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Drug Disposition and Response

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Handbook of Drug-Nutrient Interactions

Part of the book series: Nutrition and Health ((NH))

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Objectives

•Review basic principles of pharmacokinetics related to the absorption, distribution, metabolism, and elimination of drugs and nutrients.

•Discuss factors that can affect these processes.

•Review basic principles of pharmacodynamics and the quantification of drug and nutrient action.

•Highlight potential pharmacokinetic and pharmacodynamic sites of drug–nutrient interactions.

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References

  1. Raffa RB, Rawls SM, Portyansky-Beyzarov E. Netter’s Illustrated Pharmacology. Philadelphia, PA: Elsevier, 2005.

    Google Scholar 

  2. Rang HP, Dale MM, Ritter JM, et al. Pharmacology. New York: Churchill Livingstone, 1995:74–79.

    Google Scholar 

  3. Jacob LS. NMS Pharmacology. 4th ed. Philadelphia, PA: Williams & Wilkins, 1996:3–4.

    Google Scholar 

  4. Xie H-G, Kim RB, Wood AJJ, et al. Molecular basis of ethnic differences in drug disposition and response. Annu Rev Pharmacol Toxicol 2001;41:815–850.

    Article  CAS  Google Scholar 

  5. Pratt WB. The entry, distribution, and elimination of drugs. In: Pratt WB, Taylor P, eds. Principles of Drug Action: the Basis of Pharmacology. 3rd ed. New York: Churchill Livingstone, 1990:231–236.

    Google Scholar 

  6. Holford NHG, Benet LZ. Pharmacokinetics & pharmacodynamics: dose selection & the time course of drug action. In: Katzung BG, ed. Basic & Clinical Pharmacology. 7th ed. Stamford, CT: Appleton & Lange, 1998:34–49.

    Google Scholar 

  7. de Boer AG, van der Sandt ICJ, Gaillard PJ. The role of drug transporters at the blood–brain barrier. Annu Rev Pharmacol Toxicol 2003;43:629–656.

    Article  Google Scholar 

  8. Levine RR. Pharmacology: Drug Actions and Reactions. 5th ed. New York: Parthenon, 1996:51–74.

    Google Scholar 

  9. Benet LZ, Kroetz DL, Sheiner LB. Pharmacokinetics: the dynamics of drug absorption, distribution, and elimination. In: Hardman JG, Limbird LE, eds-in-chief. Goodman & Gilman's the Pharmacological Basis of Therapeutics. 9th ed. New York: McGraw-Hill, 1996:11–16.

    Google Scholar 

  10. Lin JH, Lu AYH. Inhibition and induction of cytochrome P450 and the clinical implications. Clin Pharmacokinet 1998;35:361–390.

    Article  CAS  Google Scholar 

  11. Park BK, Kitteringham NR, Pirmohamed M, et al. Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications. Br J Clin Pharmacol 1996;41:477–491.

    Article  CAS  Google Scholar 

  12. Lin JH, Lu AYH. Interindividual variability in inhibition and induction of cytochrome P450 enzymes. Annu Rev Pharmacol Toxicol 2001;41:535–567.

    Article  CAS  Google Scholar 

  13. Shargel L, Yu ABC. Applied Biopharmaceutics and Pharmacokinetics. 3rd ed. Stamford, CT: Appleton & Lange, 1993:265–292.

    Google Scholar 

  14. Raffa RB. Mechanisms of drug action. In: Raffa RB, ed. Quick Look Pharmacology. Madison, CT: Fence Creek, 1999:14–15.

    Google Scholar 

  15. Boeynaems JM, Dumont JE. Outlines of Receptor Theory. Amsterdam: Elsevier/North-Holland, 1980:1–226.

    Google Scholar 

  16. Raffa RB. Drug-Receptor Thermodynamics: Introduction and Applications. Chichester, UK; John Wiley & Sons, 2001:1–781.

    Google Scholar 

  17. Roerig SC. Drug receptors and signaling. In: Raffa RB, ed. Quick Look Pharmacology. Madison, CT: Fence Creek, 1999:16–17.

    Google Scholar 

  18. Strader CD, Fong TM, Tota MR, et al. Structure and function of G protein-coupled receptors. Annu Rev Biochem 1994;63:101–132.

    Article  CAS  Google Scholar 

  19. Gudermann T, Kalkbrenner F, Schultz G. Diversity and selectivity of receptor-G protein interaction. Annu Rev Pharmacol Toxicol 1996;36:429–459.

    CAS  Google Scholar 

  20. Tallarida RJ, Jacob LS. The dose–response relation in pharmacology. New York: Springer-Verlag, 1979:1–207.

    Google Scholar 

  21. Tallarida RJ. Drug synergism and dose-effect data analysis. Boca Raton, FL: Chapman & Hall/CRC, 2000:1–247.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Professor of Pharmacology, Temple University School of Pharmacy, Philadelphia, PA, USA

    Robert B. Raffa

Authors
  1. Robert B. Raffa
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Editor information

Editors and Affiliations

  1. School of Nursing, University of Pennsylvania, Guardian Dr. 420, Philadelphia, 19104, U.S.A.

    Joseph I. Boullata

  2. Dept. Surgery, Temple University Hospital, N. Broad St. 3401, Philadelphia, 19140, U.S.A.

    Vincent T. Armenti

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Raffa, R.B. (2009). Drug Disposition and Response. In: Boullata, J., Armenti, V. (eds) Handbook of Drug-Nutrient Interactions. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60327-362-6_2

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  • DOI: https://doi.org/10.1007/978-1-60327-362-6_2

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-363-3

  • Online ISBN: 978-1-60327-362-6

  • eBook Packages: MedicineMedicine (R0)

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