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Growth Related Role for the Nicotinic α-Bungarotoxin Receptor

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Effects of Nicotine on Biological Systems II

Part of the book series: Advances in Pharmacological Sciences ((APS))

Summary

Accumulating evidence now suggests that neurotransmitters are not only involved in synaptic transmission but may also exert a trophic or developmental function in the nervous system. This includes acetylcholine which may mediate such a role through an interaction with nicotinic receptors. In neuronal tissue, a nicotinic receptor population which has been implicated in the modulation of neurite outgrowth is the nicotinic α-bungarotoxin receptor. Interestingly, earlier work had shown that activation of nicotinic α-bungarotoxin sites on muscle cells led to muscle cell degeneration. Furthermore, α-bungarotoxin sites present on non-neuronal cells also appear to be involved in a trophic role as exposure of these cells to nicotine elicits an increase in cell number which is blocked by α-bungarotoxin. These combined studies suggest a common role of the α-bungarotoxin receptor in growth related activities.

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Authors and Affiliations

  1. Department of Pharmacology, McGill University, 3655 Drummond St., Montreal, Quebec, H3G 1Y6, Canada

    M. Quik

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  1. M. Quik
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, H3G 1Y6, Montreal, Québec, Canada

    Paul Brian Sydenham Clarke  & Maryka Quik  & 

  2. Stiftung für Verhalten und Umwelt, Pettenkoferstrasse 12, D-80336, München, Germany

    Franz Adlkofer (Sekretär) (Sekretär)

  3. Physiologisches Institut, Universität München, Pettenkoferstrasse 12, D-80336, München, Germany

    Klaus Thurau (Vorstand) (Vorstand)

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© 1995 Birkhäuser Verlag Basel

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Quik, M. (1995). Growth Related Role for the Nicotinic α-Bungarotoxin Receptor. In: Clarke, P.B.S., Quik, M., Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems II. Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7445-8_18

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  • DOI: https://doi.org/10.1007/978-3-0348-7445-8_18

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7447-2

  • Online ISBN: 978-3-0348-7445-8

  • eBook Packages: Springer Book Archive

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