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Neuropathology and Cardiovascular Regulation

Clinical Aspects

  • Chapter
The Nervous System and the Heart

Abstract

The most important physiological role of the autonomic nervous system (ANS) is to regulate the functions of various organs, which means it aims to adapt and modulate the somatic behavior to the changing circumstances of endogenous or environmental origin. Therefore, reactions of ANS are linked to almost all the physiological and pathological conditions of the human body. In addition, there are diseases that may primarily or secondarily affect ANS. However, we have to admit that, at the moment, our knowledge of the frequency and severity of the diseases of ANS is inadequate and contradictory, which may be explained by the limited number and reliability of the diagnostic methods, but the situation is rapidly improving, and in the near future, these problems are certainly overcome.

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References

  1. Bannister, R. (1988) Autonomic failure, in A Textbook of Clinical Disorders of the Autonomic Nervous System ( Bannister, R., ed.), Oxford Medical Publications, Oxford, UK.

    Google Scholar 

  2. Ewing, D. J., Campbell, I. W., Burt, A. A., and Clarke, B. F. (1973) Vascular reflexes in diabetic autonomic neuropathy. Lancet 2, 1354.

    Article  PubMed  CAS  Google Scholar 

  3. Persson, A. and Solders, G. (1983) R—R variations in Guillain—Barré syndrome: a test of autonomic dysfunction. Acta Neurol. Scand. 67, 294–300.

    Article  PubMed  CAS  Google Scholar 

  4. Solders, G., Persson, A., and Gutierrez, A. (1985) Autonomic dysfunction in non-diabetic terminal uraemia. Acta Neurol. Scand. 71, 321–327.

    PubMed  CAS  Google Scholar 

  5. Ewing, D. J., Campbell, I. W., and Clarke, B. F. (1980) Assessment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications. Ann. Intern. Med. 92, 308–311.

    PubMed  CAS  Google Scholar 

  6. Ewing, D. J., Campbell, I. W., and Clarke, B. F. (1980) The natural history of diabetic autonomic neuropathy. Quart. J. Med. 49, 95–108.

    PubMed  CAS  Google Scholar 

  7. Ewing, D. J., Campbell, I. W., and Clarke, B. F. (1976) Mortality in diabetic autonomic neuropathy. Lancet 1, 601–603.

    Article  PubMed  CAS  Google Scholar 

  8. Page, M. and Watkins, P. (1978) Cardio-respiratory arrest and diabetic autonomic neuropathy. Lancet 1, 14–16.

    Article  PubMed  CAS  Google Scholar 

  9. Lloyd-Mostyn, R. H. and Watkins, P. J. (1976) Total cardiac denervation diabetic autonomic neuropathy. Diabetes 25, 748.

    Article  PubMed  CAS  Google Scholar 

  10. Faerman, J., Faccio, E., Milei, J., Nunez, R., Jadzinsky, M., Fox, D., et al. (1977) Autonomic neuropathy and painless myocardial infarction in diabetic patients. Histolocic evidence of their relationship. Diabetes 26, 1147–1158.

    Article  PubMed  CAS  Google Scholar 

  11. Johnsson, R. H. and Robinson, B. J. (1988) Mortality in alcoholics with autonomic neuropathy. J. Neurosurg. 51, 476.

    Google Scholar 

  12. Malik, M., Farrel, T., and Camm, A. J. (1990) Circadian rhythm of heart rate variability after acute myocardial infarction and its influence on the prognostic value of heart rate variability. Am. J. Cardiol. 66, 1049–1054.

    Article  PubMed  CAS  Google Scholar 

  13. Huikuri, H. V., Niemelä, M. J., Ojala, S., Rantala, A., Ikäheimo, M. J., and Airaksinen, K. E. J. (1994) Circadian rhythms of frequency domain measures of heart rate variability in healthy subjects and patients with coronary artery disease. Circulation 90, 121–126.

    Article  PubMed  CAS  Google Scholar 

  14. Vanoli, E., Adamson, P. B., Ba-Lin, M. P. H., Pinna, G. D., Lazzara, R., and Orr, W. C. (1995) Heart rate variability during specific sleep stages: a comparison of health subjects with patients after myocardial infarction. Circulation 91, 1918–1922.

    Article  PubMed  CAS  Google Scholar 

  15. Frank, J. I., Ropper, A. H., and Zuflica, G. (1992) Acute intracranial lesions and respiratory sinus arrhythmia. Arch. Neurol. 49, 1200–1203.

    Article  PubMed  CAS  Google Scholar 

  16. Barron, S. A., Rogovski, Z., and Hemli, J. (1994) Autonomic consequences of cerebral hemisphere infarction. Stroke 25, 113–116.

    Article  PubMed  CAS  Google Scholar 

  17. Korpelainen, J. T., Sotaniemi, K. A., Suominen, K., Tolonen, U., and Myllylä, V. V. (1994) Cardiovascular autonomic reflexes in brain infarction. Stroke 25, 787–792.

    Article  PubMed  CAS  Google Scholar 

  18. Korpelainen, J. T., Sotaniemi, K. A., Huikuri, H. V., and Myllylä, V. V. (1996) Abnormal heart rate variability as a manifestation of autonomic dysfunction in hemispheric brain infarction. Stroke 27, 2059–2063.

    Article  PubMed  CAS  Google Scholar 

  19. Korpelainen, J. T., Huikuri, H. V., Sotaniemi, K. A., and Myllylä, V. V. (1996) Abnormal heart rate variability reflecting autonomic dysfunction in brainstem infarction. Acta Neurol. Scand. 94, 337–342.

    Article  PubMed  CAS  Google Scholar 

  20. Naver, H. K., Blomstrand, C., and Wallin, B. G. (1996) Reduced heart rate variability after right-sided stroke. Stroke 27, 247–251.

    Article  PubMed  CAS  Google Scholar 

  21. Nogues, M. A., Newman, P. K., Male, V. J., and Foster, J. B. (1982) Cardiovascular reflexes in syringomyelia. Brain 105, 835.

    Google Scholar 

  22. Turkka, J. (1986) Autonomic dysfunction in Parkinson’s disease. Doctoral thesis. Acta Universitatis Ouluensis, Series D, Medica No 142, University of Oulu, Oulu, Finland.

    Google Scholar 

  23. Ravits, J. M. (1997) AAEM minimonograph 48: autonomic nervous system testing. Muscle Nerve 20, 919–937.

    Google Scholar 

  24. Omboni, S., Parati, G., DiRienzo, Wieling W., and Mancia, G. (1996) Blood pressure and heart rate variability in autonomic disorders: a critical review. Clin. Auton. Res. 6, 171–182.

    Article  PubMed  CAS  Google Scholar 

  25. Wallin, G. B. and Elam, M. (1997) Microneurography and autonomic dysfunction, in Clinical Autonomic Disorders ( Low, P. A., ed.), Lippincott-Raven, Philadelphia, pp. 233–243.

    Google Scholar 

  26. The Consensus Committee of the American Autonomic Society and the American Academy of Neurology. Consensus statement of the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology 46, (1996) 1470.

