Skip to main content

Causes of Secondary Hypertension in Children and Adolescents

  • Chapter
  • First Online:
Book cover Hypertension in Children and Adolescents

Abstract

Children, unlike adults, are more likely to have an identifiable secondary cause for hypertension. Generally, the younger the child, the greater the likelihood of finding a specific cause of hypertension. From a medical perspective, it is imperative that these children are diagnosed correctly as many of these secondary causes can be treated if not cured.

This chapter will explore the most prevalent causes of secondary hypertension in children and adolescents. Specifically, we will focus on renal parenchymal disease, renovascular hypertension, coarctation of the aorta and endocrine causes (both catecholamine and corticosteroid related). The chapter will also briefly explore the less common respiratory, medication related, monogenic and cerebral causes of secondary hypertension in children and adolescents.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Gupta-Malhotra M, Banker A, Shete S, et al. Essential hypertension vs. secondary hypertension among children. Am J Hypertens. 2015;28(1):73–80.

    Article  PubMed  Google Scholar 

  2. Wyszyńska T, Cichocka E, Wieteska-Klimczak A, Jobs K, Januszewicz P. A single pediatric center experience with 1025 children with hypertension. Acta Paediatr. 1992;81(3):244–6.

    Article  PubMed  Google Scholar 

  3. Lobeck IN, Alhajjat AM, Dupree P, et al. The management of pediatric renovascular hypertension: a single center experience and review of the literature. J Pediatr Surg. 2018;53(9):1825–31.

    Article  PubMed  Google Scholar 

  4. Tullus K. Secondary forms of hypertension. New York: Humana Press; 2011.

    Book  Google Scholar 

  5. Flynn JT. Neonatal hypertension. J Med Liban. 2010;58(3):149–55.

    PubMed  Google Scholar 

  6. Flynn JT. Evaluation and management of hypertension in childhood. Prog Pediatr Cardiol. 2001;12(2):177–88.

    Article  PubMed  Google Scholar 

  7. Quirino IG, Diniz JS, Bouzada MC, et al. Clinical course of 822 children with prenatally detected nephrouropathies. Clin J Am Soc Nephrol. 2012;7(3):444–51.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Flynn JT, Mitsnefes M, Pierce C, et al. Blood pressure in children with chronic kidney disease: a report from the chronic kidney disease in children study. Hypertension. 2008;52(4):631–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Wühl E, van Stralen KJ, Verrina E, et al. Timing and outcome of renal replacement therapy in patients with congenital malformations of the kidney and urinary tract. Clin J Am Soc Nephrol. 2013;8(1):67–74.

    Article  PubMed  Google Scholar 

  10. Baracco R, Kapur G, Mattoo T, et al. Prediction of primary vs secondary hypertension in children. J Clin Hypertens (Greenwich). 2012;14(5):316–21.

    Article  Google Scholar 

  11. Wühl E, Trivelli A, Picca S, et al. Strict blood-pressure control and progression of renal failure in children. N Engl J Med. 2009;361(17):1639–50.

    Article  PubMed  Google Scholar 

  12. Balasubramanian R, Marks SD. Post-infectious glomerulonephritis. Paediatr Int Child Health. 2017;37(4):240–7.

    Article  PubMed  Google Scholar 

  13. Mizerska-Wasiak M, Turczyn A, Such A, et al. IgA nephropathy in children: a multicenter study in Poland. Adv Exp Med Biol. 2016;952:75–84.

    Article  CAS  PubMed  Google Scholar 

  14. Dell KM. The spectrum of polycystic kidney disease in children. Adv Chronic Kidney Dis. 2011;18(5):339–47.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Guay-Woodford LM, Desmond RA. Autosomal recessive polycystic kidney disease: the clinical experience in North America. Pediatrics. 2003;111(5. Pt 1):1072–80.

    Article  PubMed  Google Scholar 

  16. Schrier RW, Abebe KZ, Perrone RD, et al. Blood pressure in early autosomal dominant polycystic kidney disease. N Engl J Med. 2014;371(24):2255–66.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  17. Krmar RT, Ferraris JR, Ramirez JA, et al. Ambulatory blood pressure monitoring after recovery from hemolytic uremic syndrome. Pediatr Nephrol. 2001;16(10):812–6.

    Article  CAS  PubMed  Google Scholar 

  18. Tullus K, Brennan E, Hamilton G, et al. Renovascular hypertension in children. Lancet. 2008;371(9622):1453–63.

    Article  CAS  PubMed  Google Scholar 

  19. Marks SD, Tullus K. Update on imaging for suspected renovascular hypertension in children and adolescents. Curr Hypertens Rep. 2012;14(6):591–5.

