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Lipoproteins and the Tumor Microenvironment

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Tumor Microenvironment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1272))

Abstract

The tumor microenvironment (TME) plays a key role in enhancing the growth of malignant tumors and thus contributing to “aggressive phenotypes,” supporting sustained tumor growth and metastasis. The precise interplay between the numerous components of the TME that contribute to the emergence of these aggressive phenotypes is yet to be elucidated and currently under intense investigation. The purpose of this article is to identify specific role(s) for lipoproteins as part of these processes that facilitate (or oppose) malignant growth as they interact with specific components of the TME during tumor development and treatment. Because of the scarcity of literature reports regarding the interaction of lipoproteins with the components of the tumor microenvironment, we were compelled to explore topics that were only tangentially related to this topic, to ensure that we have not missed any important concepts.

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Acknowledgments

The authors’ research is supported by the Rutledge Cancer Foundation, the Texas Alzheimer’s Research and Care Consortium, the Virginia Kincaid Charitable Trust, and Wheels for Wellness, Fort Worth TX.

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Authors and Affiliations

  1. Lipoprotein Drug Delivery Research Laboratory, Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA

    Akpedje Serena Dossou, Nirupama Sabnis, Bhavani Nagarajan, Ezek Mathew, Rafal Fudala & Andras G. Lacko

  2. Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA

    Rafal Fudala

  3. Departments of Physiology/Anatomy and Pediatrics, University of North Texas Health Science Center, Fort Worth, TX, USA

    Andras G. Lacko

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  1. Akpedje Serena Dossou
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  2. Nirupama Sabnis
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  3. Bhavani Nagarajan
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  4. Ezek Mathew
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  5. Rafal Fudala
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Correspondence to Andras G. Lacko .

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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Dossou, A.S., Sabnis, N., Nagarajan, B., Mathew, E., Fudala, R., Lacko, A.G. (2020). Lipoproteins and the Tumor Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironment . Advances in Experimental Medicine and Biology, vol 1272. Springer, Cham. https://doi.org/10.1007/978-3-030-48457-6_6

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