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The Isotypes of Tubulin

Distribution and Functional Significance

  • Chapter
The Role of Microtubules in Cell Biology, Neurobiology, and Oncology

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The tubulin molecule is an α/β heterodimer. In most eukaryotes both α-and β-tubulin consist of isotypes encoded by different genes and differing in amino acid sequence. Differences among isotypes are often highly conserved in evolution, suggesting that they have functional significance. The complex isotype families in mammals, Drosophila and higher plants have been particularly well studied. Different isotypes often have different cellular and tissue distributions. In addition, purified isotypes display different properties including assembly, GTPase, conformation, dynamics, and ability to interact with anti-tumor drugs. The different cellular, tissue, and species distribution, as well as their primary structures and their in vitro properties give clues as to the possible functions of the different isotypes, which will be discussed in this chapter.

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  1. Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX

    Richard F. Ludueña PhD & Asok Banerjee PhD

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  1. Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD

    Tito Fojo MD, PhD

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Ludueña, R.F., Banerjee, A. (2008). The Isotypes of Tubulin. In: Fojo, T. (eds) The Role of Microtubules in Cell Biology, Neurobiology, and Oncology. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-336-3_6

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