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Pathogenesis of Hypertension and Renal Disease in Obesity

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Pediatric Obesity

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

Obesity, hypertension, and renal injury are linked by complex inter-relationships. Obesity-associated metabolic abnormalities promote both systemic hypertension and renal injury; hypertension in turn results from, and contributes to, progressive renal damage, regardless of primary cause. It is now well established that obesity dramatically increases the risks of type-II diabetes and diabetic nephropathy; yet even in the absence of diabetes, obesity predisposes to chronic kidney disease and accelerates its progression. In this chapter we discuss the pathogenesis of hypertension and renal disease in obese adults and children and reflect on their implications for therapy.

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Authors and Affiliations

  1. Division of Pediatric Nephrology, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University School of Medicine, Nashville, TN, USA

    Tracy E. Hunley & Valentina Kon

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  1. Tracy E. Hunley
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  1. Department of Pediatric Endocrinology, and Diabetes, Duke University, DUMC 3080, Durham, 27710, North Carolina, USA

    Michael Freemark

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Hunley, T.E., Kon, V. (2010). Pathogenesis of Hypertension and Renal Disease in Obesity. In: Freemark, M. (eds) Pediatric Obesity. Contemporary Endocrinology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-60327-874-4_16

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