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The IGF Axis in the Male Reproductive System

  • Chapter
The IGF System

Part of the book series: Contemporary Endocrinology ((COE,volume 17))

Abstract

The insulin-like growth factor (IGF) system is a multilayered network of molecules involved in the regulation of cell growth and death in many organs and tissues, normal and pathologic. The IGF system also participates in the modulation of important cell- and tissue-specific physiological and metabolic functions, via endocrine, paracrine, and autocrine interactions. The IGFs, IGF-receptors (IGF-R), IGF binding proteins (IGFBPs), and the IGFBP-receptors and proteases all feature prominently in the healthy prostate and in the common conditions of abnormal prostate growth, benign prostatic hypertrophy (BPH), and prostatic carcinoma (CaP). The IGF system similarly participates in the proliferation and hypertrophy of the bladder, both in congenital obstructive conditions and in acquired diseases of the urinary system. In the testis, the IGF system interacts with gonodatropins, androgens, and multiple other peptide hormones in the coordination of growth, spermatogenesis, and steroidogenesis.

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Authors
  1. Stuart A. Weinzimer MD
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  2. Pinchas Cohen MD
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, OR, USA

    Ron G. Rosenfeld MD

  2. Oregon Health Sciences University, Portland, OR, USA

    Charles T. Roberts Jr. PhD

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Weinzimer, S.A., Cohen, P. (1999). The IGF Axis in the Male Reproductive System. In: Rosenfeld, R.G., Roberts, C.T. (eds) The IGF System. Contemporary Endocrinology, vol 17. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-712-3_18

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  • DOI: https://doi.org/10.1007/978-1-59259-712-3_18

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-138-7

  • Online ISBN: 978-1-59259-712-3

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