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Nanoparticle-Cell Interactions: Overview of Uptake, Intracellular Fate and Induction of Cell Responses

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Book cover Biological Responses to Nanoscale Particles

Part of the book series: NanoScience and Technology ((NANO))

Abstract

The range of engineered nanoparticles (NPs) designed as specific carriers for biomedical applications, e.g. cell targeting and drug delivery, is still on the raise and the question on how NPs are interacting with single cells and sub-cellular structures remains important. The delivery to the cell surface as well as the interaction of NPs with cellular structures with possible subsequent response is highly influenced by various parameters such as (a) the physico-chemical properties of the NPs, (b) the cell and tissue type and (c) the intracellular fate of the NPs in the various organelles including biopersistence, exocytosis and/or transfer to other cells. The aim of this book chapter is to discuss, on the basis of existing literature, the interaction of NPs with single cells including the intracellular fate and their interference with signaling pathways.

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Acknowledgements

We would like to acknowledge the Swiss National Science Foundation (310030_159847/1), the National Center of Competence in Research for Bio-Inspired Materials and the Adolphe Merkle Foundation for financial support. We kindly thank Dr. Miguel Spuch Calvar for the graphical design.

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Authors and Affiliations

  1. BioNanomaterials, Adolphe Merkle Institute, Chemin des Verdiers 4, 1700, Fribourg, Switzerland

    Barbara Rothen-Rutishauser, Joël Bourquin & Alke Petri-Fink

  2. Department of Chemistry, University of Fribourg, Chemin du Museé 9, 1700, Fribourg, Switzerland

    Alke Petri-Fink

Authors
  1. Barbara Rothen-Rutishauser
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  2. Joël Bourquin
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  3. Alke Petri-Fink
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Correspondence to Barbara Rothen-Rutishauser .

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Editors and Affiliations

  1. Institute of Anatomy, University of Bern, Bern, Switzerland

    Peter Gehr

  2. Institute of Physical Chemistry, University of Duisburg-Essen, Essen, Germany

    Reinhard Zellner

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Rothen-Rutishauser, B., Bourquin, J., Petri-Fink, A. (2019). Nanoparticle-Cell Interactions: Overview of Uptake, Intracellular Fate and Induction of Cell Responses. In: Gehr, P., Zellner, R. (eds) Biological Responses to Nanoscale Particles. NanoScience and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-12461-8_6

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