Skip to main content
SpringerLink
Log in
Book cover

Nanotheranostics pp 245–276Cite as

Superparamagnetic Iron Oxide Nanoparticles for Cancer Theranostic Applications

  • Chapter
  • First Online:

Abstract

In the last few decades, superparamagnetic iron oxide nanoparticles (SPIONs—particularly magnetite (Fe3O4)/maghemite (Fe2O3) nanoparticles) have gained a great deal of attention in many biomedical applications, including magnetic targeting based cell isolation/sorting, tissue engineering, gene delivery, and magnetofection, due to their unique magnetic properties, excellent chemical stability, biodegradability, and low toxicity as compared to other magnetic materials (for instance, Co, Mn, and Ni). But recently, SPIONs (in the form of ferrofluids—i.e., SPIONs dispersed in a carrier fluid) have become a highly promising candidate for their use as therapeutic and diagnostic (theranostic) agents in cancer treatment applications such as magnetic fluid hyperthermia (MFH) and magnetic resonance imaging (MRI), respectively. However, the theranostic efficacies of the SPIONs (or ferrofluids) might alter due to the differences in their physicochemical/dispersibility/magnetic properties that are significantly impacted by their synthesis methods and their stabilization process. In this chapter, we have initially discussed the crystal structure/composition and different synthesis methods of the SPIONs. Then, we have described the role of the SPIONs in the formation of the ferrofluids along with their stabilization process via diverse interactions. Finally, we have discussed about their (1) intrinsic cancer theranostic applications of SPIONs such as magnetic fluid hyperthermia, magnetic resonance imaging, and magnetic nanoparticle-based drug delivery and (2) combined cancer theranostics applications including MRI as an adjuvant to fluorescence imaging, thermo-chemotherapy, thermo-radiotherapy, and thermo-immunotherapy.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Abadeer NS, Murphy CJ. Recent progress in cancer thermal therapy using gold nanoparticles. J Phys Chem C. 2016;120(9):4691–716.

    Article  CAS  Google Scholar 

  • Ahn T, Kim JH, Yang HM, Lee JW, Kim JD. Formation pathways of magnetite nanoparticles by coprecipitation method. J Phys Chem C. 2012;116(10):6069–76.

    Article  CAS  Google Scholar 

  • Aires A, Ocampo SM, Simões BM, Josefa Rodríguez M, Cadenas JF, Couleaud P, Cortajarena AL. Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells. Nanotechnology. 2016;27(6):065103.

    Article  PubMed  CAS  Google Scholar 

  • Ali A, Zafar H, Zia M, ul Haq I, Phull AR, Ali JS, Hussain A. Synthesis, characterization, applications, and challenges of iron oxide nanoparticles. Nanotechnol Sci Appl. 2016;9:49–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ali LMA, Marzola P, Nicolato E, Fiorini S, De M. Polymer-coated superparamagnetic iron oxide nanoparticles as T2 contrast agent for MRI and their uptake in liver. Future Sci OA. 2017;5:FSO235.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ansari MO, Ahmad MF, Shadab GGHA, Siddique HR. Superparamagnetic iron oxide nanoparticles based cancer theranostics: a double edge sword to fight against cancer. J Drug Deliv Sci Technol. 2018;45:177–83.

    Article  CAS  Google Scholar 

  • Araki EH, Ehlers J, Hepp K, Tvergaard JSV, Potier-ferry M. Colloidal magnetic fluids: basics, development and application of ferrofluid, Lecture notes in physics. Berlin: Springer Science & Business Media; 2009.

    Google Scholar 

  • Arriortua OK, Garaio E, de la Parte BH, Insausti M, Lezama L, Plazaola F, et al. Antitumor magnetic hyperthermia induced by RGD-functionalized Fe3O4 nanoparticles, in an experimental model of colorectal liver metastases. Beilstein J Nanotechnol. 2016;7(1):1532–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Baskar R, Dai J, Wenlong N, Yeo R, Yeoh K-W. Biological response of cancer cells to radiation treatment. Front Mol Biosci. 2014;1:1–9.

    Article  CAS  Google Scholar 

  • Bastow TJ, Trinchi A. NMR analysis of ferromagnets: Fe oxides. Solid State Nucl Magn Reson. 2009;35(1):25–31.

    Article  CAS  PubMed  Google Scholar 

  • Bedanta S, Kleemann W. Supermagnetism. J Phys D Appl Phys. 2009;42(1):013001.

    Article  CAS  Google Scholar 

  • Boutonnet M, Lögdberg S, Elm Svensson E. Recent developments in the application of nanoparticles prepared from w/o microemulsions in heterogeneous catalysis. Curr Opin Colloid Interface Sci. 2008;13(4):270–86.

    Article  CAS  Google Scholar 

  • Burgess A, Shah K, Hough O, Hynynen K. Next generation superparamagnetic iron oxide nanoparticles for cancer theranostics. Drug Discov Today. 2016;15(5):477–91.

    Google Scholar 

  • Chopra M, Kandasamy G, Maity D. Multifunctional magnetic nanoparticles—a promising approach for cancer treatment. J Nanomed Res. 2016;4(1):3–4.

    Google Scholar 

  • Cornell RM, Schwertmann U. Introduction to iron oxides. In: The iron oxides: structure, properties, reactions, occurences and uses. Weinheim: Wiley; 2004. p. 1–7. https://doi.org/10.1002/3527602097. ISBN: 9783527302741 (Print); 9783527602094 (Online).

    Chapter  Google Scholar 

  • Corot C, Warlin D. Superparamagnetic iron oxide nanoparticles for MRI: contrast media pharmaceutical company R&D perspective. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013;5(5):411–22.

    Article  CAS  PubMed  Google Scholar 

  • Danhier F, Feron O, Préat V. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release. 2010;148(2):135–46.

    Article  CAS  PubMed  Google Scholar 

  • Datta NR, Ordóñez SG, Gaipl US, Paulides MM, Crezee H, Gellermann J, et al. Local hyperthermia combined with radiotherapy and-/or chemotherapy: recent advances and promises for the future. Cancer Treat Rev. 2015;41(9):742–53.

    Article  CAS  PubMed  Google Scholar 

  • Demirer GS, Okur AC, Kizilel S. Synthesis and design of biologically inspired biocompatible iron oxide nanoparticles for biomedical applications. J Mater Chem B. 2015;3(40):7831–49.

    Article  CAS  PubMed  Google Scholar 

  • Desouky O, Ding N, Zhou G. Targeted and non-targeted effects of ionizing radiation. J Radiat Res Appl Sci. 2015;8(2):247–54.

    Article  CAS  Google Scholar 

  • Efremova MV, Naumenko VA, Spasova M, Garanina AS, Abakumov MA, Blokhina AD, et al. Magnetite-gold nanohybrids as ideal all-in-one platforms for theranostics. Sci Rep. 2018;8(1):1–19.

    Article  CAS  Google Scholar 

  • Evans ER, Bugga P, Asthana V, Drezek R. Metallic nanoparticles for cancer immunotherapy. Mater Today. 2018;21(6):673–85.

    Article  CAS  Google Scholar 

  • Farkona S, Diamandis EP, Blasutig IM. Cancer immunotherapy: the beginning of the end of cancer? BMC Med. 2016;14(1):1–18.

    Article  CAS  Google Scholar 

  • Fass L. Imaging and cancer: a review. Mol Oncol. 2008;2:115–52.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferreira RV, Martins TM, Goes AM, Fabris JD, Cavalcante LCD, Outon LEF, Domingues RZ. Thermosensitive gemcitabine-magnetoliposomes for combined hyperthermia and chemotherapy. Nanotechnology. 2016;27(8):085105.

    Article  PubMed  CAS  Google Scholar 

  • Fu C, Ravindra NM. Magnetic iron oxide nanoparticles: synthesis and applications. Bioinspir Biomim Nanobiomater. 2012;1(4):229–44.

    Article  CAS  Google Scholar 

  • Ganipineni LP, Ucakar B, Joudiou N, Bianco J, Danhier P, Zhao M, et al. Magnetic targeting of paclitaxel-loaded poly(lactic-co-glycolic acid)-based nanoparticles for the treatment of glioblastoma. Int J Nanomed. 2018;13:4509–21.

    Article  CAS  Google Scholar 

  • Gilchrist RK, Medal R, Shorey WD, Hanselman RC, Parrott JC, Taylor CB. Selective inductive heating of lymph nodes. Ann Surg. 1957;146(4):596–606.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gkanas EI. In vitro magnetic hyperthermia response of iron oxide MNP’s incorporated in DA3, MCF-7 and HeLa cancer cell lines. Cent Eur J Chem. 2013;11(7):1042–54.

    CAS  Google Scholar 

  • Grifantini R, Taranta M, Gherardini L, Naldi I, Parri M, Grandi A, Cinti C. Magnetically driven drug delivery systems improving targeted immunotherapy for colon-rectal cancer. J Control Release. 2018;280:76–86.

    Article  CAS  PubMed  Google Scholar 

  • Grover VPB, Tognarelli JM, Crossey MME, Cox IJ, Taylor-Robinson SD, McPhail MJW. Magnetic resonance imaging: principles and techniques: lessons for clinicians. J Clin Exp Hepatol. 2015;5(3):246–55.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gupta KM, Gupta N. Advanced electrical and electronics materials: processes and applications. Hoboken, NJ: Wiley; 2015.

    Book  Google Scholar 

  • Hairston RJ. The management of cytomegalovirus-associated retinal detachments. J Int Assoc Phys AIDS Care. 1996;2(5):31–4.

    CAS  Google Scholar 

  • Hayashi K, Sato Y, Sakamoto W, Yogo T. Theranostic nanoparticles for MRI-guided thermochemotherapy: “tight” clustering of magnetic nanoparticles boosts relaxivity and heat-generation power. ACS Biomater Sci Eng. 2017;3(1):95–105.

    Article  CAS  PubMed  Google Scholar 

  • Hervault A, Thanh NTK. Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer. Nanoscale. 2014;6(20):11553–73.

    Article  CAS  PubMed  Google Scholar 

  • Ibarra J, Encinas D, Blanco M, Barbosa S, Taboada P, Juárez J, Valdez MA. Co-encapsulation of magnetic nanoparticles and cisplatin within biocompatible polymers as multifunctional nanoplatforms: synthesis, characterization, and in vitro assays. Mater Res Express. 2018;5(1):015023.

    Article  CAS  Google Scholar 

  • Issa B, Obaidat IM, Albiss BA, Haik Y. Magnetic nanoparticles: surface effects and properties related to biomedicine applications. Int J Mol Sci. 2013;14(11):21266–305.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ito A, Ito Y, Matsushima S, Tsuchida D, Ogasawara M, Hasegawa J, et al. New whole-body multimodality imaging of gastric cancer peritoneal metastasis combining fluorescence imaging with ICG-labeled antibody and MRI in mice. Gastric Cancer. 2014;17(3):497–507.

    Article  CAS  PubMed  Google Scholar 

  • Jacques V, Dumas S, Sun W-C, Troughton J, Greenfield MT, Caravan P. High relaxivity MRI contrast agents part 2: optimization of inner- and second-sphere relaxivity. Investig Radiol. 2010;45(10):613–24.

    Article  CAS  Google Scholar 

  • Jena BP. Atomic force microscope: providing new insights on the structure and function of living cells. Cell Biol Int. 1997;21(11):683–4.

    Article  CAS  PubMed  Google Scholar 

  • Jiang PS, Tsai HY, Drake P, Wang FN, Chiang CS. Gadolinium-doped iron oxide nanoparticles induced magnetic field hyperthermia combined with radiotherapy increases tumour response by vascular disruption and improved oxygenation. Int J Hyperth. 2017;33:1–9.

    Article  CAS  Google Scholar 

  • Jo SD, Ku SH, Won YY, Kim SH, Kwon IC. Targeted nanotheranostics for future personalized medicine: recent progress in cancer therapy. Theranostics. 2016;6:1362–77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R. Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem. 2002;13(3):554–60.

    Article  CAS  PubMed  Google Scholar 

  • Kalikmanov VI. Ferrofluids. In: Statistical physics of fluids Texts and Monographs in Physics. https://doi.org/10.1007/978-3-662-04536-7. Springer, Berlin, Heidelberg 2001. pp. 223–238.

    Book  Google Scholar 

  • Kandasamy G, Maity D. Recent advances in superparamagnetic iron oxide nanoparticles (SPIONs) for in vitro and in vivo cancer nanotheranostics. Int J Pharm. 2015;496(2):191–218.

    Article  CAS  PubMed  Google Scholar 

  • Kandasamy G, Sudame A, Bhati P, Chakrabarty A, Maity D. Systematic investigations on heating effects of carboxyl-amine functionalized superparamagnetic iron oxide nanoparticles (SPIONs) based ferrofluids for in vitro cancer hyperthermia therapy. J Mol Liq. 2018a;256:224–37.

    Article  CAS  Google Scholar 

  • Kandasamy G, Sudame A, Luthra T, Saini K, Maity D. Functionalized hydrophilic superparamagnetic iron oxide nanoparticles for magnetic fluid hyperthermia application in liver cancer treatment. ACS Omega. 2018b;3(4):3991–4005.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kandasamy G, Khan S, Giri J, Bose S, Veerapu NS, Maity D. One-pot synthesis of hydrophilic flower-shaped iron oxide nanoclusters (IONCs) based ferrofluids for magnetic fluid hyperthermia applications. J Mol Liq. 2019a;275:699–712.

    Article  CAS  Google Scholar 

  • Kandasamy G, Soni S, Sushmita K, Veerapu NS, Bose S, Maity D. One-step synthesis of hydrophilic functionalized and cytocompatible superparamagnetic iron oxide nanoparticles (SPIONs) based aqueous ferrofluids for biomedical applications. J Mol Liq. 2019b;274:653–63.

    Article  CAS  Google Scholar 

  • Kaur P, Hurwitz MD, Krishnan S, Asea A. Combined hyperthermia and radiotherapy for the treatment of cancer. Cancers. 2011;3(4):3799–823.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim DH, Vitol EA, Liu J, Balasubramanian S, Gosztola DJ, Cohen EE, et al. Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles. Langmuir. 2013;29(24):7425–32.

    Article  CAS  PubMed  Google Scholar 

  • Kitture R, Ghosh S, Kulkarni P, Liu XL, Maity D, Patil SI, et al. Fe3O4-citrate-curcumin: promising conjugates for superoxide scavenging, tumor suppression and cancer hyperthermia. J Appl Phys. 2012;111(6):064702.

    Article  CAS  Google Scholar 

  • Kohrt H, Rajasekaran N, Chester C, Yonezawa A, Zhao X. Enhancement of antibody-dependent cell mediated cytotoxicity: a new era in cancer treatment. Immunotargets Ther. 2015;4:91.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kokura S, Yoshikawa T, Ohnishi T. Hyperthermic oncology from bench to bedside. Singapore: Springer; 2016.

    Book  Google Scholar 

  • Kosaka N, Ogawa M, Choyke PPL, Kobayashi H. Clinical implications of near-infrared fluorescence imaging in cancer. Future Oncol. 2009;5(9):1501–11.

    Article  PubMed  Google Scholar 

  • Kozissnik B, Bohorquez AC, Dobson J, Rinaldi C. Magnetic fluid hyperthermia: advances, challenges, and opportunity. Int J Hyperth. 2013;29(8):706–14.

    Article  Google Scholar 

  • Kudr J, Haddad Y, Richtera L, Heger Z, Cernak M, Adam V, Zitka O. Magnetic nanoparticles: from design and synthesis to real world applications. Nanomaterials. 2017;7(9):243.

    Article  PubMed Central  CAS  Google Scholar 

  • Kumar CSSR, Leuschner C. Nanoparticles for cancer drug delivery. In: Nanofabrication towards biomedical applications: techniques, tools, applications, and impact. Weinheim: Wiley-VCH; 2005.

    Chapter  Google Scholar 

  • Lahiri BB, Muthukumaran T, Philip J. Magnetic hyperthermia in phosphate coated iron oxide nanofluids. J Magn Magn Mater. 2016;407:101–13.

    Article  CAS  Google Scholar 

  • Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, Muller RN. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations and biological applications. Chem Rev. 2008;108(6):2064–110.

    Article  CAS  PubMed  Google Scholar 

  • Laurent S, Dutz S, Häfeli UO, Mahmoudi M. Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles. Adv Colloid Interf Sci. 2011;166(1–2):8–23.

    Article  CAS  Google Scholar 

  • Laurent S, Saei AA, Behzadi S, Panahifar A, Mahmoudi M. Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: opportunities and challenges. Expert Opin Drug Deliv. 2014;11(9):1449–70.

    Article  CAS  PubMed  Google Scholar 

  • Li W, Hinton CH, Lee SS, Wu J, Fortner JD. Surface engineering superparamagnetic nanoparticles for aqueous applications: design and characterization of tailored organic bilayers. Environ Sci Nano. 2015;3:1–20.

    Google Scholar 

  • Li X, Wei J, Aifantis KE, Fan Y, Feng Q, Cui FZ, Watari F. Current investigations into magnetic nanoparticles for biomedical applications. J Biomed Mater Res A. 2016;104:1285–96.

    Article  CAS  PubMed  Google Scholar 

  • Li Q, Kartikowati CW, Horie S, Ogi T, Iwaki T, Okuyama K. Correlation between particle size/domain structure and magnetic properties of highly crystalline Fe3O4 nanoparticles. Sci Rep. 2017;7(1):1–4.

    Article  CAS  Google Scholar 

  • Li M, Bu W, Ren J, Li J, Deng L, Gao M, et al. Enhanced synergism of thermo-chemotherapy for liver cancer with magnetothermally responsive nanocarriers. Theranostics. 2018;8(3):693–709.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liao MY, Wu CH, Lai PS, Yu J, Lin HP, Liu TM, Huang CC. Surface state mediated NIR two-photon fluorescence of iron oxides for nonlinear optical microscopy. Adv Funct Mater. 2013;23:2044–51.

    Article  CAS  Google Scholar 

  • Lin BL, Zhang JZ, Lu LJ, Mao JJ, Cao MH, Mao XH, Shen J. Superparamagnetic iron oxide nanoparticles-complexed cationic amylose for in vivo magnetic resonance imaging tracking of transplanted stem cells in stroke. Nanomaterials. 2017;7(5):107.

    Article  PubMed Central  CAS  Google Scholar 

  • Lin FC, Hsu CH, Lin YY. Nano-therapeutic cancer immunotherapy using hyperthermia-induced heat shock proteins: insights from mathematical modeling. Int J Nanomed. 2018;13:3529–39.

    Article  CAS  Google Scholar 

  • Liu S, Jia B, Qiao R, Yang Z, Yu Z, Liu Z, et al. A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: preparation, characterization and in vivo application. Mol Pharm. 2009;6(4):1074–82.

    Article  CAS  PubMed  Google Scholar 

  • Liu H, Tan Y, Xie L, Yang L, Zhao J, Bai J, et al. Self-assembled dual-modality contrast agents for non-invasive stem cell tracking via near-infrared fluorescence and magnetic resonance imaging. J Colloid Interface Sci. 2016;478:217–26.

    Article  CAS  PubMed  Google Scholar 

  • Mahmoudi M, Sant S, Wang B, Laurent S, Sen T. Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy. Adv Drug Deliv Rev. 2011;63(1–2):24–46.

    Article  CAS  PubMed  Google Scholar 

  • Maier-Hauff K, Ulrich F, Nestler D, Niehoff H, Wust P, Thiesen B, et al. Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J Neurooncol. 2011;103(2):317–24.

    Article  PubMed  Google Scholar 

  • Maity D, Agrawal DC. Synthesis of iron oxide nanoparticles under oxidizing environment and their stabilization in aqueous and non-aqueous media. J Magn Magn Mater. 2007;308(1):46–55.

    Article  CAS  Google Scholar 

  • Maity D, Ding J, Xue JM. Synthesis of magnetite nanoparticles by thermal decomposition: time, temperature, surfactant and solvent effects. Funct Mater Lett. 2008;01(3):189–93.

    Article  CAS  Google Scholar 

  • Maity D, Ding J, Xue JM. One-pot synthesis of hydrophilic and hydrophobic ferrofluid. Int J Nanosci. 2009;8(1–2):65–9.

    Article  CAS  Google Scholar 

  • Maity D, Chandrasekharan P, Si-Shen F, Xue JM, Ding J. Polyol-based synthesis of hydrophilic magnetite nanoparticles. J Appl Phys. 2010a;107(9):09B310.

    Article  Google Scholar 

  • Maity D, Chandrasekharan P, Yang CT, Chuang KH, Shuter B, Xue JM, Feng SS. Facile synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications. Nanomedicine. 2010b;5(10):1571–84.

    Article  CAS  PubMed  Google Scholar 

  • Maity D, Chandrasekharan P, Pradhan P, Chuang K-H, Xue J-M, Feng S-S, Ding J. Novel synthesis of superparamagnetic magnetite nanoclusters for biomedical applications. J Mater Chem. 2011a;21(38):14717.

    Article  CAS  Google Scholar 

  • Maity D, Pradhan P, Chandrasekharan P, Kale SN, Shuter B, Bahadur D, Ding J. Synthesis of hydrophilic superparamagnetic magnetite nanoparticles via thermal decomposition of Fe(acac)3 in 80 Vol% TREG + 20 Vol% TREM. J Nanosci Nanotechnol. 2011b;11(3):2730–4.

    Article  CAS  Google Scholar 

  • Maxwell DJ, Bonde J, Hess DA, Hohm SA, Lahey R, Zhou P, et al. Fluorophore-conjugated iron oxide nanoparticle labeling and analysis of engrafting human hematopoietic stem cells. Stem Cells. 2008;26(2):517–24.

    Article  CAS  PubMed  Google Scholar 

  • McCarthy MJ. Introduction to magnetic resonance imaging (MRI). In: Magnetic resonance imaging in foods; 2011. pp. 1–29.

    Chapter  Google Scholar 

  • Mclaughlin R, Hylton N, Imaging B. MRI in breast cancer therapy monitoring. NMR Biomed. 2015;24(6):712–20.

    Google Scholar 

  • Merbach A, Helm L, Tóth É. The chemistry of contrast agents in medical magnetic resonance imaging. 2nd ed. Oxford: Wiley-Blackwell; 2013.

    Book  Google Scholar 

  • Mishra SK, Kumar BSH, Khushu S, Tripathi RP, Gangenahalli G. Increased transverse relaxivity in ultrasmall superparamagnetic iron oxide nanoparticles used as MRI contrast agent for biomedical imaging. Contrast Media Mol Imaging. 2016;11(5):350–61.

    Article  CAS  PubMed  Google Scholar 

  • Mojica Pisciotti ML, Lima E, Vasquez Mansilla M, Tognoli VE, Troiani HE, Pasa AA, Zysler RD. In vitro and in vivo experiments with iron oxide nanoparticles functionalized with dextran or polyethylene glycol for medical applications: magnetic targeting. J Biomed Mater Res B Appl Biomater. 2014;102(4):860–8.

    Article  CAS  PubMed  Google Scholar 

  • Morel A, Nikitenko SI, Gionnet K, Wattiaux A, Lai-kee-him J, Labrugere C, Faculte A. Sonochemical approach to the synthesis of Fe3O4@SiO2 core–shell nanoparticles with tunable properties. ACS Nano. 2008;2(5):847–56.

    Article  CAS  PubMed  Google Scholar 

  • Moskowitz BM. Hitchhiker’s guide to magnetism. Environmental magnetism workshop, vol. 279(1), 1991. p. 48.

    Google Scholar 

  • Mutin PH, Vioux A. Nonhydrolytic processing of oxide-based materials: simple routes to control homogeneity, morphology, and nanostructure. Chem Mater. 2009;21(4):582–96.

    Article  CAS  Google Scholar 

  • Nitz WR, Reimer P. Contrast mechanisms in MR imaging. Eur Radiol. 1999;9(6):1032–46.

    Article  CAS  PubMed  Google Scholar 

  • Odenbach S. Ferrofluids—magnetically controllable fluids and their applications. Berlin: Springer; 2002.

    Book  Google Scholar 

  • Odenbach S. Ferrofluids—magnetically controlled suspensions. Colloids Surf A Physicochem Eng Asp. 2003;217(1–3):171–8.

    Article  CAS  Google Scholar 

  • Ohno T, Wakabayashi T, Takemura A, Yoshida J, Ito A, Shinkai M, Kobayashi T. Effective solitary hyperthermia treatment of malignant glioma using stick type CMC-magnetite. In vivo study. J Neurooncol. 2002;56(3):233–9.

    Article  PubMed  Google Scholar 

  • Okoli C, Boutonnet M, Mariey L, Jaras S, Rajarao G. Application of magnetic iron oxide nanoparticles prepared from microemulsions for protein purification. J Chem Technol Biotechnol. 2011;86(11):1386–93.

    Article  CAS  Google Scholar 

  • Ortega RA, Giorgio TD. A mathematical model of superparamagnetic iron oxide nanoparticle magnetic behavior to guide the design of novel nanomaterials. J Nanopart Res. 2012;14(12):1282.

    Article  CAS  Google Scholar 

  • Park W, Heo Y-J, Han DK. New opportunities for nanoparticles in cancer immunotherapy. Biomater Res. 2018;22(1):24.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Piñeiro Y, Vargas Z, Rivas J, Lõpez-Quintela MA. Iron oxide based nanoparticles for magnetic hyperthermia strategies in biological applications. Eur J Inorg Chem. 2015;2015(27):4495–509.

    Article  CAS  Google Scholar 

  • Pinkas J, Reichlova V, Zboril R, Moravec Z, Bezdicka P, Matejkova J. Sonochemical synthesis of amorphous nanoscopic iron(III) oxide from Fe(acac)3. Ultrason Sonochem. 2008;15(3):257–64.

    Article  CAS  PubMed  Google Scholar 

  • Polyak B, Friedman G. Magnetic targeting for site-specific drug delivery: applications and clinical potential. Expert Opin Drug Deliv. 2009;6(1):53–70.

    Article  CAS  PubMed  Google Scholar 

  • Pooley R. Fundamental Physics of MR Imaging. Radiographics. 2005;25(4):1087–99.

    Article  PubMed  Google Scholar 

  • Prashant C, Dipak M, Yang CT, Chuang KH, Jun D, Feng SS. Superparamagnetic iron oxide—loaded poly (lactic acid)-d-alpha-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent. Biomaterials. 2010;31(21):5588–97.

    Article  CAS  PubMed  Google Scholar 

  • Prijic S, Sersa G. Magnetic nanoparticles as targeted delivery systems in oncology. Radiol Oncol. 2011;45(1):1–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Qiao R, Yang C, Gao M. Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications. J Mater Chem. 2009;19(35):6274.

    Article  CAS  Google Scholar 

  • Rabias I, Tsitrouli D, Karakosta E, Kehagias T, Diamantopoulos G, Fardis M, Papavassiliou G. Rapid magnetic heating treatment by highly charged maghemite nanoparticles on Wistar rats exocranial glioma tumors at microliter volume. Biomicrofluidics. 2010;4(2):024111.

    Article  PubMed  PubMed Central  Google Scholar 

  • Raj K, Boulton RJ. Ferrofluids—properties and applications. Mater Des. 1987;8(4):233–6.

    Article  Google Scholar 

  • Raj K, Moskowitz B, Casciari R. Advances in ferrofluid technology. J Magn Magn Mater. 1995;149(1–2):174–80.

    Article  CAS  Google Scholar 

  • Rao W, Deng ZS, Liu J. A review of hyperthermia combined with radiotherapy/chemotherapy on malignant tumors. Crit Rev Biomed Eng. 2010;38(1):101–16.

    Article  PubMed  Google Scholar 

  • Revia RA, Zhang M. Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances. Mater Today. 2016;19(3):157–68.

    Article  CAS  Google Scholar 

  • Rosenblum D, Joshi N, Tao W, Karp JM, Peer D. Progress and challenges towards targeted delivery of cancer therapeutics. Nat Commun. 2018;9(1):1410.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rosensweig RE. Ferrohydrodynamics. Mineola: Dover Publications; 1997.

    Google Scholar 

  • Scherer C, Neto AMF. Ferrofluids: properties and applications. Braz J Phys. 2005;35(3):718–27.

    Article  CAS  Google Scholar 

  • Schleich N, Po C, Jacobs D, Ucakar B, Gallez B, Danhier F, Préat V. Comparison of active, passive and magnetic targeting to tumors of multifunctional paclitaxel/SPIO-loaded nanoparticles for tumor imaging and therapy. J Control Release. 2014;194:82–91.

    Article  CAS  PubMed  Google Scholar 

  • Shen B, Ma Y, Yu S, Ji C. Smart multifunctional magnetic nanoparticle-based drug delivery system for cancer thermo-chemotherapy and intracellular imaging. ACS Appl Mater Interfaces. 2016;8(37):24502–8.

    Article  CAS  PubMed  Google Scholar 

  • Shen Z, Wu A, Chen X. Iron oxide nanoparticle based contrast agents for magnetic resonance imaging. Mol Pharm. 2017;14(5):1352–64.

    Article  CAS  PubMed  Google Scholar 

  • Shin TH, Choi Y, Kim S, Cheon J. Recent advances in magnetic nanoparticle-based multi-modal imaging. Chem Soc Rev. 2015;44(14):4501–16.

    Article  CAS  PubMed  Google Scholar 

  • Silva AC, Oliveira TR, Mamani JB, Malheiros SMF, Malavolta L, Pavon LF, Gamarra LF. Application of hyperthermia induced by superparamagnetic iron oxide nanoparticles in glioma treatment. Int J Nanomed. 2011;6:591–603.

    CAS  Google Scholar 

  • Spaldin N. Magnetic materials-fundamentals and applications. Cambridge: Cambridge University Press; 2003.

    Google Scholar 

  • Stephen ZR, Kievit FM, Zhang M. Magnetite nanoparticles for medical MR imaging. Mater Today. 2012;14(11):330–8.

    Google Scholar 

  • Suto M, Hirota Y, Mamiya H, Fujita A, Kasuya R, Tohji K, Jeyadevan B. Heat dissipation mechanism of magnetite nanoparticles in magnetic fluid hyperthermia. J Magn Magn Mater. 2009;321(10):1493–6.

    Article  CAS  Google Scholar 

  • Tan YF, Chandrasekharan P, Maity D, Yong CX, Chuang KH, Zhao Y, Feng SS. Multimodal tumor imaging by iron oxides and quantum dots formulated in poly (lactic acid)-d-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles. Biomaterials. 2011;32(11):2969–78.

    Article  CAS  PubMed  Google Scholar 

  • Tartaj P, Del M, Morales P, Veintemillas-Verdaguer S, González-Carr T, Serna CJ. The preparation of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys. 2003;36(36):182–97.

    Article  Google Scholar 

  • Thanh NTK. Magnetic nanoparticles: from fabrication to clinical applications. Boca Raton, FL: CRC Press; 2012.

    Book  Google Scholar 

  • Thanh NTK. Clinical applications of magnetic nanoparticles, vol. 91. Boca Raton, FL: CRC Press; 2018.

    Book  Google Scholar 

  • Thomsen LB, Thomsen MS, Moos T. Targeted drug delivery to the brain using magnetic nanoparticles. Ther Deliv. 2015;6(10):1145–55.

    Article  CAS  PubMed  Google Scholar 

  • Toraya-Brown S, Fiering S. Local tumour hyperthermia as immunotherapy for metastatic cancer. Int J Hyperth. 2014;30(8):531–9.

    Article  CAS  Google Scholar 

  • Trohidou K, editor. Magnetic nanoparticle assemblies. Singapore: Pan Stanford Publishing; 2014.

