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Bacterial Signal Peptidases

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Bacterial Cell Walls and Membranes

Part of the book series: Subcellular Biochemistry ((SCBI,volume 92))

Abstract

Signal peptidases are the membrane bound enzymes that cleave off the amino-terminal signal peptide from secretory preproteins . There are two types of bacterial signal peptidases . Type I signal peptidase utilizes a serine/lysine catalytic dyad mechanism and is the major signal peptidase in most bacteria. Type II signal peptidase is an aspartic protease specific for prolipoproteins. This chapter will review what is known about the structure, function and mechanism of these unique enzymes.

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Acknowledgements

The author would like to thank Dr. Andreas Kuhn for the opportunity to contribute to this book.

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  1. Department of Molecular Biology and Biochemistry, Simon Fraser University, South Science Building 8888 University Drive, Burnaby, BC, V5A 1S6, Canada

    Mark Paetzel

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    Andreas Kuhn

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Paetzel, M. (2019). Bacterial Signal Peptidases. In: Kuhn, A. (eds) Bacterial Cell Walls and Membranes . Subcellular Biochemistry, vol 92. Springer, Cham. https://doi.org/10.1007/978-3-030-18768-2_7

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