Abstract
Zuccagnia punctata Cav. (Fabaceae, Caesalpiniaceae) is an argentine medicinal plant species, belonging to a monotypic genus representatives of which grow in the arid and semiarid Argentine regions, in the biogeographic Province of Monte. The taxonomic characteristics, traditional use, phytochemistry and pharmacological activity of Z. punctata aerial parts (leaves and stems) and flowers are described. A wide range of traditional uses have been described and scientifically validated by in vitro and in vivo assays. These include the antibacterial, antifungal, anti-inflammatory, antioxidant, antitumoral, antihypertensive activities, as well as the effect in the prevention of cardiovascular disease related with hypercholesterolemia and endothelial dysfunction, between others. Compounds from different chemical groups (phenolic compounds and essential oils) have also been isolated and identified in Z. punctata. The main bioactive phytochemicals in above-ground organs (leaves, stems and flowers) have been identified as 2′,4′-dihydroxy-3′-methoxychalcone and 2′,4′-dihydroxychalcone and proposed as bioactive chemical markers. No genotoxic effect of Z. punctata extracts has been demonstrated. Oral administration of Z. punctata extract and some of their isolated compounds, were not toxic in rabbits and mice models. Although no human clinical trials have been carried out so far, Z. punctata is a species widely used by local populations of the Monte ecoregion for many years, without manifestations of obvious toxicity. Therefore, extracts of aerial parts of Z. punctata could be used in herbal medicines as standardized extracts indicating the amount of major bioactive compounds (chalcones). In addition, it could be included in several phytotherapeutic preparations such as capsules, creams, gels, microencapsulates.
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Agüero MB, González M, Lima B, Svetaz L, Sánchez M, Zacchino S, Feresin G, Schmeda-Hirschmann G, Palermo J, Wunderlin D, Tapia A (2010) Argentinean propolis from Zuccagnia punctata Cav. (Caesalpinieae) exudates: phytochemical characterization and antifungal activity. J Agric Food Chem 58:194–201
Alberto MR, Nieva Moreno MI, Zampini IC, Isla MI (2007) Anti-inflammatory activity of structurally related natural flavonoids. BLACPMA 6:308–309
Álvarez AI, Real R, Pérez M, Mendoza G, Prieto JG, Merino G (2010) Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP by flavonoids and drug response). J Pharm Sci 99:598–617
Álvarez SL, Cortadi A, Juárez MA, Petenatti E, Tomi F, Casanova J, van Baren CM, Zacchino S, Vila R (2012) (−)-5,6-dehydrocamphor from the antifungal essential oil of Zuccagnia punctata. Phytochem Lett 5:194–199
Álvarez M, Enrico R., Zampini IC, Isla MI (2019) Micropropagación de una especie endémica de Argentina, Zuccagnia punctata. XIV Jornadas Internas de Investigación, Docencia y Extensión de la Facultad de Ciencias Naturales e Instituto Miguel Lillo. 3–4 December 2019, San Miguel de Tucumán, Tucumán, Argentina, p 10
ANMAT (2015) (Administración Nacional de Medicamentos, Alimentos y Tecnología Médica). Resolución N° 5418
Ávila V, Bertolotti SG, Criado S, Pappano N, Debattista N, García NA (2001) Antioxidant properties of natural flavonoids: quenching and generation of singlet molecular oxygen. J Food Sci Technol 36:25–33
Bale AT, Khan KM, Salar U, Chigurupati S, Fasina T, Ali F, Perveen S (2018) Chalcones and bis-chalcones: as potential α-amylase inhibitors; synthesis, in vitro screening, and molecular modeling studies. Bioorg Chem 79:179–189
Barboza GE, Cantero JJ, Nuñez C, Pacciaroni A, Ariza Espinar L (2009) Medicinal plants: a general review and a phytochemical and ethnopharmacological screening of the native Argentine Flora. Kurtziana 32:7–365
Batovska DI, Todorova IT (2010) Trends in utilization of the pharmacological potential of chalcones. Curr Clin Pharmacol 5:1–29
Burkart A (1952) Las Leguminosas argentinas, silvestres y cultivadas, 2nd edn. Ed. ACME, Buenos Aires, Argentina, 590 pp
Burkart R, Bárbaro NO, Sánchez RO, Gómez DA (1999) Eco-regiones de la Argentina. Ed. Secretaría de Recursos Naturales y Desarrollo Sustentable, Buenos Aires, Argentina, 42 pp
Butassi E, Svetaz LA, Ivancovich JJ, Feresin GE, Tapia A, Zacchino SA (2015) Synergistic mutual potentiation of antifungal activity of Zuccagnia punctata Cav. and Larrea nitida Cav. extracts in clinical isolates of Candida albicans and Candida glabrata. Phytomedicine 22:666–578
Cabrera AL (1976) Regiones Fitogeográficas Argentinas. In: Kugler WF (ed) Enciclopedia Argentina de Agricultura y Jardinería. Segunda edición. Ed. ACME, Buenos Aires, Argentina, 85 pp
Cabrera AL, Willink A (1973) Biogeografía de América Latina. Ed. O. E. A. Serie de Biología, Washington, DC, Argentina, 120 pp
Cai CY, Rao L, Rao Y, Guo JX, Xiao ZZ, Cao JY, Wang B (2017) Analogues of xanthone-chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates. Eur J Med Chem 130:51–59
Cantero JC, Nuñez CO, Bernardello G, Amuchástegui A, Mulko J, Brandolin P, Palchetti MV, Iparraguirre J, Virginil N, Ariza Espinar L (2019) Las plantas de importancia económica en Argentina. 1st Ed, UniRío Editora, Universidad Nacional de Río Cuarto, Río Cuarto, Argentina, 937 pp. https://botanicaargentina.org.ar/wp-content/uploads/2019/06/978-987-688-332-0-baja-resoluci%C3%B3n.pdf. (Last access, December 2019)
Carabajal MPA, Isla MI, Zampini IC (2017) Evaluation of antioxidant and antimutagenic activity of herbal teas from native plants used in traditional medicine in Argentina. S Afr J Bot 110:258–265
Carabajal MPA, Perea MC, Isla MI, Zampini IC (2020a) The use of Jarilla native plants in a Diaguita-Calchaquí indigenous community from northwestern Argentina: an ethnobotanical, phytochemical and biological approach. J Ethnopharmacol 247, 112258
Carabajal MPA, Isla MI, Borsarelli CD, Zampini IC (2020b) Influence of in vitro gastro-duodenal digestion on the antioxidant activity of single and mixed three “Jarilla” species infusions. J Herb Med 19:100296
Chieli E, Romiti N, Zampini IC, Garrido G, Isla MI (2012) Effects of Zuccagnia punctata extracts and their flavonoids on the function and expression of ABCB1/P-glycoprotein multidrug transporter. J Ethnopharmacol 144:797–801
D’Almeida RE, Alberto MR, Morgan PG, Sedensky MM, Isla MI (2015) Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans. Acta Parasitol 60:164–172
De la Rocha N, María AOM, Gianello JC, Pelzer L (2003) Cytoprotective effects of chalcones from Zuccagnia punctata and melatonin on gastroduodenal tract in rats. Pharmacol Res 48:97–99
Del Vitto LA, Petenatti EM, Petenatti ME (1997) Recursos herbolarios de San Luis (República Argentina) Primera parte: Plantas Nativas. Herbal resources of San Luis (Argentina). First part: native plants. Multequina 6:49–66
Diario Chilecito.com (2019) Available in http://www.diariochilecito.com.ar/articulo/4796.html. (Last access, December 2019)
EMA (2010) Guideline on declaration of herbal substances and herbal preparations in herbal medicinal products/traditional herbal medicinal products. Available at http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003272.pdf. (Last access, December 2019)
Falcao HS, Mariath IR, Diniz MFFM, Batista LM, Barbosa-Filho JM (2008) Plants of the American continent with antiulcer activity. Phytomedicine 15:132–146
Hatano T, Shintani Y, Aga Y, Shiota S, Tsuchiya T, Yoshida T (2000) Phenolic constituents of licorice. VIII. Structures of glycophenone and glycoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus. Chem Pharm Bull 48:1286–1292
Lahtchev KL, Batovska DI, Parushev SP, Ubiyvovk VM, Sibirny AA (2008) Antifungal activity of chalcones: a mechanistic study using various yeast strains. Eur J Med Chem 43:2220–2228
Lersten NR, Curtis JD (1996) Survey of leaf anatomy, especially secretory structures, of tribe Caesalpinieae (Leguminosae, Caesalpinioideae). Pl Syst Evol 200:1–39
Lozano L (2011) Ecofisiología de la tuna (Opuntia ficus-indica (L.) Mill.). Horticultura Argentina 30(72):37–52
Mahapatra DK, Bharti SK (2016) Therapeutic potential of chalcones as cardiovascular agents. Life Sci 148:154–172
Mahapatra DK, Asati V, Bharti SK (2015) Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives. Eur J Med Chem 92:839–865
Mercado MI, Ruiz AI, Zampini IC, Nuño G, Cuello S, Isla MI, Ponessa GI (2013) Arquitectura y morfoanatomía foliar y caulinar de Zuccagnia punctata (Fabaceae). Histolocalización de Compuestos Bioactivos. Lilloa 50:58–68
Morán Vieyra F, Boggetti H, Zampini I, Ordoñez R, Isla M, Álvarez R, De Rosso V, Mercadante A, Borsarelli C (2009) Singlet oxygen quenching and radical scavenging capacities of structurally related flavonoids present in Zuccagnia punctata Cav. Free Radic Res 43:553–564
Moreno A, Nuño G, Cuello S, Sayago J, Alberto MR, Zampini C, Isla MI (2015a) Anti-inflammatory, antioxidant and antimicrobial activity characterization and toxicity studies of flowers of “Jarilla”, a medicinal shrub from Argentina. Nat Prod Commun 6:991–994
Moreno MA, Nuño G, Cuello S, Zampini IC, Mercado M, Ponessa G, Sayago JE, Isla MI (2015b) Histochemical localization and characterization of chalcones in foliar surface of Zuccagnia punctata Cav. Insight into their physiological role. Phytochem Lett 13:134–140
Moreno MA, Gómez-Mascaraque L, Arias M, Zampini IC, Sayago JE, Pino Ramos LL, Schmeda-Hirschmann G, López-Rubio A, Isla MI (2018a) Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations. Carbohydr Polym 201:425–437
Moreno MA, Córdoba S, Zampini IC, Mercado MI, Ponessa G, Sayago JE, Pino Ramos LL, Schmeda-Hirschmann G, Isla MI (2018b) Argentinean Larrea dry extracts with potential use in vaginal candidiasis. Nat Prod Commun 13(2):171–174
Norma RE-84-2010-Secretaria de Agricultura y Desarrollo sustentable de la Nación, Argentina. http://www.loa.org.ar/legNormaDetalle.aspx?id=11091. (Last access, December 2019)
Nuño G, Alberto M, Zampini I, Cuello S, Ordoñez R, Sayago J, Baroni V, Wunderlin D, Isla MI (2014) The effect of Zuccagnia punctata Cav, an Argentina medicinal plant, on virulence factors from Candida species. Nat Prod Commun 9:933–936
Nuño G, Alberto MR, Arena ME, Zampini IC, Isla MI (2018) Effect of Zuccagnia punctata Cav. (Fabaceae) extract on pro-inflammatory enzymes and on planktonic cells and biofilm from Staphylococcus aureus. Toxicity studies. Saudi J Biol Sci 25:1713–1719
Ortega CA, María AOM, Gianello JC (2000) Chemical components and biological activity of Bidens subalternans, B. aurea (Astereaceae) and Zuccagnia punctata (Fabaceae). Molecules 5:465–470