    Article  CAS  PubMed  Google Scholar 

  20. Sadowski RH, Falkner B. Hypertension in pediatric patients. Am J Kidney Dis. 1996;27(3):305–15.

    Article  CAS  PubMed  Google Scholar 

  21. Daniels SR, Loggie JM, McEnery PT, Towbin RB. Clinical spectrum of intrinsic renovascular hypertension in children. Pediatrics. 1987;80(5):698–704.

    CAS  PubMed  Google Scholar 

  22. Deal JE, Snell MF, Barratt TM, Dillon MJ. Renovascular disease in childhood. J Pediatr. 1992;121(3):378–84.

    Article  CAS  PubMed  Google Scholar 

  23. Rumman RK, Matsuda-Abedini M, Langlois V, et al. Management and outcomes of childhood renal artery stenosis and middle aortic syndrome. Am J Hypertens. 2018;31(6):687–95.

    Article  PubMed  Google Scholar 

  24. Vo NJ, Hammelman BD, Racadio JM, Strife CF, Johnson ND. Anatomic distribution of renal artery stenosis in children: implications for imaging. Pediatr Radiol. 2006;36(10):1032–6.

    Article  PubMed  Google Scholar 

  25. Baek JW, Jo KI, Park JJ, Jeon P, Kim KH. Prevalence and clinical implications of renal artery stenosis in pediatric moyamoya disease. Eur J Paediatr Neurol. 2016;20(1):20–4.

    Article  PubMed  Google Scholar 

  26. Tullus K. Renovascular hypertension—is it fibromuscular dysplasia or Takayasu arteritis. Pediatr Nephrol. 2013;28(2):191–6.

    Article  PubMed  Google Scholar 

  27. Stanley JC, Zelenock GB, Messina LM, Wakefield TW. Pediatric renovascular hypertension: a thirty-year experience of operative treatment. J Vasc Surg. 1995;21(2):212–26; discussion 226-217

    Article  CAS  PubMed  Google Scholar 

  28. Stanley JC, Criado E, Upchurch GR, et al. Pediatric renovascular hypertension: 132 primary and 30 secondary operations in 97 children. J Vasc Surg. 2006;44(6):1219–28; discussion 1228-1219

    Article  PubMed  Google Scholar 

  29. Tyagi S, Gupta MD, Singh P, Shrimal D, Girish MP. Percutaneous revascularization of sole arch artery for severe cerebral ischemia resulting from Takayasu arteritis. J Vasc Interv Radiol. 2008;19(12):1699–703.

    Article  PubMed  Google Scholar 

  30. Kumar S, Parmar KM, Prasad S, Rani J. Malignant pelvic pheochromocytoma presenting as nonfunctioning kidney and accelerated hypertension: a rare presentation. Case Rep Nephrol. 2014;2014:985615.

    PubMed  PubMed Central  Google Scholar 

  31. Bayazit AK, Yalcinkaya F, Cakar N, et al. Reno-vascular hypertension in childhood: a nationwide survey. Pediatr Nephrol. 2007;22(9):1327–33.

    Article  PubMed  Google Scholar 

  32. Slovut DP, Olin JW. Fibromuscular dysplasia. N Engl J Med. 2004;350(18):1862–71.

    Article  CAS  PubMed  Google Scholar 

  33. Stanley JC, Fry WJ. Pediatric renal artery occlusive disease and renovascular hypertension. Etiology, diagnosis, and operative treatment. Arch Surg. 1981;116(5):669–76.

    Article  CAS  PubMed  Google Scholar 

  34. Dillon MJ. The diagnosis of renovascular disease. Pediatr Nephrol. 1997;11(3):366–72.

    Article  CAS  PubMed  Google Scholar 

  35. Shroff R, Roebuck DJ, Gordon I, et al. Angioplasty for renovascular hypertension in children: 20-year experience. Pediatrics. 2006;118(1):268–75.

    Article  PubMed  Google Scholar 

  36. Kari JA, Roebuck DJ, McLaren CA, et al. Angioplasty for renovascular hypertension in 78 children. Arch Dis Child. 2015;100(5):474–8.

    Article  PubMed  Google Scholar 

  37. Lurbe E, Agabiti-Rosei E, Cruickshank JK, et al. 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens. 2016;34(10):1887–920.

