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Metabolic Pathways in Immune Cells Commitment and Fate

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Essential Aspects of Immunometabolism in Health and Disease

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Abstract

Cellular metabolism, with catabolic and anabolic pathways, is responsible to supply energy and essential molecules involved in cell growth and maintenance. In the last decade, evidence reported that cellular metabolism is an important regulator of immune cell differentiation and function. Immune cells, such as macrophages, B, and T cells are components of the innate and adaptive immune systems that play an important role in several diseases and homeostasis. To perform their function, these cells go through an activation and differentiation process intimately linked to a reprogram of their metabolism of glucose, amino acid, and fatty acid at the expense to generate energy and substances essential to support their function and survival. This chapter reviews the progress of research and the rapid growth of the immunometabolism field that has improved our understanding of the impact of metabolic pathways on immune cells’ commitment and fate. The role of metabolites and metabolic reprogramming involving B and T cells, macrophages, and DC activation and differentiation are discussed. Understanding how all these metabolic adaptations impact the activities of the immune cells in specific conditions, such as homeostasis, inflammation, immune diseases, and even in cancer becomes paramount to design strategies to envisage modulate the immune response in these contexts.

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Acknowledgements

This study was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP): grant number: 2019/14755-0. Vinicius Andrade-Oliveira is also a fellow of Pew Latin American Fellow program of the Pew Foundation.

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Authors and Affiliations

  1. Center for Human and Natural Sciences, Federal University of ABC, Santo Andre, SP, Brazil

    Renan Willian Alves, Lorena Doretto-Silva & Vinicius Andrade-Oliveira

  2. Paulista Medical School, Federal University of São Paulo, Sao Paulo, Brazil

    Eloisa Martins da Silva

Authors
  1. Renan Willian Alves
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  2. Eloisa Martins da Silva
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  3. Lorena Doretto-Silva
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  4. Vinicius Andrade-Oliveira
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Corresponding author

Correspondence to Vinicius Andrade-Oliveira .

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Editors and Affiliations

  1. Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, Brazil

    Niels Olsen Saraiva Camara

  2. Department of Pharmacology, University of São Paulo, São Paulo, Brazil

    Jose C Alves-Filho

  3. Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil

    Pedro Manoel Mendes de Moraes-Vieira

  4. Bernardo’s Lab, Center for Natural and Human Sciences, Federal University of ABC, São Paulo, Brazil

    Vinicius Andrade-Oliveira

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Alves, R.W., da Silva, E.M., Doretto-Silva, L., Andrade-Oliveira, V. (2022). Metabolic Pathways in Immune Cells Commitment and Fate. In: Camara, N.O.S., Alves-Filho, J.C., Moraes-Vieira, P.M.M.d., Andrade-Oliveira, V. (eds) Essential Aspects of Immunometabolism in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-86684-6_4

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