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Hashimoto’s Disease

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Thyroid Disease

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Abstract

Hashimoto disease is part of the spectrum of autoimmune thyroid diseases, characterized by destruction of thyroid cells by various cell- and antibody-mediated immune processes. It was not until 1956 when a link between antibodies to thyroid cells present in the serum of patients and Hashimoto disease was made. Over time scientists recognized the association of this disease with other autoimmune diseases and thyroid cancer. The increasing use of needle biopsy and serologic tests for antibodies has led to much more frequent recognition; it is now one of the most common thyroid disorders. This chapter addresses a wide range of topics related to Hashimoto’s disease (thyroiditis).

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References

  1. Fava A, Oliverio R, Giuliano S, et al. Clinical evolution of autoimmune thyroiditis in children and adolescents. Thyroid. 2009;19(4):361–7.

    CAS  PubMed  Google Scholar 

  2. Nagar S, Angelos P. Hakaru Hashimoto. In: Pasieka JL, Lee JA, editors. Surgical endocrinopathies, vol. 8. New York, NY: Springer; 2015. p. 43–8.

    Google Scholar 

  3. Rose NR, Witebsky E. Studies on organ specificity. V. Changes in thyroid glands of rabbits following active immunization with rabbit thyroid extracts. J Immunol. 1956;76:417–9.

    CAS  PubMed  Google Scholar 

  4. Roitt IM, Doniach D, Campbell PN, Hudson RV. Auto- antibodies in Hashimoto’s thyroiditis (lymphadenoid goiter). Lancet. 1956;2:820–3.

    Google Scholar 

  5. Gordin A, Maatela J, Miettinen A, Helenius T, Lamberg B-A. Serum thyrotropin and circulating thyroglobulin and thyroid microsomal antibodies in a Finnish population. Acta Endocrinol. 1979;90:33–9.

    CAS  PubMed  Google Scholar 

  6. Ling SM, Kaplan SA, Weitzman JJ, Reed GB, Costin G, Landing BH. Euthyroid goiters in children. Correlation of needle biopsy with other clinical and laboratory findings in chronic lymphocytic thyroiditis and simple goiter. Pediatrics. 1969;44:695699.

    Google Scholar 

  7. Tunbridge WMG, Evered DC, Hall R, et al. The spectrum of thyroid disease in a community. The Whickham Survey. Clin Endocrinol. 1977;7:481–6.

    CAS  Google Scholar 

  8. Vanderpump MP, French JM, Appleton D. The prevalence of hyperprolactinaemia and association with markers of autoimmune thyroid disease in survivors of the Whickham Survey cohort. Clin Endocrinol. 1998;48(1):39–44.

    CAS  Google Scholar 

  9. Vanderpump MP, Tunbridge WM, French JM. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol. 1995;43(1):55–68.

    CAS  Google Scholar 

  10. Staii A, et al. Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state. Thyroid Res. 2010;3:11–6.

    PubMed  PubMed Central  Google Scholar 

  11. Inoue M, Taketani N, Sato T, Nakajima H. High incidence of chronic lymphocytic thyroiditis in apparently healthy school children: epidemiological and clinical study. Endocrinol Jpn. 1975;22:483–7.

    CAS  PubMed  Google Scholar 

  12. Carey C, Skosey C, Pinnamaneni KM, Barsano CP, DeGroot LJ. Thyroid abnormalities in children of parents who have Graves’ disease. Possible pre-Graves’ disease. Metabolism. 1980;29:369–74.

    CAS  PubMed  Google Scholar 

  13. Yoshida H, Amino N, Yagawa K, Uemura K, Satoh M, Miyai K, Kumahara Y. Association of serum antithyroid antibodies with lymphocytic infiltration of the thyroid gland: studies of seventy autopsied cases. J Clin Endocrinol Metab. 1978;46:859–64.

    CAS  PubMed  Google Scholar 

  14. Gordin A, Saarinen P, Pelkonen A, Lamberg B-A. Serum thyroglobulin and the response to thyrotropin releasing hormone in symptomless autoimmune thyroiditis and in borderline and overt hypothyroidism. Acta Endocrinol. 1974;75:274–7.

    CAS  PubMed  Google Scholar 

  15. Tunbridge WMG, Brewis M, French JM, Appleton D, Bird T, Clark F, Evered DC, Evans JG, Hall R, Smith P, Stephenson J, Young E. Natural history of autoimmune thyroiditis. Br Med J. 1981;282:258–63.

    CAS  Google Scholar 

  16. Simmonds MJ, Kavvoura FK, Brand OJ, Newby PR, Jackson LE, Hargreaves CE, Franklyn JA, Gough SC. Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis. J Clin Endocrinol Metab. 2014;99(1):27–31.

    Google Scholar 

  17. Klintschar M, Schwaiger P, Mannweiler S, Regauer S, Kleiber M. Evidence of fetal microchimerism in Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 2001;86:2494–8.

    CAS  PubMed  Google Scholar 

  18. Klintschar M, Immel UD, Kehlen A, Schwaiger P, Mustafa T, Mannweiler S, Regauer S, Kleiber M, Hoang-Vu C. Fetal microchimerism in Hashimoto’s thyroiditis: a quantitative approach. Eur J Endocrinol. 2006;154:237–41.

    CAS  PubMed  Google Scholar 

  19. Renné C, Ramos Lopez E, Steimle-Grauer SA, Ziolkowski P, Pani MA, Luther C, Holzer K, Encke A, Wahl RA, Bechstein WO, Usadel KH, Hansmann ML, Badenhoop K. Thyroid fetal male micro-chimerism in mothers with thyroid disorders: presence of Y-chromosomal immuno-fluorescence in thyroid infiltrating lymphocytes is more prevalent in Hashimoto’s thyroiditis and Graves’ disease than in follicular adenomas. J Clin Endocrinol Metab. 2004;89:5810–4.

    PubMed  Google Scholar 

  20. Totterman TH, Maenpaa J, Gordin A, Makinen T, Andersson AC. Blood and thyroid-infiltrating lymphocyte subclasses in juvenile autoimmune thyroiditis. Clin Exp Immunol. 1977;30:193–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Paolieri F, Pronzato C, Battifora M, Fiorino N, Canonica GW, Bagnasco M. Infiltrating gamma/delta T-cell receptor-positive lymphocytes in Hashimoto’s thyroiditis, Graves’ disease and papillary thyroid cancer. J Endocrinol Investig. 1995;18:295–8.

    CAS  Google Scholar 

  22. Iwatani Y, Hidaka Y, Matsuzuka F, Kuma K, Amino N. Intrathyroidal lymphocyte subsets, including unusual CD4+ CD8+ cells and CD3loTCR alpha beta lo/−CD4−CD8− cells, in autoimmune thyroid disease. Clin Exp Immunol. 1993;93:430–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Davies TF, Martin A, Concepcion ES, Graves P, Cohen L, Ben NA. Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. N Engl J Med. 1991;325:238–44.

    CAS  PubMed  Google Scholar 

  24. Davies TF, Concepcion ES, Ben Nun A, Graves PN, Tarjan G. T-cell receptor V gene use in autoimmune thyroid disease: direct assessment by thyroid aspiration. J Clin Endocrinol Metab. 1993;76:660–6.

    CAS  PubMed  Google Scholar 

  25. Heuer M, Aust G, Ode-Hakim S, Scherbaum WA. Different cytokine mRNA profiles in Graves’ disease, Hashimoto’s thyroiditis, and non-autoimmune thyroid disorders determined by quantitative reverse transcriptase polymerase chain reaction (RT-PCR). Thyroid. 1996;6:97–106.

