Skip to main content

Adverse Effects of Drugs

  • Chapter
  • First Online:
Absolute Geriatric Psychiatry Review
  • 616 Accesses

Abstract

In this chapter, we review some common adverse effects seen when treating older adults with psychotropic medications.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Further Reading

  • Balt SL, Galloway GP, Baggott MJ, et al. Mechanisms and genetics of antipsychotic-associated weight gain. Clin Pharmacol Ther. 2011;90(1):179–83.

    Article  CAS  Google Scholar 

  • Chew ML, Mulsant BH, Pollock BG, et al. A model of anticholinergic activity of atypical antipsychotic medications. Schizophr Res. 2006;88(1–3):63–72.

    Article  Google Scholar 

  • Chew ML, Mulsant BH, Pollock BG, et al. Anticholinergic activity of 107 medications commonly used by older adults. J Am Geriatr Soc. 2008;56(7):1333–41.

    Article  Google Scholar 

  • Cohen R, Wilkins KM, Ostroff R, et al. Olanzapine and acute urinary retention in two geriatric patients. Am J Geriatr Pharmacother. 2007;5(3):241–6.

    Article  CAS  Google Scholar 

  • de Leon J, Santoro V, D’Arrigo C, Spina E. Interactions between antiepileptics and second-generation antipsychotics. Expert Opin Drug Metab Toxicol. 2012;8(3):311–34.

    Article  Google Scholar 

  • Filippatos TD, Makri A, Elisaf MS, Liamis G. Hyponatremia in the elderly: challenges and solutions. Clin Interv Aging. 2017;12:1957–65.

    Article  CAS  Google Scholar 

  • Francis Lam YW. Warfarin and SSRIs. The Brown University Psychopharmacology Update. 2017;28(12):2–3.

    Article  Google Scholar 

  • Gareri P, Segura-García C, Manfredi VG, et al. Use of atypical antipsychotics in the elderly: a clinical review. Clin Interv Aging. 2014;9:1363–73.

    PubMed  PubMed Central  Google Scholar 

  • Gillman PK. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007;151(6):737–48.

    Article  CAS  Google Scholar 

  • Henry G, Williamson D, Tampi RR. Efficacy and tolerability of antidepressants in the treatment of behavioral and psychological symptoms of dementia, a literature review of evidence. Am J Alzheimers Dis Other Dement. 2011;26(3):169–83.

    Article  Google Scholar 

  • Kheirbek RE, Fokar A, Little JT, et al. Association between antipsychotics and all-cause mortality among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2019;74(12):1916–21.

    Article  Google Scholar 

  • Koola MM, Varghese SP, Fawcett JA. High-dose prazosin for the treatment of post-traumatic stress disorder. Ther Adv Psychopharmacol. 2014;4(1):43–7.

    Article  Google Scholar 

  • Kumar S, Kodela S, Detweiler JG, et al. Bupropion-induced psychosis: folklore or a fact? A systematic review of the literature. Gen Hosp Psychiatry. 2011;33(6):612–7.

    Article  Google Scholar 

  • Kurdyak PA, Juurlink DN, Kopp A, Herrmann N, Mamdani MM. Antidepressants, warfarin, and the risk of hemorrhage. J Clin Psychopharmacol. 2005;25(6):561–4.

    Article  CAS  Google Scholar 

  • Laliberté V, Yu C, Rej S. Acute renal and neurotoxicity in older lithium users: how can we manage and prevent these events in patients with late-life mood disorders? J Psychiatry Neurosci. 2015;40(4):E29–30.

    Article  Google Scholar 

  • McCrae CS, Ross A, Stripling A, Dautovich ND. Eszopiclone for late-life insomnia. Clin Interv Aging. 2007;2(3):313–26.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Patel K, Allen S, Haque MN, et al. Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant. Ther Adv Psychopharmacol. 2016;6(2):99–144.

    Article  CAS  Google Scholar 

  • Preskorn SH. A way of conceptualizing benzodiazepines to guide clinical use. J Psychiatr Pract. 2015;21(6):436–41.

    Article  Google Scholar 

  • Richa S, Yazbek JC. Ocular adverse effects of common psychotropic agents: a review. CNS Drugs. 2010;24(6):501–26.

    Article  CAS  Google Scholar 

  • Salem H, Nagpal C, Pigott T, Teixeira AL. Revisiting antipsychotic-induced akathisia: current issues and prospective challenges. Curr Neuropharmacol. 2017;15(5):789–98.

    Article  CAS  Google Scholar 

  • Serretti A, Mandelli L. Antidepressants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry. 2010;71(10):1259–72.

    Article  Google Scholar 

  • Sommer BR, Fenn HH. Review of topiramate for the treatment of epilepsy in elderly patients. Clin Interv Aging. 2010;5:89–99.

    Article  CAS  Google Scholar 

  • Sommer BR, Fenn H, Pompei P, et al. Safety of antidepressants in the elderly. Expert Opin Drug Saf. 2003;2(4):367–83.

    Article  CAS  Google Scholar 

  • Tambasco N, Romoli M, Calabresi P. Levodopa in Parkinson's disease: current status and future developments. Curr Neuropharmacol. 2018;16(8):1239–52.

    Article  CAS  Google Scholar 

  • Tampi RR, Tampi DJ, Balachandran S, et al. Antipsychotic use in dementia: a systematic review of benefits and risks from meta-analyses. Ther Adv Chronic Dis. 2016;7(5):229–45.

    Article  Google Scholar 

  • Teles JS, Fukuda EY, Feder D. Warfarin: pharmacological profile and drug interactions with antidepressants. Einstein (Sao Paulo). 2012;10(1):110–5.

    Article  Google Scholar 

  • Tisdale JE. Drug-induced QT interval prolongation and torsades de pointes: role of the pharmacist in risk assessment, prevention and management. Can Pharm J (Ott). 2016;149(3):139–52.

    Article  Google Scholar 

  • Tsuda Y, Saruwatari J, Yasui-Furukori N. Meta-analysis: the effects of smoking on the disposition of two commonly used antipsychotic agents, olanzapine and clozapine. BMJ Open. 2014;4(3):e004216.

    Article  Google Scholar 

  • Ware MR, Feller DB, Hall KL. Neuroleptic malignant syndrome: diagnosis and management. Prim Care Companion CNS Disord. 2018;20(1):pii: 17r02185.

    Article  Google Scholar 

  • Williams AM, Park SH. Seizure associated with clozapine: incidence, etiology, and management. CNS Drugs. 2015;29(2):101–11.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kristen Cannon .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Cannon, K. (2021). Adverse Effects of Drugs. In: Tampi, R., Tampi, D., Young, J., Hoq, R., Resnick, K. (eds) Absolute Geriatric Psychiatry Review. Springer, Cham. https://doi.org/10.1007/978-3-030-58663-8_34

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-58663-8_34

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-58662-1

  • Online ISBN: 978-3-030-58663-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics