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Insights into the Pathobiology of Secondary AML

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Acute Leukemias

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

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Abstract

Secondary acute myeloid leukemia (s-AML) is recognized as AML arising from prior hematological disease, usually myelodysplastic syndrome, myeloproliferative neoplasm, or aplastic anemia or has myelodysplasia related changes or develops in context of prior cytotoxic or radiation therapy. Understanding the biology of s-AML is of utmost importance as this portends a high-risk disease including a potential for lower responses to chemotherapy. Some therapeutic developments in recent times have been CPX-351 as well as venetoclax-containing combinations. Of particular ongoing and forthcoming interest is the role of targeted therapy itself or in combination with other agents. Lastly, the role of allogeneic stem cell transplantation remains crucial although debated, and with improvement in treatment strategies provides opportunities to use the two in combination for best results.

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Abbreviations

AHD:

Antecedent hematological disorder

AML:

Acute myeloid leukemia

CBF:

Core binding factor

CIBMTR:

Center for International Bone Marrow Transplant Research

EBMT:

European Society for Blood and Bone Marrow Transplantation

HCT:

Hematopoietic cell transplantation

JAK:

Janus kinase

MDS:

Myelodysplastic syndrome

MPN:

Myeloproliferative neoplasm

SNP:

Single-nucleotide polymorphism

TP:

Tumor protein

WHO:

World Health Organization

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Authors and Affiliations

  1. Division of Hematological Malignancies and Stem Cell Transplantation, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA

    Tania Jain

  2. Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Raajit K. Rampal

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  1. Tania Jain
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Correspondence to Tania Jain .

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Editors and Affiliations

  1. Reno, NV, USA

    Stefan H. Faderl

  2. Department of Leukemia, MD Anderson Cancer Center, University of Texas, Houston, TX, USA

    Hagop M. Kantarjian

  3. Clinical Research Division, Fred Hutch, Seattle, WA, USA

    Elihu Estey

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Jain, T., Rampal, R.K. (2021). Insights into the Pathobiology of Secondary AML. In: Faderl, S.H., Kantarjian, H.M., Estey, E. (eds) Acute Leukemias. Hematologic Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-030-53633-6_3

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  • DOI: https://doi.org/10.1007/978-3-030-53633-6_3

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