Abstract
The chapter of hematology and oncology contains peer-reviewed questions and critiques written by pediatric emergency medicine physicians. Each question has been tailored to the American Board of Pediatrics’ (ABP) subspecialty content specifications. These questions will help you gain insight and identify gaps in your knowledge, which will in turn help prepare you for the boards. At the end of each question, we provide detailed evidence-based explanation to the answers along with suggested references.
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Question 1
Ballas SK. Current issues in sickle cell pain and its management. ASH Education Program Book. 2007;1(2007):97–105.
Fleisher’s textbook of pediatric emergency medicine. 7th ed. p. 815.
NHLBI guidelines, Evidence based management of SCD-Expert panel report 2014, p. 50–4
Rees DC, et al. Guidelines for the management of the acute painful crisis in sickle cell disease. Br J Haematol. 2003;120(5):744–52.
Question 2
Adamkiewicz TV, Sarnaik S, Buchanan GR, et al. Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccination. J Pediatr. 2003;143:438–44.
Baskin MN, Goh XL, Heeney MM, et al. Bacteremia risk and outpatient management of febrile patients with sickle cell disease. Pediatrics. 2013;131:1035–41.
Fleisher’s textbook of pediatric emergency medicine. 7th ed. p. 818.
NHLBI guidelines, Evidence based management of SCD-Expert panel report 2014, p. 55
Yawn BP, Buchanan GR, Afenyi-Annan AN, et al. Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. JAMA. 2014;312:1033.
Question 3
Babbitt CJ, Garrett JS. Diarrhea and methemoglobinemia in an infant. Pediatr Emerg Care. 2000;16:416–7.
Fleisher’s text book of pediatric emergency medicine, 7th ed. p. 811–12
Jolly BT, Monico EP, McDevitt B. Methemoglobinemia in an infant: case report and review of the literature. Pediatr Emerg Care. 1995;11(5):294–7.
Lebby T, Roco JJ, Arcinue EL. Infantile methemoglobinemia associated with acute diarrheal illness. Am J Emerg Med. 1993;11(5):471–2.
Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med. 1999;34:646–56.
Question 4
Blanchette V, Adams M, Wang E, et al. Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura. Lancet. 1994;344:703–7.
Butros L, Bussel J. Intracranial hemorrhage in immune thrombocytopenic purpura: a retrospective analysis. J Pediatr Hematol Oncol. 2003;25:660–4.
Fleisher’s text book of pediatric emergency medicine. 7th ed. p. 822–4.
Hastings CA, Torkildson JC, Agrawal AK. Thrombocytopenia. In: Handbook of pediatric hematology and oncology: Children’s Hospital & Research Center Oakland. 2nd ed. Oxford, UK: Wiley-Blackwell; 2012.
Neunert C, et al. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood. 2011;117:4190–207.
Question 5
Dimaras H, Kimani K, Dimba E, et al. Retinoblastoma. Lancet. 2012;379:1436–46.
Fleisher’s text book of pediatric emergency medicine. 7th ed. p. 942–3.
Rodriguez-Galindo C, Orbach DB, VanderVeen D. Retinoblastoma. Pediatr Clin North Am. 2015;62(1):201–23.
Question 6
Fleisher’s text book of pediatric emergency medicine. 7th ed. p. 949.
Kaste SC, Dome JS, Babyn PS, et al. Wilms’ tumour: prognostic factors, staging, therapy and late effects. Pediatr Radiol. 2008;38:2–17.
Neville HL, Ritchey ML. Wilms’ tumor. Overview of National Wilms’ Tumor Study Group results. Urol Clin North Am. 2000;27:435–42.
Question 7
Fleisher’s text book of pediatric emergency medicine. 7th ed. p. 948.
Park JR, Eggert A, Caron H. Neuroblastoma: biology, prognosis, and treatment. Hematol/Oncol Clin N Am. 2010;24:65–86.
Question 8
Fleisher’s textbook of pediatric emergency medicine. 7th ed. p. 940–1.
Fleming AJ, Susan NC. Brain tumors in children. Curr Probl Pediatr Adolesc Health Care. 2012;42(4):80–103.
