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Cell Death in Mammalian Development

  • Chapter
Essentials of Apoptosis

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Abstract

Physiological mechanisms of cell death are required throughout the development and adulthood of all multicellular organisms (1,2). From primitive multicellular organisms to higher vertebrates, well-orchestrated cell-death events are critical for the removal of superfluous cells as a vital part of tissue sculpting during development. Physiological cell death enables the elimination of unwanted extra cells to maintain cellular homeostasis in developed adults, as well as the elimination of organisms of harmful cells or cells with serious cellular or genomic damage. Apoptosis—physiological cell death—is characterized by a distinct set of morphological and biochemical features including chromatin condensation, internucleosomal DNA fragmentation, and perhaps most important, cell-surface alterations, which signal for the rapid recognition and engulfment of apoptotic cells by neighboring phagocytic cells, thus avoiding the induction of any pathological reactions (3).

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Authors
  1. Chia-Yi Kuan
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  2. Keisuke Kuida
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Editors and Affiliations

  1. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Xiao-Ming Yin MD, PhD

  2. Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA, USA

    Zheng Dong PhD

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© 2003 Springer Science+Business Media New York

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Kuan, CY., Kuida, K. (2003). Cell Death in Mammalian Development. In: Yin, XM., Dong, Z. (eds) Essentials of Apoptosis. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-361-3_11

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  • DOI: https://doi.org/10.1007/978-1-59259-361-3_11

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5172-7

  • Online ISBN: 978-1-59259-361-3

  • eBook Packages: Springer Book Archive

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