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DNA Microarrays in Drug Discovery and Development

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Abstract

Ever since the completion of the human genome project, there has been great interest in the research community toward addressing the role played by multiple genes to orchestrate complex cellular functions. This requires techniques that allow high-throughput analysis of such target genes. Low manufacturing and application costs, flexibility, and speed of analyses in a high-throughput fashion make DNA microarrays one of the most invaluable tools in this endeavor. DNA microarrays have revolutionized genomic and pharmacologic investigations by allowing simultaneous monitoring of all the genes in different genomes, thus linking the entire genome expression with the function of the whole organism. Microarrays are widely used to address a plethora of scientific questions in the pharmaceutical industry, particularly in drug discovery and development. The technique has immense potential and promises to play a key role in furthering research in a number of fields, as discussed in this chapter.

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Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV

    Neelam Azad

  2. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Anand Krishnan V. Iyer

  3. Department of Basic Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV

    Yon Rojanasakul PhD

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  1. Neelam Azad
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  2. Anand Krishnan V. Iyer
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  3. Yon Rojanasakul PhD
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Editors and Affiliations

  1. Pharmaceutical Sciences Graduate Programs Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA

    Susanna Wu-Pong PhD (Director) (Director)

  2. Virginia Commonwealth University, Box 980581, Medical College of Virginia Campus, Richmond, VA, 23298

    Susanna Wu-Pong PhD (Director) (Director)

  3. Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV

    Yon Rojanasakul PhD (Professor of Pharmaceutical and Pharmacological Sciences) (Professor of Pharmaceutical and Pharmacological Sciences)

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© 2008 Humana Press Inc., Totowa, NJ

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Azad, N., Iyer, A.K.V., Rojanasakul, Y. (2008). DNA Microarrays in Drug Discovery and Development. In: Wu-Pong, S., Rojanasakul, Y. (eds) Biopharmaceutical Drug Design and Development. Humana Press. https://doi.org/10.1007/978-1-59745-532-9_4

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