    CAS  PubMed  Google Scholar 

  26. Gunn A, Michie W, Irvine WJ. The thymus in thyroid disease. Lancet. 1964;2:776–9.

    CAS  PubMed  Google Scholar 

  27. Michie W, Beck JS, Mahaffy RG, Honein EF, Fowler GB. Quantitative radiological and histological studies of the thymus in thyroid disease. Lancet. 1967;1:691–4.

    CAS  PubMed  Google Scholar 

  28. Mizukami Y, Michigishi T, Hashimoto T, Tonami N, Hisada K, Matsubara F, Takazakura E. Silent thyroiditis: a histologic and immunohistochemical study. Hum Pathol. 1988;19:423–31.

    CAS  PubMed  Google Scholar 

  29. Zeitlin AA, Heward JM, Newby PR, Carr-Smith JD, Franklyn JA, Gough SC, Simmonds MJ. Analysis of HLA class II genes in Hashimoto’s thyroiditis reveals differences compared to Graves’ disease. Genes Immun. 2008;9(4):358–63.

    CAS  PubMed  Google Scholar 

  30. Brix TH, Kyvik KO, Hegedus L. A population-based study of chronic autoimmune hypothyroidism in Danish twins. J Clin Endocr Metab. 2000;85:536–9.

    CAS  PubMed  Google Scholar 

  31. Simmonds MJ. GWAS in autoimmune thyroid disease: redefining our understanding of pathogenesis. Nat Rev Endocrinol. 2013;9(5):277–87.

    CAS  PubMed  Google Scholar 

  32. Cai T, Li J, An X, Yan N, Li D, Jiang Y, Wang W, Shi L, Qin Q, Song R, Wang G, Jiang W, Zhang JA. Polymorphisms in MIR499A and MIR125A gene are associated with autoimmune thyroid diseases. Mol Cell Endocrinol. 2017;15:106–15.

    Google Scholar 

  33. Duntas LH. Environmental factors and autoimmune thyroiditis. Nat Clin Pract Endocrinol Metab. 2010;4:454–60.

    Google Scholar 

  34. Mori T, Kriss JP. Measurements by competitive binding radioassay of serum anti-microsomal and anti-thyroglobulin antibodies in Graves’ disease and other thyroid disorders. J Clin Endocrinol Metab. 1971;33:688692.

    Google Scholar 

  35. Kawakami Y, Fisfalen M-E, DeGroot LJ. Proliferative responses of peripheral blood mononuclear cells from patients with autoimmune thyroid disease to synthetic peptide epitopes of human thyroid peroxidase. Autoimmunity. 1992;13:17–26.

    CAS  PubMed  Google Scholar 

  36. Ng HP, Kung AW. Induction of autoimmune thyroiditis and hypothyroidism by immunization of immunoactive T cell epitope of thyroid peroxidase. Endocrinology. 2006;147(6):3085–92.

    CAS  PubMed  Google Scholar 

  37. Muixí L, Carrascal M, Alvarez I, Daura X, Martí M, Armengol MP, Pinilla C, Abian J, Pujol-Borrell R, Jaraquemada D. Thyroglobulin peptides associate in vivo to HLA-DR in autoimmune thyroid glands. J Immunol. 2008;181(1):795–807.

    PubMed  Google Scholar 

  38. Hidaka Y, Amino N, Iwatani Y, Kaneda T, Nasu M, Mitsuda N, Tanizawa O, Miyai K. Increase in peripheral natural killer cell activity in patients with autoimmune thyroid disease. Autoimmunity. 1992;11:239–43.

    CAS  PubMed  Google Scholar 

  39. Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T Cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol. 1999;162:5317–26.

    CAS  PubMed  Google Scholar 

  40. McLachlan SM, Nagayama Y, Pichurin PN, et al. The link between Graves’ disease and Hashimoto’s thyroiditis: a role for regulatory T cells. Endocrinology. 2007;148(12):5724–33.

    CAS  PubMed  Google Scholar 

  41. Kosugi S, Ban T, Akamizu T, Kohn LD. Identification of separate determinants on the thyrotropin receptor reactive with Graves’ thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors. Mol Endocrinol. 1992;6:168–80.

    CAS  PubMed  Google Scholar 

  42. Tamaki H, Amino N, Kimura M, Hidaka Y, Takeoka K, Miyai K. Low prevalence of thyrotropin receptor antibody in primary hypothyroidism in Japan. J Clin Endocrinol Metab. 1990;71:1382–7.

    CAS  PubMed  Google Scholar 

  43. Okamura K, Sato K, Yoshinari M, Ikenoue H, Kuroda T, Nakagawa M, Tsuji H, Washio M, Fujishima M. Recovery of the thyroid function in patients with atrophic hypothyroidism and blocking type TSH binding inhibitor immunoglobulin. Acta Endocrinol. 1990;122:107–14.

    CAS  PubMed  Google Scholar 

  44. Takasu N, Yamada T, Takasu M, Komiya I, Nagasawa Y, Asawa T, Shinoda T, Aizawa T, Koizumi Y. Disappearance of thyrotropin-blocking antibodies and spontaneous recovery from hypothyroidism in autoimmune thyroiditis. N Engl J Med. 1992;326:513–8.

    CAS  PubMed  Google Scholar 

  45. Mori T, Akamizu T, Kosugi S, Sugawa H, Inoue D, Okuda J, Ueda Y. Recent progress in TSH receptor studies with a new concept of “Autoimmune TSH receptor disease”. Endocr J. 1994;41:1–11.

    CAS  PubMed  Google Scholar 

  46. Kotani T, Aratake Y, Hirai K, et al. Apoptosis in thyroid tissue from patients with Hashimoto’s thyroiditis. Autoimmunity. 1995;20:231–5.

    CAS  PubMed  Google Scholar 

  47. Giordano C, Stassi G, Maria R, Todaro M, Richiusa P, Papoff G, Ruberti G, Bagnasco M, Testi R, Galluzzo A. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto’s thyroidiitis. Science. 1997;275:960–5.

    CAS  PubMed  Google Scholar 

  48. Mitsiiades N, Poulaki V, Kotoula V, Mastorakos G, Balafouta S, Koutras DA, Tsokos M. Fas/Fas ligand up-regulation and BCL-2 down-regulation may be significant in the pathogenesis of Hashimoto’ thyroiditis. J Clin Endocr Metab. 1998;83:2199–204.

    Google Scholar 

  49. Kawakami A, Eguchi K, Matsuoka N, Tsuboi M, Kawabe Y, Ishikawa N, Ito K, Nagataki S. Thyroid-stimulating hormone inhibits Fas antigen-mediated apoptosis of human thyrocytes in vitro. Endocrinology. 1996;137:3163–8.

    CAS  PubMed  Google Scholar 

  50. Batteux F, Lores P, Bucchini D, Chiocchia G. Transgenic expression of Fas ligand on thyroid follicular cells prevents autoimmune thyroiditis. J Immunol. 2000;164:1681–8.

    CAS  PubMed  Google Scholar 

  51. Stassi G, DeMaria R. Autoimmune thyroid disease: new models of cell death in autoimmunity. Nat Rev Immunol. 2002;2:195–204.

    CAS  PubMed  Google Scholar 

  52. Dong Z, Takakuwa T, Takayama H, Luo WJ, Takano T, Amino N, Matsuzuka F, Aozasa K. Fas and Fas ligand gene mutations in Hashimoto’s thyroiditis. Lab Investig. 2002;82:1611–6.

    CAS  PubMed  Google Scholar 

  53. Takakuwa T, Dong Z, Takayama H, Matsuzuka F, Nagata S, Aozasa K. Frequent mutations of Fas gene. Cancer Res. 2001;61(4):1382–5.

    CAS  PubMed  Google Scholar 

  54. Atkins MB, Mier JW, Parkinson DR, Gould JA, Berkman EM, Kaplan MM. Hypothyroidism after treatment with interleukin-2 and lymphokine-activated killer cells. N Engl J Med. 1988;318:1557–63.

    CAS  PubMed  Google Scholar 

  55. Coles AJ, Wing M, Smith S, Coraddu F, Greer S, Taylor C, Weetman A, Hale G, Chatterjee VK, Waldmann H, Compston A. Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis. Lancet. 1999;354:1691–5.

    CAS  PubMed  Google Scholar 

  56. Hirst CL, Pace A, Pickersgill TP, Jones R, McLean BN, Zajicek JP, Scolding NJ, Robertson NP. Campath 1-H treatment in patients with aggressive relapsing remitting multiple sclerosis. J Neurol. 2008;255(2):231–8.

    CAS  PubMed  Google Scholar 

  57. Figueroa-Vega N, Alfonso-Pérez M, Benedicto I, Sánchez-Madrid F, González-Amaro R, Marazuela M. Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 2010;95(2):953–62.

    CAS  PubMed  Google Scholar 

  58. Horie I, Abiru N, Nagayama Y, Kuriya G, Saitoh O, Ichikawa T, Iwakura Y, Eguchi K. T helper type 17-immune-response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice. Endocrinology. 2009;150(11):5135–42.

    CAS  PubMed  Google Scholar 

  59. Li C, Yuan J, Zhu YF, Yang XJ, Wang Q, Xu J, He ST, Zhang JA. Imbalance of Th17/Treg in different subtypes of autoimmune thyroid diseases. Cell Physiol Biochem. 2016;40(1–2):245–52.

    CAS  PubMed  Google Scholar 

  60. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N, Kiyosawa K. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344(10):737–328.

    Google Scholar 

  61. Komatsu K, Hamano H, Ochi Y, Takayama M, Muraki T, Yoshizawa K, Sakurai A, Ota M, Kawa S. High prevalence of hypothyroidism in patients with autoimmune pancreatitis. Dig Dis Sci. 2005;50(6):1052–7.

    PubMed  Google Scholar 

  62. Li Y, Bai Y, Liu Z, Ozaki T, Taniguchi E, Mori I, Nagayama K, Nakamura H, Kakudo K. Immunohistochemistry of IgG4 can help subclassify Hashimoto’s autoimmune thyroiditis. Pathol Int. 2009;59(9):636–41.

    CAS  PubMed  Google Scholar 

  63. Dahlgren M, Khosroshahi A, Nielsen GP, Deshpande V, Stone JH. Riedel’s thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum. Arthritis Care Res (Hoboken). 2010;62:1312–8.

    Google Scholar 

  64. Kakudo K, Li Y, Taniguchi E, Mori I, Ozaki T, Nishihara E, Matsuzuka F, Miyauchi A. IgG4-related disease of the thyroid glands [review]. Endocr J. 2012;59(4):273–81.

    CAS  PubMed  Google Scholar 

  65. Nystrom E, Bengtsson C, Lapidus L, Petersen K, Lindstedt G. Smoking—a risk factor for hypothyroidism. J Endocrinol Investig. 1993;16:129–31.

    CAS  Google Scholar 

  66. Pacini F, Vorontsova T, Molinaro E, Kuchinskaya E, Agate L, Shavrova E, Astachova L, Chiovato L, Pinchera A. Prevalence of thyroid autoantibodies in children and adolescents from Belarus exposed to the Chernobyl radioactive fallout. Lancet. 1998;352(9130):763–7666.

    CAS  PubMed  Google Scholar 

  67. Agate L, Mariotti S, Elisei R, Mossa P, Pacini F, Molinaro E, Grasso L, Masserini L, Mokhort T, Vorontsova T, Arynchyn A, Tronko MD, Tsyb A, Feldt-Rasmussen U, Juul A, Pinchera A. Thyroid autoantibodies and thyroid function in subjects exposed to Chernobyl fallout during childhood: evidence for a transient radiation-induced elevation of serum thyroid antibodies without an increase in thyroid autoimmune disease. J Clin Endocrinol Metab. 2008;93(7):2729–36.

    CAS  PubMed  Google Scholar 

  68. Elfström P, Montgomery SM, Kämpe O, Ekbom A, Ludvigsson JF. Risk of thyroid disease in individuals with celiac disease. J Clin Endocrinol Metab. 2008;93(10):3915–21.

    PubMed  Google Scholar 

  69. Betterle C, Lazzarotto F, Presotto F. Autoimmune polyglandular syndrome Type 2: the tip of an iceberg? Clin Exp Immunol. 2004;137(2):225–33.

    CAS  PubMed  PubMed Central  Google Scholar 

  70. Molitch ME, Gillam MP. Lymphocytic hypophysitis. Horm Res. 2007;68(Suppl 5):145–50.

    PubMed  Google Scholar 

  71. Xiao C, Rajewsky K. MicroRNA control in the immune system: basic principles. Cell. 2009;136:26–36.

    CAS  PubMed  Google Scholar 

  72. Thai T-H, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science. 2007;316:604–6.

    CAS  PubMed  Google Scholar 

  73. Zhu J, Zhang Y, Zhang W, Zhang W, Fan L, Wang L, Liu Y, Liu S, Guo Y, Wang Y, Yi J, Yan Q, Wang Z, Huang G. MicroRNA-142-5p contributes to Hashimoto’s thyroiditis by targeting CLDN1. J Transl Med. 2016;14(1):166–8.

    PubMed  PubMed Central  Google Scholar 

  74. Buchanan WW, Harden RM. Primary hypothyroidism and Hashimoto’s thyroiditis. Arch Intern Med. 1965;115:411–5.

    CAS  PubMed  Google Scholar 

  75. Kon YC, Degroot LJ. Painful Hashimoto’s thyroiditis as an indication for thyroidectomy: clinical characteristics and outcome in seven patients. J Clin Endocrinol Metab. 2003;88:2667–72.

    CAS  PubMed  Google Scholar 

  76. Radetti G, Gottardi E, Bona G, Corrias A, Salardi S, Loche S, Study Group for Thyroid Diseases of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED). The natural history of euthyroid Hashimoto’s thyroiditis in children. J Pediatr. 2006;149:827–32.

    PubMed  Google Scholar 

  77. Moriuchi A, Yokoyama S, Kashima K, Andoh T, Nakayama I, Noguchi S. Localized primary anyloid tumor of the thyroid developing in the course of Hashimoto’s thyroiditis. Acta Pathol Jpn. 1992;42:210–6.

    CAS  PubMed  Google Scholar 

  78. Shaw PJ, Walls TJ, Newman PK, Cleland PG, Cartlidge NE. Hashimoto’s encephalopathy: a steroid-responsive disorder associated with high antithyroid antibody titers – report of five cases. Neurology. 1991;41:228–33.

    CAS  PubMed  Google Scholar 

  79. Khardori R, Eagleton LE, Soler NG, McConnachie PR. Lymphocytic interstitial pneumonitis in autoimmune thyroid disease. Am J Med. 1991;90:649–52.

    CAS  PubMed  Google Scholar 

  80. Eisenbart GS, Wilson PW, Ward F, Buckley C, Lebovitz H. The polyglandular failure syndrome. Disease inheritance, HLA type, and immune function. Ann Intern Med. 1979;91:528.

    Google Scholar 

  81. Loviselli A, Mathieu A, Pala R, Mariotti S, Cau S, Marongiu C, Mazzoleni AP, Maggio P, Martino E. Development of thyroid disease in patients with primary and secondary Sjogren’s syndrome. J Endocrinol Investig. 1988;11:653–7.