    Article  CAS  PubMed  Google Scholar 

  38. Candel-Pau J, Castilla-Fernández Y, Madrid-Aris A, et al. Hypertension and segmental renal infarction in children: apropos of two cases. Pediatr Nephrol. 2008;23(5):841–5.

    Article  PubMed  Google Scholar 

  39. Kaneko K, Shimazaki S, Ino T, Yabuta K, Nakazawa T, Takahashi H. Severe hyponatremia in a patient with renovascular hypertension: case report. Nephron. 1994;68(2):252–5.

    Article  CAS  PubMed  Google Scholar 

  40. Trautmann A, Roebuck DJ, McLaren CA, Brennan E, Marks SD, Tullus K. Non-invasive imaging cannot replace formal angiography in the diagnosis of renovascular hypertension. Pediatr Nephrol. 2017;32(3):495–502.

    Article  PubMed  Google Scholar 

  41. Tullus K. Renal artery stenosis: is angiography still the gold standard in 2011? Pediatr Nephrol. 2011;26(6):833–7.

    Article  PubMed  Google Scholar 

  42. Garel L, Dubois J, Robitaille P, et al. Renovascular hypertension in children: curability predicted with negative intrarenal Doppler US results. Radiology. 1995;195(2):401–5.

    Article  CAS  PubMed  Google Scholar 

  43. Baxter GM, Aitchison F, Sheppard D, et al. Colour Doppler ultrasound in renal artery stenosis: intrarenal waveform analysis. Br J Radiol. 1996;69(825):810–5.

    Article  CAS  PubMed  Google Scholar 

  44. Castelli PK, Dillman JR, Kershaw DB, Khalatbari S, Stanley JC, Smith EA. Renal sonography with Doppler for detecting suspected pediatric renin-mediated hypertension - is it adequate? Pediatr Radiol. 2014;44(1):42–9.

    Article  PubMed  Google Scholar 

  45. Abdulsamea S, Anderson P, Biassoni L, et al. Pre- and postcaptopril renal scintigraphy as a screening test for renovascular hypertension in children. Pediatr Nephrol. 2010;25(2):317–22.

    Article  PubMed  Google Scholar 

  46. Eklöf H, Ahlström H, Magnusson A, et al. A prospective comparison of duplex ultrasonography, captopril renography, MRA, and CTA in assessing renal artery stenosis. Acta Radiol. 2006;47(8):764–74.

    Article  PubMed  Google Scholar 

  47. Rountas C, Vlychou M, Vassiou K, et al. Imaging modalities for renal artery stenosis in suspected renovascular hypertension: prospective intraindividual comparison of color Doppler US, CT angiography, GD-enhanced MR angiography, and digital subtraction angiography. Ren Fail. 2007;29(3):295–302.

    Article  CAS  PubMed  Google Scholar 

  48. Dillon MJ, Shah V, Barratt TM. Renal vein renin measurements in children with hypertension. Br Med J. 1978;2(6131):168–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Goonasekera CD, Shah V, Wade AM, Dillon MJ. The usefulness of renal vein renin studies in hypertensive children: a 25-year experience. Pediatr Nephrol. 2002;17(11):943–9.

    Article  PubMed  Google Scholar 

  50. Tullus K, Roebuck DJ, McLaren CA, Marks SD. Imaging in the evaluation of renovascular disease. Pediatr Nephrol. 2010;25(6):1049–56.

    Article  PubMed  Google Scholar 

  51. Lindblad B. Renovascular hypertension in children - time to further centralise handling? Eur J Vasc Endovasc Surg. 2011;41(6):778–9.

    Article  CAS  PubMed  Google Scholar 

  52. Huang Y, Duncan AA, McKusick MA, et al. Renal artery intervention in pediatric and adolescent patients: a 20-year experience. Vasc Endovasc Surg. 2007;41(6):490–9.

    Article  Google Scholar 

  53. Alexander A, Richmond L, Geary D, Salle JL, Amaral J, Connolly B. Outcomes of percutaneous transluminal angioplasty for pediatric renovascular hypertension. J Pediatr Surg. 2017;52(3):395–9.

    Article  PubMed  Google Scholar 

  54. Jariwala P. Paediatric renal intervention using drug eluting stents for resistant renovascular hypertension secondary to Takayasu’s aortoarteritis: a new ray of hope. J Indian Coll Cardiol. 2017;7:169–71.

