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The Regulation of Reactive Neuroblastosis, Neuroplasticity, and Nutraceuticals for Effective Management of Autism Spectrum Disorder

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Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 24))

Abstract

Autism spectrum disorder (ASD) encompasses a cluster of neurodevelopmental and genetic disorders that has been characterized mainly by social withdrawal, repetitive behavior, restricted interests, and deficits in language processing mainly in children. ASD has been known to severely impair behavioral patterns and cognitive functions including learning and memory due to defects in neuroplasticity. The biology of the ASD appears to be highly complex and heterogeneous, and thus, finding a therapeutic target for autism remains obscure. There has been no complete prevention or disease-modifying cure for this disorder. Recently, individuals with autism have been characterized by reactive neurogenesis, obstructions in axonal growth, heterotopia, resulting from dysplasia of neuroblasts in different brain regions. Therefore, it can be assumed that the aforementioned neuropathological correlates seen in the autistic individuals might originate from the defects mainly in the regulation of neuroblasts in the developing as well as adult brain. Nutrient deficiencies during early brain development and intake of certain allergic foods have been proposed as main reasons for the development of ASD. However, the integrated understanding of neurodevelopment and functional aspects of neuroplasticity working through neurogenesis in ASD is highly limited. Moreover, neurogenesis at the level of neuroblasts can be regulated by nutrition. Hence, defects in neuroblastosis underlying the severity of autism potentially could be rectified by appropriate implementation of nutraceuticals.

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Acknowledgments

MK has been supported by the Faculty Recharge Programme, University Grants Commission (UGC-FRP), New Delhi, India. MK would like to acknowledge a start-up grant from UGC-FRP, a research grant (EEQ/2016/000639) and an Early Career Research Award (ECR/2016/000741) from DST-SERB, New Delhi, India. AY has been supported as JRF from DST SERB-EEQ/2016/000639. RKR has been supported as JRF from DST SERB-ECR/2016/000741. SAR has been supported as JRF from Department of Biotechnology (DBT), New Delhi, India. The authors acknowledge UGC-SAP, DST-FIST, and PURSE for the infrastructure of the Department of Animal Science and Department of Biochemistry, Bharathidasan University.

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Author notes

  1. G. P. Poornimai Abirami and Risna Kanjirassery Radhakrishnan share the first authorship.

Authors and Affiliations

  1. School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

    G. P. Poornimai Abirami, Anusuyadevi Muthuswamy & Mahesh Kandasamy

  2. Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

    Risna Kanjirassery Radhakrishnan, Esther Johnson, Ajisha Yesudhas, Vijaya Roobini Ravichandran & Mahesh Kandasamy

  3. Molecular Gerontology Laboratory, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

    Syed Aasish Roshan, Suhadha Parveen, Abir Biswas & Anusuyadevi Muthuswamy

  4. Faculty Recharge Programme, University Grants Commission (UGC-FRP), New Delhi, India

    Mahesh Kandasamy

Authors
  1. G. P. Poornimai Abirami
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  2. Risna Kanjirassery Radhakrishnan
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Correspondence to Anusuyadevi Muthuswamy or Mahesh Kandasamy .

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Editors and Affiliations

  1. Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman

    M. Mohamed Essa

  2. World Innovation Summit for Health WISH, Qatar Foundation, Doha, Qatar

    M. Walid Qoronfleh

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Poornimai Abirami, G.P. et al. (2020). The Regulation of Reactive Neuroblastosis, Neuroplasticity, and Nutraceuticals for Effective Management of Autism Spectrum Disorder. In: Essa, M., Qoronfleh, M. (eds) Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management. Advances in Neurobiology, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-030-30402-7_8

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