Pitfield AF, Carroll AB, Kissoon N. Emergency management of increased intracranial pressure. Pediatr Emerg Care. 2012;28:200–4.
Question 9
Fleisher’s text book of pediatric emergency medicine. 7th ed. p. 940–1.
Fleming AJ, Susan NC. Brain tumors in children. Curr Probl Pediatr Adolesc Health Care. 2012;42(4):80–103.
Lanphear J, Sarnaik S. Presenting symptoms of pediatric brain tumors diagnosed in the emergency department. Pediatr Emerg Care. 2014;30:77–80.
Packer RJ, MacDonald T, Vezina G. Central nervous system tumors. Pediatr Clin North Am. 2008;55:121–45.
Question 10
Fleisher’s text book of pediatric emergency medicine. 7th ed. p. 950.
Mora J, Wollner N. Primary epidural non-Hodgkin lymphoma: spinal cord compression syndrome as the initial form of presentation in childhood non- Hodgkin lymphoma. Med Pediatr Oncol. 1999;32:102–5.
Pollono D, Tomarchia S, Drut R, Ibañez O, Ferreyra M, Cédola J. Spinal cord compression: a review of 70 pediatric patients. Pediatr Hematol Oncol. 2003;20:457–66.
Pui C, Dahl GV, Hustu HO, Murphy SB. Epidural spinal cord compression as the initial finding in childhood acute leukemia and non-Hodgkin lymphoma. J Pediatr. 1985;106:788–92.
Prusakowski MK, Cannone D. Pediatric oncologic emergencies. Emerg Med Clin North Am. 2014;32:527–48.
Question 11
Fleisher’s text book of pediatric emergency medicine. 7th ed. p. 934–9.
Hunger SP, Mullighan CG. Acute lymphoblastic leukemia in children. N Engl J Med. 2015;373(16):1541–155.
Madhusoodhan P, Carroll W, Bhatla T. Progress and prospects in pediatric leukemia. Curr Probl Pediatr Adolesc Health Care. 2016;46:229–41.
Question 12
Aguilar AE, Agrawal AK, Feusner JH. Hyperleukocytosis, supportive care in pediatric oncology a practical evidence-based approach. Berlin/Heidelberg: Springer; 2015. p. 97–110.
Fleisher’s text book of pediatric emergency medicine. 7th ed. p. 938–9.
Henry M, Sung L. Supportive care in pediatric oncology: oncologic emergencies and management of fever and neutropenia. Pediatr Clin North Am. 2015;62(1):27–46.
Prusakowski MK, Cannone D. Pediatric oncologic emergencies. Emerg Med Clin North Am. 2014;32:527–48.
Question 13
Abramson SJ, Price AP. Imaging of pediatric lymphomas. Radiol Clin North Am. 2008;46:313–38.
Fleisher’s textbook of pediatric emergency medicine. 7th ed. p. 943–4.
Hastings CA, Torkildson JC, Agrawal AK. Oncologic emergencies. In: Handbook of pediatric hematology and oncology: Children’s Hospital & Research Center Oakland. 2nd ed. Oxford, UK: Wiley-Blackwell; 2012.
Prusakowski MK, Cannone D. Pediatric oncologic emergencies. Emerg Med Clin North Am. 2014;32:527–48.
Question 14
Allen CE, Kelly KM, Bollard CM. Pediatric lymphomas and histiocytic disorders of childhood. Pediatr Clin N Am. 2015;62:139–65.
Fleisher’s text book of pediatric emergency medicine. 7th ed. p. 943–4.
Perger L, Lee EY, Shamberger RC. Management of children and adolescents with a critical airway due to compression by an anterior mediastinal mass. J Pediatr Surg. 2008;43:1990–7.
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Marneni, S.R., Chamdawala, H. (2020). Hematology and Oncology. In: Waseem, M., Barata, I., Chao, J., Foster, D., Kondamudi, N. (eds) Prepare for the Pediatric Emergency Medicine Board Examination. Springer, Cham. https://doi.org/10.1007/978-3-030-28372-8_14
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