Natural Products and Nanopharmaceuticals

Santos-Rebelo, Ana; Mota, Ana Henriques; Fonseca, Leonor; Figueira, Mariana; Bastos, Ana; Macedo, Joana; Pinto, João F.; Rijo, Patrícia; Molpeceres, Jesús; Reis, Catarina Pinto

doi:10.1007/978-3-030-44921-6_4

Ana Santos-Rebelo^8,9,
Ana Henriques Mota¹⁰,
Leonor Fonseca⁸,
Mariana Figueira¹⁰,
Ana Bastos¹⁰,
Joana Macedo¹⁰,
João F. Pinto¹⁰,
Patrícia Rijo^8,10,
Jesús Molpeceres⁹ &
…
Catarina Pinto Reis^10,11

Part of the book series: Environmental Chemistry for a Sustainable World ((ECSW,volume 47))

389 Accesses

Abstract

Drug discovery has faced many challenges, and the diversity of natural products offers a huge number of opportunities for new drug findings. Most of the potential candidates result from plants since plants have several and interesting biological activities. However, the in vivo efficacy of such candidates is frequently limited due to their low absorption. Thus, enhancing the bioavailability of natural products through the improvement of their pharmacokinetic and biodistribution features, as well as their targeting efficacy, is a crucial step in the development of new therapeutic strategies.

Here, we reviewed nanotechnology as a rising approach for drug delivery, presenting smart nanocarriers that can selectively deliver appropriate levels of a therapeutic agent. Moreover, in order to deliver the therapeutic agent to target cells, nanocarriers can also be efficient targeting systems. Another benefit here discussed in the use of nanocarriers to deliver natural products is the controlled drug release.

This review describes many types of nanocarriers with structural and functional differences between them which can be chosen accordingly to the encapsulated drug characteristics, to the specific target, or even to the desired release rate. With regard to natural products, we highlight several natural products that are already being commercialized or in clinical study phase with impressive therapeutic improvements using these nanocarriers. On the other hand, there are also a large number of natural products that are being used as encapsulant material in pioneering nanocarriers. This review aims to summarize the development in several key areas relevant to natural products in nanopharmaceuticals. Besides the potential beneficial use, also attention is drawn to the question how we should proceed with the safety and efficacy evaluation of the nanopharmaceuticals for natural product delivery. Nonetheless, research into sophisticated, science-driven solutions is still continuing; expectations related to therapeutic efficacy are high to meet clinical needs, but the progress made has been noticeable.

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CBiOS, Research Center for Biosciences & Health Technologies, ULHT, Lisbon, Portugal
Ana Santos-Rebelo, Leonor Fonseca & Patrícia Rijo
Department of Biomedical Sciences, Faculty of Pharmacy, Universidad de Alcalá, Alcalá de Henares, Spain
Ana Santos-Rebelo & Jesús Molpeceres
iMED.ULisboa, Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal
Ana Henriques Mota, Mariana Figueira, Ana Bastos, Joana Macedo, João F. Pinto, Patrícia Rijo & Catarina Pinto Reis
IBEB, Biophysics and Biomedical Engineering, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal
Catarina Pinto Reis

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Ana Santos-Rebelo
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Animal Biotechnology Centre, National Dairy Research Institute, Karnal, India
Vinod Kumar Yata
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Shivendu Ranjan
Department of Biotechnology, Institute of Engineering and Technology, Lucknow, Uttar Pradesh, India
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Santos-Rebelo, A. et al. (2021). Natural Products and Nanopharmaceuticals. In: Yata, V., Ranjan, S., Dasgupta, N., Lichtfouse, E. (eds) Nanopharmaceuticals: Principles and Applications Vol. 2. Environmental Chemistry for a Sustainable World, vol 47. Springer, Cham. https://doi.org/10.1007/978-3-030-44921-6_4

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