Summary
The polycystic ovary syndrome (PCOS) is a heterogeneous condition. Polycystic ovaries are detected in 19–33% of the “general population,” of whom approximately 80% have symptoms of PCOS, albeit for many such symptoms are usually mild. Thus, about 20% of women with polycystic ovaries are symptom free. It appears that ovarian dysfunction is expressed when the ovaries of women with polycystic ovaries alone are stressed, by either a gain in weight, a rise in circulating insulin levels, or stimulation with follicle-stimulating hormone (FSH) for assisted conception treatments. Longitudinal studies are required to better explore the evolution of signs and symptoms of the syndrome over time in women with polycystic ovaries and by comparison with those with normal ovaries.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Fauser B, Tarlatzis B, Chang J, Azziz R, Legro R, Dewailly D, Franks S, Balen AH, Bouchard P, Dahlgren E, Devoto, Diamanti E, Dunaif A, Filicori M, Homburg R, Ibanez L, Laven J, Magoffin D, Nestler J, Norman R, Pasquali R, Pugeat M, Strauss J, Tan SL, Taylor A, Wild R, Wild S. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Human Reprod 2004; 19:41–47.
Balen AH, Laven JSE, Tan SL, Dewailly D. Ultrasound assessment of the polycystic ovary: international consensus definitions. Human Reprod Update 2003; 9:505–514.
Polson DW, Adams J, Wadsworth J, Franks S. Polycystic ovaries–a common finding in normal women. Lancet 1988;1:870–872.
Michelmore KF, Balen AH, Dunger DB, Vessey MP. Polycystic ovaries and associated clinical and biochemical features in young women. Clin Endocrinol (Oxf) 1999; 51:779–786.
Balen AH, Conway GS, Kaltsas G, Techatraisak K, Manning PJ, West C, Jacobs HS. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Human Reprod 1995; 10:2705–2712.
MacDougall MJ, Tan SL, Balen A, Jacobs HS. A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization. Hum Reprod 1993; 8:233–236.
Franks S, White D, Gilling-Smith C, Carey A, Waterworth D, Williamson R. Hypersecretion of androgens by polycystic ovaries: the role of genetic factors in the regulation of cytochrome P450c17α, Ballieres Clin Endocrinol Metabol 1996, 10(2):193–203.
Rosenfield RL, Barnes RB, Cara JF, Lucky AW. Dysregulation of cytochrome P450c17α as the cause of polycystic ovarian syndrome. Fertility Sterility 1990, 53(5):785–791.
Franks S. Polycystic ovary syndrome: a changing perspective. Clin Endocrinol (Oxf) 1989; 31:87–120.
Goldzieher JW. Polycystic ovarian disease. Fertil Steril 1981; 35:371–394.
Polson DW, Adams J, Wadsworth J, Franks S. Polycystic ovaries–a common finding in normal women. Lancet 1988; 1:870–872.
Tayob Y, Robinson G, Adams J, et al. Ultrasound appearance of the ovaries during the pill-free interval. Br J Family Planning 1990; 16:94–96.
Clayton RN, Ogden V, Hodgkinson J, et al. How common are polycystic ovaries in normal women and what is their significance for the fertility of the population? [see comments]. Clin Endocrinol (Oxf) 1992; 37:127–134.
Farquhar CM, Birdsall M, Manning P, Mitchell JM, France JT. The prevalence of polycystic ovaries on ultrasound scanning in a population of randomly selected women. Aust N Z J Obstet Gynaecol 1994; 34:67–72.
Botsis D, Kassanos D, Pyrgiotis E, Zourlas PA. Sonographic incidence of polycystic ovaries in a gynecological population. Ultrasound Obstet Gynecol 1995; 6:182–185.
Cresswell JL, Barker DJ, Osmond C, Egger P, Phillips DI, Fraser RB. Fetal growth, length of gestation, and polycystic ovaries in adult life. Lancet 1997; 350:1131–1135.
Zawadski JK, Dunaif A Diagnostic criteria for polycystic ovary syndrome; towards a rational approach. In: Polycystic Ovary Syndrome. Dunaif A, Givens JR, Haseltine F, eds. Boston: Blackwell Scientific. 1992:377–384.
Dunaif A, Finegood DT. Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab 1996; 81:942–947.
Conway et al, 1993 Conway GS, Clark PM, Wong D. Hyperinsulinaemia in the polycystic ovary syndrome confirmed with a specific immunoradiometric assay for insulin. Clin Endocrinol (Oxf) 1993; 38:219–222.
