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Symptomatic and cryptogenic (probably symptomatic) focal epilepsies

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A Clinical Guide to Epileptic Syndromes and their Treatment

Abstract

Focal (anatomical, topographical or localisation related) epilepsies manifest with seizures that emanate from an epileptogenic focus anywhere within the brain.1 Ictal symptoms, particularly at onset, are determined by localisation and not aetiology. However, specific anatomical localisation is sometimes difficult, as, for example, when seizures originate from clinically silent epileptogenic regions.

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References

  1. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389–399.

    Google Scholar 

  2. Engel J, Jr. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: Report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001;42:796–803.

    PubMed  Google Scholar 

  3. Engel J, Jr. Report of the ILAE Classification Core Group. Epilepsia 2006;47:1558–1568.

    PubMed  Google Scholar 

  4. Banerjee PN, Hauser WA. Incidence and prevalence of epilepsy. In: Engel J, Jr., Pedley TA, eds. Epilepsy: a comprehensive textbook. Second Edition, pp 45–56. Philadelphia: Lippincott Williams and Wilkins, 2008.

    Google Scholar 

  5. Crawford PM. Epidemiology of intractable focal epilepsy. In: Oxbury JM, Polkey CE, Duchowny M, eds. Intractable focal epilepsy, pp 25–40. London: W. B. Saunders, 2000.

    Google Scholar 

  6. Wiebe S. Epidemiology of temporal lobe epilepsy. Can J Neurol Sci 2000;27Suppl 1:S6–S10.

    PubMed  Google Scholar 

  7. Sisodiya SM. Malformations of cortical development: burdens and insights from important causes of human epilepsy. Lancet Neurol 2004;3:29–38.

    PubMed  Google Scholar 

  8. Panayiotopoulos CP, Benbadis SR, Sisodiya S (eds). Focal Epilepsies, Vol 5. Seizures and syndromes. Oxford: Medicinae, 2008.

    Google Scholar 

  9. Panayiotopoulos CP, Benbadis SR, Sisodiya S (eds). Focal Epilepsies, Vol 5. Aetiology, diagnostic procedures and management. Oxford: Medicinae, 2008.

    Google Scholar 

  10. van Buren JM. The abdominal aura: a study of abdominal sensations occurring in epilepsy and produced by depth stimulation. Electroencephalogr Clin Neurophysiol 1963;15:1–19.

    Google Scholar 

  11. Duncan JS, Sagar HJ. Seizure characteristics, pathology, and outcome after temporal lobectomy. Neurology 1987;37:405–409.

    PubMed  CAS  Google Scholar 

  12. French JA, Williamson PD, Thadani VM, Darcey TM, Mattson RH, Spencer SS, et al. Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann Neurol 1993;34:774–780.

    PubMed  CAS  Google Scholar 

  13. Fisher RS, van Emde BW, Blume W, Elger C, Genton P, Lee P, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 2005;46:470–472.

    PubMed  Google Scholar 

  14. Gloor P, Olivier A, Quesney LF, Andermann F, Horowitz S. The role of the limbic system in experiential phenomena of temporal lobe epilepsy. Ann Neurol 1982;12:129–144.

    PubMed  CAS  Google Scholar 

  15. Bancaud J, Brunet-Bourgin F, Chauvel P, Halgren E. Anatomical origin of deja vu and vivid ‘memories’ in human temporal lobe epilepsy. Brain 1994:117 Pt 1:71–90.

    PubMed  Google Scholar 

  16. Adachi N, Koutroumanidis M, Elwes RD, Polkey CE, Binnie CD, Reynolds EH, et al. Interictal 18FDG PET findings in temporal lobe epilepsy with deja vu. J Neuropsychiatry Clin Neurosci 1999;11:380–386.

    PubMed  CAS  Google Scholar 

  17. Gloor P. Experiential phenomena of temporal lobe epilepsy. Facts and hypotheses. Brain 1990;113 Pt 6:1673–1694.

    PubMed  Google Scholar 

  18. Penfield W, Jasper HH. Epilepsy and the functional anatomy of the human brain. Boston: Little, Brown & Co., 1954.

    Google Scholar 

  19. Wieser HG, Mazzola G. Musical consonances and dissonances: are they distinguished independently by the right and left hippocampi? Neuropsychologia 1986;24:805–812.

    PubMed  CAS  Google Scholar 

  20. Wieser HG, Walter R. Untroubled musical judgement of a performing organist during early epileptic seizure of the right temporal lobe. Neuropsychologia 1997;35:45–51.

    PubMed  CAS  Google Scholar 

  21. Lennox WG, Lennox MA. Epilepsy and related disorders. Boston: Little, Brown & Co., 1960.

    Google Scholar 

  22. Acharya V, Acharya J, Luders H. Olfactory epileptic auras. Neurology 1998;51:56–61.

    PubMed  CAS  Google Scholar 

  23. Ebner A, Kerdar MS. Olfactory and gustatory auras. In: Luders HO, Noachtar S, eds. Epileptic seizures. Pathophysiology and clinical semiology, pp 313–319. New York: Churchill Livingstone, 2000.

    Google Scholar 

  24. Chen C, Shih YH, Yen DJ, Lirng JF, Guo YC, Yu HY, et al. Olfactory auras in patients with temporal lobe epilepsy. Epilepsia 2003;44:257–260.

    PubMed  Google Scholar 

  25. Van Paesschen W, King MD, Duncan JS, Connelly A. The amygdala and temporal lobe simple partial seizures: a prospective and quantitative MRI study. Epilepsia 2001;42:857–862.

    PubMed  Google Scholar 

  26. Hausser-Hauw C, Bancaud J. Gustatory hallucinations in epileptic seizures. Electrophysiological, clinical and anatomical correlates. Brain 1987;110 Pt 2:339–359.

    PubMed  Google Scholar 

  27. Holmes G. Sabill memorial oration on focal epilepsy. Lancet 1927;i:957–962.

    Google Scholar 

  28. Manford M, Fish DR, Shorvon SD. An analysis of clinical seizure patterns and their localizing value in frontal and temporal lobe epilepsies. Brain 1996;119 Pt 1:17–40.

    PubMed  Google Scholar 

  29. Dantas FG, Yacubian EM, Jorge CL, Pedreira CC, Bueno JF, Valerio RM. Clinical and EEG analysis of mesial and lateral temporal lobe seizures. Arq Neuropsiquiatr 1998;56:341–349.

    PubMed  CAS  Google Scholar 

  30. Fakhoury T, Abou-Khalil B, Peguero E. Differentiating clinical features of right and left temporal lobe seizures. Epilepsia 1994;35:1038–1044.

    PubMed  CAS  Google Scholar 

  31. Duchowny M, Jayakar P, Resnick T, Levin B, Alvarez L. Posterior temporal epilepsy: electroclinical features. Ann Neurol 1994;35:427–431.

    PubMed  CAS  Google Scholar 

  32. Engel J, Jr., Williamson PD, Wieser HG. Mesial temporal lobe epilepsy with hippocampal sclerosis. In: Engel JJ, Pedley TA, eds. Epilepsy: A comprehensive textbook, Second Edition. pp 2487–2493. Philadelphia: Lippincott william and Wilkins, 2008.

    Google Scholar 

  33. Yang X, Chen L, Liu Y et al. Motor trajectories in automatisms and their quantitative analysis. Epilepsy Res 2009;83:97–102.

    PubMed  Google Scholar 

  34. Kotagal P, Luders HO, Williams G, Nichols TR, McPherson J. Psychomotor seizures of temporal lobe onset: analysis of symptom clusters and sequences. Epilepsy Res 1995;20:49–67.

    PubMed  CAS  Google Scholar 

  35. Blume WT, Luders HO, Mizrahi E, Tassinari C, van Emde BW, Engel J, Jr. Glossary of descriptive terminology for ictal semiology: report of the ILAE task force on classification and terminology. Epilepsia 2001;42:1212–1218.

    PubMed  CAS  Google Scholar 

  36. Jackson JH. On the anatomical,physiological and pathological investigation of the epilepsies. West Riding Lunatic Asylum Medical Reports 1873;3:315–339 (In: Taylor J, ed. Selected writings of John Hughlings Jackson, pp 90–111. London: Hodder and Stoughton, 1958).

    Google Scholar 

  37. Jackson HJ. On temporary mental disorders after epilepsy paroxysms. West Riding Lunatic Asylum Medical Reports 1875;v:-(In: Taylor J, ed. Selected writings of John Hughlings Jackson, pp 119–134. London: Hodder and Stoughton, 1958).

    Google Scholar 

  38. Gastaut H. Dictionary of epilepsies. Part I: definitions. Geneva: World Health Organisation, 1973.

    Google Scholar 

  39. Williamson PD, Thadani VM, French JA, Darcey TM, Mattson RH, Spencer SS, et al. Medial temporal lobe epilepsy: videotape analysis of objective clinical seizure characteristics. Epilepsia 1998;39:1182–1188.

    PubMed  CAS  Google Scholar 

  40. Yen DJ, Su MS, Yiu CH, Shih, Kwan SY, Tsai CP, et al. Ictal speech manifestations in temporal lobe epilepsy: a video-EEG study. Epilepsia 1996;37:45–49.

    PubMed  CAS  Google Scholar 

  41. Panayiotopoulos CP. The epilepsies: seizures, syndromes and management. Oxford: Bladon Medical Publishing, 2009.

    Google Scholar 

  42. Hecker A, Andermann F, Rodin EA. Spitting automatism in temporal lobe seizures with a brief review of ethological and phylogenetic aspects of spitting. Epilepsia 1972;13:767–772.

    PubMed  CAS  Google Scholar 

  43. Sussman NM, Jackel RA, Kaplan LR, Harner RN. Bicycling movements as a manifestation of complex partial seizures of temporal lobe origin. Epilepsia 1989;30:527–531.

    PubMed  CAS  Google Scholar 

  44. Remillard GM, Andermann F, Testa GF, Gloor P, Aube M, Martin JB, et al. Sexual ictal manifestations predominate in women with temporal lobe epilepsy: a finding suggesting sexual dimorphism in the human brain. Neurology 1983;33:323–330.

    PubMed  CAS  Google Scholar 

  45. Wieser HG, Hajek M, Gooss A, Aguzzi A. Mesial temporal lobe epilepsy syndrome with hippocampal and amygdala sclerosis. In: Oxbury JM, Polkey CE, Duchowny M, eds. Intractable focal epilepsy, pp 131–158. London: W.B. Saunders, 2000.

