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Functional Magnetic Resonance Imaging in Awake Rats: Studies Relevant to Addiction and the Reward Circuitry

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Animal Models of Eating Disorders

Part of the book series: Neuromethods ((NM,volume 74))

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Abstract

Functional magnetic resonance imaging (fMRI) has been used to investigate human and laboratory animal brain reward function using a variety of experimental paradigms. The most popular functional imaging technique relies on the blood oxygen level-dependent (BOLD) contrast mechanism first reported in the anesthetized rat by Seiji Ogawa and coworkers in the early 1990s. A significant advantage of fMRI is that it allows a functional characterization of the awake rodent brain under different treatment and pharmacological conditions. We have performed fMRI of the neural actions of cocaine in awake male and female rats and the lactation stimulus in postpartum rats. Animal studies have the design flexibility to verify results with a multiplicity of invasive brain methods that can inform human work and aid in data interpretations. This review provides a summary of the methods used for fMRI experiments in rats with a special focus on awake imaging methods used in our laboratory, which can be applied to feeding behavior.

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Acknowledgments

The author is supported by NIH grant DA019946.

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Authors and Affiliations

  1. Department of Psychiatry, University of Florida, Gainesville, FL, USA

    Marcelo Febo Ph.D.

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  1. Marcelo Febo Ph.D.
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Correspondence to Marcelo Febo Ph.D. .

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  1. College of Medicine, Department of Psychiatry, University of Florida, S. Newell Dr. 100, Gainesville, 32610, Florida, USA

    Nicole M. Avena

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Febo, M. (2013). Functional Magnetic Resonance Imaging in Awake Rats: Studies Relevant to Addiction and the Reward Circuitry. In: Avena, N. (eds) Animal Models of Eating Disorders. Neuromethods, vol 74. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-104-2_21

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  • DOI: https://doi.org/10.1007/978-1-62703-104-2_21

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