    Google Scholar 

  27. Van Lieshout, J. J., Wieling, W., Karemaker, J. M., and Eckberg, D. L. (1991) The vasovagal response (Review). Clin. Sci. 81, 575–586.

    PubMed  Google Scholar 

  28. Braune, S., Auer, A., Schulte-Mönting, J., Schwerbrock, S., and Luking, C. H. (1996) Cardiovascular parameters: sensitivity to detect autonomic dysfunction and influence of age and sex in normal subjects. Clin. Auton. Res. 6, 3–15.

    Article  PubMed  CAS  Google Scholar 

  29. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurements, physiological interpretation and clinical use. Circulation 93, (1996) 1043–1065.

    Google Scholar 

  30. Diehl, R. R., Linden, D., and Berlit, P. (1997) Determinants of heart rate variability during deep breathing: basic findings and clinical applications. Clin. Auton. Res. 7, 131–135.

    Article  PubMed  CAS  Google Scholar 

  31. Khurana, R. K. and Nicholas, E. M. (1996) Head-up tilt table test: how far and how long? Clin. Auton. Res. 6, 335–341.

    Article  PubMed  CAS  Google Scholar 

  32. Sundkvist, G., Lilja, B., and Almer, L. O. (1980) Abnormal diastolic blood pressure and heart rate reactions to tilting in diabetes mellitus. Diabetologia 19, 433–438.

    Article  PubMed  CAS  Google Scholar 

  33. Novak, V., Novak, P., and Low, P. A. (1997) Time-frequency analysis of cardiovascular function and its clinical applications, in Clinical Autonomic Disorders ( Low, P. A., ed.), Lippincott-Raven, Philadelphia, pp. 323–348.

    Google Scholar 

  34. Khurana, R. K. and Setty, A. (1996) The value of the isometric hand-grip test—studies in various autonomic disorders. Clin. Auton. Res. 6, 211–218.

    Article  PubMed  CAS  Google Scholar 

  35. Ewing, D. J. (1988) Recent advances in the non-invasive investigation of diabetic autonomic neuropathy, in Autonomic Failure. A Text-book of Clinical Disorders of the Autonomic Nervous System (Bannister, R., ed.), Oxford University Press, Oxford, pp. 667–689.

    Google Scholar 

  36. Piha, S. J. (1991) Cardiovascular autonomic reflex tests: normal responses and age-related reference values. Clin. Physiol. 11, 277–290.

    Article  PubMed  CAS  Google Scholar 

  37. Turkka, J., Suominen, K., Tolonen, U., Sotaniemi, K., and Myllylä, V. V. (1997) Selegeline diminishes cardiovascular autonomic responses in Parkinsons disease. Neurology 48, 662–667.

    Article  PubMed  CAS  Google Scholar 

  38. Freeman, R., Weiss, S. T., Roberts, M., Zbikowski, S. M, and Sparrow, D. (1995) The relationship between heart rate variability and measures of body habitus. Clin. Au ton. Res. 5, 261–266.

    Article  CAS  Google Scholar 

  39. Genovely, H. and Pfeifer, M. A. (1988) RR-variation: the autonomic test of choice in diabetes. Diabetes Metab. Rev. 4, 255–271.

    Article  PubMed  CAS  Google Scholar 

  40. Low, P. A., Opfer-Gehrking, T. L, McPhee, B. R., Fealey, R. D., Benarroch, E. E, Willner, C. L., et al. (1995) Prospective evaluation of clinical characteristics of orthostatic hypotension. Mayo Clin. Proc. 70, 617–622.

    Article  PubMed  CAS  Google Scholar 

  41. Huikuri, H. V. (1995) Heart rate variability in coronary artery disease. J. Intern. Med. 237, 349–357.

    Article  PubMed  CAS  Google Scholar 

  42. Karemaker, J. M. (1997) Analysis of blood pressure and heart rate variability-theoretical considerations, in Clinical Autonomic Disorders ( Low, P. A., ed.), Lippincott-Raven, Philadelphia, pp. 309–322.

    Google Scholar 

  43. Peleg, S., Naor, J., Hartley, R., and Avnir, D. (1984) Multiple resolution texture and classification. IEEE Trans. Pattern Anal. Machine. Intell. 6, 518–523.

    Article  CAS  Google Scholar 

  44. Korpelainen, J. T., Sotaniemi, K. A., Huikuri, H. V., and Myllylä, V. V. (1997) Circadian rhythm of heart rate variability is reversibly abolished in ischemic stroke. Stroke 28, 2150–2154.

    Article  PubMed  CAS  Google Scholar 

  45. Talman, W. T. (1985) Cardiovascular regulation and the lesions of the central nervous system. Ann. Neurol. 18, 1–12.

    Article  PubMed  CAS  Google Scholar 

  46. Cruickshank, J. M., Neil-Dwyer, G., and Scott, A. (1974) The possible role of catecholamines, corticosteroids and potassium in the production of ECG changes associated with subarachnoid hemorrhage. Br. Heart J. 36 697–706.

    Google Scholar 

  47. Cechetto, D. F. (1993) Experimental cerebral ischemic lesions and autonomic and cardiac effects in cats and rats. Stroke 24(Suppl. I), I-6-I-9.

    Google Scholar 

  48. Oppenheimer, S. M., Gelb, A., Girvin, J. P., and Hachinski, V. C. (1992) Cardiovascular effects of human insular cortex stimulation. Neurology 42, 1727–1732.

    Article  PubMed  CAS  Google Scholar 

  49. Burch, G. E., Meyers, R., and Abilskov, J. A. (1954) A new electrocardiographic pattern observed in cerebrovascular accidents. Circulation 9, 719–723.

    Article  PubMed  CAS  Google Scholar 

  50. Kono, T., Morita, H., Kuroiwa, T., Onaka, H., Takatsuka, H., and Fujiwara, A. (1994) Left ventricular wall motion abnormalities in patients with subarachnoid hemorrhage: neurogenic stunned myocardium. J. Am. Coll. Cardiol. 24, 636–640.

    Article  PubMed  CAS  Google Scholar 

  51. Greenhoot, J. H. and Reichenbach, D. D. (1969) Cardiac injury and subarachnoid hemorrhage, a clinical, pathological, and physiological correlation. J. Neurosurg. 30, 521–531.

    Article  PubMed  CAS  Google Scholar 

  52. Oppenheimer, S. M., Cechetto, D. F., and Hachinski, V. C. (1990) Cerebrogenic cardiac arrhythmias: cerebral electrocardiographic influences and their role in sudden death. Arch. Neurol. 47, 513–519.

    Article  PubMed  CAS  Google Scholar 

  53. Hachinski, V. C., Oppenheimer, S. M., Wilson, J. X., Guiraudon, C., and Cechetto, D. F. (1992) Asymmetry of sympathetic consequences of experimental stroke. Arch. Neurol. 49, 697–702.

    Article  PubMed  CAS  Google Scholar 

  54. Lane, R. D., Wallace, J. D., Petrosky, P. P., Schwartz, G. E., and Gradman, A. H. (1992) Supraventricular tachycardia in patients with right hemisphere strokes. Stroke 23, 362–366.