    Google Scholar 

  46. Elger CE. Semiology of temporal lobe seizures. In: Oxbury JM, Polkey CE, Duchowny M, eds. Intractable focal epilepsy, pp 63–68. London: W. B. Saunders, 2000.

    Google Scholar 

  47. Serles W, Pataraia E, Bacher J, Olbrich A, Aull S, Lehrner J, et al. Clinical seizure lateralization in mesial temporal lobe epilepsy: differences between patients with unitemporal and bitemporal interictal spikes. Neurology 1998;50:742–747.

    PubMed  CAS  Google Scholar 

  48. Scott CA, Fish DR. Cardiac asystole in partial seizures. Epileptic Disord 2000;2:89–92.

    PubMed  CAS  Google Scholar 

  49. Ansakorpi H, Korpelainen JT, Suominen K, Tolonen U, Myllyla VV, Isojarvi JI. Interictal cardiovascular autonomic responses in patients with temporal lobe epilepsy. Epilepsia 2000;41:42–47.

    PubMed  CAS  Google Scholar 

  50. Stefan H, Feichtinger M, Black A. Autonomic phenomena of temperature regulation in temporal lobe epilepsy. Epilepsy Behav 2003;4:65–69.

    PubMed  Google Scholar 

  51. Freeman R. Cardiovascular manifestations of autonomic epilepsy. Clin Auton Res 2006;16:12–17.

    PubMed  Google Scholar 

  52. Baumgartner C, Olbrich A, Lindinger G, Pataraia E, Groppel G, Bacher J, et al. Regional cerebral blood flow during temporal lobe seizures associated with ictal vomiting: an ictal SPECT study in two patients. Epilepsia 1999;40:1085–1091.

    PubMed  CAS  Google Scholar 

  53. Chen C, Yen DJ, Yiu CH, Shih YH, Yu HY, Su MS. Ictal vomiting in partial seizures of temporal lobe origin. Eur Neurol 1999;42:235–239.

    PubMed  CAS  Google Scholar 

  54. Schauble B, Britton JW, Mullan BP, Watson J, Sharbrough FW, Marsh WR. Ictal vomiting in association with left temporal lobe seizures in a left hemisphere language-dominant patient. Epilepsia 2002;43:1432–1435.

    PubMed  Google Scholar 

  55. Koutroumanidis M. Ictal vomiting in association with left temporal lobe seizures in a left hemisphere language-dominant patient. Epilepsia 2003;44:1259.

    PubMed  Google Scholar 

  56. O’Donovan CA, Burgess RC, Lueders H. Autonomic auras. In: Luders HO, Noachtar S, eds. Epileptic seizures. Pathophysiology and clinical semiology, pp 320–335. New York: Churchill Livingstone, 2000.

    Google Scholar 

  57. Toichi M, Murai T, Sengoku A, Miyoshi K. Interictal change in cardiac autonomic function associated with EEG abnormalities and clinical symptoms: a longitudinal study following acute deterioration in two patients with temporal lobe epilepsy. Psychiatry Clin Neurosci 1998;52:499–505.

    PubMed  CAS  Google Scholar 

  58. Schuele SU, Bermeo AC, Alexopoulos AV et al. Video-electrographic and clinical features in patients with ictal asystole. Neurology 2007;69:434–441.

    PubMed  CAS  Google Scholar 

  59. Saleh Y, Kirchner A, Pauli E, Hilz MJ, Neundorfer B, Stefan H. Temporal lobe epilepsy: effect of focus side on the autonomic regulation of heart rate? Nervenarzt 2000;71:477–480.

    PubMed  CAS  Google Scholar 

  60. Baumgartner C, Lurger S, Leutmezer F. Autonomic symptoms during epileptic seizures. Epileptic Disord 2001;3:103–116.

    PubMed  CAS  Google Scholar 

  61. Blumhardt LD, Smith PE, Owen L. Electrocardiographic accompaniments of temporal lobe epileptic seizures. Lancet 1986;1:1051–1056.

    PubMed  CAS  Google Scholar 

  62. Delamont RS, Julu PO, Jamal GA. Changes in a measure of cardiac vagal activity before and after epileptic seizures. Epilepsy Res 1999;35:87–94.

    PubMed  CAS  Google Scholar 

  63. Massetani R, Strata G, Galli R, Gori S, Gneri C, Limbruno U, et al. Alteration of cardiac function in patients with temporal lobe epilepsy: different roles of EEG-ECG monitoring and spectral analysis of RR variability. Epilepsia 1997;38:363–369.

    PubMed  CAS  Google Scholar 

  64. Panayiotopoulos CP. Vomiting as an ictal manifestation of epileptic seizures and syndromes. J Neurol Neurosurg Psychiatr 1988;51:1448–1451.

    PubMed  CAS  Google Scholar 

  65. Panayiotopoulos CP. Panayiotopoulos syndrome. Lancet 2001;358:68–69.

    PubMed  CAS  Google Scholar 

  66. Panayiotopoulos CP. Autonomic seizures and autonomic status epilepticus peculiar to childhood: diagnosis and management. Epilepsy Behav 2004;5:286–295.

    PubMed  Google Scholar 

  67. Abou-Khalil B, Welch L, Blumenkopf B, Newman K, Whetsell WO, Jr. Global aphasia with seizure onset in the dominant basal temporal region. Epilepsia 1994;35:1079–1084.

    PubMed  CAS  Google Scholar 

  68. Esclapez M, Houser CR. Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy. J Comp Neurol 1999;412:488–505.

    PubMed  CAS  Google Scholar 

  69. Fernandez Torre JL, Alarcon G, Binnie CD, Polkey CE. Comparison of sphenoidal, foramen ovale and anterior temporal placements for detecting interictal epileptiform discharges in presurgical assessment for temporal lobe epilepsy. Clin Neurophysiol 1999;110:895–904.

    PubMed  CAS  Google Scholar 

  70. Kotagal P, Luders H, Morris HH, Dinner DS, Wyllie E, Godoy J, et al. Dystonic posturing in complex partial seizures of temporal lobe onset: a new lateralizing sign. Neurology 1989;39 Pt 1:196–201.

    PubMed  CAS  Google Scholar 

  71. Ajmone-Marsan C, Ralston BL. The epileptic seizure: its functional morphology and diagnostic significance. A clinical-electrographic analysis of metrazol-induced attacks. Springfield, IL: Charles C. Thomas, 1957.

    Google Scholar 

  72. Benbadis SR, Kotagal P, Klem GH. Unilateral blinking: a lateralizing sign in partial seizures. Neurology 1996;46:45–48.

    PubMed  CAS  Google Scholar 

  73. Oestreich LJ, Berg MJ, Bachmann DL, Burchfiel J, Erba G. Ictal contralateral paresis in complex partial seizures. Epilepsia 1995;36:671–675.

    PubMed  CAS  Google Scholar 

  74. Tassinari CA, Riguzzi P, Rizzi R, Passarelli D, Volpi L. Gelastic seizures. In: Tuxhorn I, Holthausen H, Boenigk H, eds. Paediatric epilepsy syndromes and their surgical treatment Vol. III, pp 429–446. London: John Libbey & Co. Ltd, 1997.

    Google Scholar 

  75. Schmitt JJ, Janszky J, Woermann F, Tuxhorn I, Ebner A. Laughter and the mesial and lateral premotor cortex. Epilepsy Behav 2006;8:773–775.

    PubMed  CAS  Google Scholar 

  76. Palmini AL, Gloor P, Jones-Gotman M. Pure amnestic seizures in temporal lobe epilepsy. Definition, clinical symptomatology and functional anatomical considerations. Brain 1992;115 Pt 3:749–769.

    PubMed  Google Scholar 

  77. Reddy DS. The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy. Epilepsy Res 2009;85:1–30.

    PubMed  CAS  Google Scholar 

  78. Foldvary-Schaefer N, Falcone T. Catamenial epilepsy: pathophysiology, diagnosis, and management. Neurology 2003;61Suppl 2:S2–S15.

    PubMed  CAS  Google Scholar 

  79. Herzog AG. Catamenial epilepsy: definition, prevalence pathophysiology and treatment. Seizure 2008;17:151–159.

    PubMed  Google Scholar 

  80. Grunewald RA, Aliberti V, Panayiotopoulos CP. Exacerbation of typical absence seizures by progesterone. Seizure 1992;1:137–138.

    PubMed  CAS  Google Scholar 

  81. Foldvary N, Lee N, Thwaites G, Mascha E, Hammel J, Kim H, et al. Clinical and electrographic manifestations of lesional neocortical temporal lobe epilepsy. Neurology 1997;49:757–763.

    PubMed  CAS  Google Scholar 

  82. Woermann FG, Vollmar C. Clinical MRI in children and adults with focal epilepsy: a critical review. Epilepsy Behav 2009;15:40–49.

    PubMed  Google Scholar 

  83. Hogan RE, Wang L, Bertrand ME, Willmore LJ, Bucholz RD, Nassif AS, et al. MRI-based high-dimensional hippocampal mapping in mesial temporal lobe epilepsy. Brain 2004;127 Pt 8:1731–1740.

    PubMed  Google Scholar 

  84. Wieser HG. ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia 2004;45:695–714.

    PubMed  Google Scholar 

  85. Babb TL. Synaptic reorganizations in human and rat hippocampal epilepsy. Adv Neurol 1999;79:763–779.

    PubMed  CAS  Google Scholar 

  86. Harvey AS, Berkovic SF, Wrennall JA, Hopkins IJ. Temporal lobe epilepsy in childhood: clinical, EEG, and neuroimaging findings and syndrome classification in a cohort with new-onset seizures. Neurology 1997;49:960–968.

    PubMed  CAS  Google Scholar 

  87. Harvey AS, Grattan-Smith JD, Desmond PM, Chow CW, Berkovic SF. Febrile seizures and hippocampal sclerosis: frequent and related findings in intractable temporal lobe epilepsy of childhood. Pediatr Neurol 1995;12:201–206.

    PubMed  CAS  Google Scholar 

  88. Baumgartner C, Groppel G, Leutmezer F, Aull-Watschinger S, Pataraia E, Feucht M, et al. Ictal urinary urge indicates seizure onset in the nondominant temporal lobe. Neurology 2000;55:432–434.