    CAS  Google Scholar 

  82. Best TB, Munro RE, Burwell S, Volpe R. Riedel’s thyroiditis associated with Hashimoto’s thyroiditis, hypoparathyroidism, and retroperitoneal fibrosis. J Endocrinol Investig. 1991;14:767–72.

    CAS  Google Scholar 

  83. Becker KL, Ferguson RH, McConahey WM. The connective-tissue diseases and symptoms associated with Hashimoto’s thyroiditis. N Engl J Med. 1963;268:277–81.

    CAS  PubMed  Google Scholar 

  84. Bastenie PA, Vanhaelst L, Golstein J, Smets P, Keys MJ, Karvonen MJ, Punsar S. Asymptomatic autoimmune thyroiditis and coronary heart-disease. Lancet. 1977;1:155–9.

    Google Scholar 

  85. Heinonen OP, Aho K, Pyorala K, Gordin A, Punsar S, Puro K. Symptomless autoimmune thyroiditis in coronary heart disease. Lancet. 1972;1:785–9.

    CAS  PubMed  Google Scholar 

  86. Jankovic B, Le KT, Hershman JM. Clinical review: Hashimoto’s thyroiditis and papillary thyroid carcinoma: is there a correlation? J Clin Endocrinol Metab. 2013;98(2):474–82.

    CAS  PubMed  Google Scholar 

  87. Lee JH, Kim Y, Choi JW, Kim YS. The association between papillary thyroid carcinoma and histologically proven Hashimoto’s thyroiditis: a meta-analysis. Eur J Endocrinol. 2013;168(3):343–9.

    CAS  PubMed  Google Scholar 

  88. Larson SD, Jackson LN, Riall TS, Uchida T, Thomas RP, Qiu S, Evers BM. Increased incidence of well-differentiated thyroid cancer associated with Hashimoto thyroiditis and the role of the PI3k/Akt pathway. J Am Coll Surg. 2007;204(5):764–673.

    PubMed  PubMed Central  Google Scholar 

  89. Dvorkin S, Robenshtok E, Hirsch D, Strenov Y, Shimon I, Benbassat CA. Differentiated thyroid cancer is associated with less aggressive disease and better outcome in patients with coexisting Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 2013;98(6):2409–14.

    CAS  PubMed  Google Scholar 

  90. Marotta V, Guerra A, Zatelli MC, Uberti ED, Di Stasi V, Faggiano A, Colao A, Vitale M. BRAF mutation positive papillary thyroid carcinoma is less advanced when Hashimoto’s thyroiditis lymphocytic infiltration is present. Clin Endocrinol. 2013;79(5):733–8.

    CAS  Google Scholar 

  91. Amino N, Miyai K, Onishi T, Hashimoto T, Arai K, Ishibashi K, Kumahara Y. Transient hypothyroidism after delivery in autoimmune thyroiditis. J Clin Endocrinol Metab. 1976;42:296–301.

    CAS  PubMed  Google Scholar 

  92. Amino N, Kuro R, Tanizawa O, Tanaka F, Hayashi C, Kotani K, Kawashima M, Miyai K, Kumahara Y. Changes of serum antithyroid antibodies during and after pregnancy in autoimmune thyroid diseases. Clin Exp Immunol. 1978;31:30–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  93. Amino N, Miyai K, Kuro R, Tanizawa O, Azukizawa M, Takai S, Tanaka F, Nishi K, Kawashima M, Kumahara Y. Transient postpartum hypothyroidism. Fourteen cases with autoimmune thyroiditis. Ann Intern Med. 1977;87:155–9.

    CAS  PubMed  Google Scholar 

  94. Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D, Mandel SJ, Stagnaro-Green A. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2007;92(8 Suppl):S1–47.

    CAS  PubMed  Google Scholar 

  95. Dosiou C, Sanders GD, Araki SS, Crapo LM. Screening pregnant women for autoimmune thyroid disease: a cost-effectiveness analysis. Eur J Endocrinol. 2008;158(6):841–51.

    CAS  PubMed  Google Scholar 

  96. Amino N, Tada H, Hidaka Y. Postpartum autoimmune thyroid syndrome: a model of aggravation of autoimmune disease. Thyroid. 1999;9:705–13.

    CAS  PubMed  Google Scholar 

  97. Poppe K, Glinoer D, Toumaye H, et al. Assisted reproduction and thyroid autoimmunity: an unfortunate combination? J Clin Endocrinol Metab. 2003;88:4129–52.

    Google Scholar 

  98. Woolf PD, Daly R. Thyrotoxicosis with painless thyroiditis. Am J Med. 1976;60:73–9.

    CAS  PubMed  Google Scholar 

  99. Hamburger JI. Occult subacute thyroiditis: diagnostic challenge. Mich Med. 1976;70:1125–9.

    Google Scholar 

  100. Woolf PD. Transient painless thyroiditis with hyperthyroidism. A variant of lymphocytic thyroiditis. Endocr Rev. 1980;1:411–6.

    CAS  PubMed  Google Scholar 

  101. Nikolai TF, Brosseau J, Kettrick MA, Roberts R, Beltaos E. Lymphocytic thyroiditis with spontaneously resolving hyperthyroidism (silent thyroiditis). Arch Intern Med. 1980;140:478–82.

    CAS  PubMed  Google Scholar 

  102. Dorfman SG, Copperman MT, Nelson RL, Depuy H, Peake RL, Young RL. Painless thyroiditis and transient hyperthyroidism without goiter. Ann Intern Med. 1977;86:24–8.

    CAS  PubMed  Google Scholar 

  103. Gorman CA, Duick DS, Woolner LB, Wahner HW. Transient hyperthyroidism in patients with lymphocytic thyroiditis. Mayo Clin Proc. 1978;53:359–65.

    CAS  PubMed  Google Scholar 

  104. Gluck FB, Nusynowitz ML, Plymate S. Chronic lymphocytic thyroiditis, thyrotoxicosis, and low radioactive iodine uptake: reports of four cases. N Engl J Med. 1975;292:624–8.

    Google Scholar 

  105. Amino N, Yabu Y, Miyai K, Fujie T, Azukizawa M, Onishi T, Kumahara Y. Differentiation of thyrotoxicosis induced by thyroid destruction from Graves’ disease. Lancet. 1978;2:344–6.

    CAS  PubMed  Google Scholar 

  106. Ota H, Amino N, Morita S, Kobayashi K, Kubota S, Fukata S, Kamiyama N, Miyauchi A. Quantitative measurement of thyroid blood flow for differentiation of painless thyroiditis from Graves’ disease. Clin Endocrinol. 2007;67:41–5.

    Google Scholar 

  107. Amino N, Tada H, Hidaka Y. Autoimmune thyroid disease and pregnancy. J Endocrinol Investig. 1996;19:59–64.

    CAS  Google Scholar 

  108. Taylor HC, Sheeler LR. Recurrence and heterogeneity in painless thyrotoxic lymphocytic thyroiditis. Report of five cases. J Am Med Assoc. 1982;248:1085–8.

    CAS  Google Scholar 

  109. Yamamoto M, Shibuya N, Chen LC, Ogata E. Seasonal recurrence of transient hypothyroidism in a patient with autoimmune thyroiditis. Endocr J. 1988;35:135–42.

    CAS  Google Scholar 

  110. Tachi J, Amino N, Miyai K. Massage therapy on neck: a contributing factor for destructive thyrotoxicosis? Thyroidology. 1990;2:25–7.

