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Synthetic, Natural Derived Lipid Nanoparticles and Polymeric Nanoparticles Drug Delivery Applications

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Integrative Nanomedicine for New Therapies

Part of the book series: Engineering Materials ((ENG.MAT.))

Abstract

In modern therapeutic field, the delivery of drugs to the desired site is a crucial bottleneck that needs to be addressed for efficacy and potency of the administrated drug. The recent advancements in the field of nanotechnology has enabled researchers to deliver the drug and other diagnostic agents without unfavorable effect in human. Though drug delivery system (DDS) is highly advantageous, the clinical success rate depends on the appropriate carrier molecules which precisely recognize the target site for the release of drug and its biocompatibility. To overcome this concern both synthetic and naturally derived lipid-based nano carriers are the preeminent option as it is biocompatible, non-toxic, enhances the bioavailability of poorly absorbed drugs, drug release modulation flexibility, improved drug loading capacity and stability. Similarly, several bioinspired synthetic polymeric nanomaterials shown advantage of controlled release with less toxic effects, better encapsulation and grand bioavailability. In this chapter, we discussed about the broad spectrum of lipids (synthetic and natural) and polymeric nanoparticles (synthetic and natural) for potential drug delivery applications.

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Acknowledgements

The authors extend their gratitude to the researcher supporting project RUSA – Phase 2.0 grant sanctioned vide Letter No. F.24 51/2014-U, Policy (TNMulti-Gen), Dept. of Edn. Govt. of India, Dt.09.10.2018.

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Authors and Affiliations

  1. Bioenergy and Bioremediation Laboratory, Department of Microbiology, Alagappa University, Karaikudi, Tamil Nadu, 630003, India

    K. Mohanrasu, G. Siva Prakash, T. Boobalan, V. Ananthi, G. H. Dinesh & A. Arun

  2. Dept. of Microbiology, PRIST University, Madurai, Tamil Nadu, 630561, India

    V. Ananthi

  3. Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences and National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa

    K. Anand

  4. Polymers and Composites, Materials Science and Manufacturing Unit, Council for Scientific and Industrial Research (CSIR), Port Elizabeth, 6001, South Africa

    M. Sudhakar

  5. Department of Chemistry, Faculty of Science, Nelson Mandela University, P.O. Box 1600, Port Elizabeth, 6000, South Africa

    M. Sudhakar

  6. Discipline of Medical Biochemistry, School of Laboratory of Medicine and Medical Sciences, College of Health Science, University of KwaZulu-Natal, Durban, 4013, South Africa

    Anil Chuturgoon

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  1. Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences and National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa

    Anand Krishnan

  2. School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa

    Anil Chuturgoon

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Mohanrasu, K. et al. (2020). Synthetic, Natural Derived Lipid Nanoparticles and Polymeric Nanoparticles Drug Delivery Applications. In: Krishnan, A., Chuturgoon, A. (eds) Integrative Nanomedicine for New Therapies. Engineering Materials. Springer, Cham. https://doi.org/10.1007/978-3-030-36260-7_6

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