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Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies pp 175–202Cite as

Role of Furans as EDCs in Metabolic Disorders

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Abstract

Furan is common compound that can be found in many products in pure form and as its derivatives. It is abundant in environment as in processed food, industrial process, pharmaceutical products and smoke. When furans are heated, they enhanced oxidative processes in lipids and proteins, and therefore play a toxic role in many cases. In many body systems furans are examined to cause toxic effects. It is commonly formed from four precursors amino acids, carbohydrates, ascorbic acids and PUFA. To detect the presence of furan and its amount in sample many methods have been involved. Most common of them are headspace analysis, headspace sampling by solid phase microextraction, and GCMS. As furan toxic effect is confirmed in many animals and it can be harmful to human health as well. The quantity of furan taken by humans are measured through quantification of furan in many food products. Many health agencies such as EFSA, FDA and IARC determine amount of furan in different foods. Further experiments were conducted to determine its harmful effects. Mouse and rats were mostly used in such tests. In rat metabolism of furan is tested and recorded that 80% of furan was eliminated through different pathways. Furan affects on digestive track is also determined. It mostly affects liver due to its prolonged presence in liver, but it was also observed to be harmful for kidneys. Some products are also tested to mitigate furan toxicity, apigenin and lycopene were found to be effective against furan toxicity. Moreover, furan itself was known to be effective against oxidative stress, which may cause many neurodegenerative disorders.

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Authors and Affiliations

  1. Department of Microbiology, Government College University Faisalabad, Faisalabad, Pakistan

    Saima Muzammil

  2. Department of Zoology, Government College University Faisalabad, Faisalabad, Pakistan

    Asma Ashraf, Rahat Andleeb & Azhar Rafique

  3. Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad, Pakistan

    Aqsa Muzammil

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  2. Asma Ashraf
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  5. Azhar Rafique
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Correspondence to Asma Ashraf .

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  1. Department of Pharmaceutical Chemistry, Government College University Faisalabad, Faisalabad, Pakistan

    Muhammad Sajid Hamid Akash

  2. Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan

    Kanwal Rehman

  3. Department of Chemistry, COMSATS University Islamabad, Islamabad, Pakistan

    Muhammad Zaffar Hashmi

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Muzammil, S., Ashraf, A., Muzammil, A., Andleeb, R., Rafique, A. (2021). Role of Furans as EDCs in Metabolic Disorders. In: Akash, M.S.H., Rehman, K., Hashmi, M.Z. (eds) Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies. Emerging Contaminants and Associated Treatment Technologies. Springer, Cham. https://doi.org/10.1007/978-3-030-45923-9_12

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