    CAS  PubMed  Google Scholar 

  111. Maruyama H, Kato M, Mizuno O, Kataoka K, Matusi S. Transient thyrotoxicosis occurred after cessation of steroid therapy in a patient with autoimmune thyroiditis and rheumatoid arthritis. Endocr J. 1982;29:583–8.

    CAS  Google Scholar 

  112. Takasu N, Komiya I, Nagasawa Y, et al. Exacerbation of autoimmune thyroid dysfunction after unilateral adrenalectomy in patients with Cushing’s syndrome due to an adrenocortical adenoma. N Engl J Med. 1990;322:1708–12.

    CAS  PubMed  Google Scholar 

  113. Negro R, Greco G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H. The influence of selenium supplementation on postpartum thyroid status in pregnant women in thyroid perioxidase auto-antibodies. J Clin Endocrinol Metab. 2007;92(4):1263–8.

    CAS  PubMed  Google Scholar 

  114. Peschen-rosin R, Schabet M, Dichgans J. Manifestation of Hashimoto’s encephalopathy years before onset of thyroid disease. Eur Neurol. 1999;41:79–84.

    CAS  PubMed  Google Scholar 

  115. Brain L, Jellinek EH, Ball K. Hashimoto’s disease and encephalopathy. Lancet. 1966;2:512–4.

    CAS  PubMed  Google Scholar 

  116. Pozo-Rosich P, Villoslada P, Canton A, Simo R, Rovira A, Montalban X. Reversible white matter alterations in encephalopathy associated with autoimmune thyroid disease. J Neurol. 2002;249:1063–5.

    PubMed  Google Scholar 

  117. Canton A, de Fabregas O, Tintore M, Mesa J, Codina A, Simo R. Encephalopathy associated to autoimmune thyroid disease: a more appropriate term for an underestimated condition? J Neurol Sci. 2000;176:65–9.

    CAS  PubMed  Google Scholar 

  118. Ochi H, Horiuchi I, Araki N, Toda T, Araki T, Sato K, Murai H, Osoegawa M, Yamada T, Okamura K, Ogino T, Mizumoto K, Yamashita H, Saya H, Kira J. Proteomic analysis of human brain identifies α-enolase as a Nobel autoantigen in Hashimoto’s encephalopathy. FEBS Lett. 2002;528:197–202.

    CAS  PubMed  Google Scholar 

  119. Sawka AM, Fatourechi V, Boeve BF, Mokri B. Rarity of encephalopathy associated with autoimmune thyroiditis: a case series from Mayo Clinic from 1950 to 1996. Thyroid. 2002;12:393–8.

    PubMed  Google Scholar 

  120. Fujii A, Yoneda M, Ito T, Yamamura O, Satomi S, Higa H, Kimura A, Suzuki M, Yamashita M, Yuasa T, Suzuki H, Kuriyama M. Autoantibodies against the amino terminal of α-enolase are a useful diagnostic marker of Hashimoto’s encephalopathy. J Neuroimmunol. 2005;162:130–6.

    CAS  PubMed  Google Scholar 

  121. Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M. High prevalence of serum autoantibodies against the amino terminal of α-enolase in Hashimoto’s encephalopathy. J Neuroimmunol. 2007;185:195–200.

    CAS  PubMed  Google Scholar 

  122. Seo SW, Lee BI, Lee JD, Park SA, Kim KS, Kim SH, Yun MJ. Thyrotoxic autoimmune encephalopathy: a repeat positron emission tomography study. J Neurol Neurosurg Psychiatry. 2003;74(4):504–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  123. Hosoi Y, Kono S, Terada T, Konishi T, Miyajima H. Hashimoto's encephalopathy associated with an elevated intrathecal IgG4 level. J Neurol. 2013;260(4):1174–6.

    PubMed  Google Scholar 

  124. Tateno F, Sakakibara R, Kishi M, Ogawa E. Hashimoto’s ophthalmopathy. Am J Med Sci. 2011;342(1):83–5.

    PubMed  Google Scholar 

  125. Yoshihara A, Yoshimura Noh J, Nakachi A, Ohye H, Sato S, Sekiya K, Kosuga Y, Suzuki M, Matsumoto M, Kunii Y, Watanabe N, Mukasa K, Inoue Y, Ito K, Ito K. Severe thyroid-associated orbitopathy in Hashimoto’s thyroiditis. Report of two cases. Endocr J. 2011;58(5):343–8.

    CAS  PubMed  Google Scholar 

  126. Skillern PG, Crile G Jr, McCullaugh EP, Hazard JB, Lewis LA, Brown H. Struma lymphomatosa: primary thyroid failure with compensatory thyroid enlargement. J Clin Endocrinol Metab. 1956;16:35–9.

    CAS  PubMed  Google Scholar 

  127. Caturegli P, et al. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014(4–5):391–7.

    Google Scholar 

  128. Genetic and Rare Diseases Information Center (GARD). Hashimoto’s encephalitis – disease – overview. Gaithersburg, MD: GARD; 2014.

    Google Scholar 

  129. Zhu Y, Yang H, Xiao F. Hashimoto’s encephalopathy: a report of three cases and relevant literature reviews. Int J Clin Exp Med. 2015;8(9):16817–26.

    Google Scholar 

  130. Ferracci F, Bertiato G, Moretto G. Hashimoto’s encephalopathy: epidemiologic data and pathogenetic considerations. J Neurol Sci. 2004;217(2):165–8. https://doi.org/10.1016/j.jns.2003.09.007.

    Article  PubMed  Google Scholar 

  131. Fujii A, Yoneda M, Ito T, Yamamura O, Satomi S, Higa H, Kimura A, Suzuki M, Yamashita M, Yuasa T, Suzuki H, Kuriyama M. Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto’s encephalopathy. J Neuroimmunol. 2005;162(1–2):130–6. https://doi.org/10.1016/j.jneuroim.2005.02.004.

    Article  CAS  PubMed  Google Scholar 

  132. Mocellin R, Walterfang M, Velakoulis D. Hashimoto’s encephalopathy: epidemiology, pathogenesis and management. CNS Drug. 2007;21:799–811.

    CAS  Google Scholar 

  133. Ihejirika DF. PASS program course notes: USMLE preparation. Lulu.com; 2014.

    Google Scholar 

  134. Castillo P, Woodruff B, Caselli R, et al. Steroid-responsive encephalopathy associated with autoimmune thyroiditis. Arch Neurol. 2006;63(2):197–202. https://doi.org/10.1001/archneur.63.2.197.

    Article  PubMed  Google Scholar 

  135. Flanagan EP, McKeon A, Lennon VA, et al. Autoimmune dementia: clinical course and predictors of immunotherapy response. Mayo Clin Proc. 2010;85(10):881–7. https://doi.org/10.4065/mcp.2010.0326.

    Article  PubMed  PubMed Central  Google Scholar 

  136. Paris J, McConahey WM, Tausie WN, Woolner LB, Bahn RC. The effect of iodides on Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 1961;21:1037–42.

    CAS  PubMed  Google Scholar 

  137. Endo T, Kaneshige M, Nakazato M, Kohgai T, Saito T, Onaya T. Autoantibody against thyroid iodide transporter in the sera from patients with Hashimoto’s thyroiditis possesses iodide transport inhibitory activity. Biochem Biophys Res Commun. 1996;228:199–204.

    CAS  PubMed  Google Scholar 

  138. Chin HS, Chin DK, Morgenthaler NG, Vassart G, Costagliola S. Rarity of anti- Na+/I-symporter (NIS) antibody with iodide uptake inhibiting activity in autoimmune thyroid diseases (AITD). J Clin Endocrinol Metab. 2000;85:3937–40.