    Article  Google Scholar 

  55. Lacombe M. Surgical treatment of renovascular hypertension in children. Eur J Vasc Endovasc Surg. 2011;41(6):770–7.

    Article  CAS  PubMed  Google Scholar 

  56. Tse Y, Marks SD, Brennan E, et al. Renal artery revascularisation can restore kidney function with absent radiotracer uptake. Pediatr Nephrol. 2012;27(11):2153–7.

    Article  PubMed  Google Scholar 

  57. Duprey A, Chavent B, Meyer-Bisch V, et al. Editor’s choice - ex vivo renal artery repair with kidney autotransplantation for renal artery branch aneurysms: long-term results of sixty-seven procedures. Eur J Vasc Endovasc Surg. 2016;51(6):872–9.

    Article  CAS  PubMed  Google Scholar 

  58. Bleacher J, Turner ME, Quivers E, Schwartz MZ. Renal autotransplantation for renovascular hypertension caused by midaortic syndrome. J Pediatr Surg. 1997;32(2):248–50; discussion 250-241

    Article  CAS  PubMed  Google Scholar 

  59. Kimura H, Sato O, Deguchi JO, Miyata T. Surgical treatment and long-term outcome of renovascular hypertension in children and adolescents. Eur J Vasc Endovasc Surg. 2010;39(6):731–7.

    Article  CAS  PubMed  Google Scholar 

  60. Rumman RK, Nickel C, Matsuda-Abedini M, et al. Disease beyond the arch: a systematic review of middle aortic syndrome in childhood. Am J Hypertens. 2015;28(7):833–46.

    Article  PubMed  Google Scholar 

  61. Porras D, Stein DR, Ferguson MA, et al. Midaortic syndrome: 30 years of experience with medical, endovascular and surgical management. Pediatr Nephrol. 2013;28(10):2023–33.

    Article  PubMed  Google Scholar 

  62. Gillett C, Wong A, Wilson DG, Wolf AR, Martin RP, Kenny D. Underrecognition of elevated blood pressure readings in children after early repair of coarctation of the aorta. Pediatr Cardiol. 2011;32(2):202–5.

    Article  PubMed  Google Scholar 

  63. Vigneswaran TV, Sinha MD, Valverde I, Simpson JM, Charakida M. Hypertension in coarctation of the aorta: challenges in diagnosis in children. Pediatr Cardiol. 2018;39(1):1–10.

    Article  PubMed  Google Scholar 

  64. Head CE, Jowett VC, Sharland GK, Simpson JM. Timing of presentation and postnatal outcome of infants suspected of having coarctation of the aorta during fetal life. Heart. 2005;91(8):1070–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Torok R. Coarctation of the aorta: management from infancy to adulthood. World J Cardiol. 2015;7:765–75.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Feltes TF, Bacha E, Beekman RH, et al. Indications for cardiac catheterization and intervention in pediatric cardiac disease: a scientific statement from the American Heart Association. Circulation. 2011;123(22):2607–52.

    Article  PubMed  Google Scholar 

  67. Meadows J, Minahan M, McElhinney DB, McEnaney K, Ringel R, COAST Investigators. Intermediate outcomes in the prospective, Multicenter Coarctation of the Aorta Stent Trial (COAST). Circulation. 2015;131(19):1656–64.

    Article  PubMed  Google Scholar 

  68. Forbes TJ, Kim DW, Du W, et al. Comparison of surgical, stent, and balloon angioplasty treatment of native coarctation of the aorta: an observational study by the CCISC (Congenital Cardiovascular Interventional Study Consortium). J Am Coll Cardiol. 2011;58(25):2664–74.

    Article  PubMed  Google Scholar 

  69. Rinnström D, Dellborg M, Thilén U, et al. Hypertension in adults with repaired coarctation of the aorta. Am Heart J. 2016;181:10–5.

    Article  PubMed  Google Scholar 

  70. Brown ML, Burkhart HM, Connolly HM, et al. Coarctation of the aorta: lifelong surveillance is mandatory following surgical repair. J Am Coll Cardiol. 2013;62(11):1020–5.

    Article  PubMed  Google Scholar 

  71. Havekes B, Romijn JA, Eisenhofer G, Adams K, Pacak K. Update on pediatric pheochromocytoma. Pediatr Nephrol. 2009;24(5):943–50.

    Article  PubMed  Google Scholar 

  72. Londe S. Causes of hypertension in the young. Pediatr Clin N Am. 1978;25(1):55–65.

    Article  CAS  Google Scholar 

  73. Lenders JW, Eisenhofer G, Mannelli M, Pacak K. Phaeochromocytoma. Lancet. 2005;366(9486):665–75.

    Article  PubMed  Google Scholar 

  74. Joynt KE, Moslehi JJ, Baughman KL. Paragangliomas: etiology, presentation, and management. Cardiol Rev. 2009;17(4):159–64.