    PubMed  CAS  Google Scholar 

  89. Gil-Nagel A, Risinger MW. Ictal semiology in hippocampal versus extrahippocampal temporal lobe epilepsy. Brain 1997;120 Pt 1:183–192.

    PubMed  Google Scholar 

  90. Szkiladz E, Bacia T, Bidzinski J, Checinski S, Rakowicz M. [Somatosensory potentials evoked by stimulation of the median nerves recorded during the operation from the surface of the cerebral cortex in patients with temporal lobe epilepsy.] Neurol Neurochir Pol 1989:23:355–362.

    PubMed  CAS  Google Scholar 

  91. Dennis M, Farrell K, Hoffman HJ, Hendrick EB, Becker LE, Murphy EG. Recognition memory of item, associative and serialorder information after temporal lobectomy for seizure disorder. Neuropsychologia 1988;26:53–65.

    PubMed  CAS  Google Scholar 

  92. Jobst BC, Williamson PD, Neuschwander TB, Darcey TM, Thadani VM, Roberts DW. Secondarily generalized seizures in mesial temporal epilepsy: clinical characteristics, lateralizing signs, and association with sleep-wake cycle. Epilepsia 2001;42:1279–1287.

    PubMed  CAS  Google Scholar 

  93. Licht EA, Fujikawa DG. Nonconvulsive status epilepticus with frontal features: quantitating severity of subclinical epileptiform discharges provides a marker for treatment efficacy, recurrence and outcome. Epilepsy Res 2002;51:13–21.

    PubMed  CAS  Google Scholar 

  94. Thomas P, Zifkin B, Migneco O, Lebrun C, Darcourt J, Andermann F. Nonconvulsive status epilepticus of frontal origin. Neurology 1999;52:1174–1183.

    PubMed  CAS  Google Scholar 

  95. Lugaresi E, Pazzaglia P, Tassinari CA. Differentiation of “absence status” and “temporal lobe status”. Epilepsia 1971;12:77–87.

    PubMed  CAS  Google Scholar 

  96. Shorvon SD. Status epilepticus: its clinical features and treatment in children and adults. Cambridge: Cambridge University Press, 1994.

    Google Scholar 

  97. Burneo JG, Knowlton RC, Gomez C, Martin R, Kuzniecky RI. Confirmation of nonconvulsive limbic status epilepticus with the sodium amytal test. Epilepsia 2003;44:1122–1126.

    PubMed  Google Scholar 

  98. Kopelman MD, Panayiotopoulos CP, Lewis P. Transient epileptic amnesia differentiated from psychogenic “fugue”: neuropsychological, EEG, and PET findings. J Neurol Neurosurg Psychiatr 1994;57:1002–1004.

    PubMed  CAS  Google Scholar 

  99. Gilliam FG, Maton BM, Martin RC, Sawrie SM, Faught RE, Hugg JW, et al. Hippocampal 1H-MRSI correlates with severity of depression symptoms in temporal lobe epilepsy. Neurology 2007;68:364–368.

    PubMed  CAS  Google Scholar 

  100. Briellmann RS, Hopwood MJ, Jackson GD. Major depression in temporal lobe epilepsy with hippocampal sclerosis: clinical and imaging correlates. J Neurol Neurosurg Psychiatry 2007; In press.

    Google Scholar 

  101. Richardson EJ, Griffith HR, Martin RC, Paige AL, Stewart CC, Jones J, et al. Structural and functional neuroimaging correlates of depression in temporal lobe epilepsy. Epilepsy Behav 2007;10:242–249.

    PubMed  Google Scholar 

  102. Mathern GW, Babb TL, Vickrey BG, Melendez M, Pretorius JK. The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy. Brain 1995;118 Pt 1:105–118.

    PubMed  Google Scholar 

  103. Ohtsu M, Oguni H, Awaya Y, Osawa M. Clinical and EEG analysis of initial status epilepticus during infancy in patients with mesial temporal lobe epilepsy. Brain Dev 2002;24:231–238.

    PubMed  Google Scholar 

  104. Wolf HK, Aliashkevich AF, Blumcke I, Wiestler OD, Zentner J. Neuronal loss and gliosis of the amygdaloid nucleus in temporal lobe epilepsy. A quantitative analysis of 70 surgical specimens. Acta Neuropathol (Berl) 1997;93:606–610.

    CAS  Google Scholar 

  105. Kuzniecky R, Bilir E, Gilliam F, Faught E, Martin R, Hugg J. Quantitative MRI in temporal lobe epilepsy: evidence for fornix atrophy. Neurology 1999;53:496–501.

    PubMed  CAS  Google Scholar 

  106. Kuzniecky R, Ho SS, Martin R, Faught E, Morawetz R, Palmer C, et al. Temporal lobe developmental malformations and hippocampal sclerosis: epilepsy surgical outcome. Neurology 1999;52:479–484.

    PubMed  CAS  Google Scholar 

  107. Berkovic SF, Jackson GD. The hippocampal sclerosis whodunit: enter the genes. Ann Neurol 2000;47:557–558.

    PubMed  CAS  Google Scholar 

  108. Jefferys JG. Hippocampal sclerosis and temporal lobe epilepsy: cause or consequence? Brain 1999;122 Pt 6:1007–1008.

    PubMed  Google Scholar 

  109. Fernandez G, Effenberger O, Vinz B, Steinlein O, Elger CE, Dohring W, et al. Hippocampal malformation as a cause of familial febrile convulsions and subsequent hippocampal sclerosis. Neurology 1998;50:909–917.

    PubMed  CAS  Google Scholar 

  110. VanLandingham KE, Heinz ER, Cavazos JE, Lewis DV. Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions. Ann Neurol 1998;43:413–426.

    PubMed  CAS  Google Scholar 

  111. Scott RC. Childhood status epilepticus: structural consequences and assessment of a novel treatment. London, UK: Institute of Child Health, UCL Medical School, 1999.

    Google Scholar 

  112. Brines ML, Sundaresan S, Spencer DD, de Lanerolle NC. Quantitative autoradiographic analysis of ionotropic glutamate receptor subtypes in human temporal lobe epilepsy: up-regulation in reorganized epileptogenic hippocampus. Eur J Neurosci 1997;9:2035–2044.

    PubMed  CAS  Google Scholar 

  113. Engel J, Jr., Wilson C, Bragin A. Advances in understanding the process of epileptogenesis based on patient material: what can the patient tell us? Epilepsia 2003;44Suppl 12:60–71.

    PubMed  Google Scholar 

  114. Meierkord H, Shorvon S, Lightman S, Trimble M. Comparison of the effects of frontal and temporal lobe partial seizures on prolactin levels. Arch Neurol 1992;49:225–230.

    PubMed  CAS  Google Scholar 

  115. Cendes F. Radiological evaluation of hippocampal sclerosis. In: Oxbury JM, Polkey CE, Duchowny M, eds. Intractable focal epilepsy, pp 571–594. London: W. B. Saunders, 2000.

    Google Scholar 

  116. Cendes F, Li LM, Watson C, Andermann F, Dubeau F, Arnold DL. Is ictal recording mandatory in temporal lobe epilepsy? Not when the interictal electroencephalogram and hippocampal atrophy coincide. Arch Neurol 2000;57:497–500.

    PubMed  CAS  Google Scholar 

  117. Kobayashi E, Li LM, Lopes-Cendes I, Cendes F. Magnetic resonance imaging evidence of hippocampal sclerosis in asymptomatic, first-degree relatives of patients with familial mesial temporal lobe epilepsy. Arch Neurol 2002;59:1891–1894.

    PubMed  Google Scholar 

  118. Williamson PD, French JA, Thadani VM, Kim JH, Novelly RA, Spencer SS, et al. Characteristics of medial temporal lobe epilepsy: II. Interictal and ictal scalp electroencephalography, neuropsychological testing, neuroimaging, surgical results, and pathology. Ann Neurol 1993;34:781–787.

    PubMed  CAS  Google Scholar 

  119. Koutroumanidis M, Binnie CD, Panayiotopoulos CP. Positron emission tomography in partial epilepsies: the clinical point of view. Nucl Med Commun 1998;19:1123–1126.

    PubMed  CAS  Google Scholar 

  120. Koutroumanidis M, Binnie CD, Elwes RD, Polkey CE, Seed P, Alarcon G, et al. Interictal regional slow activity in temporal lobe epilepsy correlates with lateral temporal hypometabolism as imaged with 18FDG PET: neurophysiological and metabolic implications. J Neurol Neurosurg Psychiatry 1998;65:170–176.

    PubMed  CAS  Google Scholar 

  121. Koutroumanidis M, Martin-Miguel C, Hennessy MJ, Akanuma N, Valentin A, Alarcon G, et al. Interictal temporal delta activity in temporal lobe epilepsy: correlations with pathology and outcome. Epilepsia 2004;45:1351–1367.

    PubMed  Google Scholar 

  122. Risinger MW, Engel J, Jr, Van Ness PC, Henry TR, Crandall PH. Ictal localization of temporal lobe seizures with scalp/sphenoidal recordings. Neurology 1989;39:1288–1293.

    PubMed  CAS  Google Scholar 

  123. Meyer MA, Zimmerman AW, Miller CA. Temporal lobe epilepsy presenting as panic attacks: detection of interictal hypometabolism with positron emission tomography. J Neuroimaging 2000;10:120–122.

    PubMed  CAS  Google Scholar 

  124. Lin YY, Su MS, Yiu CH, Shih YH, Yen DJ, Kwan SY, et al. Relationship between mesial temporal seizure focus and elevated serum prolactin in temporal lobe epilepsy. Neurology 1997;49:528–532.

    PubMed  CAS  Google Scholar 

  125. Panayiotopoulos CP, Chroni E, Daskalopoulos C, Baker A, Rowlinson S, Walsh P. Typical absence seizures in adults: clinical, EEG, video-EEG findings and diagnostic/syndromic considerations. J Neurol Neurosurg Psychiatr 1992;55:1002–1008.

    PubMed  CAS  Google Scholar 

  126. Hauser WA. The natural history of temporal lobe epilepsy. In: Luders HO, ed. Epilepsy surgery, pp 133–141. New York: Raven Press, 1992.

    Google Scholar 

  127. Engel J, Jr., Wiebe S, French J, Sperling M, Williamson P, Spencer D, et al. Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neurological Surgeons. Neurology 2003;60:538–547.

