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Chitosan-Based Mucosal Nanovaccines

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Nanovaccines

Abstract

The race for vaccine development has as priority the formulation of subunit vaccines capable of developing robust and safe immune responses, which will overcome the disadvantages of the vaccines formulated with whole pathogens, namely high reactogenicity and in some cases the risk to develop the disease to which the vaccine is supposed to protect against. Moreover, the development of efficacious vaccines against non-communicable diseases imposes the challenge of efficiently breaking the immune tolerance against self-antigens. Chitosan is an attractive polymer that has been employed to develop nanovaccines with promising findings in preclinical evaluations. In the present chapter, an overview of the nanovaccines based on chitosan nanoparticles targeting human and animal diseases is presented. Chitosan-based nanovaccines have shown promising efficacy in animal models of several diseases with many of them being highly immunogenic when administered by mucosal routes, which are the most attractive approach for massive and painless immunization. Clinical evaluation of some chitosan-based adjuvants adds potential to this field.

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Authors and Affiliations

  1. Facultad de Ciencias Químicas, Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico

    Sergio Rosales-Mendoza

  2. Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí , San Luis Potosí, Mexico

    Omar González-Ortega

Authors
  1. Sergio Rosales-Mendoza
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  2. Omar González-Ortega
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Rosales-Mendoza, S., González-Ortega, O. (2019). Chitosan-Based Mucosal Nanovaccines. In: Nanovaccines. Springer, Cham. https://doi.org/10.1007/978-3-030-31668-6_8

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