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In Vitro Nanotoxicity: Toward the Development of Safe and Effective Treatments

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Preclinical Evaluation of Antimicrobial Nanodrugs

Part of the book series: Nanotechnology in the Life Sciences ((NALIS))

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Abstract

One of the major limitations in the translation of the research results obtained in nanomaterial investigations is the presence of toxicity in organs and tissues. This toxicity can eventually lead to tissue damage, necrosis, and chronic inflammation, with potential induction of the phenomenon of carcinogenesis. Thus, it is a priority in any initiative that aims to design nanomedicaments to have adequate screening platforms to predict the toxicological behavior of the products obtained. Then, in this order of ideas, several aspects must be considered, depending on the use and mechanism of action of the nanocomposites, as well as the nanostructures, which must involve the risk, the correlation between the minimum effective and toxic doses, as well as the different possibilities to implement risk mitigation strategies during therapy. For the above reasons, the objective of this chapter is to integrate the necessary concepts that are required in case you want to evaluate and determine the risk of toxicity of nanomaterials, with a view to establishing adequate safety parameters in the discovery of new antimicrobial drugs.

The ten commandments according to Leó Szilárd1.

1. Recognize the connections of things and laws of conduct of men, so that you may know what you are doing.

2. Let your acts be directed toward a worthy goal, but do not ask if they will reach it; they are to be models and examples, not means to an end.

3. Speak to all men as you do to yourself, with no concern for the effect you make, so that you do not shut them out from your world; lest in isolation the meaning of life slips out of sight and you lose the belief in the perfection of creation.

4. Do not destroy what you cannot create.

5. Touch no dish, except that you are hungry.

6. Do not covet what you cannot have.

7. Do not lie without need.

8. Honor children. Listen reverently to their words and speak to them with infinite love.

9. Do your work for six years; but in the seventh, go into solitude or among strangers, so that the memory of your friends does not hinder you from being what you have become.

10. Lead your life with a gentle hand and be ready to leave whenever you are called.Leo Szilard (1898–1964) “Die Stimme der Delphine.”

Utopische Erzählungen. Rowohit Taschenbuch Verlag. 1963.

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Acknowledgments

The author thanks Sebastian Ritoré for his collaboration and invaluable support during the writing of this chapter, as well as the graphics contained in this book.

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  1. Senior Researcher, Research Center of Bioprospecting and Biotechnology for Biodiversity Foundation (BIOLABB), Armenia, Quindio, Colombia

    Juan Bueno

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Bueno, J. (2020). In Vitro Nanotoxicity: Toward the Development of Safe and Effective Treatments. In: Preclinical Evaluation of Antimicrobial Nanodrugs. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-43855-5_4

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