willoughby, D.A., Tomlinson, A. (eds) Inducible Enzymes in the Inflammatory Response. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8747-2_2
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