    PubMed  Google Scholar 

  128. Al-Kaylani M, Konrad P, Lazenby B, Blumenkopf B, bou-Khalil B. Seizure freedom off antiepileptic drugs after temporal lobe epilepsy surgery. Seizure 2007;16:95–98.

    PubMed  Google Scholar 

  129. Bonilha L, Yasuda CL, Rorden C, Li LM, Tedeschi H, de O E, et al. Does resection of the medial temporal lobe improve the outcome of temporal lobe epilepsy surgery? Epilepsia 2007;48:571–578.

    PubMed  Google Scholar 

  130. Cross JH, Jayakar P, Nordli D, Delalande O, Duchowny M, Wieser HG, et al. Proposed criteria for referral and evaluation of children for epilepsy surgery: recommendations of the Subcommission for Pediatric Epilepsy Surgery. Epilepsia 2006;47:952–959.

    PubMed  Google Scholar 

  131. Mizrahi EM, Kellaway P, Grossman RG, Rutecki PA, Armstrong D, Rettig G, et al. Anterior temporal lobectomy and medically refractory temporal lobe epilepsy of childhood. Epilepsia 1990;31:302–312.

    PubMed  CAS  Google Scholar 

  132. Sakai Y, Nagano H, Sakata A, Kinoshita S, Hamasaki N, Shima F, et al. Localization of epileptogenic zone in temporal lobe epilepsy by ictal scalp EEG. Seizure 2002;11:163–168.

    PubMed  Google Scholar 

  133. Sadler M, Desbiens R. Scalp EEG in temporal lobe epilepsy surgery. Can J Neurol Sci 2000;27Suppl 1:S22–S28.

    PubMed  Google Scholar 

  134. Schulz R, Luders HO, Hoppe M, Tuxhorn I, May T, Ebner A. Interictal EEG and ictal scalp EEG propagation are highly predictive of surgical outcome in mesial temporal lobe epilepsy. Epilepsia 2000;41:564–570.

    PubMed  CAS  Google Scholar 

  135. Salanova V, Morris HH, Van Ness P, Kotagal P, Wyllie E, Luders H. Frontal lobe seizures: electroclinical syndromes. Epilepsia 1995;36:16–24.

    PubMed  CAS  Google Scholar 

  136. Chauvel P, Delgado-Escueta AV, Halgren E, Bancaud J (eds). Advances in neurology, Vol 57: Frontal lobe seizures and epilepsies. New York: Raven, 1992.

    Google Scholar 

  137. Bancaud J, Talairach J. Clinical semiology of frontal lobe seizures. Adv Neurol 1992;57:3–58.

    PubMed  CAS  Google Scholar 

  138. Jasper H, Riggio S, Goldman-Rakie P. Epilepsy and the functional anatomy of the frontal lobe. New York: Raven Press, 1995.

    Google Scholar 

  139. Chauvel P, Kliemann F, Vignal JP, Chodkiewicz JP, Talairach J, Bancaud J. The clinical signs and symptoms of frontal lobe seizures. Phenomenology and classification. Adv Neurol 1995;66:115–125.

    PubMed  CAS  Google Scholar 

  140. Williamson PD. Frontal lobe epilepsy. Some clinical characteristics. Adv Neurol 1995;66:127–150.

    PubMed  CAS  Google Scholar 

  141. Kotagal P, Arunkumar GS. Lateral frontal lobe seizures. Epilepsia 1998;39Suppl 4:S62–S68.

    PubMed  Google Scholar 

  142. Niedermeyer E. Frontal lobe epilepsy: the next frontier. Clin Electroencephalogr 1998;29:163–169.

    PubMed  CAS  Google Scholar 

  143. Bartolomei F, Chauvel P. Seizure symptoms and cerebral localization:frontal lobe and rolandic seizures. In: Oxbury JM, Polkey CE, Duchowny M, eds. Intractable focal epilepsy, pp 55–62. London: W.B. Saunders, 2000.

    Google Scholar 

  144. Blume WT, Ociepa D, Kander V. Frontal lobe seizure propagation: scalp and subdural EEG studies. Epilepsia 2001;42:491–503.

    PubMed  CAS  Google Scholar 

  145. Sinclair DB, Wheatley M, Snyder T. Frontal lobe epilepsy in childhood. Pediatr Neurol 2004;30:169–176.

    PubMed  Google Scholar 

  146. Goldman-Rakie P. Anatomical and functional circuits in prefrontal cortex of non-human primates. Relevance to epilepsy. Adv Neurol 1995;66:51–65.

    Google Scholar 

  147. Rasmussen T. Characteristics of a pure culture of frontal lobe epilepsy. Epilepsia 1983;24:482–493.

    PubMed  CAS  Google Scholar 

  148. Manford M, Hart YM, Sander JW, Shorvon SD. National General Practice Study of Epilepsy (NGPSE): partial seizure patterns in a general population. Neurology 1992;42:1911–1917.

    PubMed  CAS  Google Scholar 

  149. Bonelli SB, Lurger S, Zimprich F, Stogmann E, ssem-Hilger E, Baumgartner C. Clinical seizure lateralization in frontal lobe epilepsy. Epilepsia 2007;48:517–523.

    PubMed  Google Scholar 

  150. Laich E, Kuzniecky R, Mountz J, Liu HG, Gilliam F, Bebin M, et al. Supplementary sensorimotor area epilepsy. Seizure localization, cortical propagation and subcortical activation pathways using ictal SPECT. Brain 1997;120 Pt 5:855–864.

    PubMed  Google Scholar 

  151. Baumgartner C, Flint R, Tuxhorn I, Van Ness PC, Kosalko J, Olbrich A, et al. Supplementary motor area seizures: propagation pathways as studied with invasive recordings. Neurology 1996;46:508–514.

    PubMed  CAS  Google Scholar 

  152. King DW, Smith JR. Supplementary sensorimotor area epilepsy in adults. Adv Neurol 1996;70:285–291.

    PubMed  CAS  Google Scholar 

  153. Spencer DD, Schumacher J. Surgical management of patients with intractable supplementary motor area seizures. The Yale experience. Adv Neurol 1996;70:445–450.

    PubMed  CAS  Google Scholar 

  154. Connolly MB, Langill L, Wong PK, Farrell K. Seizures involving the supplementary sensorimotor area in children: a video-EEG analysis. Epilepsia 1995;36:1025–1032.

    PubMed  CAS  Google Scholar 

  155. So NK. Supplementary motor area epilepsy: the clinical syndrome. In: Wolf P, ed. Epileptic seizures and syndromes, pp 299–317. London: John Libbey & Co. Ltd, 1994.

    Google Scholar 

  156. Holthausen H, Hoppe M. Hypermotor seizures. In: Luders HO, Noachtar S, eds. Epileptic seizures. Pathophysiology and clinical semiology, pp 439–448. New York: Churchill Livingstone, 2000.

    Google Scholar 

  157. Luders HO, Noachtar S, Burgess RC. Semiologic classification of epileptic seizures. In: Luders HO, Noachtar S, eds. Epileptic seizures. Pathophysiology and clinical semiology, pp 263–285. New York: Churchill Livingstone, 2000.

    Google Scholar 

  158. Penfield W. The supplementary motor area in the cerebral cortex of man. Arch Psychiatr 1950;185:670–674.

    CAS  Google Scholar 

  159. Marchesi GF, Macchi G, Cianchetti C, Chinzari P. [Supplementary motor areas in the cat: electrophysiological studies of the suprasylvian and ectosylvian regions.] Boll Soc Ital Biol Sper 1972;48:70–74.

    PubMed  CAS  Google Scholar 

  160. Van Ness PC, Bleasel A, Tuxhorn I. Supplementary motor seizures:localization of the epileptogenic zone. In: Wolf P, ed. Epileptic seizures and syndromes, pp 319–330. London: John Libbey & Co. Ltd, 1994.

    Google Scholar 

  161. Bancaud J. Kojewnikow’s syndrome (epilepsia partialis continua) in children. In: Roger J, Bureau M, Dravet C, Dreifuss FE, Perret A, Wolf P, eds. Epileptic syndromes in infancy, childhood and adolescence, pp 363–374. London: John Libbey, 1992.

    Google Scholar 

  162. Foerster O, Penfield W. The structural basis of traumatic epilepsy and results of radical operation. Seventh edition, pp 569–591, 1929.

    Google Scholar 

  163. Gastaut H, Jasper H, Bancaud J, Waltregny A. The physiopathogenesis of the epilepsies. Springfield,Illinois: Charles C Thomas, 1969.

    Google Scholar 

  164. Bancaud J. Physiopathogenesis of generalised epilepsies of organic nature (stereo-electroencephalographic study). In: Gastaut H, Jasper H, Bancaud J, Waltregny A, eds. The physiopathogenesis of the epilepsies, pp 158–185. Springfield: Charles C Thomas, 1969.

    Google Scholar 

  165. Bauer G, Dobesberger J, Bauer R, Embacher N, Benke T, Unterberger I, et al. Prefrontal disturbances as the sole manifestation of simple partial nonconvulsive status epilepticus 13. Epilepsy Behav 2006;8:331–335.

    PubMed  Google Scholar 

  166. Chauvel P, Bancaud J. The spectrum of frontal lobe seizures:with a note of frontal lobe syndromatology. In: Wolf P, ed. Epileptic seizures and syndromes, pp 331–334. London: John Libbey & Co. Ltd, 1994.

    Google Scholar 

  167. Janszky J, Jokeit H, Schulz R, Hoppe M, Ebner A. EEG predicts surgical outcome in lesional frontal lobe epilepsy. Neurology 2000;54:1470–1476.

    PubMed  CAS  Google Scholar 

  168. Woermann FG, Vollmar C. Clinical MRI in children and adults with focal epilepsy: a critical review. Epilepsy Behav 2009;15:40–49.

    PubMed  Google Scholar 

  169. Genow A, Hummel C, Scheler G, Hopfengartner R, Kaltenhauser M, Buchfelder M, et al. Epilepsy surgery, resection volume and MSI localization in lesional frontal lobe epilepsy. Neuroimage 2004;21:444–449.

    PubMed  CAS  Google Scholar 

  170. Ferri R, Stam CJ, Lanuzza B, Cosentino FI, Elia M, Musumeci SA, et al. Different EEG frequency band synchronization during nocturnal frontal lobe seizures. Clin Neurophysiol 2004;115:1202–1211.

