Abstract
The use of supercritical CO2 (SC–CO2) antisolvent for micronization, coprecipitation, and fractionation of high-value products for biorefining of plant matrices into marketable products has been a promising and increasing research topic. These SC–CO2 antisolvent processes are able to microencapsulate many materials that are difficult to treat with conventional techniques. In addition, the control of the morphology of materials by adjusting nucleation and growth during particle production is provided. The use of supercritical antisolvent processes is advantageous when compared with other methods like freeze-drying, drying at high temperatures and spray-drying such as uniform particle size distribution in the products and high efficiency to obtain nano or microparticles. The optimization of the process on the yield and quality of obtained particles properties depend mainly on the operational conditions such as pressure, temperature, and concentration of the bioactives solution, in terms of extract and polymer. Thus, this chapter provides some insights about the fundamentals and effects of operational conditions of these SC–CO2 antisolvent processes.
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Acknowledgements
Diego T. Santos thanks CNPq (processes 401109/2017-8; 150745/2017-6) for the post-doctoral fellowship. Ricardo A. C. Torres thanks Capes for their doctorate assistantship. Ádina L. Santana thanks CAPES (1764130) for the post-doctoral fellowship. M. Angela A. Meireles thanks CNPq for the productivity grant (302423/2015-0). The authors acknowledge the financial support from CNPq (process 486780/2012-0) and FAPESP (processes 2012/10685-8; 2015/13299-0).
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Santos, D.T. et al. (2020). Supercritical Fluid Biorefining Using Supercritical CO2 as an Antisolvent for Micronization, Coprecipitation, and Fractionation: Fundamentals, Processing, and Effect of Process Conditions. In: Supercritical Fluid Biorefining. SpringerBriefs in Applied Sciences and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-47055-5_1
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DOI: https://doi.org/10.1007/978-3-030-47055-5_1
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