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Spindle Cell Lesions

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Atlas of Differential Diagnosis in Breast Pathology

Part of the book series: Atlas of Anatomic Pathology ((AAP))

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Abstract

A spindle cell is a fusiform cell that is tapered at both ends. Although both luminal epithelial and myoepithelial cells may assume spindle shapes, spindle cell lesions of the breast usually refer to conditions that are composed of mesenchymal or mesenchymal-like cells that harbour elongated and stretched cytoplasm. A variety of different lesions may comprise mesenchymal spindle cells, including nodular fasciitis, fibrous scarring, pseudoangiomatous stromal hyperplasia, myofibroblastoma, fibromatosis, stromal overgrowth in phyllodes tumour, and sarcoma. Mesenchymal-like malignant epithelial cells are encountered in fibromatosis-like and spindle cell metaplastic carcinomas.

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References

  1. Polat P, Kantarci M, Alper F, Gursan N, Suma S, Okur A. Nodular fasciitis of the breast and knee in the same patient. Am J Roentgenol. 2002;178:1426–8.

    Article  CAS  Google Scholar 

  2. Son YM, Nahm JH, Moon HJ, Kim MJ, Kim EK. Imaging findings for malignancy-mimicking nodular fasciitis of the breast and a review of previous imaging studies. Acta Radiol Short Rep. 2013;2:2047981613512830.

    PubMed  PubMed Central  Google Scholar 

  3. Brogi E. Benign and malignant spindle cell lesions of the breast. Semin Diagn Pathol. 2004;21:57–64.

    Article  PubMed  Google Scholar 

  4. Gocht A, Bösmüller HC, Bässler R, Tavassoli FA, Moinfar F, Katenkamp D, et al. Breast tumors with myofibroblastic differentiation: clinico-pathological observations in myofibroblastoma and myofibrosarcoma. Pathol Res Pract. 1999;195:1–10.

    Article  CAS  PubMed  Google Scholar 

  5. Taccagni G, Rovere E, Masullo M, Christensen L, Eyden B. Myofibrosarcoma of the breast: review of the literature on myofibroblastic tumors and criteria for defining myofibroblastic differentiation. Am J Surg Pathol. 1997;21:489–96.

    Article  CAS  PubMed  Google Scholar 

  6. Mizuta N, Sakaguchi K, Mizuta M, Imai A, Nakatsukasa K, Morita M, et al. Myoid hamartoma of the breast that proved difficult to diagnose: a case report. World J Surg Oncol. 2012;10:12.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Magro G, Longo FR, Salvatorelli L, Vasquez E, Vecchio GM. Lipomatous myofibroblastoma of the breast: case report with diagnostic and histogenetic considerations. Pathologica. 2014;106:36–40.

    CAS  PubMed  Google Scholar 

  8. Dwyer JB, Clark BZ. Low-grade fibromatosis-like spindle cell carcinoma of the breast. Arch Pathol Lab Med. 2015;139:552–7.

    Article  PubMed  Google Scholar 

  9. Gobbi H, Simpson JF, Jensen RA, Olson SJ, Page DL. Metaplastic spindle cell breast tumors arising within papillomas, complex sclerosing lesions, and nipple adenomas. Mod Pathol. 2003;16:893–901.

    Article  PubMed  Google Scholar 

  10. Lacroix-Triki M, Geyer FC, Lambros MB, Savage K, Ellis IO, Lee AH, Reis-Filho JS. β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast. Mod Pathol. 2010;23:1438–48.

    Article  CAS  PubMed  Google Scholar 

  11. Takano EA, Hunter SM, Campbell IG, Fox SB. Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous. J Clin Pathol. 2015;68:362–7.

    Article  PubMed  Google Scholar 

  12. Reis-Filho JS, Lakhani SR, Gobbi H, Sneige N. Metaplastic carcinoma. In: Lakhani SR, Ellis IO, Schnitt SJ, Tan PH, van de Vijver MJ, editors. WHO classification of tumours of the breast. Lyon: IARC Press; 2012. p. 48–52.

    Google Scholar 

  13. Rakha EA, Aleskandarany MA, Lee AH, Ellis IO. An approach to the diagnosis of spindle cell lesions of the breast. Histopathology. 2016;68:33–44.

    Article  PubMed  Google Scholar 

  14. Chia Y, Thike AA, Cheok PY, Chong LY, Tse GM, Tan PH. Stromal keratin expression in phyllodes tumours of the breast: a comparison with other spindle cell breast lesions. J Clin Pathol. 2012;65:339–47.

    Article  PubMed  Google Scholar 

  15. Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, et al. Phyllodes tumours of the breast: a consensus review. Histopathology. 2016;68:5–21.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Cimino-Mathews A, Sharma R, Illei PB, Vang R, Argani P. A subset of malignant phyllodes tumors express p63 and p40: a diagnostic pitfall in breast core needle biopsies. Am J Surg Pathol. 2014;38:1689–96.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Lim SZ, Ong KW, Tan BK, Selvarajan S, Tan PH. Sarcoma of the breast: an update on a rare entity. J Clin Pathol. 2016;69:373–81.

    Article  PubMed  Google Scholar 

  18. Schnitt SJ. Spindle cell lesions of the breast. Surg Pathol. 2009;2:375–90.

    Article  Google Scholar 

  19. McMenamin ME, DeSchryver K, Fletcher CDM. Fibrous lesions of the breast. A review. Int J Surg Pathol. 2000;8:99–108.

    Article  PubMed  Google Scholar 

  20. Lee SJ, Mahoney MC, Shaughnessy E. Dermatofibrosarcoma protuberans of the breast: imaging features and review of the literature. AJR Am J Roentgenol. 2009;193:W64–9.

    Article  PubMed  Google Scholar 

  21. Cribier B, Noacco G, Peltre B, Grosshans E. Stromelysin 3 expression: a useful marker for the differential diagnosis dermatofibroma versus dermatofibrosarcoma protuberans. J Am Acad Dermatol. 2002;46:408–13.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Pathology, Singapore General Hospital, Singapore, Singapore

    Puay Hoon Tan

  2. The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA

    Aysegul A. Sahin

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  1. Puay Hoon Tan
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Tan, P.H., Sahin, A.A. (2017). Spindle Cell Lesions. In: Atlas of Differential Diagnosis in Breast Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6697-4_11

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  • DOI: https://doi.org/10.1007/978-1-4939-6697-4_11

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-6695-0

  • Online ISBN: 978-1-4939-6697-4

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