    PubMed  Google Scholar 

  171. Hopkins H. The time of appearance of epileptic seizures in relation to age, duration and type of the syndrome. J Nerv Ment Dis 1933;77:153–162.

    Google Scholar 

  172. Allen PJ, Fish DR, Smith SJ. Very high-frequency rhythmic activity during SEEG suppression in frontal lobe epilepsy. Electroencephalogr Clin Neurophysiol 1992;82:155–159.

    PubMed  CAS  Google Scholar 

  173. Bautista RE, Spencer DD, Spencer SS. EEG findings in frontal lobe epilepsies. Neurology 1998;50:1765–1771.

    PubMed  CAS  Google Scholar 

  174. Williamson A, Spencer SS, Spencer DD. Depth electrode studies and intracellular dentate granule cell recordings in temporal lobe epilepsy. Ann Neurol 1995;38:778–787.

    PubMed  CAS  Google Scholar 

  175. Ferrie CD, Giannakodimos S, Robinson RO, Panayiotopoulos CP. Symptomatic typical absence seizures. In: Duncan JS, Panayiotopoulos CP, eds. Typical absences and related epileptic syndromes, pp 241–252. London: Churchill Communications Europe, 1995.

    Google Scholar 

  176. Kudo T, Sato K, Yagi K, Seino M. Can absence status epilepticus be of frontal lobe origin? Acta Neurol Scand 1995;92:472–477.

    PubMed  CAS  Google Scholar 

  177. Pavone A, Niedermeyer E. Absence seizures and the frontal lobe. Clin Electroencephalogr 2000;31:153–156.

    PubMed  CAS  Google Scholar 

  178. Prevost J, Lortie A, Nguyen D, Lassonde M, Carmant L. Nonlesional frontal lobe epilepsy (FLE) of childhood: clinical presentation, response to treatment and comorbidity. Epilepsia 2006;47:2198–2201.

    PubMed  Google Scholar 

  179. Oldani A, Manconi M, Zucconi M, Martinelli C, Ferini-Strambi L. Topiramate treatment for nocturnal frontal lobe epilepsy. Seizure 2006;15:649–652.

    PubMed  Google Scholar 

  180. Elsharkawy AE, Alabbasi AH, Pannek H et al. Outcome of frontal lobe epilepsy surgery in adults. Epilepsy Res 2008;81:97–106.

    PubMed  Google Scholar 

  181. Jeha LE, Najm I, Bingaman W, Dinner D, Widdess-Walsh P, Luders H. Surgical outcome and prognostic factors of frontal lobe epilepsy surgery. Brain 2007;130 Pt 2:574–584.

    PubMed  Google Scholar 

  182. Cockerell OC, Rothwell J, Thompson PD, Marsden CD, Shorvon SD. Clinical and physiological features of epilepsia partialis continua. Cases ascertained in the UK. Brain 1996;119 Pt 2:393–407.

    PubMed  Google Scholar 

  183. Wieser HG, Chauvel P. Simple partial status epileticus and epilepsia partialis continua of Kozhevnikov. In: Engel J, Jr., Pedley TA, eds. Epilepsy: A comprehensive textbook. Second Edition, pp 705–724. Philadelphia: Lippincott Williams and Wilkins, 2008.

    Google Scholar 

  184. Shigeto H, Tobimatsu S, Morioka T, Yamamoto T, Kobayashi T, Kato M. Jerk-locked back averaging and dipole source localization of magnetoencephalographic transients in a patient with epilepsia partialis continua. Electroencephalogr Clin Neurophysiol 1997;103:440–444.

    PubMed  CAS  Google Scholar 

  185. Molyneux PD, Barker RA, Thom M, van Paesschen W, Harkness WF, Duncan JS. Successful treatment of intractable epilepsia partialis continua with multiple subpial transections. J Neurol Neurosurg Psychiatry 1998;65:137–138.

    PubMed  CAS  Google Scholar 

  186. Bien CG, Elger CE. Epilepsia partialis continua: semiology and differential diagnoses. Epileptic Disord 2008;10:3–7.

    PubMed  Google Scholar 

  187. Obeso JA, Rothwell JC, Marsden CD. The spectrum of cortical myoclonus. From focal reflex jerks to spontaneous motor epilepsy. Brain 1985;108 Pt 1:193–124.

    PubMed  Google Scholar 

  188. Caraballo R, Tenembaum S, Cersosimo R, Pomata H, Medina C, Soprano AM et al. [Rasmussen syndrome.] Rev Neurol 1998;26:978–983.

    PubMed  CAS  Google Scholar 

  189. Thomas JE, Reagan TJ, Klass DW. Epilepsia partialis continua. A review of 32 cases. Arch Neurol 1977;34:266–275.

    PubMed  CAS  Google Scholar 

  190. Schomer DL. Focal status epilepticus and epilepsia partialis continua in adults and children. Epilepsia 1993;34Suppl 1:S29–S36.

    PubMed  Google Scholar 

  191. Silver K, Andermann F, Meagher-Villemure K. Familial alternating epilepsia partialis continua with chronic encephalitis: another variant of Rasmussen syndrome? Arch Neurol 1998;55:733–736.

    PubMed  CAS  Google Scholar 

  192. Velasco M, Velasco F, Alcala H, Diaz de Leon AE. Wakefulness-sleep modulation of EEG-EMG epileptiform activities: a quantitative study on a child with intractable epilepsia partialis continua. Int J Neurosci 1990:54:325–337.

    PubMed  CAS  Google Scholar 

  193. Dereux J. Le syndrome de Kojewnikow (epilepsie partialis continue). Paris: Thesis, 1955.

    Google Scholar 

  194. Hart H, Andermann F. Rasmussen’s syndrome. In: Roger J, Bureau M, Dravet C, Genton P, Tassinari CA, Wolf P, eds. Epileptic syndromes in infancy, childhood and adolescence. Fourth edition, pp 537–554. Montrouge, France: John Libbey Eurotext Ltd 2005.

    Google Scholar 

  195. Panayiotopoulos CP, Andermann F. Kozhevnikov-Rasmussen syndrome and the new proposal on classification. Epilepsia 2002;43:948–950.

    PubMed  CAS  Google Scholar 

  196. Adams RD, Victor M, Ropper AH. Principles of neurology, sixth edition. New York: McGraw-Hill, 1997.

    Google Scholar 

  197. Rasmussen T. Surgery for central, parietal and occipital epilepsy. Can J Neurol Sci 1991;18Suppl:611–616.

    PubMed  CAS  Google Scholar 

  198. Cascino GD, Hulihan JF, Sharbrough FW, Kelly PJ. Parietal lobe lesional epilepsy: electroclinical correlation and operative outcome. Epilepsia 1993;34:522–527.

    PubMed  CAS  Google Scholar 

  199. Salanova V, Andermann F, Rasmussen T, Olivier A, Quesney LF. Parietal lobe epilepsy. Clinical manifestations and outcome in 82 patients treated surgically between 1929 and 1988. Brain 1995;118 Pt 3:607–627.

    PubMed  Google Scholar 

  200. Salanova V, Andermann F, Rasmussen T, Olivier A, Quesney LF. Tumoural parietal lobe epilepsy. Clinical manifestations and outcome in 34 patients treated between 1934 and 1988. Brain 1995;118 Pt 5:1289–1304.

    PubMed  Google Scholar 

  201. Kasowski HJ, Stoffman MR, Spencer SS, Spencer DD. Surgical management of parietal lobe epilepsy. Adv Neurol 2003;93:347–356.

    PubMed  Google Scholar 

  202. Kim DW, Lee SK, Yun CH, Kim KK, Lee DS, Chung CK, et al. Parietal lobe epilepsy: the semiology, yield of diagnostic workup, and surgical outcome. Epilepsia 2004;45:641–649.

    PubMed  Google Scholar 

  203. Kim CH, Chung CK, Lee SK, Lee YK, Chi JG. Parietal lobe epilepsy: surgical treatment and outcome. Stereotact Funct Neurosurg 2004;82:175–185.

    PubMed  Google Scholar 

  204. Rasmussen T. Surgery for epilepsy arising in regions other than the temporal and frontal lobes. Adv Neurol 1975;8:207–226.

    PubMed  CAS  Google Scholar 

  205. Tuxhorn I, Kerdar MS. Somatosensory auras. In: Luders HO, Noachtar S, eds. Epileptic seizures. Pathophysiology and clinical semiology, pp 286–297. New York: Churchill Livingstone, 2000.

    Google Scholar 

  206. Siegel AM, Williamson PD, Roberts DW, Thadani VM, Darcey TM. Localized pain associated with seizures originating in the parietal lobe. Epilepsia 1999;40:845–855.

    PubMed  CAS  Google Scholar 

  207. Panayiotopoulos CP. Benign childhood partial seizures and related epileptic syndromes. London: John Libbey & Co. Ltd, 1999.

    Google Scholar 

  208. Siegel AM, Williamson PD. Parietal lobe epilepsy. Adv Neurol 2000;84:189–199.

    PubMed  CAS  Google Scholar 

  209. Sveinbjornsdottir S, Duncan JS. Parietal and occipital lobe epilepsy: a review [published erratum appears in Epilepsia 1994;35:467]. Epilepsia 1993;34:493–521.

    PubMed  CAS  Google Scholar 

  210. Blume WT, Jones DC, Young GB, Girvin JP, McLachlan RS. Seizures involving secondary sensory and related areas. Brain 1992;115 Pt 5:1509–1520.

    PubMed  Google Scholar 

  211. Williamson PD, Boon PA, Thadani VM, Darcey TM, Spencer DD, Spencer SS, et al. Parietal lobe epilepsy: diagnostic considerations and results of surgery. Ann Neurol 1992;31:193–201.

    PubMed  CAS  Google Scholar 

  212. Stoffels C, Munari C, Bonis A, Bancaud J, Talairach J. [Genital and sexual manifestations occurring in the course of partial seizures in man.] Rev Electroencephalogr Neurophysiol Clin 1980;10:386–392.

    PubMed  CAS  Google Scholar 

  213. Daly DD. Ictal clinical manifestations of complex partial seizures. Adv Neurol 1975;11:57–83.

    PubMed  CAS  Google Scholar 

  214. Grand’Maison F, Reiher J, Lebel ML, Rivest J. Transient anosognosia for episodic hemiparesis: a singular manifestation of TIAs and epileptic seizures. Can J Neurol Sci 1989;16:203–205.

    CAS  Google Scholar 

  215. Heilman KM, Howell GJ. Seizure-induced neglect. J Neurol Neurosurg Psychiatry 1980;43:1035–1040.

    PubMed  CAS  Google Scholar 

  216. Schwartz TH, Resor SR, Jr, De La PR, Goodman RR. Functional magnetic resonance imaging localization of ictal onset to a dysplastic cleft with simultaneous sensorimotor mapping: intraoperative electrophysiological confirmation and postoperative follow-up: technical note. Neurosurgery 1998;43:639–644.

    PubMed  CAS  Google Scholar 

  217. Russell WR, Whitty CWM. Studies in traumatic epilepsy. 2. Focal motor and somatic sensory fits: A study of 85 cases. J Neurol Neurosurg Psychiatr 1953;16:73–97.

    PubMed  CAS  Google Scholar 

  218. Mauguiere F, Courjon J. Somatosensory epilepsy. A review of127 cases. Brain 1978;101:307–332.

    PubMed  CAS  Google Scholar 

  219. Fish DR, Gloor P, Quesney FL, Olivier A. Clinical responses to electrical brain stimulation of the temporal and frontal lobes in patients with epilepsy. Pathophysiological implications. Brain 1993;116 Pt 2:397–414.

    PubMed  Google Scholar 

  220. Palmini A, Gloor P. The localizing value of auras in partial seizures: a prospective and retrospective study. Neurology 1992;42:801–808.

    PubMed  CAS  Google Scholar 

  221. Penfield W, Boldrey E. Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical stimulation. Brain 1937;60:389–443.

    Google Scholar 

  222. Fujino O, Hashimoto K, Enokido H, Komatsuzaki H, Fujita T, Takaishi Y, et al. [Epileptic vertiginous seizure in a Japanese boy: a case report.] No To Hattatsu 1996;28:515–519.

    PubMed  CAS  Google Scholar 

  223. Penfield W, Kristiansen K. Epileptic seizure patterns. Springfield, IL: Charles C Thomas, 1951.

    Google Scholar 

  224. Kogeorgos J, Scott DF, Swash M. Epileptic dizziness. Br Med J (Clin Res Ed) 1981;282:687–689.

    CAS  Google Scholar 

  225. Ho SS, Berkovic SF, Newton MR, Austin MC, McKay WJ, Bladin PF. Parietal lobe epilepsy: clinical features and seizure localization by ictal SPECT. Neurology 1994;44:2277–2284.

    PubMed  CAS  Google Scholar 

  226. Lesser RP, Lueders H, Conomy JP, Furlan AJ, Dinner DS. Sensory seizure mimicking a psychogenic seizure. Neurology 1983;33:800–802.

    PubMed  CAS  Google Scholar 

  227. Foerster O. The cerebral cortex in man. Lancet 1931;2:309–312.

    Google Scholar 

  228. Penfield W, Gage L. Cerebral localization of epileptic manifestations. Arch Neurol Psychiatry 1933;30:709–727.

    Google Scholar 

  229. Vignal JP, Biraben A, Chauvel PY, Reutens DC. Reflex partial seizures of sensorimotor cortex (including cortical reflex myoclonus and startle epilepsy). Adv Neurol 1998;75:207–226.

    PubMed  CAS  Google Scholar 

  230. Van Ness PC, Lesser RP, Duchowny MS. Neocortical sensory seizures. In: Engel J, Jr., Pedley TA, eds. Epilepsy: a comprehensive textbook, second edition. pp 529–540. Philadelphia: Lippincott Williams and Wilkins, 2008.

    Google Scholar 

  231. Reder AT, Wright FS. Epilepsy evoked by eating: the role of peripheral input. Neurology 1982;32:1065–1069.

    PubMed  CAS  Google Scholar 

  232. Sutherling WW, Hershman LM, Miller JQ, Lee SI. Seizures induced by playing music. Neurology 1980;30:1001–1004.

    PubMed  CAS  Google Scholar 

  233. Koutroumanidis M, Pearce R, Sadoh DR, Panayiotopoulos CP. Tooth brushing-induced seizures: a case report. Epilepsia 2001;42:686–688.

    PubMed  CAS  Google Scholar 

  234. Devinsky O, Kelley K, Porter RJ, Theodore WH. Clinical and electroencephalographic features of simple partial seizures. Neurology 1988;38:1347–1352.

    PubMed  CAS  Google Scholar 

  235. Kaibara M, Blume WT. The postictal electroencephalogram. Electroencephalogr Clin Neurophysiol 1988;70:99–104.

    PubMed  CAS  Google Scholar 

  236. Poeck K. [Differential diagnosis of “migraine accompagnee” and sensory jacksonian seizures]. Dtsch Med Wochenschr 1972;97:637–641.

    PubMed  CAS  Google Scholar 

  237. Andermann F, Beaumanoir A, Mira E, Roger J, Tassinari CA. Occipital seizures and epilepsies in children. Mariani Foundation Paediatric Neurology, pp 1–246. London: John Libbey & Co. Ltd, 1993.

    Google Scholar 

  238. Salanova V, Andermann F, Rasmussen TB. Occipital lobe epilepsy. In: Wyllie E, ed. The treatment of epilepsy, pp 533–540. Philadelphia: Lee & Febiger, 1993.

    Google Scholar 

  239. Williamson PD. Seizures with origin in the occipital or parietal lobes. In: Wolf P, ed. Epileptic seizures and syndromes, pp 383–390. London: John Libbey & Co. Ltd, 1994.

    Google Scholar 

  240. Kuzniecky R, Gilliam F, Morawetz R, Faught E, Palmer C, Black L. Occipital lobe developmental malformations and epilepsy: clinical spectrum, treatment, and outcome. Epilepsia 1997;38:175–181.

    PubMed  CAS  Google Scholar 

  241. Kuzniecky R. Symptomatic occipital lobe epilepsy. Epilepsia 1998;39Suppl 4:S24–S31.

    PubMed  Google Scholar 

  242. Panayiotopoulos CP. Visual phenomena and headache in occipital epilepsy: a review, a systematic study and differentiation from migraine. Epileptic Disord 1999;1:205–216.

    PubMed  CAS  Google Scholar 

  243. Taylor I, Scheffer IE, Berkovic SF. Occipital epilepsies: identification of specific and newly recognized syndromes. Brain 2003;126 Pt 4:753–769.

    PubMed  Google Scholar 

  244. Panayiotopoulos CP. Occipital seizures and related epileptic syndromes. In: Panayiotopoulos CP, ed. Benign childhood partial seizures and related epileptic syndromes, pp 101–228. London: John Libbey & Co. Ltd, 1999.

    Google Scholar 

  245. Panayiotopoulos CP. Idiopathic photosensitive occipital spikes seizures. In: Panayiotopoulos CP, ed. Benign childhood partial seizures and related epileptic syndromes, pp 241–255. London: John Libbey & Co. Ltd, 1999.

    Google Scholar 

  246. Panayiotopoulos CP. Basilar migraine: a review. In: Panayiotopoulos CP, ed. Benign childhood partial seizures and related epileptic syndromes, pp 303–308. London: John Libbey & Co. Ltd, 1999.

    Google Scholar 

  247. Maillard L, Vignal JP, Anxionnat R, TaillandierVespignani L. Semiologic value of ictal autoscopy. Epilepsia 2004;45:391–394.

    PubMed  Google Scholar 

  248. Blanke O, Landis T, Spinelli L, Seeck M. Out-of-body experience and autoscopy of neurological origin. Brain 2004;127 Pt 2:243–258.

    PubMed  Google Scholar 

  249. Herschel JFW. Familiar lectures on scientific aspects. London: Alexander Straham, 1866.

    Google Scholar 

  250. Plant GT. The fortification spectra of migraine [published erratum appears in Br Med J (Clin Res Ed) 1987;294:90]. Br Med J (Clin Res Ed) 1986;293:1613–1617.

    CAS  Google Scholar 

  251. Gowers WR. Subjective sensations of sight and sound; a biotrophy and other lectures. Philadelphia: P. Blackinston’s Son & Co., 1904.

    Google Scholar 

  252. Schmidt EM, Bak MJ, Hambrecht FT, Kufta CV, O’Rourke DK, Vallabhanath P. Feasibility of a visual prosthesis for the blind based on intracortical microstimulation of the visual cortex. Brain 1996;119 Pt 2:507–522.

    PubMed  Google Scholar 

  253. Airy H. On a distinct form of transient hemiopsia. Philos Trans R Soc Lond 1870;160:247–270.

    Google Scholar 

  254. Manford M, Hart YM, Sander JW, Shorvon SD. The National General Practice Study of Epilepsy. The syndromic classification of the International League Against Epilepsy applied to epilepsy in a general population. Arch Neurol 1992;49:801–808.

    PubMed  CAS  Google Scholar 

  255. Panayiotopoulos CP. Elementary visual hallucinations in migraine and epilepsy. J Neurol Neurosurg Psychiatry 1994;57:1371–1374.

    PubMed  CAS  Google Scholar 

  256. Panayiotopoulos CP. Elementary visual hallucinations, blindness, and headache in idiopathic occipital epilepsy: differentiation from migraine. J Neurol Neurosurg Psychiatry 1999;66:536–540.

    PubMed  CAS  Google Scholar 

  257. Panayiotopoulos CP. Elementary visual hallucinations in migraine and epilepsy. J Neurol Neurosurg Psychiatr 1994;57:1371–1374.

    PubMed  CAS  Google Scholar 

  258. Panayiotopoulos CP. Differentiating occipital epilepsies from migraine with aura, acephalgic migraine and basilar migraine. In: Panayiotopoulos CP, ed. Benign childhood partial seizures and related epileptic syndromes, pp 281–302. London: John Libbey & Co. Ltd, 1999.

    Google Scholar 

  259. Russell WR, Whitty CWM. Studies in traumatic epilepsy 3. Visual fits. J Neurol Neurosurg Psychiatr 1955;18:79–96.

    PubMed  CAS  Google Scholar 

  260. Ludwig BI, Marsan CA. Clinical ictal patterns in epileptic patients with occipital electroencephalographic foci. Neurology 1975;25:463–471.

    PubMed  CAS  Google Scholar 

  261. Penfield W, Rasmussen T. The cerebral cortex of man: A clinical study of localisation of function. Fourth Edition. New York: Macmillan Co., 1957.