    CAS  PubMed  Google Scholar 

  139. Seissler J, Wagner S, Schott M, Feldkamp J, Scherbaum WA, Morgenthaler NG. Low frequency of autoantibodies to the human Na+/I -symporter (NIS) in patients with autoimmune thyroid disease. J Clin Endocrinol Metab. 2000;85:4630–4.

    CAS  PubMed  Google Scholar 

  140. Brown TR, Zhao G, Palmer KC, Sundick RS. Thyroid injury, autoantigen availability, and the initiation of autoimmune thyroiditis. Autoimmunity. 1998;27:1–12.

    CAS  PubMed  Google Scholar 

  141. Laurberg P, Pedersen KM, Hreidarsson A, Sigfusson N, Iversen E, Knudsen PR. Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. J Clin Endocr Metab. 1998;83:765–9.

    CAS  PubMed  Google Scholar 

  142. Nagata K, Takasu N, Akamine H, Ohshiro C, Komiya I, Murakami K, Suzawa A, Nomura T. Urinary iodine and thyroid antibodies in Okinawa, Yamagata, Hyogo, and Nagano, Japan: the differences in iodine intake do not affect thyroid antibody positivity. Endocr J. 1998;45:797–803.

    CAS  PubMed  Google Scholar 

  143. Tajiri J, Higashi K, Morita M, Umeda T, Sato T. Studies of hypothyroidism in patients with high iodine intake. J Clin Endocr Metab. 1986;63:412–7.

    CAS  PubMed  Google Scholar 

  144. Ruwhof C, Drexhage HA. Iodine and thyroid autoimmune disease in animal models. Thyroid. 2001;11:427–36.

    CAS  PubMed  Google Scholar 

  145. Dai YD, Rao VP, Carayanniois G. Enhanced iodination of thyroglobulin facilitates processing and presentation of a cryptic pathogenic peptide. J Immunol. 2002;168:5907–11.

    CAS  PubMed  Google Scholar 

  146. McConahey WM, Keating FR, Butt HR, Owen CA. Comparison of certain laboratory tests in the diagnosis of Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 1961;21:879–83.

    CAS  PubMed  Google Scholar 

  147. Glynne A, Thomson JA. Serum immunoglobulin levels in thyroid disease. Clin Exp Immunol. 1972;12:71–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  148. Monteleone JA, Davis RK, Tung KSK, Ramos CV, Peden VH. Differentiation of chronic lymphocytic thyroiditis and simple goiter in pediatrics. J Pediatr. 1973;83:381–5.

    CAS  PubMed  Google Scholar 

  149. Zhang L, et al. Clinical features of papillary thyroid cancer in the patients from an area with a high prevalence of Hashimoto’s disease. BMC Cancer. 2012;12:610–5.

    PubMed  PubMed Central  Google Scholar 

  150. Fiore E, et al. Hashimoto’s thyroiditis is associated with papillary thyroid carcinoma: role of TSH and treatment with L-thyroxine. Endocr Relat Cancer. 2011;18:429–37.

    CAS  PubMed  Google Scholar 

  151. Krysiak R, Okopien B. The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 2011;96:2206–15.

    CAS  PubMed  Google Scholar 

  152. Wozniak R, et al. Maltoma of the thyroid in a man with Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 1999;4:84–8.

    Google Scholar 

  153. Miller BS, Paul G. Image in endocrinology: thyroid lymphoma arising from Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 1991;10:3711–2.

    Google Scholar 

  154. Takano T, Miyauchi A, Matsuzuka F, Yoshida H, Kuma K, Amino N. Diagnosis of thyroid malignant lymphoma by reverse transcription-polymerase chain reaction detecting the monoclonality of immunoglobulin heavy chain messenger ribonucleic acid. J Clin Endocr Metab. 2000;85:671–5.

    CAS  PubMed  Google Scholar 

  155. McConahey WM, Woolner LB, Black BM, Keating FR Jr. Effect of desiccated thyroid in lymphocytic (Hashimoto’s) thyroiditis. J Clin Endocrinol Metab. 1959;19:45–9.

    CAS  PubMed  Google Scholar 

  156. Antonaci A, Consorti F, Mardente S, Giovannone G. Clinical and biological relationship between chronic lymphocytic thyroiditis and papillary thyroid carcinoma. Oncol Res. 2009;17:495–503.

    PubMed  Google Scholar 

  157. Ahmed R, Al-Shaikh S, Akhtar M. Hashimoto’s thyroiditis: a century later. Adv Anat Pathol. 2012;19:181–6.

    CAS  PubMed  Google Scholar 

  158. Kim KW, Park YJ, Kim EH, Park SY, Park-do J, Ahn SH, Jang HC, Cho BY. Elevated risk of papillary thyroid cancer in Korean patients with Hashimoto’s thyroiditis. Head Neck. 2011;33:691–5.

    PubMed  Google Scholar 

  159. Consorti F, Loponte M, Milazzo F, Potasso L, Antonaci A. Risk of malignancy from thyroid nodular disease as an element of clinical management of patients with Hashimoto’s thyroiditis. Eur Surg Res. 2010;45:333–7.

    CAS  PubMed  Google Scholar 

  160. Mazokopakis EE, Tzortzinis AA, Dalieraki-Ott EI, Tsartsalis AN, Syros PK, Karefilakis CM, Papadomanolaki MG, Starakis IK. Coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma. A retrospective study. Hormones. 2010;9:312–7.

    PubMed  Google Scholar 

  161. Fiore E, Rago T, Scutari M, Ugolini C, Proietti A, Di Coscio G, et al. Papillary thyroid cancer, although strongly associated with lymphocytic infiltration on histology, is only weakly predicted by serum thyroid autoantibodies in patients with nodular thyroid diseases. J Endocrinol Investig. 2009;32:344–51.

    CAS  Google Scholar 

  162. Kurukahvecioglu O, Taneri F, Yuksel O, Aydin A, Tezel E, Onuk E. Total thyroidectomy for the treatment of Hashimoto’s thyroiditis coexisting with papillary thyroid carcinoma. Adv Ther. 2007;24:510–6.

    PubMed  Google Scholar 

  163. Matsumoto F, Fujii H, Abe M, Kajino K, Kobayashi T, Matsumoto T, Ikeda K, Hino O. A novel tumor marker. Niban, is expressed in subsets of thyroid tumors and Hashimoto’s thyroiditis. Human Pathol. 2006;37:1592–600.

    CAS  Google Scholar 

  164. Cipolla C, Sandonato L, Graceffa G, Fricano S, Torcivia A, Vieni S, Latteri S, Latteri MA. Hashimoto’s thyroiditis coexistent with papillary thyroid carcinoma. Am Surg. 2005;71:874–8.

    PubMed  Google Scholar 

  165. Tamimi DM. The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol. 2002;10:141–6.

    PubMed  Google Scholar 

  166. O’Hanlon DM, Little MP, Given HF, Quill DS. Thyroid disease in the west of Ireland: an atypical incidence of neoplasia. Irish Med J. 1997;90:70–1.

    Google Scholar 

  167. Okayasu I, Fujiwara M, Hara Y, Tanaka Y, Rose NR. Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans. Cancer. 1995;76:2312–8.

    CAS  PubMed  Google Scholar 

  168. McLeod MK, East ME, Burney RE, Harness JK, Thompson NW. Hashimoto’s thyroiditis revisited: the association with thyroid cancer remains obscure. World J Surg. 1988;12:509–16.

    CAS  PubMed  Google Scholar 

  169. Huang BY, Hseuh C, Chao TC, Lin KJ, Lin JD. Well-differentiated thyroid carcinoma with concomitant Hashimoto’s thyroiditis present with less aggressive clinical stage and low recurrence. Endocr Pathol. 2011;22:144–9.