    Article  PubMed  Google Scholar 

  75. Pamporaki C, Hamplova B, Peitzsch M, et al. Characteristics of Pediatric vs Adult Pheochromocytomas and Paragangliomas. J Clin Endocrinol Metab. 2017;102(4):1122–32.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Bausch B, Wellner U, Bausch D, et al. Long-term prognosis of patients with pediatric pheochromocytoma. Endocr Relat Cancer. 2014;21(1):17–25.

    Article  PubMed  Google Scholar 

  77. Fishbein L, Merrill S, Fraker DL, Cohen DL, Nathanson KL. Inherited mutations in pheochromocytoma and paraganglioma: why all patients should be offered genetic testing. Ann Surg Oncol. 2013;20(5):1444–50.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Pham TH, Moir C, Thompson GB, et al. Pheochromocytoma and paraganglioma in children: a review of medical and surgical management at a tertiary care center. Pediatrics. 2006;118(3):1109–17.

    Article  PubMed  Google Scholar 

  79. Chen H, Sippel RS, O’Dorisio MS, et al. The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas. 2010;39(6):775–83.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Stratakis CA, Carney JA. The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications. J Intern Med. 2009;266(1):43–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Stratakis CA. New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors. Mol Cell Endocrinol. 2009;300(1–2):152–7.

    Article  CAS  PubMed  Google Scholar 

  82. Bholah R, Bunchman TE. Review of pediatric pheochromocytoma and paraganglioma. Front Pediatr. 2017;5:155.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Januszewicz P, Wieteska-Klimczak A, Wyszyńska T. Pheochromocytoma in children: difficulties in diagnosis and localization. Clin Exp Hypertens A. 1990;12(4):571–9.

    CAS  PubMed  Google Scholar 

  84. Ludwig AD, Feig DI, Brandt ML, Hicks MJ, Fitch ME, Cass DL. Recent advances in the diagnosis and treatment of pheochromocytoma in children. Am J Surg. 2007;194(6):792–6; discussion 796-797

    Article  CAS  PubMed  Google Scholar 

  85. Jain V, Yadav J, Satapathy AK. Pheochromocytoma presenting as diabetes insipidus. Indian Pediatr. 2013;50(11):1056–7.

    Article  PubMed  Google Scholar 

  86. Walther MM, Reiter R, Keiser HR, et al. Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma. J Urol. 1999;162(3 Pt 1):659–64.

    Article  CAS  PubMed  Google Scholar 

  87. Pomares FJ, Cañas R, Rodriguez JM, Hernandez AM, Parrilla P, Tebar FJ. Differences between sporadic and multiple endocrine neoplasia type 2A phaeochromocytoma. Clin Endocrinol. 1998;48(2):195–200.

    Article  CAS  Google Scholar 

  88. Eisenhofer G, Goldstein DS, Sullivan P, et al. Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine. J Clin Endocrinol Metab. 2005;90(4):2068–75.

    Article  CAS  PubMed  Google Scholar 

  89. Weise M, Merke DP, Pacak K, Walther MM, Eisenhofer G. Utility of plasma free metanephrines for detecting childhood pheochromocytoma. J Clin Endocrinol Metab. 2002;87(5):1955–60.

    Article  CAS  PubMed  Google Scholar 

  90. Pacak K, Linehan WM, Eisenhofer G, Walther MM, Goldstein DS. Recent advances in genetics, diagnosis, localization, and treatment of pheochromocytoma. Ann Intern Med. 2001;134(4):315–29.

    Article  CAS  PubMed  Google Scholar 

  91. Levine DS, Metzger DL, Nadel HR, Oviedo A, Adam MJ, Skarsgard E. Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome. Pediatr Radiol. 2011;41(10):1321–5.

    Article  PubMed  Google Scholar 

  92. Romero M, Kapur G, Baracco R, Valentini RP, Mattoo TK, Jain A. Treatment of hypertension in children with catecholamine-secreting tumors: a systematic approach. J Clin Hypertens (Greenwich). 2015;17(9):720–5.

    Article  CAS  Google Scholar 

  93. Pacak K, Eisenhofer G, Ahlman H, et al. Pheochromocytoma: recommendations for clinical practice from the First International Symposium. October 2005. Nat Clin Pract Endocrinol Metab. 2007;3(2):92–102.