    Google Scholar 

  262. Babb TL, Halgren E, Wilson C, Engel J, Crandall P. Neuronal firing patterns during the spread of an occipital lobe seizure to the temporal lobes in man. Electroencephalogr Clin Neurophysiol 1981;51:104–107.

    PubMed  CAS  Google Scholar 

  263. Guerrini R, Dravet C, Genton P, Bureau M, Bonanni P, Ferrari AR, et al. Idiopathic photosensitive occipital lobe epilepsy [published erratum appears in Epilepsia 1996;37:310]. Epilepsia 1995;36:883–891.

    PubMed  CAS  Google Scholar 

  264. Walker MC, Smith SJ, Sisodiya SM, Shorvon SD. Case of simple partial status epilepticus in occipital lobe epilepsy misdiagnosed as migraine: clinical, electrophysiological, and magnetic resonance imaging characteristics. Epilepsia 1995;36:1233–1236.

    PubMed  CAS  Google Scholar 

  265. Thom M, Moran NF, Plant GT, Stevens JM, Scaravilli F. Cortical dysplasia with angiodysgenesis and chronic inflammation in multifocal partial epilepsy. Neurology 1999;52:654–657.

    PubMed  CAS  Google Scholar 

  266. Bien CG, Benninger FO, Urbach H, Schramm J, Kurthen M, Elger CE. Localizing value of epileptic visual auras. Brain 2000;123 Pt 2:244–253.

    PubMed  Google Scholar 

  267. Critchley M. Butterworths medical dictionary. London: Butterworth & Co. Ltd, 1986.

    Google Scholar 

  268. Shahar E, Barak S. Favorable outcome of epileptic blindness in children. J Child Neurol 2003;18:12–16.

    PubMed  Google Scholar 

  269. Panayiotopoulos CP. Basilar migraine? Seizures, and severe epileptic EEG abnormalities. Neurology 1980;30:1122–1125.

    PubMed  CAS  Google Scholar 

  270. Ayala G. Status epilepticus amauroticus. Boll Accad Med Roma 1929;55:288–290.

    Google Scholar 

  271. Barry E, Sussman NM, Bosley TM, Harner RN. Ictal blindness and status epilepticus amauroticus. Epilepsia 1985;26:577–584.

    PubMed  CAS  Google Scholar 

  272. Sawchuk KS, Churchill S, Feldman E, Drury I. Status epilepticus amauroticus. Neurology 1997;49:1467–1469.

    PubMed  CAS  Google Scholar 

  273. Williamson PD, Engel J, Jr. Limbic seizures. In: Engel J, Jr, Pedley TA, eds. Epilepsy: A comprehensive textbook, second edition. pp 541–552. Philadelphia: Lippincott Williams and Wilkins, 2008.

    Google Scholar 

  274. Ito M, Adachi N, Nakamura F, Koyama T, Okamura T, Kato M, et al. Multi-center study on post-ictal headache in patients with localizationrelated epilepsy. Psychiatry Clin Neurosci 2003;57:385–389.

    PubMed  Google Scholar 

  275. Ito M, Adachi N, Nakamura F, Koyama T, Okamura T, Kato M, et al. Characteristics of postictal headache in patients with partial epilepsy. Cephalalgia 2004;24:23–28.

    PubMed  CAS  Google Scholar 

  276. Blau JN. Classical migraine: symptoms between visual aura and headache onset. Lancet 1992;340:355–356.

    PubMed  CAS  Google Scholar 

  277. Plazzi G, Tinuper P, Cerullo A, Provini F, Lugaresi E. Occipital lobe epilepsy: a chronic condition related to transient occipital lobe involvement in eclampsia. Epilepsia 1994;35:644–647.

    PubMed  CAS  Google Scholar 

  278. Gobbi G, Bertani G, Italian Working Group on Coeliac Disease and Epilepsy. Coeliac disease and epilepsy. In: Gobbi G, Andermann F, Naccarato S, Banchini G, eds. Epilepsy and other neurological disorders in coeliac disease, pp 65–79. London: John Libbey & Co. Ltd, 1997.

    Google Scholar 

  279. Berkovic SF. Progressive myoclonus epilepsies. In: Engel J, Jr, Pedley TA, eds. Epilepsy: A comprehensive textbook, second edition. pp 2525–2536. Philadelphia: Lippincott Williams and Wilkins, 2008.

    Google Scholar 

  280. Roger J, Genton P, Bureau M, Dravet C. Progressive myoclonus epilepsies in childhood and adolescence. In: Roger J, Bureau M, Dravet C, Dreifuss FE, Perret A, Wolf P, eds. Epileptic syndromes in childhood and adolescence. Second edition, pp 381–400. London: John Libbey & Co. Ltd, 1992.

    Google Scholar 

  281. Minassian BA. Lafora’s disease: towards a clinical, pathologic, and molecular synthesis. Pediatr Neurol 2001;25:21–29.

    PubMed  CAS  Google Scholar 

  282. Hirano M, Kunz WS, DiMauro S. Mitochondrial diseases. In: Engel J, Jr, Pedley TA, eds. Epilepsy: A comprehensive textbook, second edition. pp 2621–2630. Philadelphia: Lippincott Williams and Wilkins, 2008.

    Google Scholar 

  283. Gobbi G, Andermann F, Naccarato S, Banchini G. Epilepsy and other neurological disorders in coeliac disease. London: John Libbey & Co. Ltd, 1997.

    Google Scholar 

  284. Lawn N, Laich E, Ho S, Martin R, Faught E, Knowlton R, et al. Eclampsia, hippocampal sclerosis, and temporal lobe epilepsy: accident or association? Neurology 2004;62:1352–1356.

    PubMed  CAS  Google Scholar 

  285. Salanova V, Andermann F, Olivier A, Rasmussen T, Quesney LF. Occipital lobe epilepsy: electroclinical manifestations, electrocorticography, cortical stimulation and outcome in 42 patients treated between 1930 and 1991. Surgery of occipital lobe epilepsy. Brain 1992;115 Pt 6:1655–1680.

    PubMed  Google Scholar 

  286. Welch KM. Pathogenesis of migraine. Semin Neurol 1997;17:335–341.

    PubMed  CAS  Google Scholar 

  287. Ogunyemi A, Adams D. Migraine-like symptoms triggered by occipital lobe seizures: response to sumatriptan. Can J Neurol Sci 1998;25:151–153.

    PubMed  CAS  Google Scholar 

  288. Panayiotopoulos CP. Difficulties in differentiating migraine and epilepsy based on clinical and EEG findings. In: Andermann F, Lugaresi E, eds. Migraine and epilepsy, pp 31–46. Boston: Butterworths, 1987.

    Google Scholar 

  289. Andermann F, Zifkin B. The benign occipital epilepsies of childhood: an overview of the idiopathic syndromes and of the relationship to migraine. Epilepsia 1998;39Suppl 4:S9–S23.

    PubMed  Google Scholar 

  290. Hart YM, Andermann F. Migraine aura, seizures, and temporal lobe epilepsy. Adv Neurol 1999;81:145–152.

    PubMed  CAS  Google Scholar 

  291. Andermann F. Migraine and the benign partial epilepsies of childhood:evidence for an association. Epileptic Disord 2000:2Suppl 1:S37–S39.

    PubMed  Google Scholar 

  292. Kim SK, Lee DS, Lee SK, Kim YK, Kang KW, Chung CK, et al. Diagnostic performance of [18F]FDG-PET and ictal [99mTc]-HMPAO SPECT in occipital lobe epilepsy. Epilepsia 2001;42:1531–1540.

    PubMed  CAS  Google Scholar 

  293. Menon B. Symptomatic occipital epilepsy misdiagnosed as migraine. Headache 2007;47:287–289.

    PubMed  Google Scholar 

  294. Williamson PD, Thadani VM, Darcey TM, Spencer DD, Spencer SS, Mattson RH, et al. Occipital lobe epilepsy: clinical characteristics, seizure spread patterns, and results of surgery. Ann Neurol 1992;31:3–13.

    PubMed  CAS  Google Scholar 

  295. Olivier A, Boling W, Jr. Surgery of parietal and occipital lobe epilepsy. Adv Neurol 2000;84:533–575.

    PubMed  CAS  Google Scholar 

  296. Yun CH, Lee SK, Lee SY, Kim KK, Jeong SW, Chung CK. Prognostic factors in neocortical epilepsy surgery: multivariate analysis. Epilepsia 2006;47:574–579.

    PubMed  Google Scholar 

  297. Kramer G. The limitations of antiepileptic drug monotherapy. Epilepsia 1997;38Suppl 5:S9–S13.

    Google Scholar 

  298. Cockerell OC, Johnson AL, Sander JW, Shorvon SD. Prognosis of epilepsy: a review and further analysis of the first nine years of the British National General Practice Study of Epilepsy, a prospective population-based study. Epilepsia 1997;38:31–46.

    PubMed  CAS  Google Scholar 

  299. Mattson RH, Cramer JA, Collins JF, Smith DB, Delgado-Escueta AV, Browne TR, et al. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. N Engl J Med 1985;313:145–151.

    PubMed  CAS  Google Scholar 

  300. Perucca E. Inroduction to the choice of antiepileptic drugs. In: Shorvon S, Perucca E, Engel J Jr, eds. The treatment of epilepsy (3nd edition). Oxford: Willey-Blackwell, 2009:389–398.

    Google Scholar 

  301. Panayiotopoulos CP. Evidence-based epileptology, randomised controlled trials, and SANAD: A critical clinical view. Epilepsia 2007;48:1268–1274.

    PubMed  Google Scholar 

  302. French JA. First-choice drug for newly diagnosed epilepsy. Lancet 2007;369:970–971.

    PubMed  Google Scholar 

  303. French JA, Kryscio RJ. Active control trials for epilepsy: avoiding bias in head-to-head trials. Neurology 66:1294–1295.

    Google Scholar 

  304. Gamble C, Williamson PR, Chadwick DW, Marson AG. A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy. Neurology 2006;66:1310–1317.

    PubMed  CAS  Google Scholar 

  305. Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet 2007;369:1016–1026.

    PubMed  CAS  Google Scholar 

  306. Ferrie CD, Grunewald RA, Livingston JH, Panayiotopoulos CP. Treatment of newly diagnosed epilepsies: the shortcomings of SANAD. Dev Med Child Neurol 2008;50:247.

    PubMed  Google Scholar 

  307. Brodie MJ, Perucca E, Ryvlin P, Ben-Menachem E, Meencke HJ. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 2007;68:402–408.

    PubMed  CAS  Google Scholar 

  308. Jeavons PM, Clark JE, Maheshwari MC. Treatment of generalized epilepsies of childhood and adolescence with sodium valproate (“Epilim”). Dev Med Child Neurol 1977;19:9–25.

    PubMed  CAS  Google Scholar 

  309. Covanis A, Gupta AK, Jeavons PM. Sodium valproate: monotherapy and polytherapy. Epilepsia 1982;23:693–720.

    PubMed  CAS  Google Scholar 

  310. Bourgeois B, Beaumanoir A, Blajev B, de la Cruz N, Despland PA, Egli M, et al. Monotherapy with valproate in primary generalized epilepsies. Epilepsia 1987;28Suppl 2:S8–S11.

    PubMed  Google Scholar 

  311. Heller AJ, Chesterman P, Elwes RD, Crawford P, Chadwick D, Johnson AL, et al. Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial. J Neurol Neurosurg Psychiatr 1995;58:44–50.

    PubMed  CAS  Google Scholar 

  312. Verity CM, Hosking G, Easter DJ. A multicentre comparative trial of sodium valproate and carbamazepine in paediatric epilepsy. The Paediatric EPITEG Collaborative Group. Dev Med Child Neurol 1995;37:97–108.

    PubMed  CAS  Google Scholar 

  313. Chadwick DW. Valproate monotherapy in the management of generalized and partial seizures. Epilepsia 1987;28Suppl 2:S12–S17.

    PubMed  Google Scholar 

  314. Chadwick D. Valproate in the treatment of partial epilepsies. Epilepsia 1994;35Suppl 5:S96–S98.

    PubMed  Google Scholar 

  315. Sugai K. Clobazam as a new antiepileptic drug and clorazepate dipotassium as an alternative antiepileptic drug in Japan. Epilepsia 2004;45Suppl:20–25.

    PubMed  CAS  Google Scholar 

  316. Dalby MA. Clobazam. In: Shorvon S, Perucca E, Fish D, Dodson E, eds. The treatment of epilepsy. Second edition, pp 358–364. Oxford: Blackwell Publishing, 2004.

    Google Scholar 

  317. Ng YT, Collins SD. Clobazam. Neurotherapeutics 2007;4:138–144.

    PubMed  CAS  Google Scholar 

  318. Montenegro MA, Ferreira CM, Cendes F, Li LM, Guerreiro CA. Clobazam as add-on therapy for temporal lobe epilepsy and hippocampal sclerosis. Can J Neurol Sci 2005;32:93–96.

    PubMed  Google Scholar 

  319. Shorvon SD. The choice of drugs and approach to drug treatments in partial epilepsy. In: Shorvon S, Perucca E, Fish D, Dodson E, eds. The Treatment of Epilepsy. Second edition, pp 317–333. Oxford: Blackwell Publishing, 2004.

    Google Scholar 

  320. Perucca E. An introduction to antiepileptic drugs. Epilepsia 2005;46Suppl 4:31–37.

    PubMed  CAS  Google Scholar 

  321. Patsalos PN. Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies. Epilepsia 2005;46Suppl 9:140–148.

    PubMed  CAS  Google Scholar 

  322. Patsalos PN. Levetiracetam. Rev Contemp Pharm 2004;13:1–168.

    CAS  Google Scholar 

  323. Patsalos PN. Anti-Epileptic Drug Interactions: A Clinical Guide. Cranleigh, U.K.: Clarius Press Ltd; 2005.

    Google Scholar 

  324. Perucca E. General principles of medical management. In: Shorvon S, Perucca E, Engel J Jr, eds. The treatment of epilepsy (3nd edition), pp 121–139. Oxford: Willey-Blackwell, 2009.

    Google Scholar 

  325. Willmore LJ, Pickens IV A, Pellock JM. Monitoring for Adverse Effects of Antiepileptic Drugs, 4th Edition. In: Wyllie E, Gupta A, Lachhwani D, editors. Philadelphia: Lippincott Williams & Wilkins; 2006;737–743.

    Google Scholar 

  326. Johannessen SI, Tomson T. Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed? Clin Pharmacokinet 2006;45:1061–1075.

    PubMed  CAS  Google Scholar 

  327. Vimpat® (lacosamide). Summary of product characteristics. UCB Pharma Ltd, 2008.

    Google Scholar 

  328. Ben-Menachem E. Lacosamide: an investigational drug for adjunctive treatment of partial-onset seizures. Drugs Today (Barc) 2008;44:35–40.

    CAS  Google Scholar 

  329. Rogawski MA. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res 2006;69:273–294.

    PubMed  CAS  Google Scholar 

  330. Gillard M, Chatelain P, Fuks B. Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein. Eur J Pharmacol 2006;536:102–108.

    PubMed  CAS  Google Scholar 

  331. Perucca E. Clinically relevant drug interactions with antiepileptic drugs. Br J Clin Pharmacol 2006;61:246–255.

    PubMed  CAS  Google Scholar 

  332. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol 2003;2:473–481.

    PubMed  CAS  Google Scholar 

  333. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs. Lancet Neurol 2003;2:347–356.

    PubMed  CAS  Google Scholar 

  334. Crawford P. Interactions between antiepileptic drugs and hormonal contraception. CNS Drugs 2002;16:263–272.

    PubMed  CAS  Google Scholar 

  335. Zupanc ML. Antiepileptic drugs and hormonal contraceptives in adolescent women with epilepsy. Neurology 2006;66:S37–S45.

    PubMed  CAS  Google Scholar 

  336. Holmes LB, Wyszynski DF, Baldwin EJ, Haebecker E, Glassman LH, Smith CR. Increased risk for non-syndromic cleft palate among infants exposed to lamotrigine during pregnancy. Birth Defects Res A Clin Mol Teratol 2006;76:318.

    Google Scholar 

  337. French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, et al. Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004;62:1252–1260.

    PubMed  CAS  Google Scholar 

  338. Frisium® (clobazam). Summary of product characteristics. Sanofiaventis, 2007.

    Google Scholar 

  339. Rivotril® (clonazepam). Summary of product characteristics. Roche Products Ltd, 2008.

    Google Scholar 

  340. Zarontin® (ethosuximide). Summary of product characteristics. Pfizer Ltd, 2007.

    Google Scholar 

  341. Lamictal® (lamotrigine). Summary of product characteristics. GlaxoSmithKline UK Ltd, 2007.

    Google Scholar 

  342. Keppra® (levetiracetam). Summary of product characteristics. UCB Pharma Ltd, 2008.

    Google Scholar 

  343. Trileptal® (oxcarbazepine). Summary of product characteristics. Novartis Pharmaceuticals UK Ltd, 2006.

    Google Scholar 

  344. Patsalos PN. Clinical pharmacokinetics of levetiracetam. Clin Pharmacokinet 2004;43:707–724.

    PubMed  CAS  Google Scholar 

  345. Patsalos PN. The pharmacokinetic characteristics of levetiracetam. Methods Find Exp Clin Pharmacol 2003;25:123–129.

    PubMed  CAS  Google Scholar 

  346. Tomson T, Dahl M, Kimland E. Therapeutic monitoring of antiepileptic drugs for epilepsy. Cochrane Database Syst Rev 2007;(1):CD002216.

    PubMed  Google Scholar 

  347. Czapinski P, Blaszczyk B, Czuczwar SJ. Mechanisms of action of antiepileptic drugs. Curr Top Med Chem 2005;5:3–14.

    PubMed  CAS  Google Scholar 

  348. Kwan P, Sills GJ, Brodie MJ. The mechanisms of action of commonly used antiepileptic drugs. Pharmacol Ther 2001;90:21–34.

    PubMed  CAS  Google Scholar 

  349. Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Perucca E, Tomson T. Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII). Epilepsy Res 2007;73:1–52.

    PubMed  Google Scholar 

  350. Zaccara G, Messori A, Cincotta M, Burchini G. Comparison of the efficacy and tolerability of new antiepileptic drugs: what can we learn from long-term studies? Acta Neurol Scand 2006;114:157–168.

    PubMed  CAS  Google Scholar 

  351. Beydoun A, D’Souza J, Hebert D, Doty P. Lacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partialonset seizures. Expert Rev Neurother 2009;9:33–42.

    PubMed  CAS  Google Scholar 

  352. Curia G, Biagini G, Perucca E, Avoli M. Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs 2009;23:555–568.

    PubMed  CAS  Google Scholar 

  353. Biton V, Rosenfeld WE, Whitesides J, Fountain NB, Vaiciene N, Rudd GD. Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures. Epilepsia 2008;49:418–424.

    PubMed  CAS  Google Scholar 

  354. Guberman AH, Besag FM, Brodie MJ, Dooley JM, Duchowny MS, Pellock JM, et al. Lamotrigine-associated rash: risk/benefit considerations in adults and children. Epilepsia 1999;40:985–991.

    PubMed  CAS  Google Scholar 

  355. Arif H, Buchsbaum R, Weintraub D, Pierro J, Resor SR, Jr., Hirsch LJ. Patient-reported cognitive side effects of antiepileptic drugs: predictors and comparison of all commonly used antiepileptic drugs. Epilepsy Behav 2009;14:202–209.

    PubMed  Google Scholar 

  356. Chadwick D. Safety and efficacy of vigabatrin and carbamazepine in newly diagnosed epilepsy: a multicentre randomised double-blind study. Vigabatrin European Monotherapy Study Group. Lancet 1999;354:13–19.

    PubMed  CAS  Google Scholar 

  357. French JA. Vigabatrin. Epilepsia 1999;40Suppl 5:S11–S16.

    PubMed  CAS  Google Scholar 

  358. Eke T, Talbot JF, Lawden MC. Severe persistent visual field constriction associated with vigabatrin. BMJ 1997;314:180–181.

    PubMed  CAS  Google Scholar 

  359. Wild JM, Chiron C, Ahn H et al. Visual field loss in patients with refractory partial epilepsy treated with vigabatrin: final results from an open-label, observational, multicentre study. CNS Drugs 2009;23:965–982.

    PubMed  CAS  Google Scholar 

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Panayiotopoulos, C.P. (2010). Symptomatic and cryptogenic (probably symptomatic) focal epilepsies. In: A Clinical Guide to Epileptic Syndromes and their Treatment. Springer, London. https://doi.org/10.1007/978-1-84628-644-5_15

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