Isojarvi IT, Laatikainen T, Pakarinen AJ, Juntunen KTS, Myllyla VV. Polycystic ovaries and hyperandrogenism in women taking valporate for epilepsy. N Engl J Med 1993; 329:1383–1388.
Webber LJ, Stubbs S, Stark J, Trew GH, Franks S. Formation and early development of follicles in the polycystic ovary. Lancet 2003; 362:1017–1021.
White DW, Leigh A, Wilson C, et al. Gonadotrophin and gonadal steriod response to a single dose of a long-acting agonist of gonadotrophin-releasing hormone in ovulatory and anovulatory women with polycystic ovary syndrome. Clin Endocrinol 1995, 42:475–481.
Barnes, RB, Rosenfield RL, Burstein S et al, Pituitary-ovarian response to nafarelin testing in the polycystic ovary syndrome. N Engl J Med 1989; 320:559–563.
Erickson GF, Magoffin DA, Garza VG, et al., Granulosa cells of polycystic ovaries: are they normal or abnormal? Hum Reprod 1992 , 7:293–299.
Mason HD, Willis DS, Beard RW, et al. Estradiol production by granulosa cells of normal and polycystic ovaries (PCO): relationship to menstrual cycle history and to concentrations of gonadotrophins and sex steroids in follicular fluid. J Clin Endocrinol Metab 1994, 79:1355.
Anderson R, Groome N, Baird D. Inhibin A and inhibin B in women with polycystic ovarian syndrome during treatment with FSH to induce mono-ovulation. Clin Endocrinol 1998, 48:577–582.
Schachter M, Balen AH, Patel A, Jacobs HS. Hypogonadotrophic patients with ultrasonographically diagnosed polycystic ovaries have aberrant gonadotropin secretion when treated with pulsatile gonadotrophin releasing hormone–a new insight into the pathophysiology of polycystic ovary syndrome. Gynecol Endocrinol 1996; 10:327–335.
MacDougall JM, Tan SL, Hall V, Balen AH, Mason BA, Jacobs HS. Comparison of natural with clomiphene citrate-stimulated cycles in IVF: a prospective randomized trial. Fertil Steril 1994; 61:1052–1057.
Balen AH, Braat DDM, West C, Patel A, Jacobs HS. Cumulative conception and live birth rates after the treatment of anovulatory infertility. An analysis of the safety and efficacy of ovulation induction in 200 patients. Hum Reprod 1994; 9:1563–1570.
Smitz J, Camus M, Devroey P, Evard P, Wisanto A, Van Steirteghem AC. Incidence of severe ovarian hyperstimulation syndrome after gonadotropin releasing hormone agonist/HMG superovulation for in-vitro fertilization. Hum Reprod 1991; 6:933–937.
Dor J, Shulman A, Levran D, Ben-Rafael Z, Rudak E, Mashiach S. The treatment of patients with polycystic ovary syndrome by in-vitro fertilization: a comparison of results with those patients with tubal infertility. Hum Reprod 1990; 5:816–818.
Homburg R, Berkowitz D, Levy T, Feldberg D, Ashkenazi J, Ben-Rafael Z. In-vitro fertilization and embryo transfer for the treatment of infertility associated with polycystic ovary syndrome. Fertil Steril 1993; 60:858–863.
Mulders-Annemarie-G-M-G-J, Laven-Joop-S-E, Eijkemans-Marinus-J-C, de-Jong-Frank-H, Themmen-Axel-P-N, Fauser-Bart-C-J-M. Changes in anti-Müllerian hormone serum cocentrations over time suggest delayed ovarian ageing in normogonadotrophic anovulatory infertility. Hum Reprod Sep 2004; 19(9):2036–2042.
Nikolaou-D, Gilling-Smith-C. Early ovarian ageing: are women with polycystic ovaries protected? Hum Reprod Oct 2004; 19(10):2175–2179.
Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanisms and implication for pathogenesis. Endocr Rev 1997; 18:774–800.
Bergh C, Carlsson B, Olsson JH, Selleskog U, Hillensjo T. Regulstion of androgen production in cultured human thecal cells by insulin-like growth factor I and insulin. Fertil Steril 1993; 59:323–331.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Humana Press
About this chapter
Cite this chapter
Balen, A. (2008). Polycystic Ovary Versus Polycystic Ovary Syndrome. In: Dunaif, A., Chang, R.J., Franks, S., Legro, R.S. (eds) Polycystic Ovary Syndrome. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59745-108-6_4
Download citation
DOI: https://doi.org/10.1007/978-1-59745-108-6_4
Publisher Name: Humana Press
Print ISBN: 978-1-58829-831-7
Online ISBN: 978-1-59745-108-6
eBook Packages: MedicineMedicine (R0)