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Heme Oxygenase-1, Inflammation and Atherosclerosis

  • Chapter
Inflammatory and Infectious Basis of Atherosclerosis

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Cell injury and inflammation evoke several adaptive responses that are beneficial and protective. Many of these cellular responses occur due to inflammatory stimuli such as cytokines, endotoxin, growth factors (e.g. transforming growth factor-p), lipid derivatives (e.g. oxidized LDL) and a diverse array of oxidants [1, 2]. One such cellular response in cells and tissues exposed to these stimuli is the induction of heme oxygenase-1 (HO-1), a — 32 kDa microsomal enzyme [3-9]. HO-1 catalyzes the rate limiting step in heme degradation resulting in the liberation of equimolar quantities of biliverdin, iron and carbon monoxide (CO) as shown below. Biliverdin is subsequently converted to bilirubin. Heme is derived from ubiquitously distributed heme proteins such as cytochromes, peroxidases, respiratory burst oxidases, pyrrolases, catalase, nitric oxide synthases, hemoglobin and myoglobin; all crucial in the maintenance of normal cellular functions [6]. Recent attention has focussed on the by product(s) of this reaction which possess important antioxidant, anti-inflammatory, anti-apoptotic and possible immune modulatory functions [10-17].

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Authors and Affiliations

  1. Department of Medicine, Division of Nephrology, Hypertension and Transplantation, JHMHC, 1600, SW

    Anupam Agarwal & Nathalie Hill-Kapturczak

  2. Department of Neuroscience, University of Florida, Archer Road, Box 100224, Gainesville, FL, 32610, USA

    Harry S. Nick

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  1. Anupam Agarwal
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  1. Division of Cardiovascular Disease, University of Arkansas for Medical Sciences, 4301 West Markham, Mail Slot 532, Little Rock, AR, 72205-7199, USA

    Jay L. Mehta

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Agarwal, A., Hill-Kapturczak, N., Nick, H.S. (2001). Heme Oxygenase-1, Inflammation and Atherosclerosis. In: Mehta, J.L. (eds) Inflammatory and Infectious Basis of Atherosclerosis. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8239-2_10

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  • DOI: https://doi.org/10.1007/978-3-0348-8239-2_10

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