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Apoptosis and Breast Cancer

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Apoptosis and Cancer Chemotherapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Apoptosis is an integral part of normal mammary gland development, differentiation, and function. Numerous descriptive and mechanistic studies of programmed cell death pathways in normal and malignant mammary cells have been presented. This chapter reviews the evidence that established breast cancer treatments act via apoptotic pathways, and how ongoing laboratory work defining these pathways might lead to the development of new therapeutic ap proaches. Also, the possibility that evaluation of apoptotic-related molecules or events might serve as prognostic or predictive factors is discussed.

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Authors
  1. Nancy E. Davidson MD
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  2. Hillary A. Hahm MD, PhD
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  3. Deborah K. Armstrong MD
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Editor information

Editors and Affiliations

  1. Cancer Research Campaign, Molecular and Cellular Pharmacology Group, School of Biological Sciences, University of Manchester, UK

    John A. Hickman  & Caroline Dive  & 

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© 1999 Springer Science+Business Media New York

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Davidson, N.E., Hahm, H.A., Armstrong, D.K. (1999). Apoptosis and Breast Cancer. In: Hickman, J.A., Dive, C. (eds) Apoptosis and Cancer Chemotherapy. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-720-8_19

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  • DOI: https://doi.org/10.1007/978-1-59259-720-8_19

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-165-3

  • Online ISBN: 978-1-59259-720-8

  • eBook Packages: Springer Book Archive

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