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Surgery and Multimodality Treatment in Malignant Pleural Mesothelioma

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Mesothelioma

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Abstract

Malignant pleural mesothelioma (MPM) is an aggressive neoplasia with a poor prognosis. The optimal treatment of MPM is still a matter of debate and yet today there is no effective therapy for this tumor. Multimodality treatments, including the association of induction and/or adjuvant therapeutic regimens with surgery, have been reported to give encouraging results.

The aim of surgical approach is to obtain a maximal cytoreduction and/or to control the symptoms, however its curative role/potential is still controversial in the management of this neoplasia. Surgical options include extrapleural pneumonectomy (EPP) and pleurectomy/decortication (P/D).

Today it is well known that multimodality therapy offers acceptable outcomes, with better results reported for trimodality treatment, even though each therapeutic option has some specific advantages and drawbacks that should be taken into consideration.

Individualization of care for each patient is mandatory in choosing the most appropriate treatment to minimize the complications and to maximize the benefits.

The aim of this chapter is to give an overview on the current state of multimodality treatment in MPM.

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Authors and Affiliations

  1. Thoracic Surgery Unit, Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy

    Federico Rea, Eleonora Faccioli & Giuseppe Marulli

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  1. Federico Rea
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  2. Eleonora Faccioli
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  3. Giuseppe Marulli
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Correspondence to Federico Rea .

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Editors and Affiliations

  1. Department of Medical Oncology, Humanitas Gavazzeni Hospital, Bergamo, Italy

    Giovanni Luca Ceresoli

  2. Scientific Direction, Humanitas Gavazzeni Hospital, Bergamo, Italy

    Emilio Bombardieri

  3. Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy

    Maurizio D'Incalci

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Rea, F., Faccioli, E., Marulli, G. (2019). Surgery and Multimodality Treatment in Malignant Pleural Mesothelioma. In: Ceresoli, G., Bombardieri, E., D'Incalci, M. (eds) Mesothelioma. Springer, Cham. https://doi.org/10.1007/978-3-030-16884-1_13

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