    Google Scholar 

  • Turcheniuk K, Tarasevych AV, Kukhar VP, Boukherroub R, Szunerits S. Recent advances in surface chemistry strategies for the fabrication of functional iron oxide based magnetic nanoparticles. Nanoscale. 2013;5(22):10729.

    Article  CAS  PubMed  Google Scholar 

  • Veiseh O, Gunn J, Zhang M. Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev. 2011;62(3):284–304.

    Article  CAS  Google Scholar 

  • Wang W. NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy. Front Immunol. 2015;6(11):683–4.

    Google Scholar 

  • Wang YJ, Xuan S, Port M, Idee J. Recent advances in superparamagnetic iron oxide nanoparticles for cellular imaging and targeted therapy research. Curr Pharm Des. 2013;19:6575–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wei H, Bruns OT, Kaul MG, Hansen EC, Barch M, Wiśniowska A, et al. Exceedingly small iron oxide nanoparticles as positive MRI contrast agents. Proc Natl Acad Sci. 2017;114(9):2325–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu W, He Q, Jiang C. Magnetic iron oxide nanoparticles: synthesis and surface functionalization strategies. Nanoscale Res Lett. 2008;3(11):397–415.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu W, Wu Z, Yu T, Jiang C, Kim W-S. Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications. Sci Technol Adv Mater. 2015;16(2):023501.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wu F, Su H, Zhu X, Wang K, Zhang Z, Wong WK. Near-infrared emissive lanthanide hybridized carbon quantum dots for bioimaging applications. J Mater Chem B. 2016;4(38):6366–72.

    Article  CAS  PubMed  Google Scholar 

  • Xu C, Sun S. New forms of superparamagnetic nanoparticles for biomedical applications. Adv Drug Deliv Rev. 2013;65:732–43.

    Article  CAS  PubMed  Google Scholar 

  • Yagawa Y, Tanigawa K, Kobayashi Y, Yamamoto M. Cancer immunity and therapy using hyperthermia with immunotherapy, radiotherapy, chemotherapy, and surgery. J Cancer Metastasis Treat. 2017;3(10):218.

    Article  CAS  Google Scholar 

  • Yanase M, Shinkai M, Honda H, Wakabayashi T, Yoshida J, Kobayashi T. Antitumor immunity induction by intracellular hyperthermia using magnetite cationic liposomes. Jpn J Cancer Res. 1998;89(7):775–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yin X, Zhang J, Wang X. Sequential injection analysis system for the determination of arsenic by hydride generation atomic absorption spectrometry. Fenxi Huaxue. 2004;32(10):1365–7.

    CAS  Google Scholar 

  • Yoffe S, Leshuk T, Everett P, Gu F. Superparamagnetic iron oxide nanoparticles (SPIONs): synthesis and surface modification techniques for use with MRI and other biomedical applications. Curr Pharm Des. 2013;19:493–509.

    Article  CAS  PubMed  Google Scholar 

  • Yu MK, Park J, Jon S. Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Theranostics. 2012;2(1):3–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang Y, Zhang B, Liu F, Luo J, Bai J. In vivo tomographic imaging with fluorescence and MRI using tumor-targeted dual-labeled nanoparticles. Int J Nanomed. 2013;9(1):33–41.

    Article  Google Scholar 

  • Zhu L, Zhou Z, Mao H, Yang L. Magnetic nanoparticles for precision oncology: theranostic magnetic iron oxide nanoparticles for image-guided and targeted cancer therapy. Nanomedicine. 2017;12(1):73–87.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical Engineering, Institute of Chemical Technology Mumbai, IOC Campus, Bhubaneswar, OD, India

    Dipak Maity

  2. Department of Biomedical Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, TN, India

    Ganeshlenin Kandasamy

  3. Department of Mechanical Engineering, Shiv Nadar University, Dadri, UP, India

    Atul Sudame

Authors
  1. Dipak Maity
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ganeshlenin Kandasamy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Atul Sudame
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biotechnology, Nanobiotechnology Laboratory, Amravati, Maharashtra, India, Department of Chemistry, Federal University of Piauí, Teresina, Piauí, Brazil

    Mahendra Rai

  2. Department of DMLS, University of Lahore, Islamabad, Pakistan

    Bushra Jamil

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Maity, D., Kandasamy, G., Sudame, A. (2019). Superparamagnetic Iron Oxide Nanoparticles for Cancer Theranostic Applications. In: Rai, M., Jamil, B. (eds) Nanotheranostics. Springer, Cham. https://doi.org/10.1007/978-3-030-29768-8_12

Download citation

Publish with us

Policies and ethics

Search

Navigation