    PubMed  Google Scholar 

  170. Repplinger D, Bargren A, Zhang YW, Adler JT, Haymart M, Chen H. Is Hashimoto’s thyroiditis a risk factor for papillary thyroid cancer? J Surg Res. 2008;150:49–52.

    PubMed  Google Scholar 

  171. Van Savell H Jr, Hughes SM, Bower C, Parham DM. Lymphocytic infiltration in pediatric thyroid carcinomas. Pediatr Dev Pathol. 2004;7:487–92.

    PubMed  Google Scholar 

  172. Harach HR, Escalante DA, Day ES. Thyroid cancer and thyroiditis in Salta, Argentina: a 40-yr study in relation to iodine prophylaxis. Endoc Pathol. 2002;13:175–81.

    Google Scholar 

  173. Loh KC, Greenspan FS, Dong F, Miller TR, Yeo PP. Influence of lymphocytic thyroiditis on the prognostic outcome of patients with papillary thyroid carcinoma. J Clin Endocrinol Metab. 1999;84:458463.

    Google Scholar 

  174. Singh B, Shaha AR, Trivedi H, Carew JF, Poluri A, Shah JP. Coexistent Hashimoto’s thyroiditis with papillary thyroid carcinoma: impact on presentation, management, and outcome. Surgery. 1999;126:1070–6.

    CAS  PubMed  Google Scholar 

  175. Schaffler A, Palitzsch KD, Seiffarth C, Hohne HM, Riedhammer FJ, Hofstadter F, Scholmerich J, Ruschoff J. Coexistent thyroiditis is associated with lower tumour stage in thyroid carcinoma. Eur J Clin Investig. 1998;28:838–44.

    CAS  Google Scholar 

  176. Mancini A, Rabitti C, Conte G, Gullotta G, De Marinis L. Lymphocytic infiltration in thyroid neoplasms. Preliminary prognostic assessments. Minerva Chir. 1993;48:1283–8.

    CAS  PubMed  Google Scholar 

  177. Baroni CD, Manente L, Maccallini V, Di Matteo G. Primary malignant tumors of the thyroid gland. Histology, age and sex distribution and pathologic correlations in 139 cases. Tumori. 1983;69:205–13.

    CAS  PubMed  Google Scholar 

  178. Peterson CA. Lymphocytic thyroiditis in 757 thyroid operations. Am J Surg. 1957;94:223–8.

    CAS  PubMed  Google Scholar 

  179. Yoon YH, Kim HJ, Lee JW, Kim JM, Koo BS. The clinicopathologic differences in papillary thyroid carcinoma with or without co-existing chronic lymphocytic thyroiditis. Eur Arch Otorhinolaryngol. 2012;269:1013–7.

    PubMed  Google Scholar 

  180. Muzza M, Degl’Innocenti D, Colombo C, Perrino M, Ravasi E, Rossi S, Cirello V, Beck-Peccoz P, Borrello MG, Fugazzola L. The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: clinical and molecular studies. Clin Endocrinol. 2010;72:702–8.

    CAS  Google Scholar 

  181. Kim HS, Choi YJ, Yun JS. Features of papillary thyroid microcarcinoma in the presence and absence of lymphocytic thyroiditis. Endoc Pathol. 2010;21:149–53.

    Google Scholar 

  182. French JD, Weber ZJ, Fretwell DL, Said S, Klopper JP, Haugen BR. Tumor-associated lymphocytes and increased FoxP3C regulatory T cell frequency correlate with more aggressive papillary thyroid cancer. J Clin Endocrinol Metab. 2010;95:2325–33.

    CAS  PubMed  PubMed Central  Google Scholar 

  183. Kim EY, Kim WG, Kim WB, Kim TY, Kim JM, Ryu JS, Hong SJ, Gong G, Shong YK. Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma. Clin Endocrinol. 2009;71:581–6.

    Google Scholar 

  184. Kim SK, Song KH, Lim SD, Lim YC, Yoo YB, Kim JS, Hwang TS. Clinical and pathological features and the BRAF(V600E) mutation. Thyroid. 2009;19:137–41.

    PubMed  Google Scholar 

  185. Bruland O, Fluge O, Akslen LA, Eiken HG, Lillehaug JR, Varhaug JE, Knappskog PM. Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas. BMC Cancer. 2009;9:425–9.

    PubMed  PubMed Central  Google Scholar 

  186. Onak Kandemir N, Barut F, Keser S, Karadayi N, Bektas S, Dogan Gun BB, Bahadir B, Yurdakan G, Ozdamar SO. Chronic lymphocytic thyroiditis and tumor-infiltrating lymphocytes combined in thyroid papillary carcinoma. Turk J Oncol. 2009;24:172–6.

    Google Scholar 

  187. Ohmori N, Miyakawa M, Ohmori K, Takano K. Ultrasonographic findings of papillary thyroid carcinoma with Hashimoto’s thyroiditis. Int Med. 2007;46:547–50.

    Google Scholar 

  188. Neuhold N, Kaiser H, Kaserer K. Latent carcinoma of the thyroid in Austria: a systematic autopsy study. Endocr Pathol. 2001;12:23–31.

    CAS  PubMed  Google Scholar 

  189. Kebebew E, Treseler PA, Ituarte PH, Clark OH. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg. 2001;25:632–7.

    CAS  PubMed  Google Scholar 

  190. Kashima K, Yokoyama S, Noguchi S, Murakami N, Yamashita H, Watanabe S, et al. Chronic thyroiditis as a favorable prognostic factor in papillary thyroid carcinoma. Thyroid. 1998;8:197–202.

    CAS  PubMed  Google Scholar 

  191. Asanuma K, Sugenoya A, Kasuga Y, Itoh N, Kobayashi S, Amano J. The relationship between multiple intrathyroidal involvement in papillary thyroid carcinoma and chronic non-specific thyroiditis. Cancer Lett. 1998;122:177–80.

    CAS  PubMed  Google Scholar 

  192. Gomez Saez JM, Gomez Arnaiz N, Sahun de la Vega M, Soler Ramon J. Prevalence and significance of lymphocyte infiltration in papillary carcinoma of the thyroid gland. An Med Interna. 1997;14:403–5.

    CAS  PubMed  Google Scholar 

  193. Matsubayashi S, Kawai K, Matsumoto Y, Mukuta T, Morita T, Hirai K, Matsuzuka F, Kakudoh K, Kuma K, Tamai H. The correlation between papillary thyroid carcinoma and lymphocytic infiltration in the thyroid gland. J Clin Endocrinol Metab. 1995;80:3421–4.

    CAS  PubMed  Google Scholar 

  194. Del Rio P, Cataldo S, Sommaruga L, Concione L, Arcuri MF, Sianesi M. The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer? Minerva Endocrinol. 2008;33:1–5.

    PubMed  Google Scholar 

  195. Gul K, Dirikoc A, Kiyak G, Ersoy PE, Ugras NS, Ersoy R, Cakir B. The association between thyroid carcinoma and Hashimoto’s thyroiditis: the ultrasonographic and histopathologic characteristics of malignant nodules. Thyroid. 2010;20:873–8.

    PubMed  Google Scholar 

  196. Feldt-Rasmussen U, Rasmussen AK. Autoimmunity in differentiated thyroid cancer: significance and related clinical problems. Hormones. 2010;9:109–17.

    PubMed  Google Scholar 

  197. Haberal AN, Toru S, Ozen O, Arat Z, Bilezikci B. Diagnostic pitfalls in the evaluation of fine needle aspiration cytology of the thyroid: correlation with histopathology in 260 cases. Cytopathology. 2009;20:103–8.