Paoli H, Bianchi AR, Yáñez CE, Volante JN, Fernández DR, Mattalía MC, Noé YE (2002) Recursos Hídricos de la Puna, Valles y Bolsones áridos del Noroeste Argentino. Convenio INTA EEA Salta-CIED, Argentina, pp 51–54
Pederiva R, Giordano O (1984) 3,7-Dihydroxy-8-methoxyflavone from Zuccagnia punctata. Phytochemistry 23:1340–1341
Pederiva R, Kavka J, D’Arcangelo AT (1975) Chalconas y flavanonas aisladas de Larrea nitida Cav. An Asoc Quim Argent 63:85–90
Ratera EL, Ratera MO (1980) Plantas de la flora argentina empleadas en medicina popular. Ed. Hemisferio Sur. Buenos Aires, Argentina, 189 pp
Roco J, Alarcón G, Sierra L, Zampini C, Isla MI, Jérez S (2017) Beneficial effects of hydroalcoholic extract and flavonoids from Zuccagnia punctata in a rabbit model of vascular dysfunction induced by high cholesterol diet. Med Chem Res 26:2336–2344
Roco J, Alarcón G, Medina M, Zampini C, Isla MI, Jérez S (2018) Oral administration of Zuccagnia punctata extract improves lipid profile, reduces oxidative stress and prevents vascular dysfunction in hypercholesterolemic rabbits. Phytomedicine 48:104–111
Svetaz L, Tapia A, López S, Furlán R, Petenatti E, Pioli R, Schmeda-Hirschmann G, Zacchino S (2004) Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. J Agric Food Chem 52:3297–3300
Svetaz L, Agüero MB, Álvarez S, Luna L, Feresin G, Derita M, Tapia A, Zacchino S (2007) Antifungal activity of chalcones from Zuccagnia punctata Cav. acting against clinically important fungi and studies of mechanism of action. Planta Med 73:1074–1080
Tangarife-Castaño V, Correa-Royero J, Zapata-Londono B, Durán C, Stanshenko E, Mesa-Arango AC (2011) Anti-Candida albicans activity, cytotoxicity and interaction with antifungal drugs of essential oils and extracts from aromatic and medicinal plants. Infection 15:160–167
Toursarkissian M (1980) Plantas medicinales de la Argentina; sus nombres botánicos, vulgares, usos y distribución geográfica. Ed. Hemisferio Sur, Buenos Aires, Argentina, 178 pp
Ulibarri EA (2005) Zuccagnia punctata (Leguminosae): ¿nuevo o viejo endemismo argentino? Darwiniana 43:212–215
Zampini IC, Vattuone MA, Isla MI (2005) Antibacterial activity of Zuccagnia punctata Cav. ethanolic extracts. J Ethnopharmacol 102:450–456
Zampini IC, Villarini M, Moretti M, Dominici L, Isla MI (2008) Evaluation of genotoxic and antigenotoxic effects of hydroalcoholic extracts of Zuccagnia punctata Cav. J Ethnopharmacol 115:330–335
Zampini IC, Villena J, Salva S, Herrera M, Isla MI, Álvarez S (2012) Potentiality of standardized extract and isolated flavonoids from Zuccagnia punctata for the treatment of respiratory infections by Streptococcus pneumoniae: In vitro and in vivo studies. J Ethnopharmacol 140:287–292
Zuloaga FO, Morrone O (1999) Catálogo de las Plantas Vasculares de la República Argentina. II. Fabaceae-Zygophyllaceae (Dicotyledoneae). Monography Systematic Botany. Missouri Botany Garden, USA, p 74
Acknowledgments
The authors acknowledge the cooperation of the inhabitants of the studied areas and the financial support from the SCAIT-UNT (PIUNT 2018 G-637), the Agencia Nacional de Promoción Científica y Técnica (ANPCyT, PICT 2014-3136 and PICT 2017-4436), the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, PUE -0011, Argentina).
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Isla, M.I., Moreno, M.A., de los Ángeles Álvarez, M., Zampini, I.C. (2021). Zuccagnia punctata Cav.. In: Máthé, Á., Bandoni, A. (eds) Medicinal and Aromatic Plants of South America Vol. 2. Medicinal and Aromatic Plants of the World, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-030-62818-5_42
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