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Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)

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Cancer Regional Therapy

Abstract

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel intraperitoneal drug-delivery technique with the capability of distributing drugs as a pressurized aerosol. Pharmacological advantages of PIPAC are a better homogeneity of drug distribution, a deeper penetration, and a higher drug concentration in the target tissue than intraperitoneal chemotherapy with liquids. PIPAC is a generic technique allowing aerosolization of a large range of therapeutic substances. Current indication is palliative therapy of advanced peritoneal metastasis in various gastrointestinal and gynecological tumors. PIPAC has been shown to be feasible in the vast majority of patients, is safe, has no significant organ toxicity, and is well tolerated. PIPAC does not deteriorate quality of life. Encouraging efficacy data from several phase II clinical studies call for prospective randomized trials. PIPAC might have significant advantages over existing chemotherapy techniques, which are not very effective for treating peritoneal metastasis and are associated with a high risk of adverse events. As an experimental technique, PIPAC has been used in patients who already failed multiple treatment regimens, but it might not be limited to that group of patients in the future.

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Author information

Authors and Affiliations

  1. University Hospital of Tübingen, National Center for Pleura and Peritoneum, Tübingen, Baden-Württemberg, Germany

    Marc A. Reymond

  2. University Hospital of Tübingen, Institute of Pathology, Tübingen, Baden-Württemberg, Germany

    Wiebke Solass

  3. University Hospital of Tübingen, Department of General and Transplant Surgery, Tübingen, Baden-Württemberg, Germany

    Giorgi Nadiradze, Philipp Horvath & Alfred Königsrainer

Authors
  1. Marc A. Reymond
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  2. Wiebke Solass
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  3. Giorgi Nadiradze
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  4. Philipp Horvath
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  5. Alfred Königsrainer
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Corresponding author

Correspondence to Marc A. Reymond .

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Editors and Affiliations

  1. City Of Hope National Medical Center, Duarte, CA, USA

    Yuman Fong

  2. Medical College of Wisconsin, Milwaukee, WI, USA

    T. Clark Gamblin

  3. City Of Hope National Medical Center, Duarte, CA, USA

    Ernest S. Han

  4. City Of Hope National Medical Center, Duarte, CA, USA

    Byrne Lee

  5. Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA

    Jonathan S. Zager

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Reymond, M.A., Solass, W., Nadiradze, G., Horvath, P., Königsrainer, A. (2020). Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC). In: Fong, Y., Gamblin, T., Han, E., Lee, B., Zager, J. (eds) Cancer Regional Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-28891-4_20

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  • DOI: https://doi.org/10.1007/978-3-030-28891-4_20

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