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Models of neurogenic inflammation as it relates to migraine

  • Chapter
Migraine: A Neuroinflammatory Disease?

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

For more than half a century, migraine was believed to be a vascular disorder with the aura attributed to cerebral vasoconstriction and ischemia and the headache to dilation and inflammation of extracranial arteries. However, there is mounting evidence that cortical spreading depression is the mechanism underlying the migraine aura and that (neurogenic) inflammation is more important than vasodilation in the migraine headache. This chapter focuses on the experimental models related to the putative migraine mechanisms of cortical spreading depression and neurogenic inflammation (Tab. 1).

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Authors and Affiliations

  1. Charité, Neurologische Klinik und Poliklinik, Humboldt Universität zu Berlin, Schumannstrasse 20-21, Berlin, 10098, Germany

    Uwe Reuter & Guy Arnold

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  1. Uwe Reuter
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  2. Guy Arnold
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  1. Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    Egilius L. H. Spierings

  2. Headache Unit, Department of Neurology, Fundación Hospital Alcorcón Juan Carlos I University, Madrid, Spain

    Margarita Sánchez del Río

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© 2002 Springer Basel AG

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Reuter, U., Arnold, G. (2002). Models of neurogenic inflammation as it relates to migraine. In: Spierings, E.L.H., Sánchez del Río, M. (eds) Migraine: A Neuroinflammatory Disease?. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8131-9_5

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  • DOI: https://doi.org/10.1007/978-3-0348-8131-9_5

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9449-4

  • Online ISBN: 978-3-0348-8131-9

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