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Role of non-neuronal and neuronal acetylcholine in the airways

  • Chapter
Muscarinic Receptors in Airways Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

It is well known that acetylcholine represents a dominant neurotransmitter within mammalian airways and that airway functions, like smooth muscle activity and secretion, are under a continuous cholinergic tone. However, the teleology of this basal cholinergic tone, assumed to originate from neuronal activity, appears difficult to understand, whereas neuronal cholinergic reflex activity can be regarded as a rational regulatory pathway to protect the airways from injury [1-3]. Based on recent experimental observations, both phenomena may reflect two different biological roles of acetylcholine, acting first as a universal cytomolecule (non-neuronal) and second as a classical neurotransmitter (neuronal).

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Authors and Affiliations

  1. Institutes of Pharmacology, University of Mainz, Obere Zahlbacher Str. 67, D-55101, Mainz, Germany

    Ignaz K. Wessler

  2. Pathology, University of Mainz, Obere Zahlbacher Str. 67, D-55101, Mainz, Germany

    Charles J. Kirkpatrick

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  1. Dept. of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands

    Johan Zaagsma  & Herman Meurs  & 

  2. Department of Research Management, Pharma Bio-Research Group B.V., P.O. Box 200, 9470 AE, Zuidlaren, The Netherlands

    Ad F. Roffel

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Wessler, I.K., Kirkpatrick, C.J. (2001). Role of non-neuronal and neuronal acetylcholine in the airways. In: Zaagsma, J., Meurs, H., Roffel, A.F. (eds) Muscarinic Receptors in Airways Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8358-0_2

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  • DOI: https://doi.org/10.1007/978-3-0348-8358-0_2

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