    Article  PubMed  CAS  Google Scholar 

  55. Talman, W. T., Alonso, D. R., and Reis, D. J. (1980) Chronic lability of arterial pressure in the rat does not evolve hypertension. Clin. Sci. 59, 405–407.

    Google Scholar 

  56. Hoff, J. T. and Reis, D. J. (1970) Localization of regions mediating the Cushing response in CNS of cat. Arch. Neurol. 23, 228–240.

    Article  PubMed  CAS  Google Scholar 

  57. Dopa, N., Beresford, H. R., and Reis, D. J. (1975) Changes in regional blood flow and cardiodynamics associated with electrically and chemically induced epilepsy in rat. Brain Res. 90, 115–132.

    Article  Google Scholar 

  58. Ross, C. A., Ruggiero, D. A., and Park, D. H. (1984) Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulations of the area containing Cl adrenaline neurons on arterial pressure, heart rate and plasma catecholamines and vasopressin. J. Neurosci. 4, 474–494.

    PubMed  CAS  Google Scholar 

  59. Lip, G. Y. H., Zarifis, J., Farooqi, I. S., Page, A., Sagar, G., and Beevers, D. G. (1997) Ambulatory blood pressure monitoring in acute stroke. Stroke 28, 31–35.

    Article  PubMed  CAS  Google Scholar 

  60. Morfis, L., Schwarz, R. S., Poulos, R., and Howes, L. G. (1997) Blood pressure changes in acute cerebral infarction and hemorrhage. Stroke 28, 1401–1405.

    Article  PubMed  CAS  Google Scholar 

  61. Korpelainen, J. (1993) Autonomic dysfunction in brain infarction. Doctoral thesis, Acta Universitatis Ouluensis, Series D, Medica No. 266, University of Oulu, Oulu, Finland.

    Google Scholar 

  62. Robinson, T. G. and Potter, J. F. (1995) Postprandial and orthostatic cardiovascular changes after acute stroke. Stroke 26, 1811–1816.

    Article  PubMed  CAS  Google Scholar 

  63. Hsu, C. Y., Hogan, E. L., Wingfield, W., Webb, J. G., Perot, P. L., Privitera, P. J., et al. (1984) Orthostatic hypotension with brainstem tumors. Neurology 34, 1137–1143.

    Article  PubMed  CAS  Google Scholar 

  64. Kita, Y., Ishise, J., Yoshita, Y., Aizawa, Y., Yoshio, H., Minagava, F., et al. (1993) Power spectral analysis of heart rate and arterial blood pressure oscillations in brain-dead patients. J. Autonom. Nerv. Syst. 44, 101–107.

    Article  CAS  Google Scholar 

  65. Novak, V., Novak, P., De Marchie, M., and Schondorf, R. (1995) The effect of severe brainstem injury on heart rate and blood pressure oscillations. Clin. Autonom. Res. 5, 24–30.

    Article  CAS  Google Scholar 

  66. Freitas, J., Puig, J., Rocha, A. P., Lago, P., Teixeira, J., Carvalho, M. J., et al. (1996) Heart rate variability in brain dead. Clin. Autonom. Res. 6, 141–146.

    Article  CAS  Google Scholar 

  67. Oppenheimer, S. M. and Cechetto, D. F. (1990) Cardiac chronotropic organisation of the rat insular cortex. Brain Res. 533, 66–72.

    Article  PubMed  CAS  Google Scholar 

  68. Oppenheimer, S. M. (1993) The anatomy and physiology of cortical mechanisms of cardiac control. Stroke 24(Suppl. I), I-3-I-5.

    Google Scholar 

  69. Cechetto, D. F. and Saper, C. B. (1990) Role of the cerebral cortex in autonomic function, in Central Regulation of Autonomic Functions ( Loewy, A. D. and Spyer, K. M., eds.), Oxford University Press, New York, pp. 208–223.

    Google Scholar 

  70. Vingerhoets, F., Bogousslaysky, J., Regli, F., and van Malle, G. (1993) Atrial fibrillation after stroke. Stroke 24, 20–26.

    Article  Google Scholar 

  71. Aminoff, M. J. (1997) Other extrapyramidal disorders, in Clinical Autonomic Disorders, 2nd ed. ( Low, P. A., ed.), Lippincott-Raven, Philadelphia, pp. 577–584.

    Google Scholar 

  72. Spiegel, E. A., Wycis, H. T,. Schor, S., Schwartz, H. A., and Fabioni, F. R. (1969) The incidence of vegetative symptoms in Parkinson patients with and without bradykinesia, in Third Symposium on Parkinson’s Disease ( Gillingham, F. J. and Donaldson, T. M. C., eds.), Livingstone, Edinburg, p. 200.

    Google Scholar 

  73. Marttila, R. (1974) Epidemiological, clinical, and virus-serological studies of Parkinson’s disease. Doctoral thesis,. University of Turku.

    Google Scholar 

  74. Calne, D. B., Brennan, J., Spiers A. S. D., and Stern, G. M. (1970) Hypotension caused by L-dopa. Br. Med. J. 1, 474–475.

    Article  PubMed  CAS  Google Scholar 

  75. McDowell, F. H. and Lee, J. E. (1970) Levodopa, Parkinson’s disease, and hypotension. Ann. Intern. Med. 72, 751–752.

    PubMed  CAS  Google Scholar 

  76. Aminoff, M. J. and Wilcox, C. S. (1971) Assessment of autonomic function in patients with a parkinsonian syndrome. Br. Med. J. 4, 80–84.

    Article  PubMed  CAS  Google Scholar 

  77. Appenzeller, O. and Goss, J. E. (1971) Autonomic deficits in Parkinson’s syndrome. Arch. Neurol. 24, 50–57.

    Article  PubMed  CAS  Google Scholar 

  78. Gross, M., Bannister, R., and Godwin-Austen, R. (1972) Orthostatic hypotension in Parkinson’s disease. Lancet 22, 174–176.

    Article  Google Scholar 

  79. Barbeau, A., Mars, H., and Gillo-Joffroy, L. (1971) Adverse clinical side effects of levodopa therapy, in Recent Advances in Parkinson’s Disease ( McDowell, F. H. and Markham, C. H., eds.), Blackwell, Oxford, pp. 203–237.

    Google Scholar 

  80. Yahr, M. D. (1970) General discussion on clinical effects of L-dopa upon blood pressure, in L-Dopa and Parkinsonism ( Barbeau, A. and McDowell, F. H., eds.), Davis, Philadelphia, pp. 266–268.

    Google Scholar 

  81. Struck, L. K., Rodnitzky, R. L., and Dobson, J. K. (1990) Stroke and its modification in Parkinson’s disease. Stroke 21, 1395–1399.

    Article  PubMed  CAS  Google Scholar 

  82. Aminoff, M. J., Gross, M., Laatz, B., Vakil, S. D., Petrie, A., and Calne, D. B. (1975) Arterial blood pressure in patients with Parkinson’s disease. J. Neurol. Neurosurg. Psychiatry 38, 73–77.

    Article  PubMed  CAS  Google Scholar 

  83. Turkka, J. T., Tolonen, U., and Myllylä, V. V. (1987) Cardiovascular reflexes in Parkinson’s disease. Eur. Neurol. 26, 104–112.

    Article  PubMed  CAS  Google Scholar 

  84. Kuroiwa, Y., Shimada, Y., and Toyokura, Y. (1983) Postural hypotension and low R-R interval variability in parkinsonism, spinocerebellar degeneration, and Shy-Drager syndrome. Neurology 33, 463–467.

    Article  PubMed  CAS  Google Scholar 

  85. Goetz, C. G., Lutge, W., and Tanner, C. M. (1986) Autonomic dysfunction in Parkinson’s disease. Neurology 36, 73–75.

    Article  PubMed  CAS  Google Scholar 

  86. Churchyard, A., Mathias, C. J., Boonkongchuen, P., and Lees, A. J. (1997) Autonomic effects of selegiline: possible cardiovascular toxicity in Parkinson’s disease. J. Neurol. Neurosurg. Psychiatry 63, 228–234.

    Article  PubMed  CAS  Google Scholar 

  87. Turkka, J. T. (1987) Correlation of the severity of autonomic dysfunction to cardiovascular reflexes and to plasma noradrenaline levels in Parkinson’s disease. Eur. Neurol. 26, 203–210.

    Article  PubMed  CAS  Google Scholar 

  88. Turkka, J. T., Juujärvi, K. K., Lapinlampi, T. O., and Myllylä, V. V. (1986) Serum noradrenaline response to standing up in patients with Parkinson’s disease. Eur. Neurol. 25, 355–361.

    Article  PubMed  CAS  Google Scholar 

  89. Mesec, A., Sega, S., and Kiauta, T. (1993) The influence of the type, duration, severity and levodopa treatment of Parkinson’s disease on cardiovascular autonomic responses. Clin. Au ton. Res. 3, 339–344.

    Article  CAS  Google Scholar 

  90. Orskov, L., Jakobsen, J., Dupont, E., Olivarius, B., and Christensen, N. J. (1987) Autonomic function in parkinsonian patients relates to duration of disease. Neurology 37, 1173–1178.

    Article  PubMed  CAS  Google Scholar 

  91. Murata, Y., Harada, T., Ishizaki, F., Izumi, Y., and Nakamura, S. (1997) Autonomic dysfunction in Parkinson’s disease and vascular parkinsonism. Acta Neurol. Scand. 96, 359–365.

    Article  PubMed  CAS  Google Scholar 

  92. Thomaides, T., Bleasdale-Barr, K., Chaudhuri, K. R., Pavitt, D., Marsden, C. D., and Mathias, C. J. (1993) Cardiovascular and hormonal responses to liquid food challenge in idiopathic Parkinson’s disease, multiple system atrophy, and pure autonomic failure. Neurology 43, 900–904.

    Article  PubMed  CAS  Google Scholar 

  93. Micieli, G., Martignoni, E., Cavallini, A., Sandrini, G., and Nappi, G. (1987) Postprandial and orthostatic hypotension in Parkinson’s disease. Neurology 37, 386–393.

    Article  PubMed  CAS  Google Scholar 

  94. Lieberman, A. N., Horowitz, L., Redmond, P., Pachter, L., Lieberman, I., and Leibowitz, M. (1980) Dysphagia in Parkinson’s disease. Am. J. Gastroenterol. 74. 157–160.

    PubMed  CAS  Google Scholar 

  95. Wakabayashi, K., Takahashi, H., Ohama, E., Takeda, S., and Ikuta, F. (1993) Lewy bodies in the visceral autonomic nervous system in Parkinson’s Disease. Adv. Neurol. 60, 609–612.

    PubMed  CAS  Google Scholar 

  96. Dejerine, J. and Thomas, A. A. (1900) L’atrophie olivo-pontocérébelleuse. Nouv. Iconog. Salpêtriére 13, 330–370.

    Google Scholar 

  97. Shy, G. M. and Drager, G. A. (1960) A neurological syndrome associated with orthostatic hypotension. Arch. Neurol. 2, 511–527.

    Article  PubMed  CAS  Google Scholar 

  98. Adams, R. D., van Bogaert, L., and van der Eecken, H. (1961) Dégénérescences nigro-striées et cérébello-nigro-striées. Psychiat. Neurol. 142, 219–259.

    Article  CAS  Google Scholar 

  99. Graham, J. G. and Oppenheimer, D. R. (1969) Orhostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. J. Neurol. Neurosurg. Psychiatry 32, 28–34.

    Article  PubMed  CAS  Google Scholar 

  100. Wenning, G. K., Shlomo, Y. B., Magalhäes, M., Daniel, S. E., and Quinn, N. P. (1994) Clinical features and natural history of multiple system atrophy an analysis of 100 cases. Brain 117, 835–845.

    Article  PubMed  Google Scholar 

  101. Low, P. A. and Bannister, S. R. (1997) Multiple system atrophy and pure autonomic failure, in Clinical Autonomic Disorders ( Low, P. A., ed. ), pp. 555–575

    Google Scholar 

  102. Low, P. A., Walsh, J. C., Huang, C.-Y., and McLeod, J. G. (1975) The sympathetic nervous system in diabetic neuropathy—a clinical and pathological study. Brain 98, 341–356.

    Article  PubMed  CAS  Google Scholar 

  103. Mathias, C. J., Fosbraey, P., da Costa, D. F., Thornley, A., and Bannister, R. (1986) The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure. Br. Med. J. Clin. Res. Ed. 293, 353–354.

    Article  PubMed  CAS  Google Scholar 

  104. Smith, G. D., Watson, L. P., Pavitt, D. V., and Mathias, C. J. (1995) Abnormal cardiovascular and catecholamine responses to supine exercise in human subjects with sympathetic dysfunction. J. Physiol. 484, 255–265.

    PubMed  CAS  Google Scholar 

  105. Wilcox, C. S. and Aminoff, M. J. (1976) Blood pressure responses to noradrenaline and dopamine infusions in Parkinson’s disease and the Shy-Drager syndrome. Br. J. Clin. Pharmacol. 3, 207–214.

    Article  PubMed  CAS  Google Scholar 

  106. Cohen, J., Low, P., Fealey, R., Sheps, S., and Jiang, N. S. (1987) Somatic and autonomic function in progressive autonomic failure and multiple system atrophy. Ann. Neurol. 22, 692–699.

    Article  PubMed  CAS  Google Scholar 

  107. Wenning, G. K., Tison, F., Shlomo, B., Daniel, S. E., and Quinn, N. P. (1997) Multiple system atrophy: a review of 203 pathologically proven cases. Movement Disorders 12, 133–147.

    Article  PubMed  CAS  Google Scholar 

  108. Schultze, V. (1887) Über einen fall von kleinhirnschwund mit degenerationen im verlängerten marke and im rückenmarke (wahrscheinlich in folge von alkoholismus). Virchows Arch. Pathol. Anat. 108, 331–343.

    Article  Google Scholar 

  109. Bannister, R. and Oppenheimer, D. R. (1972) Degenerative diseases of the nervous system associated with autonomic failure. Brain 95, 457–474.

    Article  PubMed  CAS  Google Scholar 

  110. Benarroch, E. E., Smithson, I. L., Low, P. A., and Parisi, J. E. (1998) Depletion of catecholaminergic neurons of the rostral ventrolateral medulla in multiple systems atrophy with autonomic failure. Ann. Neurol. 43, 156–163.

    Article  PubMed  CAS  Google Scholar 

  111. Puritz, R., Lightman, S. L., Wilcox, C. S., Forsling, M., and Bannister, R. (1983) Blood pressure and vasopressin in progressive autonomic failure. Response to postural stimulation, L-dopa and nalaxone. Brain 106, 503–511.

    Article  PubMed  Google Scholar 

  112. Kaufman, H., Oribe, E., Miller, M., Knott, P., Wiltshire-Clement, M., and Yahr, M. D. (1992) Hypotension-induced vasopressin release distinguishes between pure autonomic failure and multiple system atrophy with autonomic failure. Neurology 42, 590–593.

    Article  Google Scholar 

  113. Polinsky, R. J. (1990) Clinical autonomic neuropharmacology. Neurol. Clin. 8, 77–92.

    PubMed  CAS  Google Scholar 

  114. Chokroverty, S. (1988) Sleep apnoea and respiratory disturbances in multiple system atrophy with autonomic failure, in Autonomic Failure (Bannister, R., ed.), Oxford Medical Publications, Oxford, pp. 432–450.

    Google Scholar 

  115. Paty, D. W., Oger, J. J. F., Kastrukoff, L. F., Hashimoto, S. A., Hooge, J. P. Eisen, A. A., et al. (1988) MRI in the diagnosis in MS: a prospective study in comparison of clinical evaluation evoked potentials, oligoclonal banding and CT. Neurology 38, 180–185.

    Article  PubMed  CAS  Google Scholar 

  116. Bradley, W. E. (1978) Urinary bladder dysfunction in multiple sclerosis. Neurology 28, 52–58.

    Article  PubMed  CAS  Google Scholar 

  117. Jensen, D., Jr. (1987) The urinary bladder in multiple sclerosis, J. Oslo City Hosp. 37, 123–128.

    PubMed  Google Scholar 

  118. Vas, C. J. (1969) Sexual impotence and some autonomic disturbances in men with multiple sclerosis. Acta Neurol. Scand. 45, 166–182.

    Article  PubMed  CAS  Google Scholar 

  119. Cartlidge, N. (1972) Autonomic function in multiple sclerosis. Brain 95, 661–64.

    Article  PubMed  CAS  Google Scholar 

  120. Noronha, M. J., Vas, C. J., and Aziz, H. (1968) Autonomic dysfunction (sweating responses) in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 31, 19–22.

    Article  PubMed  CAS  Google Scholar 

  121. Elie, B. and Louboutin, J. P. (1995) Sympathetic skin response (SSR) is abnormal in multiple sclerosis. Muscle Nerve 18, 185–189.

    Article  PubMed  CAS  Google Scholar 

  122. Caminero, A. B., Pérez-Jiménez, A., Barreiro, P., Ferrer, T. (1995) Sympathetic skin response: correlation with autonomic and somatic involvement in multiple sclerosis, Electromyogr. Clin. Neurophysiol. 35, 457–462.

    PubMed  CAS  Google Scholar 

  123. Senaratne, M. P., Carroll, D., Warren, K. G., and Kappagoda, T. (1984) Evidence for cardiovascular autonomic nerve dysfunction in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 47, 947–952.

    Article  PubMed  CAS  Google Scholar 

  124. Sterman, A. B., Coyle, P. K., Panasci, D. J., and Grimson, R. (1985) Disseminated abnormalities of cardiovascular autonomic functions in multiple sclerosis. Neurology 35, 1665–1668.

    Article  PubMed  CAS  Google Scholar 

  125. Pentland, B. and Ewing, D. J. (1987) Cardiovascular reflexes in multiple sclerosis. Eur. Neurol. 26, 46–50.

    Article  PubMed  CAS  Google Scholar 

  126. Nordenbo, A. M., Boesen, F., and Andersen, E. B. (1989) Cardiovascular autonomic function in multiple sclerosis. J. Au ton. Nerv. Syst. 26, 77–84.

    Article  CAS  Google Scholar 

  127. Anema, J. R., Heijenbrok, M. W., Faes, T. J., Heimans, J. J., Lanting, P., and Polman, C. H. (1991) Cardiovascular autonomic function in multiple sclerosis. J. Neurol. Sci. 104, 129–134.

    Article  PubMed  CAS  Google Scholar 

  128. Vita, G., Fazio, M. C., Milone, S., Blandino, A., Salvi, L., and Messina, C. (1993) Cardiovascular autonomic dysfunction in multiple sclerosis is likely related to brainstem lesions. J. Neurol. Sci. 120, 82–86.

    Article  PubMed  CAS  Google Scholar 

  129. Thomaides, T. N., Zoukos, Y., Chaudhuri, K. R., and Mathias, C. J. (1993) Physiological assessment of aspects of autonomic function in patients with secondary progressive multiple sclerosis. J. Neurol. 240, 139–143.

    Article  PubMed  CAS  Google Scholar 

  130. Diamond, B. J., Kim, H., DeLuca, J., and Cordero, D. L. (1995) Cardiovascular regulation in multiple sclerosis. Multiple Sclerosis 1, 156–162.

    PubMed  CAS  Google Scholar 

  131. Frontoni, M., Fiorini, M., Strano, S., Cerutti, S., Giubilei, F., Urani, C., et al. (1996) Power spectrum analysis contribution to the detection of cardiovascular dysautonomia in multiple sclerosis. Acta Neurol. Scand. 93, 241–245.

    Article  PubMed  CAS  Google Scholar 

  132. Linden, D., Diehl, R. R., Kretzschmar, A., and Berlit, P. (1997) Autonomic evaluation by means of standard tests and power spectral analysis in multiple sclerosis. Muscle Nerve 20, 809–814.

    Article  PubMed  CAS  Google Scholar 

  133. Sakakibira, R., Mori, M., Fukutake, T., Kita, K., and Hattori, T. (1997) Orthostatic hypotension in a case of multiple sclerosis. Clin. Au ton. Res. 7, 163–165.

    Article  Google Scholar 

  134. Giroud, M., Guard, O., and Dumas, R. (1988) Cardio-respiratory anomalies in disseminated sclerosis. Rev. Neurol. 144, 284–288.

    PubMed  CAS  Google Scholar 

  135. Buyse, B., Demedts, M., Meekers, J., Vandegaer, L., Rochette, F., and Kerkhofs, L. (1997) Respiratory dysfunction in multiple sclerosis: a prospective analysis of 60 patients. Eur. Respir. J. 10, 139–145.

    Article  PubMed  CAS  Google Scholar 

  136. Tantucci, C., Massucci, M., Piperno, R., Betti, L., Grassi, V., and Sorbini, C. A. (1994) Control of breathing and respiratory muscle strength in patients with multiple sclerosis. Chest 105, 1163–1170.

    Google Scholar 

  137. Howard, R. S., Wiles, C. M., Hirsch, N. P., Loh, L., Spencer, G. T., and Newsom-Davis, J. (1992) Respiratory involvement in multiple sclerosis, Brain 115, 479–494.

    Google Scholar 

  138. Auer, R. N., Rowlands, C. G., Perry, S. F., and Remmers, J. E. (1996) Multiple sclerosis with medullary plaques and fatal sleep apnea (Ondine’s curse). Clin. Neuropathol. 15, 101-105.

    Google Scholar 

  139. Wennerholm, M. (1961) Postural vascular reactions in cases with migraine and related vascular headaches. Acta Med. Scand. 167, 131–139.

    Google Scholar 

  140. Appenzeller, O., Davidson, K., and Marshall, J. (1963) Reflex vasomotor abnormalities in the hands of migrainous subjects. J. Neurol. Neurosurg. Psychiatry 26, 447.

    Article  PubMed  CAS  Google Scholar 

  141. French, E. B., Lassers, P. W., and Desai, M. G. (1967) Reflex vasomotor responses in the hands of migrainous subjects. J. Neurol. Neurosurg. Psychiatry 30, 276.

    Article  PubMed  CAS  Google Scholar 

  142. Hockaday, J. M. and McMillan, A. L. (1967)The effect of migraine and ergotamine upon reflex vasodilatation to radiant heating, in Fourth European Congress on Microcirculation (Harders, H., ed.), S. Basel Karger, Cambridge.

    Google Scholar 

  143. Steiner, T. J., Smith, F. R., and Rose, F. C. (1981) Vasomotor reactivity in migraine, in Progress in Migraine Research ( Rose, F. C. and Zilkha, K. J., eds.), Pitman, Tunbridge Wells, UK, pp. 33–40.

    Google Scholar 

  144. Gotoh, F., Komatsumoto, S., Araki, N., and Gomi S. (1984) Noradrenergic nervous activity in migraine. Arch. Neurol. 41, 951–955.

    Article  PubMed  CAS  Google Scholar 

  145. Havanka-Kanniainen, H., Tolonen, U., and Myllylä, V. V. (1986) Cardiovascular reflexes in young migraine patients. Headache 26, 420–424.

    Article  PubMed  CAS  Google Scholar 

  146. Havanka-Kanniainen, H., Tolonen, U., and Myllylä, V. V. (1986) Autonomic dysfunction in adult migraineurs. Headache 26, 425–430.

    Article  PubMed  CAS  Google Scholar 

  147. Havanka-Kanniainen, H. (1986) Cardiovascular reflex responses during migraine attack. Headache 26, 442–446.

    Article  PubMed  CAS  Google Scholar 

  148. Havanka-Kannianen, H., Juujärvi, K., Tolonen, U., and Myllylä, V. V. (1987) Cardiovascular reflexes and plasma noradrenaline levels in migraine patients before and during nimodipine medication. Headache 27, 34–44.

    Article  Google Scholar 

  149. Havanka-Kanniainen, H., Tolonen, U., and Myllylä, V. V. (1988) Autonomic dysfunction in migraine: a survey of 188 patients. Headache 28, 465–470.

    Article  PubMed  CAS  Google Scholar 

  150. Shuaib, A., Klein, G., and Deer, R. (1987) Migraine headache and atrial fibrillation. Headache 27, 252–253.

    Article  PubMed  CAS  Google Scholar 

  151. Petersen, J., Scruton, D., and Downie, A. W. (1977) Basilar artery migraine with transient atrial fibrillation. Br. Med. J. 2, 1125–1126.

    Article  Google Scholar 

  152. Gilroy, J. and Lerman, W. (1982) Cardiac arrhythmia in basilar migraine. Headache 22, 140.

    Article  PubMed  CAS  Google Scholar 

  153. Cirignotta, F., Sacquegna, T., D’Alessandro, R., Baldrati, A., DeCarolis, P., Coccagna, G., et al. (1982) Systemic arterial pressure and heart-rate changes during migraine and cluster headache. Headache 22, 35–37.

    Article  PubMed  CAS  Google Scholar 

  154. Boiardi, A., Munari, L., Milanesi, I., Paggetta, C., Lamperti, E., and Bussone, G. (1988) Inpaired cardiovascular reflexes in cluster headache and migraine patients. Evidence for an autonomic dysfunction. Headache 28, 417–422.

    Article  PubMed  CAS  Google Scholar 

  155. Mikamo, K., Takeshima, T., and Takahashi, K. (1989) Cardiovascular sympathetic hypofunction in muscle contraction headache and migraine. Headache 29, 86–89.

    Article  PubMed  CAS  Google Scholar 

  156. Martin, R., Ribera, C., Molto, J. M., Ruiz, C., Galiano, L., and MatiasGuiu, J. (1992) Cardiovascular reflexes in patients with vascular headache. Cephalalgia 12, 360–364.

    Article  PubMed  CAS  Google Scholar 

  157. Appel, S., Kuritzky, A., Zahavi, I., Zigelman, M., and Akselrod, S. (1992) Evidence for instability of the autonomic nervous system in patients with migraine headache. Headache 32, 10–17.

    Article  PubMed  CAS  Google Scholar 

  158. Pogacnik, T., Sega, S., Pecnik, B., and Kiauta, T. (1993) Autonomic function testing in patients with migraine. Headache 33, 545–550.

    Article  PubMed  CAS  Google Scholar 

  159. Cortelli, P., Pierangeli, G., Parchi, P., Contin, M., Baruzzi, A., and Lugaresi, E. (1991) Autonomic nervous system function in migraine without aura. Headache 31, 457–462.

    Article  PubMed  CAS  Google Scholar 

  160. Steiner, T. J. and Clifford Rose, F. (1982) Autonomic reflexes in migraine, in Advances in Migraine ( Clifford Rose, F., ed.), Raven, New York

    Google Scholar 

  161. Hsu, L. K. G., Crisp, A. H., Kalucy, R. S., Koval, J., Chen, C. N., Carruthers, M., et al. (1977) Early morning migraine: nocturnal plasma levels of catecholamines, tryptophan, glucose and free fatty acids and sleep encephalographs. Lancet 2, 447–451.

    Google Scholar 

  162. Hsu, L. K. G., Crisp, A. H., Kalucy, R. S., Koval, C. N, Chen, C. N., Carruthers, M., et al. (1978) Nocturnal plasma levels of catecholamines, tryptophan, glucose and free fatty acids and the sleeping encephalographs of subjects experiencing early morning migraine, in Current Concepts in Migraine Research ( Greene, R., ed.), Raven, New York, pp 121–130.

    Google Scholar 

  163. Fog-Moller, F., Genefke, I. K., and Bryndum, B. (1978) Changes in the concentrations of catecholamines in blood during spontaneous migraine attacks and reserpine induced attacks, in Current Concepts in Migraine Research ( Greene, R., ed.), Raven, New York, pp. 115–119.

    Google Scholar 

  164. Anthony, M. (1981) Biochemical indices of sympathetic activity in migraine. Cephalalgia 1, 83–89.

    Google Scholar 

  165. Schoenen, J., de Noordhout, A. M., and Delwaide, P. J. (1985) Plasma catecholamines in headache patients, clinical correlations, in Proceedings of the Second International Headache Congress (Olesen, J., Tfelt-Hansen, P., and Jensen, K., eds.), Headache 1985, Stourgaard/ Jensen, Copenhagen, pp. 23–24.

    Google Scholar 

  166. Jacobson, L. B. (1969) Cluster headache: a rare cause of bradycardia. Headache 8, 159–161.

    Google Scholar 

  167. Bruyn, G. W., Bootsma, B. K., and Klawans, H. L. (1976) Cluster headache and bradycardia. Headache 16, 11–15.

    Google Scholar 

  168. Manzoni, G. C., Terzano, M. G., Moretti, G., and Cocchi, M. (1981) Clinical observations of 76 cluster headache cases. Eur. Neurol. 20, 88–94.

    Article  PubMed  CAS  Google Scholar 

  169. Kruszewski, P., Bordini, C., Brubakk, A. O., and Sjaastad, O. (1992) Cluster headache: alterations in heart rate, blood pressure and orthostatic responses during spontaneous attacks. Cephalalgia 12, 172–177.

    Google Scholar 

  170. Ekbom, K. (1970) Heart rate, blood pressure and electrocardiographic changes in provoked attacks of cluster headache. Acta Neurol. Scand. 46, 215–224

    Article  PubMed  CAS  Google Scholar 

  171. Russel, D. and Storstein, L. (1983) Cluster headache: a computerized analysis of 24 h Holter ECG rhythm disturbances. Cephalalgia 3, 83–107.

    Article  Google Scholar 

  172. Attanasia, A., Capria, A., Quotrana, M., Piccoldig, C., Bisceglia, A., Formisano, R., et al. (1990) Sinus bradycardia, junctional rhythm and blood pressure increase during repeated cluster headache attacks. Headache 30, 509–510.

    Article  Google Scholar 

  173. Russel, D. and Van der Lippe, A. (1982) Cluster headache: heart rate and blood pressure changes during spontaneous attacks. Cephalalgia 2, 61–70.

    Google Scholar 

  174. Sacquengna, T., Cortelli, P., Amici, R., Pich, E. M., DeCarolis, P., Baldrati, A., et al. (1985) Cardiovascular changes in cluster headaches. Headache 25, 75–78.

    Article  Google Scholar 

  175. De Marinis, M., Strano, S., Granata, M., Urani, C., Lino, S., Calcagninig, G., et al. (1995) Sympathetic-parasympathetic activation during spontaneous attacks of cluster headache evaluating by spectral analysis of heart rate fluctuations. Cephalalgia 15, 504–510.

    Article  PubMed  Google Scholar 

  176. Saunte, C., Russell, D., and Sjaastad, O. (1983) Cluster headache: on the mechanism behind attack-related sweating. Cephalalgia 3, 175–185.

    Google Scholar 

  177. Saunte, C. (1984) Autonomic disorders in cluster headache, with special reference to salivation, nasal secretion and tearing. Cephalalgia 4, 57–64.

    Article  PubMed  CAS  Google Scholar 

  178. Sjaastad, O., Saunte, C., Russell, D., Hestnes, A., and Mârvik, R. (1981) Cluster headache. The sweating pattern during spontaneous attacks. Cephalalgia 1, 233–244.

    Article  PubMed  CAS  Google Scholar 

  179. Atkinson, P. P. and Atkinson, J. L. (1996) Spinal shock. Mayo Clin. Proc. 71, 384–389.

    Article  PubMed  CAS  Google Scholar 

  180. Mathias, C. J. and Frankel, H. L. (1992) Autonomic disturbances in spinal cord lesions, in Autonomic Failure, 3rd ed. (Bannister, R. and Mathias, C. J., ed.), Oxford University Press, Oxford, pp. 839–881.

    Google Scholar 

  181. Yamamoto, M., Meyer, J. S., Sakai, F., and Jakoby, R. (1980) Effect of differential spinal cord transection on human cerebral blood flow. J. Neurol. Sci. 47, 395–406.

    Article  PubMed  CAS  Google Scholar 

  182. Rosner, M. J., Elias, Z., and Coley, I. (1984) New principles of resuscitation for brain and spinal injury. NC Med. J. 45, 701–706.

    CAS  Google Scholar 

  183. Dollfus, P. and Frankel, H. L. (1965) Cardiovascular reflexes in tracheostomised tetraplegics. Paraplegia 2, 227–235.

    Article  PubMed  CAS  Google Scholar 

  184. Frankel, H. L., Michaelis, L. S., Golding, D. R., and Beral, V. (1972) Blood pressure in paraplegia. I. Paraplegia 10, 193–198.

    Article  PubMed  CAS  Google Scholar 

  185. Mathias, C. J., Christensen, N. J., Corbett, J. L., Frankel, H. L., and Spalding, J. M. K. (1976) Plasma catecholamines during paroxysmal neurogenic hypertension in quadriplegic man. Circ. Res. 39, 204–208.

    Google Scholar 

  186. Stjernberg, L., Blumberg, H., and Wallin, B. G. (1986) Sympathetic activity in man after spinal cord injury: outflow to muscle below the lesion. Brain 109, 695–715.

    Article  PubMed  Google Scholar 

  187. Gonzalez, F., Chang, J. Y., Banovac, K., Messina, D., MartinezArizala, A., and Kelley, R. E. (1991) Autoregulation of cerebral blood flow in patients with orthostatic hypotension after spinal cord injury. Paraplegia 29, 1–7.

    Article  PubMed  CAS  Google Scholar 

  188. Coutts, K. D., Rhodes, E. C., and McKenzie, D. C. (1983) Maximal exercise responses of tetraplegics and paraplegics. J. Appl. Physiol. 55, 479–482.

    PubMed  CAS  Google Scholar 

  189. Eriksson, P., Lofsröm, L., and Ekblom, B. (1988) Aerobic power during maximal exercise in untrained and well-trained persons with quadriplegia and paraplegia. Scand. J. Rehabil. Med. 20, 141–147.

    PubMed  CAS  Google Scholar 

  190. Nitsche, B., Perschak, H., and Dietz, V. (1996) Loss of circadian blood pressure variability in complete tetraplegia. J. Hum. Hypertens. 10, 311–317.

    PubMed  CAS  Google Scholar 

  191. Grimm, D. R., Meersman, R. E., Almenoff, P. L., Spungen, A. M., and Bauman, W. A. (1997) Sympathovagal balance of the heart in subjects with spinal cord injury. Am. J. Physiol. 272, H835–842.

    PubMed  CAS  Google Scholar 

  192. Colachis, S. C. (1992) Autonomic hyperreflexia with spinal cord injury. J. Am. Paraplegia Soc. 15, 171–186.

    PubMed  Google Scholar 

  193. Harati, Y. (1997) Autonomic disorders associated with spinal cord injury, in Clinical Autonomic Disorders, 2nd ed. ( Low, P. A., ed.), Lippincott-Raven, Philadelphia, pp. 455–461.

    Google Scholar 

  194. Arnold, J. M., Feng, Q. P., Delaney, G. A. and Teasell, R. W. (1995) Autonomic dysreflexia in tetraplegic patients: evidence for alphaadrenoceptor hyper-responsiveness. Clin. Autonom. Res. 5, 267–270.

    Article  CAS  Google Scholar 

  195. Teasell, R. W., Arnold, J. M. O., and Delaney, G. A. (1996) Sympathetic nervous system dysfunction in high-level spinal cord injuries. Phys. Med. Rehabil.: State Art Rev. 10, 37–60.

    Google Scholar 

  196. Braddom, R. L. and Rocco, J. F. (1991) Autonomic dysreflexia. A survey of current treatment. Am. J. Phys. Med. Rehabil. 70, 234–241.

    Article  PubMed  CAS  Google Scholar 

  197. McLeod, J. G. (1992) Invited review: autonomic dysfunction in peripheral nerve disease. Muscle Nerve 15, 3–13.

    Article  PubMed  CAS  Google Scholar 

  198. Ropper, A. H. (1992) The Guillain-Barré syndrome. N. Engl. J. Med. 326, 1130–1136.

    Article  PubMed  CAS  Google Scholar 

  199. Zochodne, D. W. (1994) Autonomic involvement in Guillain-Barré syndrome: a review. Muscle Nerve 17, 1145–1155.

    Article  PubMed  CAS  Google Scholar 

  200. Singh, N. K., Jaiswal, A. K., Misra, S., and Srivastava, P. K. (1987) Assessment of autonomic dysfunction in Guillain-Barré syndrome and its prognostic implications. Acta Neurol. Scand. 75, 101–105.

    Article  PubMed  CAS  Google Scholar 

  201. Flachenecker, P., Wermuth, P., Hartung, H. P., and Reiners, K. (1997) Quantitative assessment of cardiovascular autonomic function in Guillain-Barré syndrome. Ann. Neurol. 42, 171–179.

    Article  PubMed  CAS  Google Scholar 

  202. Fagius, J. and Wallin, G. (1983) Microneurographic evidence of excessive sympathetic outflow in the Guillain-Barré syndrome. Brain 106, 589–600.

    Article  PubMed  Google Scholar 

  203. Winer, J. B. and Hughes, R. A. (1988) Identification of patients at risk of arrhythmia in the Guillain-Barré syndrome. Quart. J. Med. 68, 735–739.

    PubMed  CAS  Google Scholar 

  204. Tuck, H. R. and McLeod, J. G. (1981) Autonomic dysfunction in Guillain-Barré syndrome. J. Neurol. Neurosurg. Psychiatry 44, 983–990.

    Article  PubMed  CAS  Google Scholar 

  205. Flachenecker, P., Hartung, H. P., and Reiners, K. (1997) Power spectrum analysis of heart rate variability in Guillain-Barré syndrome. A longitudinal study. Brain 120, 1885–1894.

    Article  PubMed  Google Scholar 

  206. Matthews, W. B., Howell, D. A., and Hughes, R. C. (1970) Relapsing corticosteroid-dependent polyneuritis. J. Neurol. Neurosurg. Psychiatry 33, 330–337.

    Article  PubMed  CAS  Google Scholar 

  207. Dyck, P. J., Lais, A. C., Ohta, M., Bastron, J. A., Okazaki, H., and Groover, R. V. (1975) Chronic inflammatory polyradiculoneuropathy. Mayo Clin. Proc. 50, 621–637.

    PubMed  CAS  Google Scholar 

  208. Prineas, J. W. and McLeod, J. G. (1976) Chronic relapsing polyneuritis. Neurol. Sci. 27, 427–458.

    Article  CAS  Google Scholar 

  209. Ingall, T. J. and McLeod, J. G., Tamura, N. (1990) Autonomic function and unmyelinated fibers in chronic inflammatory demyelinating polyradiculoneuropathy. Muscle Nerve 13, 70–76.

    CAS  Google Scholar 

  210. Neil, H. A. W. (1992) The epidemiology of diabetic autonomic neuropathy, in Autonomic Failure, 3rd ed. (Bannister, R. and Mathias, C. J., eds.), Oxford University Press, Oxford, pp. 682–697.

    Google Scholar 

  211. Töyry, J. P., Partanen, J. V., Niskanen, L. K., Länsimies, E. A., and Uusitupa, M. I. (1997) Divergent development of autonomic and peripheral somatic neuropathies in NIDDM. Diabetologia 40, 953–958.

    Article  PubMed  Google Scholar 

  212. Orchard, T. J., Lloyd, C. E., Maser, R. E., and Kuller, L. H. (1996) Why does diabetic autonomic neuropathy predict IDDM mortality? Diabetes Res. Clin. Prac. 34, S165 - S171.

    Article  Google Scholar 

  213. Mulder, D. W. (1961) The neuropathies associated with diabetes mellitus: a clinical and electromyographic study of 103 unselected diabetic patients. Neurology 11, 275–284.

    PubMed  Google Scholar 

  214. Veglio, M. (1990) Autonomic neuropathy in non-insulin-dependent diabetic patients: correlation with age, sex, duration and metabolic control of diabetes. Diabetes Metab. 16, 200–206.

    CAS  Google Scholar 

  215. Ewing, D. J., Neilson, J. M. M., Shapiro, C. M., and Reid, W. (1991) Twenty four hour heart rate variability: effects of posture, sleep, and time of day in healthy controls and comparison with bedside tests of autonomic function in diabetic patients. Br. Heart J. 65, 239–244.

    Article  PubMed  CAS  Google Scholar 

  216. Ewing, D. J., Borsey, D. Q., Bellavere, F., and Clarke, B. F. (1981) Cardiac autonomic neuropathy in diabetes: comparison of measures of R-R interval variation. Diabetologia 21, 18–24.

    Article  PubMed  CAS  Google Scholar 

  217. Lishner, M., Akselrod, S., Mor Avi, V., Oz, O., Divon, M., and Ravid, M. (1987) Spectral analysis of heart rate fluctuations. A non-invasive, sensitive method for the early diagnosis of autonomic neuropathy in diabetes mellitus. J. Auton. Nerv. Syst. 19, 119–125.

    Article  PubMed  CAS  Google Scholar 

  218. Pagani, M., Malfatto, G., Pierini, S., Casati, R., Masu, A. M., Poli, M., et al. (1988) Spectral analysis of heart rate variability in assessment of autonomic diabetic neuropathy. J. Auton. Nerv. Syst. 23, 143153.

    Google Scholar 

  219. Freeman, R., Saul, P., Roberts, M. S., Berger, R. D., Broadbridge, C., and Cohen, R. J. (1991) Spectral analysis of heart rate in diabetic autonomic neuropathy. Arch. Neurol. 48, 185–190.

    Article  PubMed  CAS  Google Scholar 

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Myllylä, V.V., Korpelainen, J.T., Tolonen, U., Havanka, H., Saari, A. (2000). Neuropathology and Cardiovascular Regulation. In: Ter Horst, G.J. (eds) The Nervous System and the Heart. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-713-0_5

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