    CAS  PubMed  Google Scholar 

  198. Wirtschafter A, Schmidt R, Rosen D, Kundu N, Santoro M, Fusco A, Multhaupt H, Atkins JP, Rosen MR, Keane WM, et al. Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto’s thyroiditis. Laryngoscope. 1997;107:95–100.

    CAS  PubMed  Google Scholar 

  199. Powell DJ Jr, Russell J, Nibu K, Li G, Rhee E, Liao M, Goldstein M, Keane WM, Santoro M, Fusco A, et al. The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids. Cancer Res. 1998;58:5523–8.

    CAS  PubMed  Google Scholar 

  200. Vickery AL, Hamlin E Jr. Struma lymphomatosa (Hashimoto’s thyroiditis): observations on repeated biopsies in 16 patients. N Engl J Med. 1961;264:226–9.

    CAS  PubMed  Google Scholar 

  201. Aksoy DY, Kerimoglu U, Okur H, Canpinar H, Karaagaoglu E, Yetgin S, Kansu E, Gedik O. Effects of prophylactic thyroid hormone replacement in euthyroid Hashimoto’s thyroiditis. Endocr J. 2005;52(3):337–43.

    CAS  PubMed  Google Scholar 

  202. Papapetrou PD, MacSween RNM, Lazarus JH, Harden RMG. Long-term treatment of Hashimoto’s thyroiditis with thyroxine. Lancet. 1972;2:7786–9.

    Google Scholar 

  203. Takasu N, Komiya I, Asawa T, Nagasawa Y, Yamada T. Test for recovery from hypothyroidism during thyroxine therapy in Hashimoto’s thyroiditis. Lancet. 1990;336:1084–6.

    CAS  PubMed  Google Scholar 

  204. Campbell NRC, et al. Effect of ferrous sulfate on thyroid hormone replacement in hypothyroidism. Ann Int Med. 1992;117:1010–3.

    CAS  PubMed  Google Scholar 

  205. Padberg S, Heller K, Usadel KH, Schumm-Draeger PM. One-year prophylactic treatment of euthyroid Hashimoto’s thyroiditis patients with levothyroxine: is there a benefit? Thyroid. 2001;11:249–55.

    CAS  PubMed  Google Scholar 

  206. Mariotti S, Zoncu S, Pigliaru F, Putzu C, Cambuli VM, Vargiu S, Deidda M, Mercuro G. Cardiac effects of l-thyroxine administration in borderline hypothyroidism. Int J Cardiol. 2008;126(2):190–5.

    PubMed  Google Scholar 

  207. Tagami T, Tamanaha T, Shimazu S, et al. Lipid profiles in the untreated patients with Hashimoto thyroiditis and the effects of thyroxine treatment on subclinical hypothyroidism with Hashimoto thyroiditis. Endocr J. 2010;57(3):253–8.

    CAS  PubMed  Google Scholar 

  208. Karges B, Muche R, Knerr I, Ertelt W, Wiesel T, Hub R, Neu A, Klinghammer A, Aufschild J, Rapp A, Schirbel A, Boehm BO, Debatin KM, Heinze E, Karges W. Levothyroxine in euthyroid autoimmune thyroiditis and type 1 diabetes: a randomized, controlled trial. J Clin Endocrinol Metab. 2007;92(5):1647–52.

    CAS  PubMed  Google Scholar 

  209. Escobar-Morreale HF, Botella-Carretero JI, Escobar del Rey F, et al. REVIEW: Treatment of hypothyroidism with combinations of levothyroxine plus liothyronine. J Clin Endocrinol Metab. 2005;90(8):4946–54.

    CAS  PubMed  Google Scholar 

  210. Yamada T, Ikejiri K, Kotani M, Kusakabe T. An increase of plasma triiodothyronine and thyroxine after administration of dexamethasone to hypothyroid patients with Hashimoto’s thyroiditis. J Clin Endocrinol Metab. 1981;46:784–9.

    Google Scholar 

  211. Blizzard RM, Hung M, Chandler RW, Aceto T Jr, Kyle M, Winship T. Hashimoto’s thyroiditis. Clinical and laboratory response to prolonged cortisone therapy. N Engl J Med. 1962;267:1015–9.

    CAS  PubMed  Google Scholar 

  212. Ito S, Tamura T, Nishikawa M. Effects of desiccated thyroid, prednisolone and chloroquine on goiter and antibody titer in chronic thyroiditis. Metabolism. 1968;17:317–22.

    CAS  PubMed  Google Scholar 

  213. Negro R, Greco G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol Metab. 2007;92:1263–8.

    CAS  PubMed  Google Scholar 

  214. Mazokopakis EE, Papadakis JA, Papadomanolaki MG, Batistakis AG, Giannakopoulos TG, Protopapadakis EE, Ganotakis ES. Effects of 12 months treatment with l-selenomethionine on serum anti-TPO levels in patients with Hashimoto’s thyroiditis. Thyroid. 2007;17(7):609–12.

    CAS  PubMed  Google Scholar 

  215. Wichman J, Winther KH, Bonnema SJ, Hegedüs L. Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis. Thyroid. 2016;26(12):1681–92.

    CAS  PubMed  Google Scholar 

  216. Winther KH, Wichman JE, Bonnema SJ, Hegedüs L. Insufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis, based on a systematic review and meta-analysis. Endocrine. 2017;55(2):376–85.

    CAS  PubMed  Google Scholar 

  217. Nordio M, Pajalich R. Combined treatment with myo-inositol and selenium ensures euthyroidism in subclinical hypothyroidism patients with autoimmune thyroiditis. J Thyroid Res. 2013;13:4241–63.

    Google Scholar 

  218. Nordio M, Basciani S. Treatment with myo-inositol and selenium ensures euthyroidism in patients with autoimmune thyroiditis. Int J Endocrinol. 2017;2017:2549491. https://doi.org/10.1155/2017/2549491.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  219. Caturegli P, De Remigis A, Ferlito M, Landek-Salgado MA, Iwama S, Tzou SC, Ladenson PW. Anatabine ameliorates experimental autoimmune thyroiditis. Endocrinology. 2012;153(9):4580–7.

    CAS  PubMed  Google Scholar 

  220. Schmeltz LR, Blevins TC, Aronoff SL, et al. Anatabine supplementation decreases thyroglobulin antibodies in patients with chronic lymphocytic autoimmune (Hashimoto's) thyroiditis: a randomized controlled clinical trial. J Clin Endocrinol Metab. 2014;99(1):E137–42.

    PubMed  Google Scholar 

  221. Amino N, Tada H, Hidaka Y. The spectrum of postpartum thyroid dysfunction: diagnosis, management, and long-term prognosis. Endocr Pract. 1996;2:406–12.

    CAS  PubMed  Google Scholar 

  222. Bozkurt NC, Karbek B, Ucan B, Sahin M, Cakal E, Ozbek M, et al. The association between severity of vitamin D deficiency and Hashimoto’s thyroiditis. Endocr Pract. 2013;21:1–14.

    Google Scholar 

  223. Kahaly GJ, Diana T, Glang J, et al. Thyroid stimulating antibodies are highly prevalent in Hashimoto’s thyroiditis and associated orbitopathy. J Clin Endocrinol Metab. 2016;101(5):1998–2004.

    CAS  PubMed  Google Scholar 

  224. Kim KW, Park YJ, Kim EH, et al. Elevated risk of papillary thyroid cancer in Korean patients with Hashimoto’s thyroiditis. Head Neck. 2011;33(5):691–5.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, University of Alexandria, Alexandria, Egypt

    Mahmoud F. Sakr

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Sakr, M.F. (2020). Hashimoto’s Disease. In: Thyroid Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-48775-1_2

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