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Immunophenotypic Diagnosis of Leukemic B-Cell Chronic Lymphoproliferative Disorders Other Than Chronic Lymphocytic Leukemia

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Book cover Chronic Lymphocytic Leukemia

Part of the book series: Contemporary Hematology ((CH))

Abstract

Leukemic B-cell chronic lymphoproliferative disorders (B-CLPD) are a relatively heterogeneous group of diseases, all of which exhibit a clonal expansion of mature-appearing B-lymphoid cells in the peripheral blood (PB). Both primary leukemias and the leukemic phase of primary lymphomas are included in this category (1). Among the primary B-cell leukemias, chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PLL), and hairy cell leukemia (HCL) are usually considered; within the primary lymphomas, follicular lymphoma (FL), mantle cell lymphoma (MCL), marginal zone splenic lymphoma (MZSL), lymphoplasmacytic lymphoma (LPL), and the large B-cell lymphomas (LCLs) exhibit PB involvement more frequently (1).

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Authors
  1. Alberto Orfao MD, PhD
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  2. Julia Almeida MD, PhD
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  3. Maria Luz Sanchez PhD
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  4. Jesus F. San Miguel MD, PhD
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Editors and Affiliations

  1. Section of Hematology/Oncology, Veterans Affairs Medical Center, Augusta, GA, USA

    Guy B. Faguet MD

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Orfao, A., Almeida, J., Sanchez, M.L., San Miguel, J.F. (2004). Immunophenotypic Diagnosis of Leukemic B-Cell Chronic Lymphoproliferative Disorders Other Than Chronic Lymphocytic Leukemia. In: Faguet, G.B. (eds) Chronic Lymphocytic Leukemia. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-412-2_9

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