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Energy Metabolism in Cardiomyocyte

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Cardiomyocytes in Health and Disease

Abstract

Development, differentiation, and postnatal growth of cardiomyocyte are accompanied by substantial changes in its energy metabolism. These changes influence cardiomyocyte proliferation during the early phases of development of the heart and also terminal differentiation of the cardiomyocyte during later stages. In the early phase, glycolysis is a major source of energy for proliferating cardiomyocytes. After birth, there is an increase in the workload of the heart. The adult heart does not have energy reserves and hence has to ceaselessly produce energy in the form of adenosine triphosphate to meet the demands of uninterrupted contractile function. Cardiomyocyte improves its contractile capacity by shifting to a more efficient energy source (lipids) and by adapting to specialized systems for energy transfer. Metabolic maturation precedes the maturation of excitation–contraction coupling. The exact interacting mechanisms are unclear. As cardiomyocytes become terminally differentiated, its mitochondrial oxidative capacity increases and fatty acid β-oxidation is the major source of energy. Energy metabolism drives the post-natal development of cardiomyocyte and its complex architecture. The cell microenvironment modulates the cross-talk between cytoskeletal architecture and metabolism in cardiomyocytes.

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Kartha, C.C. (2021). Energy Metabolism in Cardiomyocyte. In: Cardiomyocytes in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-85536-9_7

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