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Fertility Preservation in Cancer Patients

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The Biology of Mammalian Spermatogonia

Abstract

Chemotherapy and radiation treatments for cancer or other conditions can cause permanent infertility. This condition not only affects the ability to bear children after cure, but may also have a lasting impact on psychosocial well-being, relationships and overall health. Adolescent and adult patients may have the options to preserve eggs, sperm, or embryos prior to treatment to preserve their future fertility. These options are not available to prepubertal patients who are not producing mature eggs or sperm. This is a critical human health concern because most children will survive their cancer and still have their entire reproductive life in front of them. This review focuses on stem cell-based methods that may provide new fertility-sparing options for boys receiving gonadotoxic therapies for cancer or other conditions.

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  1. Department of Obstetrics, Gynecology and Reproductive Sciences, Molecular Genetics and Developmental Biology Graduate Program, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA, 15213, USA

    Sherin David & Kyle E. Orwig

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  1. Sherin David
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  2. Kyle E. Orwig
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Correspondence to Kyle E. Orwig .

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  1. Centre for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, USA

    Jon M. Oatley

  2. School of Molecular Biosciences, Washington State University, Pullman, Washington, USA

    Michael D. Griswold

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David, S., Orwig, K.E. (2017). Fertility Preservation in Cancer Patients. In: Oatley, J., Griswold, M. (eds) The Biology of Mammalian Spermatogonia. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7505-1_13

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