    Article  PubMed  Google Scholar 

  94. Hack HA. The perioperative management of children with phaeochromocytoma. Paediatr Anaesth. 2000;10(5):463–76.

    Article  CAS  PubMed  Google Scholar 

  95. Caballero R, Pirmohamed R, Wright JA. Use of alpha-methyl-tyrosine for refractory hypertension in a child with neuroblastoma. Crit Care Med. 1992;20(7):1060–2.

    Article  CAS  PubMed  Google Scholar 

  96. King KS, Prodanov T, Kantorovich V, et al. Metastatic pheochromocytoma/paraganglioma related to primary tumor development in childhood or adolescence: significant link to SDHB mutations. J Clin Oncol. 2011;29(31):4137–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Libuit LG, Karageorgiadis AS, Sinaii N, et al. A gender-dependent analysis of Cushing’s disease in childhood: pre- and postoperative follow-up. Clin Endocrinol. 2015;83(1):72–7.

    Article  Google Scholar 

  98. Stratakis CA. Cushing syndrome caused by adrenocortical tumors and hyperplasias (corticotropin- independent Cushing syndrome). Endocr Dev. 2008;13:117–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Stratakis CA. Cushing syndrome in pediatrics. Endocrinol Metab Clin N Am. 2012;41(4):793–803.

    Article  Google Scholar 

  100. Onder A, Kendirci HN, Bas VN, Agladioglu SY, Cetinkaya S, Aycan Z. A pediatric Conn syndrome case. J Pediatr Endocrinol Metab. 2012;25(1–2):203–6.

    PubMed  Google Scholar 

  101. Trnka P, Orellana L, Walsh M, Pool L, Borzi P. Reninoma: an uncommon cause of renin-mediated hypertension. Front Pediatr. 2014;2:89.

    Article  PubMed  PubMed Central  Google Scholar 

  102. Maccabee-Ryaboy N, Thomas W, Kyllo J, et al. Hypertension in children with congenital adrenal hyperplasia. Clin Endocrinol. 2016;85(4):528–34.

    Article  CAS  Google Scholar 

  103. Flynn JT. Hypertension in the neonatal period. Curr Opin Pediatr. 2012;24(2):197–204.

    Article  PubMed  Google Scholar 

  104. Hinkle J, Connolly HV, Adams HR, Lande MB. Severe obstructive sleep apnea in children with elevated blood pressure. J Am Soc Hypertens. 2018;12(3):204–10.

    Article  PubMed  PubMed Central  Google Scholar 

  105. Lee CH, Kang KT, Chiu SN, et al. Association of adenotonsillectomy with blood pressure among hypertensive and nonhypertensive children with obstructive sleep apnea. JAMA Otolaryngol Head Neck Surg. 2018;144(4):300–7.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Aronow WS. Drug-induced causes of secondary hypertension. Ann Transl Med. 2017;5(17):349.

    Article  PubMed  PubMed Central  Google Scholar 

  107. Cortese S, Holtmann M, Banaschewski T, et al. Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. J Child Psychol Psychiatry. 2013;54(3):227–46.

    Article  PubMed  Google Scholar 

  108. Grossman E, Messerli FH. Drug-induced hypertension: an unappreciated cause of secondary hypertension. Am J Med. 2012;125(1):14–22.

    Article  CAS  PubMed  Google Scholar 

  109. Kapur G, Baracco R. Evaluation of hypertension in children. Curr Hypertens Rep. 2013;15(5):433–43.

    Article  CAS  PubMed  Google Scholar 

  110. Brady TM, Feld LG. Pediatric approach to hypertension. Semin Nephrol. 2009;29(4):379–88.

    Article  PubMed  Google Scholar 

  111. Chiong JR, Aronow WS, Khan IA, et al. Secondary hypertension: current diagnosis and treatment. Int J Cardiol. 2008;124(1):6–21.

    Article  PubMed  Google Scholar 

  112. Aggarwal A, Rodriguez-Buritica D. Monogenic hypertension in children: a review with emphasis on genetics. Adv Chronic Kidney Dis. 2017;24(6):372–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kjell Tullus .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Lalji, R., Tullus, K. (2019). Causes of Secondary Hypertension in Children and Adolescents. In: Lurbe, E., Wühl, E. (eds) Hypertension in Children and Adolescents. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-030-18167-3_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-18167-3_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-18166-6

  • Online ISBN: 978-3-030-18167-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics