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Bovine Tuberculosis in Ghana

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Tuberculosis in Animals: An African Perspective

Abstract

Mycobacterium bovis is not host-specific and can infect a wide range of mammals including humans. With the semi-high human immunodeficiency virus (HIV) prevalence of 1.9% in Ghana, which translates into close to 500,000 people living with HIV (PLHIV), the zoonotic risk from BTB represents a great health threat to humans. This chapter discusses the prevalence of bovine TB, the available diagnostics, bovine TB (BTB) in humans, and the control strategy and challenges in Ghana. We reviewed published data by different groups providing information about BTB in live cattle and carcasses in abattoirs and humans. Although there is limited information about the prevalence of bovine tuberculosis in Ghana, available information indicates that BTB is endemic in cattle in the country. A recent study in humans by our group confirmed a prevalence of 1% of humans infected with M. bovis. Control of BTB in Ghana is hampered by logistical constrains, inadequate governmental funding to sustain the test-and-slaughter policy, and a lack of laboratory infrastructure in the Veterinary Service Department of the Ministry of Agriculture. In addition, application of the protocol of the Economic Community of West-African States makes the control of animal movement across borders difficult and disease control almost impossible.

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References

  • Addo K, Owusu-Darko K, Yeboah-Manu D et al (2007) Mycobacterial species causing pulmonary tuberculosis at the Korle Bu Teaching Hospital, Accra, Ghana. Ghana Med J 41:52–57

    PubMed  PubMed Central  Google Scholar 

  • Alexander KA, Laver PN, Michel AL et al (2010) Novel Mycobacterium tuberculosis complex pathogen, M. mungi. Emerg Infect Dis 16:1296–1299

    Article  PubMed  PubMed Central  Google Scholar 

  • Allen BW, Mitchison DA (1992) Counts of viable tubercle bacilli in sputum related to smear and culture gradings. Med Lab Sci 49:94–96

    CAS  PubMed  Google Scholar 

  • Amemor EA (2012) Bovine tuberculosis among herdsmen, North Tongu district, Volta Region, Ghana. Doctoral dissertation, University of Ghana. http://hdl.handle.net/123456789/5573

  • Ankugah DK (2000) Prevalence of bovine tuberculosis in Ho District of Ghana. A potential for human infection. In: Proceedings of the 10th conference of the association of Institutions for Tropical Veterinary Medicine, 20–23 Aug, Copenhagen, Denmark

    Google Scholar 

  • Aranaz A, Liebana E, Gomez-Mampaso E et al (1999) Mycobacterium tuberculosis subsp. caprae subsp. nov: a taxonomic study of a new member of the Mycobacterium tuberculosis complex isolated from goats in Spain. Int J Syst Bacteriol 49:1263–1273

    Article  CAS  PubMed  Google Scholar 

  • Asante-Poku A, Aning KG, Boi-Kikimoto B et al (2014) Prevalence of bovine tuberculosis in a dairy cattle farm and research farm in Ghana. Onderstepoort J Vet Res 81:1–6

    Article  Google Scholar 

  • Asante-Poku A, Otchere ID, Danso E et al (2015) Establishment and evaluation of the genotype MTBDRplus for rapid detection of drug resistant tuberculosis in Ghana. Int J Tuberc Lung Dis 19:954–959

    Article  PubMed  Google Scholar 

  • Atiadeve SK, Gyamfi OK, Mak-Mensah E et al (2014) Slaughter surveillance for tuberculosis among cattle in three metropolitan abattoirs in Ghana. J Vet Med Anim Health 6:198–207

    Article  Google Scholar 

  • Bonsu OA, Laing E, Akanmori BD (2000) Prevalence of tuberculosis in cattle in the Dangme-West district of Ghana, public health implications. Acta Trop 76:9–14

    Article  CAS  PubMed  Google Scholar 

  • Brosch R, Gordon SV, Marmiesse M et al (2002) A new evolutionary scenario for the Mycobacterium tuberculosis complex. Proc Natl Acad Sci U S A 99:3684–3689

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cagneux S, Small PM (2008) Molecular evolution of mycobacteria. In: Rubin E, Kaufmann SHE (eds) Handbook of tuberculosis: molecular biology and biochemistry, vol 1. Wiley-VCH, Weinheim, pp 393–416

    Google Scholar 

  • Cavanagh R, Begon M, Bennett M et al (2002) Mycobacterium microti infection (vole tuberculosis) in wild rodent populations. J Clin Microbiol 40:3281–3285

    Article  PubMed  PubMed Central  Google Scholar 

  • Comas I, Gagneux S (2011) A role for systems epidemiology in tuberculosis research. Trends Microbiol 19:492–500

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Corbett EL, Watt CJ, Walker N et al (2003) The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med 163(9):1009–1021

    Article  PubMed  Google Scholar 

  • Corbett EL, Marston B, Churchyard GJ et al (2006) Tuberculosis in sub-Saharan Africa: opportunities, challenges, and change in the era of antiretroviral treatment. Lancet 367:926–937

    Article  PubMed  Google Scholar 

  • Cousins DV, Bastida R, Cataldi A et al (2003) Tuberculosis in seals caused by a novel member of the Mycobacterium tuberculosis complex: Mycobacterium pinnipedii sp. nov. Int J Syst Evol Microbiol 53:1305–1314

    Article  CAS  PubMed  Google Scholar 

  • Dungworth DL (1993) The respiratory system. In: Jubb KVH, Kennedy PC, Palmer N (eds) Pathology of domestic animals, 4th edn. Academic, San Diego, CA, pp 641–652

    Google Scholar 

  • Forrellad MA, Klepp LI, Gioffré A et al (2013) Virulence factors of the Mycobacterium tuberculosis complex. Virulence 4:3–66

    Article  PubMed  PubMed Central  Google Scholar 

  • Frota CC, Hunt DM, Buxton RS et al (2004) Genome structure in the vole bacillus, Mycobacterium microti, a member of the Mycobacterium tuberculosis complex with a low virulence for humans. Microbiology 150:1519–1527

    Article  CAS  PubMed  Google Scholar 

  • Garnier T, Eiglmeier K, Camus J-C et al (2003) The complete genome sequence of Mycobacterium bovis. Proc Natl Acad Sci U S A 100:7877–7882

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ghana Statistical Service (2012) Population and housing census

    Google Scholar 

  • Gibson AL, Hewinson G, Goodchild T et al (2004) Molecular epidemiology of disease due to Mycobacterium bovis in humans in the United Kingdom. J Clin Microbiol 42:431–434

    Article  PubMed  PubMed Central  Google Scholar 

  • Gushiegu District Report (2006) Ministry of Local Government and Rural Development. Ghana

    Google Scholar 

  • Hutchinson RA (1962) Stock methods of animal husbandry. In: Wills JB (ed) Agriculture and land use in Ghana. Oxford University Press, London, pp 425–436

    Google Scholar 

  • Karbo N, Otchere EO, Millar D et al (2004) West African shorthorn breeders association in the Saboba-Chereponi District of Ghana: formation, expectations and perceptions of members in participatory breed development. Ghana J Dev Stud 1:50–59

    Google Scholar 

  • Katale BZ, Mbugi EV, Kendal S et al (2012) Bovine tuberculosis at the human-livestock-wildlife interface: is it a public health problem in Tanzania? A review. Onderstepoort J Vet Res 79:84–97

    Article  Google Scholar 

  • Kurbatova EV, Kaminski DA, Erokhin VV et al (2012) Performance of Cepheid® Xpert MTB/RIF® and TB-Biochip® MDR in two regions of Russia with a high prevalence of drug-resistant tuberculosis. Eur J Clin Microbiol Infect Dis 32:735–743

    Article  PubMed  PubMed Central  Google Scholar 

  • Mawak J, Gomwalk N, Bello C et al (2006) Human pulmonary infections with bovine and environment (atypical) mycobacteria in Jos, Nigeria. Ghana Med J 40:132–136

    PubMed  PubMed Central  Google Scholar 

  • Menzies D (2000) Tuberculin skin testing. In: Reichman LB, Hershfield ES (eds) Tuberculosis: a comprehensive international approach. Marcel Dekker, New York, pp 279–322

    Google Scholar 

  • Ministry of Agriculture (2012) Annual report of the ministry of agriculture. Ghana

    Google Scholar 

  • MOH/GHS (2003) National tuberculosis annual report. Ghana Health Services, Ministry of Health

    Google Scholar 

  • MOH/GHS (2007) Guidelines for the clinical management of TB and HIV co-infection in Ghana

    Google Scholar 

  • Müller B, Dürr S, Alonso S et al (2013) Zoonotic Mycobacterium bovis-induced tuberculosis in humans. Emerg Infect Dis 19:899–908

    Article  PubMed  PubMed Central  Google Scholar 

  • Muvunyi CM, Masaisa F, Bayingana C et al (2010) Prevalence and diagnostic aspects of sputum smear positive tuberculosis cases at a tertiary care institution in Rwanda. Afr J Microbiol Res 4:88–91

    Google Scholar 

  • Neill SD, Pollock JM (2000) Testing for bovine tuberculosis – more than skin deep. Vet J 160:3–5

    Article  CAS  PubMed  Google Scholar 

  • Pearson JE, Schmitt B, Le Blanc SP et al (2008) Manual of diagnostic tests and vaccines for terrestrial animals (mammals, birds and bees), vol Vol 1, 6th edn. OIE, Paris, p 727

    Google Scholar 

  • Rothel JS, Jones SL, Corner LA et al (1990) A sandwich enzyme immunoassay for bovine interferon-gamma and its use for the detection of tuberculosis in cattle. Aust Vet J 67:134–137

    Article  CAS  PubMed  Google Scholar 

  • Skuce RA, Allen AR, McDowell SWJ (2011) Bovine tuberculosis (TB): a review of cattle-to-cattle transmission, risk factors and susceptibility. Thai Agricultural Commodity and Food Standard to Thai Agricultural Standard in accordance with the enforcement of the Agricultural Standards. London, UK, p 2551

    Google Scholar 

  • Teye GA, Sunkwa WK (2010) Carcass characteristics of tropical beef cattle breeds (West African shorthorn, Sanga and zebu) in Ghana. Afr J Food Agric Nutr Dev 10:2866–2886

    Google Scholar 

  • Thoen CO, Ebel ED (2006) Diagnostic tests for bovine tuberculosis. In: Thoen CO, Steele JH, Gilsdorf MJ (eds) Mycobacterium bovis infection in animals and humans, 2nd edn. Blackwell, Des Moines, IA, pp 49–53

    Chapter  Google Scholar 

  • van Ingen J, Rahim Z, Mulder A et al (2012) Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies. Emerg Infect Dis 18:653–655

    Article  PubMed  PubMed Central  Google Scholar 

  • Veterinary Services Directorate (VSD) (2010) Ministry of food and agriculture, Ghana

    Google Scholar 

  • Weiss MG, Ramakrishna J, Somma D (2006) Health-related stigma: rethinking concepts and interventions. Psychol Health Med 11:277–287

    Article  PubMed  Google Scholar 

  • Wells AQ (1937) Tuberculosis in wild voles. Lancet 229(5934):1221

    Article  Google Scholar 

  • Wells AQ (1946) The murine type of tubercle bacillus (the vole acid-fast bacillus). Spec Rep Ser Med Res Counc (G B) 259:1482–1483

    Google Scholar 

  • WHO (2014) Global tuberculosis report. World Health Organization, Geneva

    Google Scholar 

Download references

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Correspondence to Dorothy Yeboah-Manu .

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Yeboah-Manu, D., Asante-Poku, A. (2019). Bovine Tuberculosis in Ghana. In: Dibaba, A., Kriek, N., Thoen, C. (eds) Tuberculosis in Animals: An African Perspective. Springer, Cham. https://doi.org/10.1007/978-3-030-18690-6_15

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